Amino acid dipepetide frequency for Prevotella sp. BP1-145

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.02AlaAla: 6.02 ± 0.124
1.02AlaCys: 1.02 ± 0.031
4.795AlaAsp: 4.795 ± 0.089
5.053AlaGlu: 5.053 ± 0.098
3.148AlaPhe: 3.148 ± 0.06
4.94AlaGly: 4.94 ± 0.084
1.368AlaHis: 1.368 ± 0.035
4.833AlaIle: 4.833 ± 0.08
4.396AlaLys: 4.396 ± 0.083
6.786AlaLeu: 6.786 ± 0.101
2.165AlaMet: 2.165 ± 0.045
3.301AlaAsn: 3.301 ± 0.067
2.404AlaPro: 2.404 ± 0.051
3.266AlaGln: 3.266 ± 0.059
3.253AlaArg: 3.253 ± 0.059
4.166AlaSer: 4.166 ± 0.07
4.387AlaThr: 4.387 ± 0.085
4.837AlaVal: 4.837 ± 0.081
0.911AlaTrp: 0.911 ± 0.027
3.017AlaTyr: 3.017 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.897CysAla: 0.897 ± 0.028
0.238CysCys: 0.238 ± 0.015
0.769CysAsp: 0.769 ± 0.026
0.774CysGlu: 0.774 ± 0.028
0.585CysPhe: 0.585 ± 0.025
1.183CysGly: 1.183 ± 0.033
0.382CysHis: 0.382 ± 0.018
0.869CysIle: 0.869 ± 0.03
0.723CysLys: 0.723 ± 0.024
1.025CysLeu: 1.025 ± 0.032
0.371CysMet: 0.371 ± 0.019
0.603CysAsn: 0.603 ± 0.026
0.543CysPro: 0.543 ± 0.022
0.501CysGln: 0.501 ± 0.02
0.639CysArg: 0.639 ± 0.024
0.822CysSer: 0.822 ± 0.03
0.738CysThr: 0.738 ± 0.026
0.86CysVal: 0.86 ± 0.028
0.187CysTrp: 0.187 ± 0.011
0.632CysTyr: 0.632 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.758AspAla: 4.758 ± 0.085
0.77AspCys: 0.77 ± 0.027
3.676AspAsp: 3.676 ± 0.061
4.429AspGlu: 4.429 ± 0.075
2.946AspPhe: 2.946 ± 0.055
4.98AspGly: 4.98 ± 0.085
1.045AspHis: 1.045 ± 0.033
4.123AspIle: 4.123 ± 0.058
3.595AspLys: 3.595 ± 0.057
4.628AspLeu: 4.628 ± 0.072
1.752AspMet: 1.752 ± 0.042
3.017AspAsn: 3.017 ± 0.06
1.98AspPro: 1.98 ± 0.045
1.594AspGln: 1.594 ± 0.041
2.45AspArg: 2.45 ± 0.045
3.327AspSer: 3.327 ± 0.064
2.891AspThr: 2.891 ± 0.059
3.973AspVal: 3.973 ± 0.059
0.926AspTrp: 0.926 ± 0.027
3.115AspTyr: 3.115 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.255GluAla: 5.255 ± 0.085
0.706GluCys: 0.706 ± 0.026
3.536GluAsp: 3.536 ± 0.059
4.76GluGlu: 4.76 ± 0.084
2.359GluPhe: 2.359 ± 0.04
4.489GluGly: 4.489 ± 0.071
1.386GluHis: 1.386 ± 0.039
3.875GluIle: 3.875 ± 0.073
4.663GluLys: 4.663 ± 0.07
5.618GluLeu: 5.618 ± 0.079
2.037GluMet: 2.037 ± 0.043
3.2GluAsn: 3.2 ± 0.056
1.967GluPro: 1.967 ± 0.054
3.094GluGln: 3.094 ± 0.052
3.325GluArg: 3.325 ± 0.06
2.973GluSer: 2.973 ± 0.057
3.274GluThr: 3.274 ± 0.062
4.158GluVal: 4.158 ± 0.068
0.909GluTrp: 0.909 ± 0.034
