Amino acid dipepetide frequency for Flavobacterium beibuense F44-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.944AlaAla: 4.944 ± 0.093	0.575AlaCys: 0.575 ± 0.025	3.774AlaAsp: 3.774 ± 0.068	4.381AlaGlu: 4.381 ± 0.074	3.307AlaPhe: 3.307 ± 0.056	4.679AlaGly: 4.679 ± 0.076	1.047AlaHis: 1.047 ± 0.032	5.099AlaIle: 5.099 ± 0.084	4.594AlaLys: 4.594 ± 0.084	6.107AlaLeu: 6.107 ± 0.078	1.623AlaMet: 1.623 ± 0.041	3.647AlaAsn: 3.647 ± 0.065	2.064AlaPro: 2.064 ± 0.061	2.713AlaGln: 2.713 ± 0.052	1.977AlaArg: 1.977 ± 0.047	4.032AlaSer: 4.032 ± 0.07	4.148AlaThr: 4.148 ± 0.101	4.604AlaVal: 4.604 ± 0.077	0.67AlaTrp: 0.67 ± 0.028	2.673AlaTyr: 2.673 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.491CysAla: 0.491 ± 0.028	0.087CysCys: 0.087 ± 0.009	0.514CysAsp: 0.514 ± 0.03	0.515CysGlu: 0.515 ± 0.025	0.428CysPhe: 0.428 ± 0.022	0.72CysGly: 0.72 ± 0.038	0.184CysHis: 0.184 ± 0.015	0.618CysIle: 0.618 ± 0.025	0.456CysLys: 0.456 ± 0.02	0.647CysLeu: 0.647 ± 0.028	0.177CysMet: 0.177 ± 0.013	0.455CysAsn: 0.455 ± 0.027	0.357CysPro: 0.357 ± 0.024	0.187CysGln: 0.187 ± 0.012	0.242CysArg: 0.242 ± 0.012	0.629CysSer: 0.629 ± 0.033	0.519CysThr: 0.519 ± 0.033	0.486CysVal: 0.486 ± 0.021	0.06CysTrp: 0.06 ± 0.008	0.342CysTyr: 0.342 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.809AspAla: 3.809 ± 0.072	0.496AspCys: 0.496 ± 0.026	3.136AspAsp: 3.136 ± 0.065	4.068AspGlu: 4.068 ± 0.06	3.591AspPhe: 3.591 ± 0.062	3.82AspGly: 3.82 ± 0.075	0.791AspHis: 0.791 ± 0.033	4.64AspIle: 4.64 ± 0.065	4.226AspLys: 4.226 ± 0.071	4.76AspLeu: 4.76 ± 0.072	1.318AspMet: 1.318 ± 0.041	3.665AspAsn: 3.665 ± 0.058	1.703AspPro: 1.703 ± 0.048	1.272AspGln: 1.272 ± 0.038	1.995AspArg: 1.995 ± 0.046	3.119AspSer: 3.119 ± 0.057	3.185AspThr: 3.185 ± 0.063	3.867AspVal: 3.867 ± 0.068	0.701AspTrp: 0.701 ± 0.028	3.077AspTyr: 3.077 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.76GluAla: 4.76 ± 0.076	0.414GluCys: 0.414 ± 0.03	3.64GluAsp: 3.64 ± 0.06	5.259GluGlu: 5.259 ± 0.101	2.982GluPhe: 2.982 ± 0.053	4.127GluGly: 4.127 ± 0.065	1.131GluHis: 1.131 ± 0.031	5.147GluIle: 5.147 ± 0.075	5.834GluLys: 5.834 ± 0.103	6.109GluLeu: 6.109 ± 0.089	1.698GluMet: 1.698 ± 0.042	4.55GluAsn: 4.55 ± 0.075	1.773GluPro: 1.773 ± 0.044	2.496GluGln: 2.496 ± 0.053	2.475GluArg: 2.475 ± 0.057	3.207GluSer: 3.207 ± 0.057	3.773GluThr: 3.773 ± 0.058	4.587GluVal: 4.587 ± 0.062	0.708GluTrp: 0.708 ± 0.025	