Amino acid dipepetide frequency for Mixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.681AlaAla: 11.681 ± 0.096	1.285AlaCys: 1.285 ± 0.024	5.191AlaAsp: 5.191 ± 0.047	5.348AlaGlu: 5.348 ± 0.047	3.385AlaPhe: 3.385 ± 0.033	6.217AlaGly: 6.217 ± 0.053	2.426AlaHis: 2.426 ± 0.032	4.748AlaIle: 4.748 ± 0.037	4.642AlaLys: 4.642 ± 0.046	9.904AlaLeu: 9.904 ± 0.066	2.21AlaMet: 2.21 ± 0.025	3.103AlaAsn: 3.103 ± 0.033	5.802AlaPro: 5.802 ± 0.057	4.908AlaGln: 4.908 ± 0.049	7.177AlaArg: 7.177 ± 0.052	10.821AlaSer: 10.821 ± 0.081	6.457AlaThr: 6.457 ± 0.046	5.752AlaVal: 5.752 ± 0.039	1.212AlaTrp: 1.212 ± 0.021	2.509AlaTyr: 2.509 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.037CysAla: 1.037 ± 0.021	0.307CysCys: 0.307 ± 0.011	0.642CysAsp: 0.642 ± 0.013	0.581CysGlu: 0.581 ± 0.013	0.486CysPhe: 0.486 ± 0.013	0.788CysGly: 0.788 ± 0.016	0.342CysHis: 0.342 ± 0.012	0.639CysIle: 0.639 ± 0.014	0.525CysLys: 0.525 ± 0.012	1.305CysLeu: 1.305 ± 0.026	0.243CysMet: 0.243 ± 0.008	0.367CysAsn: 0.367 ± 0.01	0.639CysPro: 0.639 ± 0.015	0.518CysGln: 0.518 ± 0.014	0.778CysArg: 0.778 ± 0.016	1.02CysSer: 1.02 ± 0.019	0.734CysThr: 0.734 ± 0.016	0.679CysVal: 0.679 ± 0.015	0.16CysTrp: 0.16 ± 0.007	0.339CysTyr: 0.339 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.86AspAla: 5.86 ± 0.044	0.663AspCys: 0.663 ± 0.016	4.58AspAsp: 4.58 ± 0.049	4.562AspGlu: 4.562 ± 0.048	1.969AspPhe: 1.969 ± 0.029	3.758AspGly: 3.758 ± 0.032	1.388AspHis: 1.388 ± 0.023	2.583AspIle: 2.583 ± 0.032	2.262AspLys: 2.262 ± 0.03	5.592AspLeu: 5.592 ± 0.048	1.136AspMet: 1.136 ± 0.018	1.405AspAsn: 1.405 ± 0.02	3.112AspPro: 3.112 ± 0.031	2.135AspGln: 2.135 ± 0.026	3.521AspArg: 3.521 ± 0.032	4.448AspSer: 4.448 ± 0.042	2.953AspThr: 2.953 ± 0.031	3.553AspVal: 3.553 ± 0.035	0.767AspTrp: 0.767 ± 0.017	1.507AspTyr: 1.507 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.971GluAla: 5.971 ± 0.054	0.538GluCys: 0.538 ± 0.014	3.566GluAsp: 3.566 ± 0.041	4.177GluGlu: 4.177 ± 0.058	1.295GluPhe: 1.295 ± 0.02	2.975GluGly: 2.975 ± 0.031	1.522GluHis: 1.522 ± 0.024	2.616GluIle: 2.616 ± 0.028	2.259GluLys: 2.259 ± 0.03	5.474GluLeu: 5.474 ± 0.046	1.166GluMet: 1.166 ± 0.02	1.313GluAsn: 1.313 ± 0.02	3.03GluPro: 3.03 ± 0.037	2.769GluGln: 2.769 ± 0.034	4.181GluArg: 4.181 ± 0.034	4.095GluSer: 4.095 ± 0.037	3.17GluThr: 3.17 ± 0.03	2.829GluVal: 2.829 ± 0.029	0.637GluTrp: 0.637 ± 0.012	1.294GluTyr: 