2.589GluTyr: 2.589 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
2.932PheAla: 2.932 ± 0.054
0.753PheCys: 0.753 ± 0.027
2.87PheAsp: 2.87 ± 0.045
2.431PheGlu: 2.431 ± 0.046
1.928PhePhe: 1.928 ± 0.052
3.08PheGly: 3.08 ± 0.067
0.921PheHis: 0.921 ± 0.028
2.653PheIle: 2.653 ± 0.047
2.286PheLys: 2.286 ± 0.046
3.518PheLeu: 3.518 ± 0.068
1.151PheMet: 1.151 ± 0.034
2.151PheAsn: 2.151 ± 0.046
1.465PhePro: 1.465 ± 0.036
1.317PheGln: 1.317 ± 0.033
1.961PheArg: 1.961 ± 0.041
2.953PheSer: 2.953 ± 0.056
2.737PheThr: 2.737 ± 0.054
2.849PheVal: 2.849 ± 0.055
0.544PheTrp: 0.544 ± 0.024
1.776PheTyr: 1.776 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.532GlyAla: 4.532 ± 0.074
1.061GlyCys: 1.061 ± 0.035
3.974GlyAsp: 3.974 ± 0.075
4.197GlyGlu: 4.197 ± 0.074
2.998GlyPhe: 2.998 ± 0.052
5.213GlyGly: 5.213 ± 0.119
1.497GlyHis: 1.497 ± 0.034
4.965GlyIle: 4.965 ± 0.079
4.835GlyLys: 4.835 ± 0.071
5.801GlyLeu: 5.801 ± 0.079
2.124GlyMet: 2.124 ± 0.042
3.566GlyAsn: 3.566 ± 0.084
1.479GlyPro: 1.479 ± 0.049
2.591GlyGln: 2.591 ± 0.051
3.219GlyArg: 3.219 ± 0.065
4.136GlySer: 4.136 ± 0.085
4.563GlyThr: 4.563 ± 0.096
4.772GlyVal: 4.772 ± 0.079
1.043GlyTrp: 1.043 ± 0.037
3.145GlyTyr: 3.145 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.291HisAla: 1.291 ± 0.033
0.323HisCys: 0.323 ± 0.02
1.128HisAsp: 1.128 ± 0.03
1.18HisGlu: 1.18 ± 0.041
1.098HisPhe: 1.098 ± 0.03
1.414HisGly: 1.414 ± 0.046
0.685HisHis: 0.685 ± 0.033
1.471HisIle: 1.471 ± 0.04
0.968HisLys: 0.968 ± 0.031
1.876HisLeu: 1.876 ± 0.044
0.435HisMet: 0.435 ± 0.018
0.963HisAsn: 0.963 ± 0.029
1.085HisPro: 1.085 ± 0.035
0.858HisGln: 0.858 ± 0.026
1.031HisArg: 1.031 ± 0.035
1.132HisSer: 1.132 ± 0.031
1.089HisThr: 1.089 ± 0.033
1.249HisVal: 1.249 ± 0.032
0.264HisTrp: 0.264 ± 0.014
1.028HisTyr: 1.028 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
4.92IleAla: 4.92 ± 0.087
1.021IleCys: 1.021 ± 0.032
4.351IleAsp: 4.351 ± 0.066
4.146IleGlu: 4.146 ± 0.065
2.51IlePhe: 2.51 ± 0.045
4.369IleGly: 4.369 ± 0.08
1.307IleHis: 1.307 ± 0.036
4.178IleIle: 4.178 ± 0.08
3.678IleLys: 3.678 ± 0.06
4.999IleLeu: 4.999 ± 0.094
1.45IleMet: 1.45 ± 0.042
3.272IleAsn: 3.272 ± 0.064
2.769IlePro: 2.769 ± 0.056
2.212IleGln: 2.212 ± 0.046
3.131IleArg: 3.131 ± 0.051
4.042IleSer: 4.042 ± 0.066
3.932IleThr: 3.932 ± 0.064
4.348IleVal: 4.348 ± 0.072
0.709IleTrp: 0.709 ± 0.03