2.81GluTyr: 2.81 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.168PheAla: 3.168 ± 0.057	0.491PheCys: 0.491 ± 0.021	3.29PheAsp: 3.29 ± 0.062	3.322PheGlu: 3.322 ± 0.065	2.594PhePhe: 2.594 ± 0.064	3.359PheGly: 3.359 ± 0.061	0.788PheHis: 0.788 ± 0.027	3.721PheIle: 3.721 ± 0.073	3.435PheLys: 3.435 ± 0.061	4.23PheLeu: 4.23 ± 0.078	1.182PheMet: 1.182 ± 0.036	3.234PheAsn: 3.234 ± 0.055	1.654PhePro: 1.654 ± 0.04	1.209PheGln: 1.209 ± 0.033	1.648PheArg: 1.648 ± 0.037	3.671PheSer: 3.671 ± 0.067	3.646PheThr: 3.646 ± 0.07	2.913PheVal: 2.913 ± 0.056	0.507PheTrp: 0.507 ± 0.023	2.234PheTyr: 2.234 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.113GlyAla: 4.113 ± 0.074	0.753GlyCys: 0.753 ± 0.044	3.557GlyAsp: 3.557 ± 0.067	4.011GlyGlu: 4.011 ± 0.069	3.537GlyPhe: 3.537 ± 0.065	4.632GlyGly: 4.632 ± 0.108	1.124GlyHis: 1.124 ± 0.036	5.079GlyIle: 5.079 ± 0.069	4.865GlyLys: 4.865 ± 0.076	5.602GlyLeu: 5.602 ± 0.072	1.7GlyMet: 1.7 ± 0.047	3.858GlyAsn: 3.858 ± 0.068	1.365GlyPro: 1.365 ± 0.042	1.952GlyGln: 1.952 ± 0.051	2.088GlyArg: 2.088 ± 0.049	4.003GlySer: 4.003 ± 0.077	4.396GlyThr: 4.396 ± 0.107	4.381GlyVal: 4.381 ± 0.068	0.751GlyTrp: 0.751 ± 0.032	3.141GlyTyr: 3.141 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.939HisAla: 0.939 ± 0.033	0.166HisCys: 0.166 ± 0.015	0.93HisAsp: 0.93 ± 0.032	1.037HisGlu: 1.037 ± 0.037	1.037HisPhe: 1.037 ± 0.032	1.019HisGly: 1.019 ± 0.033	0.447HisHis: 0.447 ± 0.024	1.302HisIle: 1.302 ± 0.04	1.178HisLys: 1.178 ± 0.037	1.618HisLeu: 1.618 ± 0.04	0.341HisMet: 0.341 ± 0.019	1.05HisAsn: 1.05 ± 0.031	0.802HisPro: 0.802 ± 0.027	0.572HisGln: 0.572 ± 0.024	0.609HisArg: 0.609 ± 0.024	0.974HisSer: 0.974 ± 0.031	0.976HisThr: 0.976 ± 0.03	0.969HisVal: 0.969 ± 0.027	0.195HisTrp: 0.195 ± 0.012	0.896HisTyr: 0.896 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.491IleAla: 5.491 ± 0.085	0.619IleCys: 0.619 ± 0.026	4.552IleAsp: 4.552 ± 0.075	5.065IleGlu: 5.065 ± 0.073	3.094IlePhe: 3.094 ± 0.066	4.464IleGly: 4.464 ± 0.069	1.253IleHis: 1.253 ± 0.033	5.555IleIle: 5.555 ± 0.091	5.462IleLys: 5.462 ± 0.081	6.224IleLeu: 6.224 ± 0.095	1.5IleMet: 1.5 ± 0.041	4.642IleAsn: 4.642 ± 0.068	3.038IlePro: 3.038 ± 0.057	2.3IleGln: 2.3 ± 0.046	2.487IleArg: 2.487 ± 0.049	4.99IleSer: 4.99 ± 0.069	5.233IleThr: 5.233 ± 0.098	4.626IleVal: 4.626 ± 0.073	0.6IleTrp: 0.6 ± 0.025	2.881IleTyr: 2.881 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.014LysAla: 5.014 ± 0.087	0.326LysCys: 0.326 ± 0.018	4.321LysAsp: 4.321 ± 0.071	6.096LysGlu: 6.096 ± 0.106	2.734LysPhe: 2.734 ± 0.056	4.456LysGly: 4.456 ± 0.077	1.333LysHis: 1.333 ± 0.038	5.297LysIle: 5.297 ± 0.093	6.45LysLys: 6.45 ± 0.119	6.215LysLeu: 6.215 ± 0.1	2.009LysMet: 2.009 ± 0.049	4.681LysAsn: 4.681 ± 0.085	2.488LysPro: 2.488 ± 0.046	2.871LysGln: 2.871 ± 0.063	2.638LysArg: 2.638 ± 0.057	3.972LysSer: 3.972 ± 0.067	4.399LysThr: 4.399 ± 0.078	4.637LysVal: 4.637 ± 0.073	0.792LysTrp: 0.792 ± 0.031	3.008LysTyr: 3.008 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.688LeuAla: 5.688 ± 0.079	0.73LeuCys: 0.73 ± 0.028	4.76LeuAsp: 4.76 ± 0.072	5.782LeuGlu: 5.782 ± 0.088	4.665LeuPhe: 4.665 ± 0.087	5.345LeuGly: 5.345 ± 0.08	1.523LeuHis: 1.523 ± 0.039	6.21LeuIle: 6.21 ± 0.096	6.953LeuLys: 6.953 ± 0.106	8.825LeuLeu: 8.825 ± 0.126	2.091LeuMet: 2.091 ± 0.05	5.519LeuAsn: 5.519 ± 0.083	3.61LeuPro: 3.61 ± 0.065	3.204LeuGln: 3.204 ± 0.061	3.022LeuArg: 3.022 ± 0.052	6.319LeuSer: 6.319 ± 0.082	5.509LeuThr: 5.509 ± 0.081	5.174LeuVal: 5.174 ± 0.064	0.777LeuTrp: 0.777 ± 0.034	3.441LeuTyr: 3.441 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.784MetAla: 1.784 ± 0.044	0.16MetCys: 0.16 ± 0.011	1.294MetAsp: 1.294 ± 0.035	1.613MetGlu: 1.613 ± 0.047	0.942MetPhe: 0.942 ± 0.032	1.579MetGly: 1.579 ± 0.038	0.444MetHis: 0.444 ± 0.021	1.435MetIle: 1.435 ± 0.034	2.177MetLys: 2.177 ± 0.045	2.142MetLeu: 2.142 ± 0.049	0.624MetMet: 0.624 ± 0.031	1.255MetAsn: 1.255 ± 0.037	0.937MetPro: 0.937 ± 0.029	0.915MetGln: 0.915 ± 0.028	0.934MetArg: 0.934 ± 0.033	1.422MetSer: 1.422 ± 0.035	1.22MetThr: 1.22 ± 0.033	1.489MetVal: 1.489 ± 0.043	0.189MetTrp: 0.189 ± 0.014	0.818MetTyr: 0.818 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.755AsnAla: 3.755 ± 0.061	0.536AsnCys: 0.536 ± 0.032	3.507AsnAsp: 3.507 ± 0.065	3.901AsnGlu: 3.901 ± 0.062	2.875AsnPhe: 2.875 ± 0.058	4.409AsnGly: 4.409 ± 0.079	1.056AsnHis: 1.056 ± 0.034	4.693AsnIle: 4.693 ± 0.072	4.173AsnLys: 4.173 ± 0.078	5.022AsnLeu: 5.022 ± 0.07	1.397AsnMet: 1.397 ± 0.036	4.084AsnAsn: 4.084 ± 0.08	2.931AsnPro: 2.931 ± 0.063	2.033AsnGln: 2.033 ± 0.043	2.277AsnArg: 2.277 ± 0.047	3.842AsnSer: 3.842 ± 0.069	3.85AsnThr: 3.85 ± 0.075	3.641AsnVal: 3.641 ± 0.071	0.725AsnTrp: 0.725 ± 0.028	2.904AsnTyr: 2.904 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.339ProAla: 2.339 ± 0.058	0.231ProCys: 0.231 ± 0.014	2.413ProAsp: 2.413 ± 0.053	3.017ProGlu: 3.017 ± 0.051	1.881ProPhe: 1.881 ± 0.043	2.205ProGly: 2.205 ± 0.059	0.584ProHis: 0.584 ± 0.024	2.24ProIle: 2.24 ± 0.047	2.26ProLys: 2.26 ± 0.048	2.952ProLeu: 2.952 ± 0.054	0.76ProMet: 0.76 ± 0.029	2.122ProAsn: 2.122 ± 0.047	0.918ProPro: 0.918 ± 0.043	1.399ProGln: 1.399 ± 0.039	0.849ProArg: 0.849 ± 0.028	2.01ProSer: 2.01 ± 0.048	1.925ProThr: 1.925 ± 0.052	3.041ProVal: 3.041 ± 0.055	0.315ProTrp: 0.315 ± 0.016	1.579ProTyr: 1.579 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.17GlnAla: 2.17 ± 0.053	0.231GlnCys: 0.231 ± 0.016	1.716GlnAsp: 1.716 ± 0.036	2.448GlnGlu: 2.448 ± 0.056	1.562GlnPhe: 1.562 ± 0.042	1.895GlnGly: 1.895 ± 0.048	0.603GlnHis: 0.603 ± 0.026	2.318GlnIle: 2.318 ± 0.052	2.732GlnLys: 2.732 ± 0.064	3.332GlnLeu: 3.332 ± 0.062	0.907GlnMet: 0.907 ± 0.034	2.169GlnAsn: 2.169 ± 0.049	1.251GlnPro: 1.251 ± 0.042	1.704GlnGln: 1.704 ± 0.05	1.215GlnArg: 1.215 ± 0.038	1.885GlnSer: 1.885 ± 0.04	2.019GlnThr: 2.019 ± 0.045	2.033GlnVal: 2.033 ± 0.042	0.402GlnTrp: 0.402 ± 0.023	1.584GlnTyr: 1.584 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.01ArgAla: 2.01 ± 0.047	0.182ArgCys: 0.182 ± 0.014	1.808ArgAsp: 1.808 ± 0.043	2.331ArgGlu: 2.331 ± 0.047	1.88ArgPhe: 1.88 ± 0.044	1.823ArgGly: 1.823 ± 0.046	0.631ArgHis: 0.631 ± 0.028	2.722ArgIle: 2.722 ± 0.059	2.781ArgLys: 2.781 ± 0.061	3.351ArgLeu: 3.351 ± 0.056	0.928ArgMet: 0.928 ± 0.029	2.055ArgAsn: 2.055 ± 0.044	1.031ArgPro: 1.031 ± 0.031	1.101ArgGln: 1.101 ± 0.036	1.25ArgArg: 1.25 ± 0.033	1.751ArgSer: 1.751 ± 0.047	1.776ArgThr: 1.776 ± 0.042	2.229ArgVal: 2.229 ± 0.049	0.367ArgTrp: 0.367 ± 0.017	1.604ArgTyr: 1.604 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.846SerAla: 3.846 ± 0.064	0.681SerCys: 0.681 ± 0.025	3.475SerAsp: 3.475 ± 0.059	3.478SerGlu: 3.478 ± 0.056	3.754SerPhe: 3.754 ± 0.064	4.638SerGly: 4.638 ± 0.088	1.073SerHis: 1.073 ± 0.033	4.409SerIle: 4.409 ± 0.062	3.998SerLys: 3.998 ± 0.059	5.809SerLeu: 5.809 ± 0.084	1.277SerMet: 1.277 ± 0.037	3.453SerAsn: 3.453 ± 0.073	2.149SerPro: 2.149 ± 0.052	2.257SerGln: 2.257 ± 0.049	1.986SerArg: 1.986 ± 0.05	3.819SerSer: 3.819 ± 0.084	3.345SerThr: 3.345 ± 0.073	4.372SerVal: 4.372 ± 0.069	0.706SerTrp: 0.706 ± 0.031	2.852SerTyr: 2.852 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	4.677ThrAla: 4.677 ± 0.101	0.396ThrCys: 0.396 ± 0.026	3.997ThrAsp: 3.997 ± 0.082	3.951ThrGlu: 3.951 ± 0.063	2.946ThrPhe: 2.946 ± 0.054	4.717ThrGly: 4.717 ± 0.098	0.971ThrHis: 0.971 ± 0.032	4.809ThrIle: 4.809 ± 0.093	3.546ThrLys: 3.546 ± 0.063	5.445ThrLeu: 5.445 ± 0.075	1.041ThrMet: 1.041 ± 0.032	3.317ThrAsn: 3.317 ± 0.081	2.754ThrPro: 2.754 ± 0.062	2.18ThrGln: 2.18 ± 0.049	1.613ThrArg: 1.613 ± 0.036	3.628ThrSer: 3.628 ± 0.073	3.916ThrThr: 3.916 ± 0.097	4.718ThrVal: 4.718 ± 0.106	0.627ThrTrp: 0.627 ± 0.031	2.733ThrTyr: 2.733 ± 0.076	0.0ThrXaa: 0.0 ± 0.0
Val	4.434ValAla: 4.434 ± 0.069	0.586ValCys: 0.586 ± 0.027	3.413ValAsp: 3.413 ± 0.065	3.879ValGlu: 3.879 ± 0.061	3.412ValPhe: 3.412 ± 0.063	3.618ValGly: 3.618 ± 0.071	0.957ValHis: 0.957 ± 0.033	5.014ValIle: 5.014 ± 0.069	4.801ValLys: 4.801 ± 0.082	6.018ValLeu: 6.018 ± 0.087	1.574ValMet: 1.574 ± 0.045	4.108ValAsn: 4.108 ± 0.069	2.405ValPro: 2.405 ± 0.051	1.951ValGln: 1.951 ± 0.046	2.139ValArg: 2.139 ± 0.044	4.539ValSer: 4.539 ± 0.08	4.506ValThr: 4.506 ± 0.105	4.529ValVal: 4.529 ± 0.079	0.649ValTrp: 0.649 ± 0.028	2.905ValTyr: 2.905 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.634TrpAla: 0.634 ± 0.025	0.093TrpCys: 0.093 ± 0.01	0.606TrpAsp: 0.606 ± 0.026	0.711TrpGlu: 0.711 ± 0.027	0.549TrpPhe: 0.549 ± 0.024	0.645TrpGly: 0.645 ± 0.024	0.233TrpHis: 0.233 ± 0.015	0.713TrpIle: 0.713 ± 0.027	0.734TrpLys: 0.734 ± 0.027	0.931TrpLeu: 0.931 ± 0.031	0.31TrpMet: 0.31 ± 0.017	0.692TrpAsn: 0.692 ± 0.029	0.233TrpPro: 0.233 ± 0.015	0.41TrpGln: 0.41 ± 0.022	0.38TrpArg: 0.38 ± 0.021	0.621TrpSer: 0.621 ± 0.031	0.603TrpThr: 0.603 ± 0.028	0.658TrpVal: 0.658 ± 0.029	0.129TrpTrp: 0.129 ± 0.011	0.474TrpTyr: 0.474 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.593TyrAla: 2.593 ± 0.049	0.362TyrCys: 0.362 ± 0.02	2.535TyrAsp: 2.535 ± 0.059	2.617TyrGlu: 2.617 ± 0.052	2.524TyrPhe: 2.524 ± 0.057	2.756TyrGly: 2.756 ± 0.054	0.883TyrHis: 0.883 ± 0.03	3.054TyrIle: 3.054 ± 0.062	3.081TyrLys: 3.081 ± 0.065	3.808TyrLeu: 3.808 ± 0.067	0.916TyrMet: 0.916 ± 0.032	3.057TyrAsn: 3.057 ± 0.057	1.576TyrPro: 1.576 ± 0.041	1.452TyrGln: 1.452 ± 0.042	1.791TyrArg: 1.791 ± 0.04	2.943TyrSer: 2.943 ± 0.058	3.038TyrThr: 3.038 ± 0.082	2.484TyrVal: 2.484 ± 0.05	0.487TyrTrp: 0.487 ± 0.023	2.367TyrTyr: 2.367 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3263 proteins (1084350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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