Amino acid dipepetide frequency for Mycoplasma flocculare ATCC 27399

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.17AlaAla: 3.17 ± 0.179
0.262AlaCys: 0.262 ± 0.041
2.205AlaAsp: 2.205 ± 0.102
3.053AlaGlu: 3.053 ± 0.127
3.211AlaPhe: 3.211 ± 0.121
2.548AlaGly: 2.548 ± 0.136
0.758AlaHis: 0.758 ± 0.063
5.398AlaIle: 5.398 ± 0.199
6.967AlaLys: 6.967 ± 0.198
4.925AlaLeu: 4.925 ± 0.17
0.722AlaMet: 0.722 ± 0.056
4.063AlaAsn: 4.063 ± 0.144
1.393AlaPro: 1.393 ± 0.105
2.16AlaGln: 2.16 ± 0.114
1.867AlaArg: 1.867 ± 0.102
3.351AlaSer: 3.351 ± 0.123
3.112AlaThr: 3.112 ± 0.128
2.372AlaVal: 2.372 ± 0.117
0.41AlaTrp: 0.41 ± 0.047
1.421AlaTyr: 1.421 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.198CysAla: 0.198 ± 0.032
0.036CysCys: 0.036 ± 0.011
0.225CysAsp: 0.225 ± 0.034
0.253CysGlu: 0.253 ± 0.034
0.361CysPhe: 0.361 ± 0.049
0.28CysGly: 0.28 ± 0.04
0.099CysHis: 0.099 ± 0.022
0.289CysIle: 0.289 ± 0.035
0.406CysLys: 0.406 ± 0.041
0.406CysLeu: 0.406 ± 0.047
0.041CysMet: 0.041 ± 0.013
0.203CysAsn: 0.203 ± 0.026
0.194CysPro: 0.194 ± 0.043
0.23CysGln: 0.23 ± 0.041
0.113CysArg: 0.113 ± 0.025
0.325CysSer: 0.325 ± 0.048
0.122CysThr: 0.122 ± 0.024
0.212CysVal: 0.212 ± 0.031
0.063CysTrp: 0.063 ± 0.016
0.167CysTyr: 0.167 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
2.201AspAla: 2.201 ± 0.099
0.167AspCys: 0.167 ± 0.031
1.912AspAsp: 1.912 ± 0.091
3.152AspGlu: 3.152 ± 0.13
4.649AspPhe: 4.649 ± 0.154
1.885AspGly: 1.885 ± 0.108
0.537AspHis: 0.537 ± 0.054
3.946AspIle: 3.946 ± 0.148
4.64AspLys: 4.64 ± 0.151
5.308AspLeu: 5.308 ± 0.152
0.419AspMet: 0.419 ± 0.05
3.188AspAsn: 3.188 ± 0.126
1.596AspPro: 1.596 ± 0.093
1.939AspGln: 1.939 ± 0.115
1.191AspArg: 1.191 ± 0.077
3.49AspSer: 3.49 ± 0.137
1.61AspThr: 1.61 ± 0.087
2.002AspVal: 2.002 ± 0.085
0.492AspTrp: 0.492 ± 0.049
2.304AspTyr: 2.304 ± 0.115
0.0AspXaa: 0.0 ± 0.0
Glu
2.638GluAla: 2.638 ± 0.119
0.104GluCys: 0.104 ± 0.022
1.935GluAsp: 1.935 ± 0.093
3.423GluGlu: 3.423 ± 0.148
4.275GluPhe: 4.275 ± 0.169
1.858GluGly: 1.858 ± 0.117
0.627GluHis: 0.627 ± 0.056
8.812GluIle: 8.812 ± 0.208
9.822GluLys: 9.822 ± 0.215
5.908GluLeu: 5.908 ± 0.177
0.956GluMet: 0.956 ± 0.077
7.436GluAsn: 7.436 ± 0.25
1.402GluPro: 1.402 ± 0.098
2.359GluGln: 2.359 ± 0.115
1.547GluArg: 1.547 ± 0.119
3.387GluSer: 3.387 ± 0.137
2.945GluThr: 2.945 ± 0.119
2.525GluVal: 2.525 ± 0.108
0.347GluTrp: 0.347 ± 0.035