1.294 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.562PheAla: 3.562 ± 0.038	0.502PheCys: 0.502 ± 0.013	2.322PheAsp: 2.322 ± 0.028	1.971PheGlu: 1.971 ± 0.025	1.229PhePhe: 1.229 ± 0.021	2.58PheGly: 2.58 ± 0.035	0.667PheHis: 0.667 ± 0.014	1.399PheIle: 1.399 ± 0.023	1.266PheLys: 1.266 ± 0.024	2.837PheLeu: 2.837 ± 0.032	0.604PheMet: 0.604 ± 0.014	1.06PheAsn: 1.06 ± 0.021	1.356PhePro: 1.356 ± 0.02	1.021PheGln: 1.021 ± 0.018	1.719PheArg: 1.719 ± 0.024	2.651PheSer: 2.651 ± 0.032	1.803PheThr: 1.803 ± 0.029	2.419PheVal: 2.419 ± 0.027	0.472PheTrp: 0.472 ± 0.011	0.881PheTyr: 0.881 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.248GlyAla: 5.248 ± 0.041	0.739GlyCys: 0.739 ± 0.016	3.103GlyAsp: 3.103 ± 0.032	3.003GlyGlu: 3.003 ± 0.031	2.367GlyPhe: 2.367 ± 0.029	4.351GlyGly: 4.351 ± 0.055	1.656GlyHis: 1.656 ± 0.022	2.919GlyIle: 2.919 ± 0.033	3.307GlyLys: 3.307 ± 0.036	6.052GlyLeu: 6.052 ± 0.047	1.352GlyMet: 1.352 ± 0.021	1.891GlyAsn: 1.891 ± 0.027	2.989GlyPro: 2.989 ± 0.037	2.913GlyGln: 2.913 ± 0.032	3.947GlyArg: 3.947 ± 0.037	5.979GlySer: 5.979 ± 0.058	3.634GlyThr: 3.634 ± 0.035	3.469GlyVal: 3.469 ± 0.035	0.855GlyTrp: 0.855 ± 0.017	1.783GlyTyr: 1.783 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.557HisAla: 2.557 ± 0.032	0.37HisCys: 0.37 ± 0.011	1.395HisAsp: 1.395 ± 0.019	1.313HisGlu: 1.313 ± 0.019	0.882HisPhe: 0.882 ± 0.016	1.486HisGly: 1.486 ± 0.022	0.881HisHis: 0.881 ± 0.02	1.056HisIle: 1.056 ± 0.018	0.907HisLys: 0.907 ± 0.016	2.521HisLeu: 2.521 ± 0.027	0.439HisMet: 0.439 ± 0.012	0.642HisAsn: 0.642 ± 0.014	1.451HisPro: 1.451 ± 0.022	1.017HisGln: 1.017 ± 0.016	1.76HisArg: 1.76 ± 0.026	2.05HisSer: 2.05 ± 0.026	1.351HisThr: 1.351 ± 0.02	1.472HisVal: 1.472 ± 0.019	0.317HisTrp: 0.317 ± 0.011	0.693HisTyr: 0.693 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.875IleAla: 4.875 ± 0.041	0.71IleCys: 0.71 ± 0.016	3.133IleAsp: 3.133 ± 0.03	2.772IleGlu: 2.772 ± 0.034	1.62IlePhe: 1.62 ± 0.025	2.866IleGly: 2.866 ± 0.035	0.948IleHis: 0.948 ± 0.018	2.147IleIle: 2.147 ± 0.03	2.129IleLys: 2.129 ± 0.026	3.96IleLeu: 3.96 ± 0.041	0.902IleMet: 0.902 ± 0.017	1.455IleAsn: 1.455 ± 0.022	2.253IlePro: 2.253 ± 0.025	1.589IleGln: 1.589 ± 0.024	2.756IleArg: 2.756 ± 0.03	3.701IleSer: 3.701 ± 0.036	2.498IleThr: 2.498 ± 0.028	3.193IleVal: 3.193 ± 0.031	0.62IleTrp: 0.62 ± 0.016	1.213IleTyr: 1.213 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.675LysAla: 4.675 ± 0.049	0.381LysCys: 0.381 ± 0.013	2.306LysAsp: 2.306 ± 0.03	2.433LysGlu: 2.433 ± 0.031	0.974LysPhe: 0.974 ± 0.019	2.542LysGly: 2.542 ± 0.034	1.051LysHis: 1.051 ± 0.017	1.96LysIle: 1.96 ± 0.022	2.317LysLys: 2.317 ± 0.042	4.111LysLeu: 4.111 ± 0.041	0.885LysMet: 0.885 ± 0.017	1.038LysAsn: 1.038 ± 0.02	2.743LysPro: 2.743 ± 0.035	1.957LysGln: 1.957 ± 0.029	3.581LysArg: 3.581 ± 0.037	3.39LysSer: 3.39 ± 0.035	2.839LysThr: 2.839 ± 0.032	2.373LysVal: 2.373 ± 0.031	0.436LysTrp: 0.436 ± 0.013	1.002LysTyr: 1.002 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	10.648LeuAla: 10.648 ± 0.062	1.313LeuCys: 1.313 ± 0.021	5.795LeuAsp: 5.795 ± 0.043	5.112LeuGlu: 5.112 ± 0.047	3.044LeuPhe: 3.044 ± 0.038	5.728LeuGly: 5.728 ± 0.044	2.356LeuHis: 2.356 ± 0.024	4.052LeuIle: 4.052 ± 0.043	3.869LeuLys: 3.869 ± 0.04	9.365LeuLeu: 9.365 ± 0.081	1.658LeuMet: 1.658 ± 0.022	2.755LeuAsn: 2.755 ± 0.033	6.256LeuPro: 6.256 ± 0.043	4.155LeuGln: 4.155 ± 0.044	6.324LeuArg: 6.324 ± 0.043	8.579LeuSer: 8.579 ± 0.053	5.503LeuThr: 5.503 ± 0.046	5.752LeuVal: 5.752 ± 0.046	1.025LeuTrp: 1.025 ± 0.019	2.217LeuTyr: 2.217 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.055MetAla: 2.055 ± 0.03	0.191MetCys: 0.191 ± 0.008	0.971MetAsp: 0.971 ± 0.016	0.819MetGlu: 0.819 ± 0.015	0.531MetPhe: 0.531 ± 0.014	1.113MetGly: 1.113 ± 0.019	0.462MetHis: 0.462 ± 0.012	0.922MetIle: 0.922 ± 0.018	0.706MetLys: 0.706 ± 0.014	2.174MetLeu: 2.174 ± 0.028	0.458MetMet: 0.458 ± 0.012	0.558MetAsn: 0.558 ± 0.014	1.461MetPro: 1.461 ± 0.024	1.002MetGln: 1.002 ± 0.018	1.407MetArg: 1.407 ± 0.02	2.086MetSer: 2.086 ± 0.026	1.538MetThr: 1.538 ± 0.018	0.938MetVal: 0.938 ± 0.017	0.167MetTrp: 0.167 ± 0.007	0.399MetTyr: 0.399 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.258AsnAla: 3.258 ± 0.036	0.315AsnCys: 0.315 ± 0.009	1.701AsnAsp: 1.701 ± 0.026	1.61AsnGlu: 1.61 ± 0.02	0.956AsnPhe: 0.956 ± 0.018	2.449AsnGly: 2.449 ± 0.031	0.58AsnHis: 0.58 ± 0.013	1.36AsnIle: 1.36 ± 0.021	1.2AsnLys: 1.2 ± 0.021	2.728AsnLeu: 2.728 ± 0.033	0.594AsnMet: 0.594 ± 0.014	0.892AsnAsn: 0.892 ± 0.02	1.637AsnPro: 1.637 ± 0.025	0.95AsnGln: 0.95 ± 0.017	1.706AsnArg: 1.706 ± 0.027	2.089AsnSer: 2.089 ± 0.027	1.575AsnThr: 1.575 ± 0.022	1.971AsnVal: 1.971 ± 0.027	0.333AsnTrp: 0.333 ± 0.01	0.717AsnTyr: 0.717 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.912ProAla: 6.912 ± 0.059	0.526ProCys: 0.526 ± 0.014	3.297ProAsp: 3.297 ± 0.035	3.146ProGlu: 3.146 ± 0.032	1.89ProPhe: 1.89 ± 0.025	3.486ProGly: 3.486 ± 0.035	1.318ProHis: 1.318 ± 0.021	2.521ProIle: 2.521 ± 0.027	2.267ProLys: 2.267 ± 0.032	5.004ProLeu: 5.004 ± 0.044	1.102ProMet: 1.102 ± 0.021	1.654ProAsn: 1.654 ± 0.022	4.464ProPro: 4.464 ± 0.061	2.261ProGln: 2.261 ± 0.031	3.641ProArg: 3.641 ± 0.04	6.603ProSer: 6.603 ± 0.056	3.999ProThr: 3.999 ± 0.042	3.767ProVal: 3.767 ± 0.036	0.549ProTrp: 0.549 ± 0.013	1.35ProTyr: 1.35 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.981GlnAla: 4.981 ± 0.048	0.441GlnCys: 0.441 ± 0.013	2.327GlnAsp: 2.327 ± 0.031	2.205GlnGlu: 2.205 ± 0.028	1.079GlnPhe: 1.079 ± 0.017	2.412GlnGly: 2.412 ± 0.029	1.203GlnHis: 1.203 ± 0.02	1.999GlnIle: 1.999 ± 0.025	1.6GlnLys: 1.6 ± 0.025	3.98GlnLeu: 3.98 ± 0.043	0.892GlnMet: 0.892 ± 0.015	1.182GlnAsn: 1.182 ± 0.018	2.823GlnPro: 2.823 ± 0.036	2.728GlnGln: 2.728 ± 0.069	3.262GlnArg: 3.262 ± 0.033	3.941GlnSer: 3.941 ± 0.037	2.797GlnThr: 2.797 ± 0.024	2.252GlnVal: 2.252 ± 0.024	0.508GlnTrp: 0.508 ± 0.014	1.059GlnTyr: 1.059 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	6.59ArgAla: 6.59 ± 0.047	0.767ArgCys: 0.767 ± 0.016	3.519ArgAsp: 3.519 ± 0.035	3.581ArgGlu: 3.581 ± 0.038	2.093ArgPhe: 2.093 ± 0.025	3.498ArgGly: 3.498 ± 0.047	1.817ArgHis: 1.817 ± 0.025	2.965ArgIle: 2.965 ± 0.032	3.366ArgLys: 3.366 ± 0.039	6.526ArgLeu: 6.526 ± 0.044	1.384ArgMet: 1.384 ± 0.022	1.87ArgAsn: 1.87 ± 0.024	4.213ArgPro: 4.213 ± 0.039	3.495ArgGln: 3.495 ± 0.035	5.646ArgArg: 5.646 ± 0.061	6.317ArgSer: 6.317 ± 0.058	3.851ArgThr: 3.851 ± 0.041	3.336ArgVal: 3.336 ± 0.033	0.836ArgTrp: 0.836 ± 0.015	1.734ArgTyr: 1.734 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	9.507SerAla: 9.507 ± 0.071	0.916SerCys: 0.916 ± 0.02	5.086SerAsp: 5.086 ± 0.046	4.293SerGlu: 4.293 ± 0.039	2.932SerPhe: 2.932 ± 0.033	5.673SerGly: 5.673 ± 0.055	2.179SerHis: 2.179 ± 0.026	4.029SerIle: 4.029 ± 0.035	3.857SerLys: 3.857 ± 0.042	8.577SerLeu: 8.577 ± 0.057	1.901SerMet: 1.901 ± 0.025	2.662SerAsn: 2.662 ± 0.03	6.092SerPro: 6.092 ± 0.074	3.764SerGln: 3.764 ± 0.035	6.034SerArg: 6.034 ± 0.055	10.932SerSer: 10.932 ± 0.112	6.373SerThr: 6.373 ± 0.063	5.091SerVal: 5.091 ± 0.042	0.954SerTrp: 0.954 ± 0.016	2.09SerTyr: 2.09 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.298ThrAla: 6.298 ± 0.05	0.786ThrCys: 0.786 ± 0.016	3.047ThrAsp: 3.047 ± 0.033	2.855ThrGlu: 2.855 ± 0.033	2.157ThrPhe: 2.157 ± 0.028	3.967ThrGly: 3.967 ± 0.04	1.349ThrHis: 1.349 ± 0.019	2.823ThrIle: 2.823 ± 0.033	2.255ThrLys: 2.255 ± 0.028	5.913ThrLeu: 5.913 ± 0.049	1.142ThrMet: 1.142 ± 0.018	1.712ThrAsn: 1.712 ± 0.025	4.19ThrPro: 4.19 ± 0.049	2.286ThrGln: 2.286 ± 0.031	3.83ThrArg: 3.83 ± 0.034	6.374ThrSer: 6.374 ± 0.057	3.998ThrThr: 3.998 ± 0.043	3.73ThrVal: 3.73 ± 0.033	0.723ThrTrp: 0.723 ± 0.015	1.471ThrTyr: 1.471 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.626ValAla: 5.626 ± 0.043	0.844ValCys: 0.844 ± 0.017	3.445ValAsp: 3.445 ± 0.036	3.239ValGlu: 3.239 ± 0.033	2.101ValPhe: 2.101 ± 0.03	3.319ValGly: 3.319 ± 0.035	1.393ValHis: 1.393 ± 0.022	2.872ValIle: 2.872 ± 0.036	2.774ValLys: 2.774 ± 0.03	5.656ValLeu: 5.656 ± 0.047	1.196ValMet: 1.196 ± 0.018	1.813ValAsn: 1.813 ± 0.025	3.464ValPro: 3.464 ± 0.036	2.471ValGln: 2.471 ± 0.028	3.637ValArg: 3.637 ± 0.035	4.874ValSer: 4.874 ± 0.036	3.527ValThr: 3.527 ± 0.04	3.599ValVal: 3.599 ± 0.037	0.741ValTrp: 0.741 ± 0.016	1.596ValTyr: 1.596 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	0.951TrpAla: 0.951 ± 0.018	0.148TrpCys: 0.148 ± 0.006	0.653TrpAsp: 0.653 ± 0.017	0.503TrpGlu: 0.503 ± 0.011	0.37TrpPhe: 0.37 ± 0.009	0.56TrpGly: 0.56 ± 0.013	0.385TrpHis: 0.385 ± 0.012	0.581TrpIle: 0.581 ± 0.014	0.474TrpLys: 0.474 ± 0.012	1.353TrpLeu: 1.353 ± 0.022	0.234TrpMet: 0.234 ± 0.008	0.405TrpAsn: 0.405 ± 0.012	0.611TrpPro: 0.611 ± 0.014	0.767TrpGln: 0.767 ± 0.016	0.885TrpArg: 0.885 ± 0.018	1.102TrpSer: 1.102 ± 0.019	0.824TrpThr: 0.824 ± 0.017	0.522TrpVal: 0.522 ± 0.012	0.182TrpTrp: 0.182 ± 0.008	0.306TrpTyr: 0.306 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.488TyrAla: 2.488 ± 0.031	0.385TyrCys: 0.385 ± 0.011	1.674TyrAsp: 1.674 ± 0.024	1.355TyrGlu: 1.355 ± 0.02	0.964TyrPhe: 0.964 ± 0.019	1.788TyrGly: 1.788 ± 0.028	0.639TyrHis: 0.639 ± 0.014	1.147TyrIle: 1.147 ± 0.017	1.01TyrLys: 1.01 ± 0.022	2.475TyrLeu: 2.475 ± 0.029	0.461TyrMet: 0.461 ± 0.012	0.844TyrAsn: 0.844 ± 0.018	1.171TyrPro: 1.171 ± 0.021	0.963TyrGln: 0.963 ± 0.014	1.613TyrArg: 1.613 ± 0.021	1.891TyrSer: 1.891 ± 0.028	1.482TyrThr: 1.482 ± 0.023	1.489TyrVal: 1.489 ± 0.022	0.323TyrTrp: 0.323 ± 0.01	0.765TyrTyr: 0.765 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6725 proteins (3482161 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---