Amino acid dipepetide frequency for Alkanindiges hydrocarboniclasticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.248AlaAla: 9.248 ± 0.132	1.043AlaCys: 1.043 ± 0.035	4.622AlaAsp: 4.622 ± 0.089	5.066AlaGlu: 5.066 ± 0.09	3.266AlaPhe: 3.266 ± 0.065	7.022AlaGly: 7.022 ± 0.1	1.972AlaHis: 1.972 ± 0.047	6.03AlaIle: 6.03 ± 0.088	4.417AlaLys: 4.417 ± 0.086	10.55AlaLeu: 10.55 ± 0.115	2.625AlaMet: 2.625 ± 0.062	3.536AlaAsn: 3.536 ± 0.077	3.394AlaPro: 3.394 ± 0.066	5.382AlaGln: 5.382 ± 0.087	4.67AlaArg: 4.67 ± 0.081	5.944AlaSer: 5.944 ± 0.092	5.196AlaThr: 5.196 ± 0.114	6.233AlaVal: 6.233 ± 0.097	1.081AlaTrp: 1.081 ± 0.036	2.601AlaTyr: 2.601 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.769CysAla: 0.769 ± 0.027	0.135CysCys: 0.135 ± 0.012	0.477CysAsp: 0.477 ± 0.027	0.484CysGlu: 0.484 ± 0.026	0.443CysPhe: 0.443 ± 0.019	0.782CysGly: 0.782 ± 0.031	0.311CysHis: 0.311 ± 0.019	0.611CysIle: 0.611 ± 0.027	0.356CysLys: 0.356 ± 0.022	0.976CysLeu: 0.976 ± 0.034	0.239CysMet: 0.239 ± 0.017	0.4CysAsn: 0.4 ± 0.023	0.471CysPro: 0.471 ± 0.03	0.502CysGln: 0.502 ± 0.022	0.497CysArg: 0.497 ± 0.024	0.653CysSer: 0.653 ± 0.033	0.461CysThr: 0.461 ± 0.023	0.599CysVal: 0.599 ± 0.027	0.127CysTrp: 0.127 ± 0.011	0.293CysTyr: 0.293 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.67AspAla: 4.67 ± 0.083	0.488AspCys: 0.488 ± 0.023	2.712AspAsp: 2.712 ± 0.066	3.226AspGlu: 3.226 ± 0.064	2.243AspPhe: 2.243 ± 0.058	3.26AspGly: 3.26 ± 0.081	1.269AspHis: 1.269 ± 0.039	3.522AspIle: 3.522 ± 0.057	2.347AspLys: 2.347 ± 0.054	5.224AspLeu: 5.224 ± 0.083	1.359AspMet: 1.359 ± 0.041	2.127AspAsn: 2.127 ± 0.049	2.165AspPro: 2.165 ± 0.05	2.895AspGln: 2.895 ± 0.055	2.363AspArg: 2.363 ± 0.045	3.025AspSer: 3.025 ± 0.055	2.57AspThr: 2.57 ± 0.056	3.329AspVal: 3.329 ± 0.058	0.854AspTrp: 0.854 ± 0.032	1.947AspTyr: 1.947 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.832GluAla: 4.832 ± 0.081	0.424GluCys: 0.424 ± 0.024	2.355GluAsp: 2.355 ± 0.055	2.614GluGlu: 2.614 ± 0.072	2.034GluPhe: 2.034 ± 0.045	3.083GluGly: 3.083 ± 0.062	1.443GluHis: 1.443 ± 0.048	3.482GluIle: 3.482 ± 0.066	3.054GluLys: 3.054 ± 0.069	6.0GluLeu: 6.0 ± 0.091	1.269GluMet: 1.269 ± 0.038	2.37GluAsn: 2.37 ± 0.052	1.944GluPro: 1.944 ± 0.05	4.372GluGln: 4.372 ± 0.085	3.101GluArg: 3.101 ± 0.065	2.63GluSer: 2.63 ± 0.055	2.582GluThr: 2.582 ± 0.064	3.582GluVal: 3.582 ± 0.064	0.741GluTrp: 0.741 ± 0.027	1.457GluTyr: 1.457 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.546PheAla: 3.546 ± 0.067	0.475PheCys: 0.475 ± 0.023	2.468PheAsp: 2.468 ± 0.056	2.394PheGlu: 2.394 ± 0.055	1.717PhePhe: 1.717 ± 0.053	2.911PheGly: 2.911 ± 0.062	0.777PheHis: 0.777 ± 0.032	2.623PheIle: 2.623 ± 0.057	2.149PheLys: 2.149 ± 0.054	3.523PheLeu: 3.523 ± 0.08	1.067PheMet: 1.067 ± 0.036	2.026PheAsn: 2.026 ± 0.047	1.344PhePro: 1.344 ± 0.044	1.394PheGln: 1.394 ± 0.044	1.523PheArg: 1.523 ± 0.041	2.919PheSer: 2.919 ± 0.055	1.902PheThr: 1.902 ± 0.055	2.418PheVal: 2.418 ± 0.056	0.551PheTrp: 0.551 ± 0.026	1.416PheTyr: 1.416 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.35GlyAla: 5.35 ± 0.129	0.778GlyCys: 0.778 ± 0.033	3.07GlyAsp: 3.07 ± 0.058	3.635GlyGlu: 3.635 ± 0.067	3.2GlyPhe: 3.2 ± 0.058	4.563GlyGly: 4.563 ± 0.111	1.655GlyHis: 1.655 ± 0.04	4.642GlyIle: 4.642 ± 0.066	3.695GlyLys: 3.695 ± 0.068	7.533GlyLeu: 7.533 ± 0.109	1.935GlyMet: 1.935 ± 0.048	2.697GlyAsn: 2.697 ± 0.073	1.493GlyPro: 1.493 ± 0.046	3.709GlyGln: 3.709 ± 0.078	3.188GlyArg: 3.188 ± 0.065	4.168GlySer: 4.168 ± 0.094	3.622GlyThr: 3.622 ± 0.103	4.534GlyVal: 4.534 ± 0.068	1.034GlyTrp: 1.034 ± 0.034	2.397GlyTyr: 2.397 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.192HisAla: 2.192 ± 0.05	0.308HisCys: 0.308 ± 0.02	1.253HisAsp: 1.253 ± 0.035	1.271HisGlu: 1.271 ± 0.04	1.044HisPhe: 1.044 ± 0.04	1.72HisGly: 1.72 ± 0.047	0.792HisHis: 0.792 ± 0.03	1.512HisIle: 1.512 ± 0.045	0.905HisLys: 0.905 ± 0.032	2.494HisLeu: 2.494 ± 0.053	0.581HisMet: 0.581 ± 0.026	0.846HisAsn: 0.846 ± 0.033	1.382HisPro: 1.382 ± 0.048	1.437HisGln: 1.437 ± 0.047	1.138HisArg: 1.138 ± 0.039	1.467HisSer: 1.467 ± 0.042	1.141HisThr: 1.141 ± 0.033	1.385HisVal: 1.385 ± 0.039	0.431HisTrp: 0.431 ± 0.023	0.951HisTyr: 0.951 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.288IleAla: 6.288 ± 0.081	0.682IleCys: 0.682 ± 0.03	3.894IleAsp: 3.894 ± 0.059	4.118IleGlu: 4.118 ± 0.071	2.3IlePhe: 2.3 ± 0.06	4.529IleGly: 4.529 ± 0.087	1.348IleHis: 1.348 ± 0.041	3.748IleIle: 3.748 ± 0.073	3.187IleLys: 3.187 ± 0.061	5.575IleLeu: 5.575 ± 0.09	1.351IleMet: 1.351 ± 0.04	2.986IleAsn: 2.986 ± 0.054	2.811IlePro: 2.811 ± 0.058	2.868IleGln: 2.868 ± 0.059	3.248IleArg: 3.248 ± 0.06	4.036IleSer: 4.036 ± 0.073	3.276IleThr: 3.276 ± 0.062	3.915IleVal: 3.915 ± 0.069	0.648IleTrp: 0.648 ± 0.03	1.839IleTyr: 1.839 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.662LysAla: 4.662 ± 0.088	0.273LysCys: 0.273 ± 0.017	2.434LysAsp: 2.434 ± 0.055	2.131LysGlu: 2.131 ± 0.049	1.451LysPhe: 1.451 ± 0.04	2.746LysGly: 2.746 ± 0.066	1.064LysHis: 1.064 ± 0.04	3.144LysIle: 3.144 ± 0.069	2.795LysLys: 2.795 ± 0.068	4.668LysLeu: 4.668 ± 0.071	1.171LysMet: 1.171 ± 0.034	2.404LysAsn: 2.404 ± 0.054	2.639LysPro: 2.639 ± 0.063	2.938LysGln: 2.938 ± 0.072	2.435LysArg: 2.435 ± 0.055	2.714LysSer: 2.714 ± 0.058	3.135LysThr: 3.135 ± 0.059	3.197LysVal: 3.197 ± 0.062	0.461LysTrp: 0.461 ± 0.024	1.298LysTyr: 1.298 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.644LeuAla: 10.644 ± 0.11	1.026LeuCys: 1.026 ± 0.032	5.729LeuAsp: 5.729 ± 0.09	5.517LeuGlu: 5.517 ± 0.089	3.904LeuPhe: 3.904 ± 0.079	7.2LeuGly: 7.2 ± 0.1	2.421LeuHis: 2.421 ± 0.057	6.619LeuIle: 6.619 ± 0.108	5.848LeuLys: 5.848 ± 0.076	11.08LeuLeu: 11.08 ± 0.159	2.777LeuMet: 2.777 ± 0.066	5.117LeuAsn: 5.117 ± 0.086	5.326LeuPro: 5.326 ± 0.083	5.305LeuGln: 5.305 ± 0.095	4.78LeuArg: 4.78 ± 0.08	7.294LeuSer: 7.294 ± 0.101	5.893LeuThr: 5.893 ± 0.085	6.789LeuVal: 6.789 ± 0.1	1.231LeuTrp: 1.231 ± 0.041	2.739LeuTyr: 2.739 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.672MetAla: 2.672 ± 0.051	0.167MetCys: 0.167 ± 0.012	1.17MetAsp: 1.17 ± 0.034	1.009MetGlu: 1.009 ± 0.031	0.748MetPhe: 0.748 ± 0.03	1.672MetGly: 1.672 ± 0.044	0.601MetHis: 0.601 ± 0.025	1.436MetIle: 1.436 ± 0.046	1.124MetLys: 1.124 ± 0.038	2.814MetLeu: 2.814 ± 0.064	0.645MetMet: 0.645 ± 0.027	1.194MetAsn: 1.194 ± 0.038	1.364MetPro: 1.364 ± 0.038	1.698MetGln: 1.698 ± 0.042	1.251MetArg: 1.251 ± 0.037	1.71MetSer: 1.71 ± 0.047	1.609MetThr: 1.609 ± 0.044	1.631MetVal: 1.631 ± 0.045	0.196MetTrp: 0.196 ± 0.013	0.467MetTyr: 0.467 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.813AsnAla: 3.813 ± 0.07	0.398AsnCys: 0.398 ± 0.022	2.139AsnAsp: 2.139 ± 0.053	1.98AsnGlu: 1.98 ± 0.049	1.563AsnPhe: 1.563 ± 0.05	2.892AsnGly: 2.892 ± 0.069	1.012AsnHis: 1.012 ± 0.035	2.612AsnIle: 2.612 ± 0.062	1.869AsnLys: 1.869 ± 0.051	4.272AsnLeu: 4.272 ± 0.085	1.011AsnMet: 1.011 ± 0.038	2.039AsnAsn: 2.039 ± 0.059	2.582AsnPro: 2.582 ± 0.052	2.606AsnGln: 2.606 ± 0.07	2.116AsnArg: 2.116 ± 0.052	2.72AsnSer: 2.72 ± 0.07	2.547AsnThr: 2.547 ± 0.07	2.487AsnVal: 2.487 ± 0.047	0.625AsnTrp: 0.625 ± 0.025	1.387AsnTyr: 1.387 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	4.768ProAla: 4.768 ± 0.079	0.319ProCys: 0.319 ± 0.021	2.904ProAsp: 2.904 ± 0.067	3.306ProGlu: 3.306 ± 0.059	1.734ProPhe: 1.734 ± 0.049	2.01ProGly: 2.01 ± 0.052	0.966ProHis: 0.966 ± 0.038	2.323ProIle: 2.323 ± 0.044	2.0ProLys: 2.0 ± 0.049	4.457ProLeu: 4.457 ± 0.079	1.064ProMet: 1.064 ± 0.032	1.811ProAsn: 1.811 ± 0.043	1.417ProPro: 1.417 ± 0.044	2.208ProGln: 2.208 ± 0.052	1.7ProArg: 1.7 ± 0.042	2.475ProSer: 2.475 ± 0.05	2.158ProThr: 2.158 ± 0.057	4.012ProVal: 4.012 ± 0.069	0.518ProTrp: 0.518 ± 0.026	1.419ProTyr: 1.419 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	6.146GlnAla: 6.146 ± 0.117	0.461GlnCys: 0.461 ± 0.021	2.525GlnAsp: 2.525 ± 0.049	2.364GlnGlu: 2.364 ± 0.052	2.112GlnPhe: 2.112 ± 0.051	3.546GlnGly: 3.546 ± 0.076	1.9GlnHis: 1.9 ± 0.058	3.248GlnIle: 3.248 ± 0.064	2.435GlnLys: 2.435 ± 0.056	6.802GlnLeu: 6.802 ± 0.114	1.246GlnMet: 1.246 ± 0.036	2.054GlnAsn: 2.054 ± 0.061	2.895GlnPro: 2.895 ± 0.061	5.548GlnGln: 5.548 ± 0.157	2.989GlnArg: 2.989 ± 0.065	3.035GlnSer: 3.035 ± 0.064	2.815GlnThr: 2.815 ± 0.058	3.966GlnVal: 3.966 ± 0.068	0.773GlnTrp: 0.773 ± 0.03	1.688GlnTyr: 1.688 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.882ArgAla: 3.882 ± 0.074	0.421ArgCys: 0.421 ± 0.023	2.415ArgAsp: 2.415 ± 0.055	2.95ArgGlu: 2.95 ± 0.059	2.349ArgPhe: 2.349 ± 0.046	2.557ArgGly: 2.557 ± 0.054	1.417ArgHis: 1.417 ± 0.038	3.314ArgIle: 3.314 ± 0.071	2.169ArgLys: 2.169 ± 0.054	5.949ArgLeu: 5.949 ± 0.09	1.299ArgMet: 1.299 ± 0.04	1.88ArgAsn: 1.88 ± 0.039	1.942ArgPro: 1.942 ± 0.048	3.267ArgGln: 3.267 ± 0.063	2.517ArgArg: 2.517 ± 0.054	2.499ArgSer: 2.499 ± 0.054	2.246ArgThr: 2.246 ± 0.048	3.145ArgVal: 3.145 ± 0.061	0.704ArgTrp: 0.704 ± 0.028	1.883ArgTyr: 1.883 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.332SerAla: 5.332 ± 0.077	0.552SerCys: 0.552 ± 0.029	2.98SerAsp: 2.98 ± 0.059	2.928SerGlu: 2.928 ± 0.066	2.567SerPhe: 2.567 ± 0.053	4.712SerGly: 4.712 ± 0.091	1.515SerHis: 1.515 ± 0.042	3.859SerIle: 3.859 ± 0.07	2.685SerLys: 2.685 ± 0.055	6.661SerLeu: 6.661 ± 0.082	1.667SerMet: 1.667 ± 0.045	2.767SerAsn: 2.767 ± 0.067	2.658SerPro: 2.658 ± 0.057	3.195SerGln: 3.195 ± 0.064	3.099SerArg: 3.099 ± 0.066	4.333SerSer: 4.333 ± 0.081	3.57SerThr: 3.57 ± 0.078	3.866SerVal: 3.866 ± 0.061	0.782SerTrp: 0.782 ± 0.031	1.885SerTyr: 1.885 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.35ThrAla: 5.35 ± 0.109	0.478ThrCys: 0.478 ± 0.024	2.924ThrAsp: 2.924 ± 0.056	2.605ThrGlu: 2.605 ± 0.06	1.794ThrPhe: 1.794 ± 0.049	4.665ThrGly: 4.665 ± 0.121	1.248ThrHis: 1.248 ± 0.04	3.135ThrIle: 3.135 ± 0.066	1.884ThrLys: 1.884 ± 0.046	6.201ThrLeu: 6.201 ± 0.08	0.984ThrMet: 0.984 ± 0.033	1.84ThrAsn: 1.84 ± 0.065	2.989ThrPro: 2.989 ± 0.06	2.707ThrGln: 2.707 ± 0.055	2.603ThrArg: 2.603 ± 0.061	3.2ThrSer: 3.2 ± 0.073	3.405ThrThr: 3.405 ± 0.092	3.812ThrVal: 3.812 ± 0.079	0.553ThrTrp: 0.553 ± 0.027	1.462ThrTyr: 1.462 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	6.142ValAla: 6.142 ± 0.1	0.671ValCys: 0.671 ± 0.031	3.559ValAsp: 3.559 ± 0.074	3.817ValGlu: 3.817 ± 0.067	2.619ValPhe: 2.619 ± 0.061	4.249ValGly: 4.249 ± 0.069	1.352ValHis: 1.352 ± 0.042	4.389ValIle: 4.389 ± 0.083	3.077ValLys: 3.077 ± 0.061	7.071ValLeu: 7.071 ± 0.097	1.868ValMet: 1.868 ± 0.05	2.931ValAsn: 2.931 ± 0.068	2.82ValPro: 2.82 ± 0.057	3.229ValGln: 3.229 ± 0.061	3.118ValArg: 3.118 ± 0.058	4.226ValSer: 4.226 ± 0.074	3.656ValThr: 3.656 ± 0.07	4.834ValVal: 4.834 ± 0.081	0.791ValTrp: 0.791 ± 0.032	1.874ValTyr: 1.874 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.846TrpAla: 0.846 ± 0.032	0.137TrpCys: 0.137 ± 0.013	0.477TrpAsp: 0.477 ± 0.021	0.449TrpGlu: 0.449 ± 0.021	0.628TrpPhe: 0.628 ± 0.026	0.652TrpGly: 0.652 ± 0.029	0.414TrpHis: 0.414 ± 0.023	0.797TrpIle: 0.797 ± 0.032	0.474TrpLys: 0.474 ± 0.025	1.918TrpLeu: 1.918 ± 0.056	0.379TrpMet: 0.379 ± 0.023	0.5TrpAsn: 0.5 ± 0.024	0.539TrpPro: 0.539 ± 0.023	1.182TrpGln: 1.182 ± 0.04	0.737TrpArg: 0.737 ± 0.029	0.708TrpSer: 0.708 ± 0.031	0.579TrpThr: 0.579 ± 0.028	0.797TrpVal: 0.797 ± 0.036	0.178TrpTrp: 0.178 ± 0.013	0.377TrpTyr: 0.377 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.745TyrAla: 2.745 ± 0.055	0.35TyrCys: 0.35 ± 0.021	1.485TyrAsp: 1.485 ± 0.04	1.508TyrGlu: 1.508 ± 0.042	1.427TyrPhe: 1.427 ± 0.041	2.129TyrGly: 2.129 ± 0.046	0.773TyrHis: 0.773 ± 0.035	1.602TyrIle: 1.602 ± 0.05	1.29TyrLys: 1.29 ± 0.039	3.471TyrLeu: 3.471 ± 0.068	0.64TyrMet: 0.64 ± 0.025	1.145TyrAsn: 1.145 ± 0.039	1.392TyrPro: 1.392 ± 0.038	2.106TyrGln: 2.106 ± 0.047	1.733TyrArg: 1.733 ± 0.052	1.854TyrSer: 1.854 ± 0.045	1.475TyrThr: 1.475 ± 0.048	1.763TyrVal: 1.763 ± 0.048	0.488TyrTrp: 0.488 ± 0.025	0.954TyrTyr: 0.954 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2972 proteins (913620 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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