2.074GluTyr: 2.074 ± 0.111
0.0GluXaa: 0.0 ± 0.0
Phe
4.176PheAla: 4.176 ± 0.144
0.442PheCys: 0.442 ± 0.054
4.149PheAsp: 4.149 ± 0.137
4.428PheGlu: 4.428 ± 0.138
5.033PhePhe: 5.033 ± 0.229
3.545PheGly: 3.545 ± 0.12
0.812PheHis: 0.812 ± 0.062
5.466PheIle: 5.466 ± 0.177
5.055PheLys: 5.055 ± 0.141
8.09PheLeu: 8.09 ± 0.257
0.69PheMet: 0.69 ± 0.067
4.207PheAsn: 4.207 ± 0.191
1.799PhePro: 1.799 ± 0.094
2.417PheGln: 2.417 ± 0.101
2.029PheArg: 2.029 ± 0.109
6.295PheSer: 6.295 ± 0.225
2.611PheThr: 2.611 ± 0.118
3.802PheVal: 3.802 ± 0.149
0.983PheTrp: 0.983 ± 0.089
2.841PheTyr: 2.841 ± 0.124
0.0PheXaa: 0.0 ± 0.0
Gly
2.458GlyAla: 2.458 ± 0.136
0.18GlyCys: 0.18 ± 0.028
1.993GlyAsp: 1.993 ± 0.094
2.458GlyGlu: 2.458 ± 0.117
3.423GlyPhe: 3.423 ± 0.135
2.656GlyGly: 2.656 ± 0.152
0.83GlyHis: 0.83 ± 0.077
4.92GlyIle: 4.92 ± 0.226
4.997GlyLys: 4.997 ± 0.177
4.158GlyLeu: 4.158 ± 0.153
0.713GlyMet: 0.713 ± 0.056
2.309GlyAsn: 2.309 ± 0.125
1.105GlyPro: 1.105 ± 0.076
2.07GlyGln: 2.07 ± 0.087
1.443GlyArg: 1.443 ± 0.092
2.904GlySer: 2.904 ± 0.115
2.322GlyThr: 2.322 ± 0.102
2.557GlyVal: 2.557 ± 0.129
0.537GlyTrp: 0.537 ± 0.058
1.723GlyTyr: 1.723 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
0.6HisAla: 0.6 ± 0.055
0.041HisCys: 0.041 ± 0.014
0.595HisAsp: 0.595 ± 0.061
0.713HisGlu: 0.713 ± 0.051
0.997HisPhe: 0.997 ± 0.064
0.694HisGly: 0.694 ± 0.063
0.248HisHis: 0.248 ± 0.039
1.173HisIle: 1.173 ± 0.077
1.173HisLys: 1.173 ± 0.077
1.245HisLeu: 1.245 ± 0.076
0.167HisMet: 0.167 ± 0.029
0.938HisAsn: 0.938 ± 0.073
0.523HisPro: 0.523 ± 0.048
0.532HisGln: 0.532 ± 0.047
0.483HisArg: 0.483 ± 0.043
0.974HisSer: 0.974 ± 0.065
0.528HisThr: 0.528 ± 0.055
0.496HisVal: 0.496 ± 0.047
0.099HisTrp: 0.099 ± 0.02
0.51HisTyr: 0.51 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
5.727IleAla: 5.727 ± 0.183
0.564IleCys: 0.564 ± 0.058
5.141IleAsp: 5.141 ± 0.179
6.363IleGlu: 6.363 ± 0.192
6.967IlePhe: 6.967 ± 0.267
4.667IleGly: 4.667 ± 0.239
1.015IleHis: 1.015 ± 0.07
9.583IleIle: 9.583 ± 0.308
9.425IleLys: 9.425 ± 0.201
9.556IleLeu: 9.556 ± 0.27
1.195IleMet: 1.195 ± 0.08
7.229IleAsn: 7.229 ± 0.201
3.238IlePro: 3.238 ± 0.139
2.949IleGln: 2.949 ± 0.115
3.044IleArg: 3.044 ± 0.118
8.861IleSer: 8.861 ± 0.236
4.397IleThr: 4.397 ± 0.179
4.613IleVal: 4.613 ± 0.142
0.915IleTrp: 0.915 ± 0.063
3.63IleTyr: 3.63 ± 0.143
0.0IleXaa: 0.0 ± 0.0
Lys
4.78LysAla: 4.78 ± 0.17