2.538IleTyr: 2.538 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
5.161LysAla: 5.161 ± 0.096
0.557LysCys: 0.557 ± 0.024
3.821LysAsp: 3.821 ± 0.072
4.741LysGlu: 4.741 ± 0.076
2.001LysPhe: 2.001 ± 0.048
4.341LysGly: 4.341 ± 0.059
1.191LysHis: 1.191 ± 0.038
3.457LysIle: 3.457 ± 0.059
4.741LysLys: 4.741 ± 0.093
4.866LysLeu: 4.866 ± 0.068
2.273LysMet: 2.273 ± 0.041
3.188LysAsn: 3.188 ± 0.057
2.239LysPro: 2.239 ± 0.047
2.659LysGln: 2.659 ± 0.047
3.033LysArg: 3.033 ± 0.059
3.129LysSer: 3.129 ± 0.061
3.822LysThr: 3.822 ± 0.069
4.214LysVal: 4.214 ± 0.064
0.814LysTrp: 0.814 ± 0.028
2.676LysTyr: 2.676 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.249LeuAla: 6.249 ± 0.084
1.347LeuCys: 1.347 ± 0.038
4.832LeuAsp: 4.832 ± 0.071
4.82LeuGlu: 4.82 ± 0.083
3.66LeuPhe: 3.66 ± 0.065
5.486LeuGly: 5.486 ± 0.083
1.816LeuHis: 1.816 ± 0.046
4.815LeuIle: 4.815 ± 0.085
5.842LeuLys: 5.842 ± 0.08
7.945LeuLeu: 7.945 ± 0.12
2.778LeuMet: 2.778 ± 0.053
4.322LeuAsn: 4.322 ± 0.071
3.773LeuPro: 3.773 ± 0.078
3.541LeuGln: 3.541 ± 0.065
4.356LeuArg: 4.356 ± 0.083
6.096LeuSer: 6.096 ± 0.079
5.85LeuThr: 5.85 ± 0.078
5.017LeuVal: 5.017 ± 0.067
1.095LeuTrp: 1.095 ± 0.034
3.39LeuTyr: 3.39 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.576MetAla: 2.576 ± 0.048
0.301MetCys: 0.301 ± 0.017
1.588MetAsp: 1.588 ± 0.033
1.792MetGlu: 1.792 ± 0.045
0.994MetPhe: 0.994 ± 0.037
1.99MetGly: 1.99 ± 0.045
0.558MetHis: 0.558 ± 0.02
1.551MetIle: 1.551 ± 0.038
2.557MetLys: 2.557 ± 0.047
2.697MetLeu: 2.697 ± 0.052
1.069MetMet: 1.069 ± 0.03
1.523MetAsn: 1.523 ± 0.043
1.376MetPro: 1.376 ± 0.036
1.304MetGln: 1.304 ± 0.034
1.482MetArg: 1.482 ± 0.036
1.637MetSer: 1.637 ± 0.042
1.819MetThr: 1.819 ± 0.043
1.736MetVal: 1.736 ± 0.045
0.277MetTrp: 0.277 ± 0.017
0.823MetTyr: 0.823 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.645AsnAla: 3.645 ± 0.063
0.623AsnCys: 0.623 ± 0.026
2.943AsnAsp: 2.943 ± 0.065
2.92AsnGlu: 2.92 ± 0.054
1.942AsnPhe: 1.942 ± 0.047
4.146AsnGly: 4.146 ± 0.087
1.024AsnHis: 1.024 ± 0.031
3.412AsnIle: 3.412 ± 0.062
2.841AsnLys: 2.841 ± 0.049
4.04AsnLeu: 4.04 ± 0.075
1.312AsnMet: 1.312 ± 0.037
2.569AsnAsn: 2.569 ± 0.048
2.33AsnPro: 2.33 ± 0.058
1.692AsnGln: 1.692 ± 0.034
2.238AsnArg: 2.238 ± 0.046
2.673AsnSer: 2.673 ± 0.066
2.824AsnThr: 2.824 ± 0.059
3.143AsnVal: 3.143 ± 0.062
0.662AsnTrp: 0.662 ± 0.026
2.287AsnTyr: 2.287 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.769ProAla: 2.769 ± 0.064
0.411ProCys: 0.411 ± 0.019
2.586ProAsp: 2.586 ± 0.053
3.103ProGlu: 3.103 ± 0.062
1.675ProPhe: 1.675 ± 0.038
2.216ProGly: 2.216 ± 0.043
0.75ProHis: 0.75 ± 0.027
2.044ProIle: 2.044 ± 0.047
2.067ProLys: 2.067 ± 0.049
3.14ProLeu: 3.14 ± 0.062
1.028ProMet: 1.028 ± 0.033
1.661ProAsn: 1.661 ± 0.038
0.719ProPro: 0.719 ± 0.025
1.666ProGln: 1.666 ± 0.043
1.392ProArg: 1.392 ± 0.04
2.239ProSer: 2.239 ± 0.05
2.151ProThr: 2.151 ± 0.045
2.88ProVal: 2.88 ± 0.056
0.501ProTrp: 0.501 ± 0.024
1.71ProTyr: 1.71 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.823GlnAla: 2.823 ± 0.052
0.38GlnCys: 0.38 ± 0.02
1.83GlnAsp: 1.83 ± 0.04
2.416GlnGlu: 2.416 ± 0.056
1.616GlnPhe: 1.616 ± 0.04
2.439GlnGly: 2.439 ± 0.054
0.838GlnHis: 0.838 ± 0.026
2.373GlnIle: 2.373 ± 0.05
2.634GlnLys: 2.634 ± 0.058
3.957GlnLeu: 3.957 ± 0.068
1.469GlnMet: 1.469 ± 0.039
1.85GlnAsn: 1.85 ± 0.043
1.496GlnPro: 1.496 ± 0.039
2.242GlnGln: 2.242 ± 0.06
2.103GlnArg: 2.103 ± 0.047
1.931GlnSer: 1.931 ± 0.039
2.429GlnThr: 2.429 ± 0.05
2.421GlnVal: 2.421 ± 0.05
0.583GlnTrp: 0.583 ± 0.03
1.597GlnTyr: 1.597 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.753ArgAla: 2.753 ± 0.05
0.538ArgCys: 0.538 ± 0.022
2.421ArgAsp: 2.421 ± 0.052
3.153ArgGlu: 3.153 ± 0.059
2.202ArgPhe: 2.202 ± 0.042
2.628ArgGly: 2.628 ± 0.052
1.153ArgHis: 1.153 ± 0.036
3.421ArgIle: 3.421 ± 0.055
2.977ArgLys: 2.977 ± 0.059
4.597ArgLeu: 4.597 ± 0.077
1.588ArgMet: 1.588 ± 0.032
2.24ArgAsn: 2.24 ± 0.047
1.671ArgPro: 1.671 ± 0.038
2.336ArgGln: 2.336 ± 0.058
2.5ArgArg: 2.5 ± 0.054
2.337ArgSer: 2.337 ± 0.048
2.432ArgThr: 2.432 ± 0.043
2.781ArgVal: 2.781 ± 0.058
0.745ArgTrp: 0.745 ± 0.027
2.337ArgTyr: 2.337 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.275SerAla: 4.275 ± 0.071
0.795SerCys: 0.795 ± 0.031
3.576SerAsp: 3.576 ± 0.072
3.482SerGlu: 3.482 ± 0.068
2.718SerPhe: 2.718 ± 0.051
4.319SerGly: 4.319 ± 0.084
1.176SerHis: 1.176 ± 0.035
3.921SerIle: 3.921 ± 0.067
3.268SerLys: 3.268 ± 0.059
5.41SerLeu: 5.41 ± 0.078
1.529SerMet: 1.529 ± 0.04
2.708SerAsn: 2.708 ± 0.064
2.108SerPro: 2.108 ± 0.048
2.178SerGln: 2.178 ± 0.047
2.54SerArg: 2.54 ± 0.05
3.679SerSer: 3.679 ± 0.078
3.378SerThr: 3.378 ± 0.058
4.019SerVal: 4.019 ± 0.069
0.813SerTrp: 0.813 ± 0.027
2.529SerTyr: 2.529 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.467ThrAla: 4.467 ± 0.09
0.649ThrCys: 0.649 ± 0.024
3.592ThrAsp: 3.592 ± 0.066
3.355ThrGlu: 3.355 ± 0.074
2.664ThrPhe: 2.664 ± 0.053
4.337ThrGly: 4.337 ± 0.07
1.109ThrHis: 1.109 ± 0.035
4.36ThrIle: 4.36 ± 0.076
3.211ThrLys: 3.211 ± 0.055
5.76ThrLeu: 5.76 ± 0.087
1.623ThrMet: 1.623 ± 0.039
2.595ThrAsn: 2.595 ± 0.06
2.738ThrPro: 2.738 ± 0.052
1.831ThrGln: 1.831 ± 0.041
2.288ThrArg: 2.288 ± 0.038
3.616ThrSer: 3.616 ± 0.074
3.813ThrThr: 3.813 ± 0.076
4.14ThrVal: 4.14 ± 0.071
0.8ThrTrp: 0.8 ± 0.028
2.624ThrTyr: 2.624 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.82ValAla: 4.82 ± 0.073
1.053ValCys: 1.053 ± 0.034
3.854ValAsp: 3.854 ± 0.06
4.175ValGlu: 4.175 ± 0.07
2.68ValPhe: 2.68 ± 0.053
4.162ValGly: 4.162 ± 0.071
1.102ValHis: 1.102 ± 0.032
4.227ValIle: 4.227 ± 0.073
4.441ValLys: 4.441 ± 0.07
5.528ValLeu: 5.528 ± 0.087
1.945ValMet: 1.945 ± 0.047
3.393ValAsn: 3.393 ± 0.069
2.556ValPro: 2.556 ± 0.052
2.055ValGln: 2.055 ± 0.05
2.968ValArg: 2.968 ± 0.058
4.208ValSer: 4.208 ± 0.061
4.085ValThr: 4.085 ± 0.073
4.847ValVal: 4.847 ± 0.083
0.765ValTrp: 0.765 ± 0.03
2.708ValTyr: 2.708 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.887TrpAla: 0.887 ± 0.027
0.198TrpCys: 0.198 ± 0.012
0.832TrpAsp: 0.832 ± 0.031
0.746TrpGlu: 0.746 ± 0.029
0.535TrpPhe: 0.535 ± 0.024
0.951TrpGly: 0.951 ± 0.033
0.323TrpHis: 0.323 ± 0.02
0.732TrpIle: 0.732 ± 0.028
0.844TrpLys: 0.844 ± 0.033
1.307TrpLeu: 1.307 ± 0.042
0.432TrpMet: 0.432 ± 0.021
0.789TrpAsn: 0.789 ± 0.031
0.361TrpPro: 0.361 ± 0.019
0.693TrpGln: 0.693 ± 0.027
0.711TrpArg: 0.711 ± 0.029
0.775TrpSer: 0.775 ± 0.026
0.775TrpThr: 0.775 ± 0.027
0.684TrpVal: 0.684 ± 0.026
0.201TrpTrp: 0.201 ± 0.015
0.546TrpTyr: 0.546 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.038TyrAla: 3.038 ± 0.057
0.6TyrCys: 0.6 ± 0.022
2.998TyrAsp: 2.998 ± 0.06
2.5TyrGlu: 2.5 ± 0.041
2.016TyrPhe: 2.016 ± 0.046
3.027TyrGly: 3.027 ± 0.075
0.939TyrHis: 0.939 ± 0.031
2.603TyrIle: 2.603 ± 0.054
2.357TyrLys: 2.357 ± 0.047
3.53TyrLeu: 3.53 ± 0.062
1.119TyrMet: 1.119 ± 0.033
2.355TyrAsn: 2.355 ± 0.053
1.647TyrPro: 1.647 ± 0.043
1.801TyrGln: 1.801 ± 0.044
2.191TyrArg: 2.191 ± 0.041
2.546TyrSer: 2.546 ± 0.051
2.581TyrThr: 2.581 ± 0.054
2.648TyrVal: 2.648 ± 0.053
0.571TyrTrp: 0.571 ± 0.023
2.244TyrTyr: 2.244 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2923 proteins (1088372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski