Amino acid dipepetide frequency for Hymenobacter gelipurpurascens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.865AlaAla: 11.865 ± 0.136	0.754AlaCys: 0.754 ± 0.025	5.128AlaAsp: 5.128 ± 0.06	5.676AlaGlu: 5.676 ± 0.067	3.61AlaPhe: 3.61 ± 0.054	7.985AlaGly: 7.985 ± 0.084	1.885AlaHis: 1.885 ± 0.044	4.172AlaIle: 4.172 ± 0.057	3.699AlaLys: 3.699 ± 0.059	10.489AlaLeu: 10.489 ± 0.106	1.928AlaMet: 1.928 ± 0.039	3.156AlaAsn: 3.156 ± 0.052	4.987AlaPro: 4.987 ± 0.093	4.941AlaGln: 4.941 ± 0.075	5.409AlaArg: 5.409 ± 0.072	5.696AlaSer: 5.696 ± 0.074	6.49AlaThr: 6.49 ± 0.094	6.816AlaVal: 6.816 ± 0.079	1.141AlaTrp: 1.141 ± 0.035	3.46AlaTyr: 3.46 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.603CysAla: 0.603 ± 0.023	0.107CysCys: 0.107 ± 0.01	0.353CysAsp: 0.353 ± 0.017	0.36CysGlu: 0.36 ± 0.016	0.289CysPhe: 0.289 ± 0.015	0.627CysGly: 0.627 ± 0.024	0.207CysHis: 0.207 ± 0.015	0.362CysIle: 0.362 ± 0.015	0.205CysLys: 0.205 ± 0.012	0.772CysLeu: 0.772 ± 0.025	0.113CysMet: 0.113 ± 0.01	0.265CysAsn: 0.265 ± 0.013	0.404CysPro: 0.404 ± 0.021	0.303CysGln: 0.303 ± 0.014	0.402CysArg: 0.402 ± 0.018	0.42CysSer: 0.42 ± 0.02	0.463CysThr: 0.463 ± 0.02	0.471CysVal: 0.471 ± 0.017	0.09CysTrp: 0.09 ± 0.007	0.259CysTyr: 0.259 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.794AspAla: 4.794 ± 0.063	0.304AspCys: 0.304 ± 0.017	2.261AspAsp: 2.261 ± 0.047	2.924AspGlu: 2.924 ± 0.049	2.487AspPhe: 2.487 ± 0.043	3.66AspGly: 3.66 ± 0.057	0.871AspHis: 0.871 ± 0.028	2.552AspIle: 2.552 ± 0.047	2.434AspLys: 2.434 ± 0.056	4.824AspLeu: 4.824 ± 0.067	0.968AspMet: 0.968 ± 0.03	1.936AspAsn: 1.936 ± 0.038	2.292AspPro: 2.292 ± 0.045	1.966AspGln: 1.966 ± 0.033	2.385AspArg: 2.385 ± 0.045	2.635AspSer: 2.635 ± 0.047	2.69AspThr: 2.69 ± 0.044	3.575AspVal: 3.575 ± 0.045	0.727AspTrp: 0.727 ± 0.024	2.063AspTyr: 2.063 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.835GluAla: 5.835 ± 0.082	0.291GluCys: 0.291 ± 0.013	2.343GluAsp: 2.343 ± 0.048	3.525GluGlu: 3.525 ± 0.072	2.207GluPhe: 2.207 ± 0.044	3.546GluGly: 3.546 ± 0.048	1.214GluHis: 1.214 ± 0.037	2.637GluIle: 2.637 ± 0.049	2.988GluLys: 2.988 ± 0.06	6.336GluLeu: 6.336 ± 0.083	1.273GluMet: 1.273 ± 0.032	2.075GluAsn: 2.075 ± 0.038	2.319GluPro: 2.319 ± 0.038	3.257GluGln: 3.257 ± 0.052	3.18GluArg: 3.18 ± 0.056	2.372GluSer: 2.372 ± 0.041	2.943GluThr: 2.943 ± 0.045	4.073GluVal: 4.073 ± 0.052	0.691GluTrp: 0.691 ± 0.023	1.83GluTyr: 1.83 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.507PheAla: 3.507 ± 0.053	0.363PheCys: 0.363 ± 0.015	2.336PheAsp: 2.336 ± 0.04	2.259PheGlu: 2.259 ± 0.042	1.84PhePhe: 1.84 ± 0.046	3.301PheGly: 3.301 ± 0.05	0.774PheHis: 0.774 ± 0.023	1.861PheIle: 1.861 ± 0.04	1.506PheLys: 1.506 ± 0.037	4.264PheLeu: 4.264 ± 0.071	0.8PheMet: 0.8 ± 0.025	1.691PheAsn: 1.691 ± 0.031	1.829PhePro: 1.829 ± 0.037	1.712PheGln: 1.712 ± 0.037	2.568PheArg: 2.568 ± 0.044	2.812PheSer: 2.812 ± 0.048	2.849PheThr: 2.849 ± 0.047	2.861PheVal: 2.861 ± 0.048	0.578PheTrp: 0.578 ± 0.022	1.587PheTyr: 1.587 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.274GlyAla: 6.274 ± 0.082	0.649GlyCys: 0.649 ± 0.021	2.979GlyAsp: 2.979 ± 0.048	3.494GlyGlu: 3.494 ± 0.045	3.342GlyPhe: 3.342 ± 0.052	5.863GlyGly: 5.863 ± 0.085	1.821GlyHis: 1.821 ± 0.04	3.968GlyIle: 3.968 ± 0.061	3.744GlyLys: 3.744 ± 0.059	8.718GlyLeu: 8.718 ± 0.09	1.565GlyMet: 1.565 ± 0.036	2.832GlyAsn: 2.832 ± 0.048	2.805GlyPro: 2.805 ± 0.052	4.059GlyGln: 4.059 ± 0.054	4.306GlyArg: 4.306 ± 0.061	4.642GlySer: 4.642 ± 0.06	5.024GlyThr: 5.024 ± 0.084	5.046GlyVal: 5.046 ± 0.07	1.063GlyTrp: 1.063 ± 0.029	2.879GlyTyr: 2.879 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.704HisAla: 1.704 ± 0.038	0.187HisCys: 0.187 ± 0.013	1.099HisAsp: 1.099 ± 0.025	1.12HisGlu: 1.12 ± 0.026	1.09HisPhe: 1.09 ± 0.034	1.515HisGly: 1.515 ± 0.039	0.619HisHis: 0.619 ± 0.024	1.048HisIle: 1.048 ± 0.024	0.684HisLys: 0.684 ± 0.021	2.438HisLeu: 2.438 ± 0.048	0.388HisMet: 0.388 ± 0.019	0.787HisAsn: 0.787 ± 0.023	1.309HisPro: 1.309 ± 0.034	1.002HisGln: 1.002 ± 0.03	1.221HisArg: 1.221 ± 0.031	1.099HisSer: 1.099 ± 0.03	1.227HisThr: 1.227 ± 0.032	1.288HisVal: 1.288 ± 0.033	0.318HisTrp: 0.318 ± 0.014	0.918HisTyr: 0.918 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	3.948IleAla: 3.948 ± 0.059	0.417IleCys: 0.417 ± 0.018	2.52IleAsp: 2.52 ± 0.05	2.66IleGlu: 2.66 ± 0.047	1.765IlePhe: 1.765 ± 0.031	3.904IleGly: 3.904 ± 0.059	0.812IleHis: 0.812 ± 0.023	2.434IleIle: 2.434 ± 0.053	2.012IleLys: 2.012 ± 0.044	4.209IleLeu: 4.209 ± 0.062	0.839IleMet: 0.839 ± 0.027	1.989IleAsn: 1.989 ± 0.037	2.306IlePro: 2.306 ± 0.046	1.877IleGln: 1.877 ± 0.04	2.962IleArg: 2.962 ± 0.045	3.102IleSer: 3.102 ± 0.048	3.18IleThr: 3.18 ± 0.055	3.151IleVal: 3.151 ± 0.052	0.526IleTrp: 0.526 ± 0.018	1.458IleTyr: 1.458 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.304LysAla: 4.304 ± 0.06	0.196LysCys: 0.196 ± 0.011	2.114LysAsp: 2.114 ± 0.049	2.49LysGlu: 2.49 ± 0.05	1.431LysPhe: 1.431 ± 0.035	3.036LysGly: 3.036 ± 0.054	0.858LysHis: 0.858 ± 0.027	1.987LysIle: 1.987 ± 0.045	2.355LysLys: 2.355 ± 0.068	4.391LysLeu: 4.391 ± 0.062	1.158LysMet: 1.158 ± 0.032	1.696LysAsn: 1.696 ± 0.042	2.356LysPro: 2.356 ± 0.044	2.111LysGln: 2.111 ± 0.045	2.272LysArg: 2.272 ± 0.046	2.184LysSer: 2.184 ± 0.045	2.554LysThr: 2.554 ± 0.043	2.981LysVal: 2.981 ± 0.054	0.452LysTrp: 0.452 ± 0.019	1.438LysTyr: 1.438 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.026LeuAla: 11.026 ± 0.11	0.773LeuCys: 0.773 ± 0.024	5.294LeuAsp: 5.294 ± 0.068	5.466LeuGlu: 5.466 ± 0.073	4.138LeuPhe: 4.138 ± 0.064	8.261LeuGly: 8.261 ± 0.088	2.467LeuHis: 2.467 ± 0.053	4.411LeuIle: 4.411 ± 0.062	4.241LeuLys: 4.241 ± 0.058	13.725LeuLeu: 13.725 ± 0.158	2.124LeuMet: 2.124 ± 0.041	4.197LeuAsn: 4.197 ± 0.058	6.295LeuPro: 6.295 ± 0.075	4.871LeuGln: 4.871 ± 0.078	7.241LeuArg: 7.241 ± 0.081	6.554LeuSer: 6.554 ± 0.072	7.047LeuThr: 7.047 ± 0.075	7.346LeuVal: 7.346 ± 0.087	1.157LeuTrp: 1.157 ± 0.031	3.285LeuTyr: 3.285 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.057MetAla: 2.057 ± 0.04	0.112MetCys: 0.112 ± 0.008	0.839MetAsp: 0.839 ± 0.029	1.013MetGlu: 1.013 ± 0.028	0.582MetPhe: 0.582 ± 0.022	1.411MetGly: 1.411 ± 0.037	0.475MetHis: 0.475 ± 0.021	0.758MetIle: 0.758 ± 0.025	1.18MetLys: 1.18 ± 0.031	2.316MetLeu: 2.316 ± 0.043	0.475MetMet: 0.475 ± 0.021	0.829MetAsn: 0.829 ± 0.025	1.258MetPro: 1.258 ± 0.034	1.046MetGln: 1.046 ± 0.027	1.322MetArg: 1.322 ± 0.029	1.283MetSer: 1.283 ± 0.033	1.079MetThr: 1.079 ± 0.026	1.297MetVal: 1.297 ± 0.032	0.174MetTrp: 0.174 ± 0.011	0.488MetTyr: 0.488 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.278AsnAla: 3.278 ± 0.051	0.301AsnCys: 0.301 ± 0.016	1.792AsnAsp: 1.792 ± 0.037	1.847AsnGlu: 1.847 ± 0.036	1.662AsnPhe: 1.662 ± 0.036	2.994AsnGly: 2.994 ± 0.054	0.697AsnHis: 0.697 ± 0.024	1.886AsnIle: 1.886 ± 0.041	1.553AsnLys: 1.553 ± 0.037	3.937AsnLeu: 3.937 ± 0.051	0.743AsnMet: 0.743 ± 0.021	1.612AsnAsn: 1.612 ± 0.041	2.438AsnPro: 2.438 ± 0.046	1.708AsnGln: 1.708 ± 0.035	2.19AsnArg: 2.19 ± 0.038	2.184AsnSer: 2.184 ± 0.042	2.489AsnThr: 2.489 ± 0.05	2.52AsnVal: 2.52 ± 0.045	0.547AsnTrp: 0.547 ± 0.021	1.557AsnTyr: 1.557 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	6.414ProAla: 6.414 ± 0.092	0.23ProCys: 0.23 ± 0.013	3.246ProAsp: 3.246 ± 0.052	3.706ProGlu: 3.706 ± 0.048	1.9ProPhe: 1.9 ± 0.039	3.865ProGly: 3.865 ± 0.054	0.979ProHis: 0.979 ± 0.027	2.195ProIle: 2.195 ± 0.043	1.865ProLys: 1.865 ± 0.039	4.999ProLeu: 4.999 ± 0.064	0.891ProMet: 0.891 ± 0.026	2.031ProAsn: 2.031 ± 0.043	1.861ProPro: 1.861 ± 0.04	2.057ProGln: 2.057 ± 0.031	2.312ProArg: 2.312 ± 0.042	2.669ProSer: 2.669 ± 0.048	3.441ProThr: 3.441 ± 0.057	4.258ProVal: 4.258 ± 0.062	0.554ProTrp: 0.554 ± 0.02	1.588ProTyr: 1.588 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.003GlnAla: 5.003 ± 0.076	0.234GlnCys: 0.234 ± 0.016	2.126GlnAsp: 2.126 ± 0.039	2.882GlnGlu: 2.882 ± 0.048	1.764GlnPhe: 1.764 ± 0.031	2.918GlnGly: 2.918 ± 0.048	1.269GlnHis: 1.269 ± 0.035	2.013GlnIle: 2.013 ± 0.039	2.025GlnLys: 2.025 ± 0.04	5.568GlnLeu: 5.568 ± 0.088	0.966GlnMet: 0.966 ± 0.025	1.792GlnAsn: 1.792 ± 0.041	2.87GlnPro: 2.87 ± 0.054	3.439GlnGln: 3.439 ± 0.069	3.14GlnArg: 3.14 ± 0.054	2.148GlnSer: 2.148 ± 0.038	2.575GlnThr: 2.575 ± 0.045	3.504GlnVal: 3.504 ± 0.05	0.594GlnTrp: 0.594 ± 0.022	1.648GlnTyr: 1.648 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.816ArgAla: 4.816 ± 0.068	0.345ArgCys: 0.345 ± 0.016	2.486ArgAsp: 2.486 ± 0.044	3.412ArgGlu: 3.412 ± 0.054	2.706ArgPhe: 2.706 ± 0.046	3.381ArgGly: 3.381 ± 0.051	1.39ArgHis: 1.39 ± 0.036	3.036ArgIle: 3.036 ± 0.054	2.435ArgLys: 2.435 ± 0.043	6.748ArgLeu: 6.748 ± 0.086	1.355ArgMet: 1.355 ± 0.034	2.341ArgAsn: 2.341 ± 0.042	3.073ArgPro: 3.073 ± 0.054	3.439ArgGln: 3.439 ± 0.058	4.141ArgArg: 4.141 ± 0.065	2.777ArgSer: 2.777 ± 0.049	3.397ArgThr: 3.397 ± 0.049	4.171ArgVal: 4.171 ± 0.062	0.853ArgTrp: 0.853 ± 0.025	2.427ArgTyr: 2.427 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.517SerAla: 5.517 ± 0.063	0.495SerCys: 0.495 ± 0.019	2.582SerAsp: 2.582 ± 0.047	2.713SerGlu: 2.713 ± 0.046	2.852SerPhe: 2.852 ± 0.039	4.926SerGly: 4.926 ± 0.077	1.037SerHis: 1.037 ± 0.027	2.883SerIle: 2.883 ± 0.043	2.279SerLys: 2.279 ± 0.039	5.955SerLeu: 5.955 ± 0.075	1.113SerMet: 1.113 ± 0.03	2.057SerAsn: 2.057 ± 0.043	2.905SerPro: 2.905 ± 0.049	2.247SerGln: 2.247 ± 0.045	3.175SerArg: 3.175 ± 0.041	3.824SerSer: 3.824 ± 0.066	3.689SerThr: 3.689 ± 0.065	4.151SerVal: 4.151 ± 0.06	0.778SerTrp: 0.778 ± 0.023	2.088SerTyr: 2.088 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.298ThrAla: 6.298 ± 0.094	0.366ThrCys: 0.366 ± 0.017	3.308ThrAsp: 3.308 ± 0.054	3.18ThrGlu: 3.18 ± 0.047	2.485ThrPhe: 2.485 ± 0.041	5.255ThrGly: 5.255 ± 0.077	1.198ThrHis: 1.198 ± 0.03	2.993ThrIle: 2.993 ± 0.046	2.277ThrLys: 2.277 ± 0.044	6.625ThrLeu: 6.625 ± 0.074	1.051ThrMet: 1.051 ± 0.026	2.228ThrAsn: 2.228 ± 0.047	3.882ThrPro: 3.882 ± 0.065	2.355ThrGln: 2.355 ± 0.04	2.991ThrArg: 2.991 ± 0.047	3.85ThrSer: 3.85 ± 0.072	4.348ThrThr: 4.348 ± 0.08	4.713ThrVal: 4.713 ± 0.072	0.72ThrTrp: 0.72 ± 0.024	2.236ThrTyr: 2.236 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.81ValAla: 7.81 ± 0.077	0.553ValCys: 0.553 ± 0.023	3.077ValAsp: 3.077 ± 0.047	3.779ValGlu: 3.779 ± 0.056	2.872ValPhe: 2.872 ± 0.05	5.209ValGly: 5.209 ± 0.065	1.312ValHis: 1.312 ± 0.033	3.019ValIle: 3.019 ± 0.049	2.943ValLys: 2.943 ± 0.056	8.116ValLeu: 8.116 ± 0.096	1.389ValMet: 1.389 ± 0.033	2.433ValAsn: 2.433 ± 0.047	3.701ValPro: 3.701 ± 0.059	3.372ValGln: 3.372 ± 0.055	4.395ValArg: 4.395 ± 0.061	4.163ValSer: 4.163 ± 0.06	4.079ValThr: 4.079 ± 0.067	5.718ValVal: 5.718 ± 0.072	0.78ValTrp: 0.78 ± 0.024	2.235ValTyr: 2.235 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.026TrpAla: 1.026 ± 0.027	0.098TrpCys: 0.098 ± 0.008	0.537TrpAsp: 0.537 ± 0.019	0.651TrpGlu: 0.651 ± 0.022	0.54TrpPhe: 0.54 ± 0.022	0.782TrpGly: 0.782 ± 0.025	0.332TrpHis: 0.332 ± 0.016	0.466TrpIle: 0.466 ± 0.019	0.536TrpLys: 0.536 ± 0.021	1.751TrpLeu: 1.751 ± 0.041	0.3TrpMet: 0.3 ± 0.014	0.476TrpAsn: 0.476 ± 0.016	0.57TrpPro: 0.57 ± 0.021	0.857TrpGln: 0.857 ± 0.026	0.819TrpArg: 0.819 ± 0.028	0.644TrpSer: 0.644 ± 0.026	0.613TrpThr: 0.613 ± 0.022	0.821TrpVal: 0.821 ± 0.025	0.235TrpTrp: 0.235 ± 0.014	0.407TrpTyr: 0.407 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.206TyrAla: 3.206 ± 0.056	0.303TyrCys: 0.303 ± 0.014	1.929TyrAsp: 1.929 ± 0.038	1.778TyrGlu: 1.778 ± 0.031	1.736TyrPhe: 1.736 ± 0.039	2.631TyrGly: 2.631 ± 0.05	0.843TyrHis: 0.843 ± 0.023	1.392TyrIle: 1.392 ± 0.032	1.404TyrLys: 1.404 ± 0.037	3.737TyrLeu: 3.737 ± 0.058	0.556TyrMet: 0.556 ± 0.021	1.511TyrAsn: 1.511 ± 0.038	1.599TyrPro: 1.599 ± 0.038	1.86TyrGln: 1.86 ± 0.037	2.299TyrArg: 2.299 ± 0.045	2.208TyrSer: 2.208 ± 0.04	2.181TyrThr: 2.181 ± 0.047	2.196TyrVal: 2.196 ± 0.033	0.481TyrTrp: 0.481 ± 0.019	1.48TyrTyr: 1.48 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4241 proteins (1451777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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