0.307LysCys: 0.307 ± 0.039
4.009LysAsp: 4.009 ± 0.149
6.147LysGlu: 6.147 ± 0.184
5.628LysPhe: 5.628 ± 0.165
3.572LysGly: 3.572 ± 0.148
1.249LysHis: 1.249 ± 0.07
13.786LysIle: 13.786 ± 0.34
12.582LysLys: 12.582 ± 0.308
9.696LysLeu: 9.696 ± 0.246
1.908LysMet: 1.908 ± 0.102
11.617LysAsn: 11.617 ± 0.288
3.053LysPro: 3.053 ± 0.151
3.991LysGln: 3.991 ± 0.156
2.521LysArg: 2.521 ± 0.107
6.634LysSer: 6.634 ± 0.196
6.593LysThr: 6.593 ± 0.174
4.704LysVal: 4.704 ± 0.169
0.902LysTrp: 0.902 ± 0.073
3.874LysTyr: 3.874 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
6.507LeuAla: 6.507 ± 0.195
0.284LeuCys: 0.284 ± 0.038
5.813LeuAsp: 5.813 ± 0.18
7.851LeuGlu: 7.851 ± 0.234
5.529LeuPhe: 5.529 ± 0.218
4.586LeuGly: 4.586 ± 0.176
1.159LeuHis: 1.159 ± 0.075
9.736LeuIle: 9.736 ± 0.334
10.44LeuLys: 10.44 ± 0.218
8.293LeuLeu: 8.293 ± 0.239
1.037LeuMet: 1.037 ± 0.079
7.017LeuAsn: 7.017 ± 0.231
3.03LeuPro: 3.03 ± 0.118
3.071LeuGln: 3.071 ± 0.118
2.814LeuArg: 2.814 ± 0.117
6.539LeuSer: 6.539 ± 0.204
4.785LeuThr: 4.785 ± 0.166
6.106LeuVal: 6.106 ± 0.182
0.735LeuTrp: 0.735 ± 0.056
2.841LeuTyr: 2.841 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
0.915MetAla: 0.915 ± 0.076
0.045MetCys: 0.045 ± 0.014
0.419MetAsp: 0.419 ± 0.047
0.753MetGlu: 0.753 ± 0.065
0.613MetPhe: 0.613 ± 0.052
0.546MetGly: 0.546 ± 0.049
0.221MetHis: 0.221 ± 0.029
1.046MetIle: 1.046 ± 0.072
1.366MetLys: 1.366 ± 0.076
1.258MetLeu: 1.258 ± 0.071
0.198MetMet: 0.198 ± 0.031
0.834MetAsn: 0.834 ± 0.073
0.501MetPro: 0.501 ± 0.05
0.604MetGln: 0.604 ± 0.05
0.379MetArg: 0.379 ± 0.047
0.771MetSer: 0.771 ± 0.06
0.64MetThr: 0.64 ± 0.056
0.731MetVal: 0.731 ± 0.068
0.09MetTrp: 0.09 ± 0.02
0.302MetTyr: 0.302 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.188AsnAla: 3.188 ± 0.12
0.392AsnCys: 0.392 ± 0.055
3.242AsnAsp: 3.242 ± 0.153
4.658AsnGlu: 4.658 ± 0.172
7.085AsnPhe: 7.085 ± 0.246
2.877AsnGly: 2.877 ± 0.134
1.001AsnHis: 1.001 ± 0.06
5.835AsnIle: 5.835 ± 0.169
7.04AsnLys: 7.04 ± 0.225
9.917AsnLeu: 9.917 ± 0.251
0.807AsnMet: 0.807 ± 0.064
5.362AsnAsn: 5.362 ± 0.209
3.175AsnPro: 3.175 ± 0.131
3.653AsnGln: 3.653 ± 0.146
2.052AsnArg: 2.052 ± 0.088
6.386AsnSer: 6.386 ± 0.242
2.791AsnThr: 2.791 ± 0.118
2.927AsnVal: 2.927 ± 0.122
0.961AsnTrp: 0.961 ± 0.067
3.549AsnTyr: 3.549 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
1.605ProAla: 1.605 ± 0.093
0.104ProCys: 0.104 ± 0.025
1.497ProAsp: 1.497 ± 0.093
2.57ProGlu: 2.57 ± 0.133
1.831ProPhe: 1.831 ± 0.089
1.556ProGly: 1.556 ± 0.087
0.388ProHis: 0.388 ± 0.046
2.674ProIle: 2.674 ± 0.103
3.184ProLys: 3.184 ± 0.147
2.598ProLeu: 2.598 ± 0.112
0.257ProMet: 0.257 ± 0.035
2.264ProAsn: 2.264 ± 0.104
0.627ProPro: 0.627 ± 0.045
1.118ProGln: 1.118 ± 0.072
0.816ProArg: 0.816 ± 0.067
1.957ProSer: 1.957 ± 0.093
1.452ProThr: 1.452 ± 0.082
1.745ProVal: 1.745 ± 0.127
0.266ProTrp: 0.266 ± 0.034
1.078ProTyr: 1.078 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
1.926GlnAla: 1.926 ± 0.1
0.045GlnCys: 0.045 ± 0.014
1.583GlnAsp: 1.583 ± 0.094
2.706GlnGlu: 2.706 ± 0.145
1.948GlnPhe: 1.948 ± 0.09
1.637GlnGly: 1.637 ± 0.103
0.446GlnHis: 0.446 ± 0.043
4.803GlnIle: 4.803 ± 0.144
5.831GlnLys: 5.831 ± 0.173
3.08GlnLeu: 3.08 ± 0.116
0.464GlnMet: 0.464 ± 0.045
3.887GlnAsn: 3.887 ± 0.174
0.875GlnPro: 0.875 ± 0.061
1.754GlnGln: 1.754 ± 0.155
1.105GlnArg: 1.105 ± 0.068
2.138GlnSer: 2.138 ± 0.121
1.962GlnThr: 1.962 ± 0.099
1.84GlnVal: 1.84 ± 0.103
0.262GlnTrp: 0.262 ± 0.034
1.024GlnTyr: 1.024 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
1.592ArgAla: 1.592 ± 0.098
0.149ArgCys: 0.149 ± 0.028
1.412ArgAsp: 1.412 ± 0.076
1.903ArgGlu: 1.903 ± 0.113
2.016ArgPhe: 2.016 ± 0.098
1.375ArgGly: 1.375 ± 0.092
0.37ArgHis: 0.37 ± 0.042
3.08ArgIle: 3.08 ± 0.119
3.215ArgLys: 3.215 ± 0.127
2.706ArgLeu: 2.706 ± 0.112
0.478ArgMet: 0.478 ± 0.039
1.84ArgAsn: 1.84 ± 0.088
0.852ArgPro: 0.852 ± 0.058
1.375ArgGln: 1.375 ± 0.078
1.051ArgArg: 1.051 ± 0.09
1.596ArgSer: 1.596 ± 0.08
1.218ArgThr: 1.218 ± 0.064
1.466ArgVal: 1.466 ± 0.078
0.329ArgTrp: 0.329 ± 0.036
1.028ArgTyr: 1.028 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
3.847SerAla: 3.847 ± 0.162
0.37SerCys: 0.37 ± 0.042
3.441SerAsp: 3.441 ± 0.104
4.843SerGlu: 4.843 ± 0.174
5.272SerPhe: 5.272 ± 0.187
3.86SerGly: 3.86 ± 0.143
1.073SerHis: 1.073 ± 0.077
5.696SerIle: 5.696 ± 0.18
6.661SerLys: 6.661 ± 0.175
7.283SerLeu: 7.283 ± 0.226
0.794SerMet: 0.794 ± 0.063
4.383SerAsn: 4.383 ± 0.178
2.219SerPro: 2.219 ± 0.103
3.653SerGln: 3.653 ± 0.16
2.138SerArg: 2.138 ± 0.096
5.258SerSer: 5.258 ± 0.356
3.184SerThr: 3.184 ± 0.15
3.698SerVal: 3.698 ± 0.156
0.731SerTrp: 0.731 ± 0.062
2.674SerTyr: 2.674 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
2.363ThrAla: 2.363 ± 0.119
0.167ThrCys: 0.167 ± 0.034
1.989ThrAsp: 1.989 ± 0.096
2.913ThrGlu: 2.913 ± 0.126
2.737ThrPhe: 2.737 ± 0.109
2.552ThrGly: 2.552 ± 0.114
0.618ThrHis: 0.618 ± 0.059
4.798ThrIle: 4.798 ± 0.17
5.804ThrLys: 5.804 ± 0.195
4.104ThrLeu: 4.104 ± 0.151
0.478ThrMet: 0.478 ± 0.042
3.666ThrAsn: 3.666 ± 0.152
1.466ThrPro: 1.466 ± 0.083
1.632ThrGln: 1.632 ± 0.107
1.506ThrArg: 1.506 ± 0.09
3.256ThrSer: 3.256 ± 0.155
2.697ThrThr: 2.697 ± 0.136
2.111ThrVal: 2.111 ± 0.102
0.41ThrTrp: 0.41 ± 0.05
1.412ThrTyr: 1.412 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
3.175ValAla: 3.175 ± 0.129
0.271ValCys: 0.271 ± 0.037
2.746ValAsp: 2.746 ± 0.117
3.346ValGlu: 3.346 ± 0.133
3.824ValPhe: 3.824 ± 0.157
2.855ValGly: 2.855 ± 0.139
0.645ValHis: 0.645 ± 0.056
4.262ValIle: 4.262 ± 0.155
4.266ValLys: 4.266 ± 0.144
4.676ValLeu: 4.676 ± 0.167
0.568ValMet: 0.568 ± 0.047
3.085ValAsn: 3.085 ± 0.131
1.249ValPro: 1.249 ± 0.072
1.592ValGln: 1.592 ± 0.092
1.384ValArg: 1.384 ± 0.076
3.905ValSer: 3.905 ± 0.154
1.781ValThr: 1.781 ± 0.095
2.891ValVal: 2.891 ± 0.144
0.392ValTrp: 0.392 ± 0.04
1.687ValTyr: 1.687 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.433TrpAla: 0.433 ± 0.042
0.027TrpCys: 0.027 ± 0.016
0.474TrpAsp: 0.474 ± 0.053
0.582TrpGlu: 0.582 ± 0.053
0.636TrpPhe: 0.636 ± 0.054
0.496TrpGly: 0.496 ± 0.051
0.095TrpHis: 0.095 ± 0.02
1.154TrpIle: 1.154 ± 0.084
1.069TrpLys: 1.069 ± 0.061
0.884TrpLeu: 0.884 ± 0.073
0.095TrpMet: 0.095 ± 0.021
0.744TrpAsn: 0.744 ± 0.052
0.248TrpPro: 0.248 ± 0.032
0.433TrpGln: 0.433 ± 0.043
0.257TrpArg: 0.257 ± 0.035
0.401TrpSer: 0.401 ± 0.048
0.532TrpThr: 0.532 ± 0.052
0.428TrpVal: 0.428 ± 0.052
0.113TrpTrp: 0.113 ± 0.028
0.419TrpTyr: 0.419 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.867TyrAla: 1.867 ± 0.088
0.266TyrCys: 0.266 ± 0.034
1.849TyrAsp: 1.849 ± 0.097
2.264TyrGlu: 2.264 ± 0.104
2.837TyrPhe: 2.837 ± 0.141
1.709TyrGly: 1.709 ± 0.098
0.537TyrHis: 0.537 ± 0.06
2.625TyrIle: 2.625 ± 0.113
3.612TyrLys: 3.612 ± 0.156
4.086TyrLeu: 4.086 ± 0.143
0.244TyrMet: 0.244 ± 0.031
2.625TyrAsn: 2.625 ± 0.116
1.042TyrPro: 1.042 ± 0.077
1.781TyrGln: 1.781 ± 0.085
1.312TyrArg: 1.312 ± 0.078
2.647TyrSer: 2.647 ± 0.112
1.398TyrThr: 1.398 ± 0.079
1.375TyrVal: 1.375 ± 0.079
0.483TyrTrp: 0.483 ± 0.043
1.727TyrTyr: 1.727 ± 0.118
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 553 proteins (221749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski