Amino acid dipepetide frequency for Carideicomes alvinocaridis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.385AlaAla: 17.385 ± 0.16	1.01AlaCys: 1.01 ± 0.025	6.644AlaAsp: 6.644 ± 0.067	9.614AlaGlu: 9.614 ± 0.102	4.101AlaPhe: 4.101 ± 0.055	11.575AlaGly: 11.575 ± 0.111	2.341AlaHis: 2.341 ± 0.037	5.283AlaIle: 5.283 ± 0.065	3.115AlaLys: 3.115 ± 0.055	14.282AlaLeu: 14.282 ± 0.154	3.72AlaMet: 3.72 ± 0.048	2.258AlaAsn: 2.258 ± 0.042	6.312AlaPro: 6.312 ± 0.087	4.208AlaGln: 4.208 ± 0.055	9.868AlaArg: 9.868 ± 0.099	5.426AlaSer: 5.426 ± 0.068	5.945AlaThr: 5.945 ± 0.07	8.566AlaVal: 8.566 ± 0.093	1.597AlaTrp: 1.597 ± 0.039	2.508AlaTyr: 2.508 ± 0.045	0.017AlaXaa: 0.017 ± 0.003
Cys	1.0CysAla: 1.0 ± 0.029	0.113CysCys: 0.113 ± 0.009	0.574CysAsp: 0.574 ± 0.019	0.446CysGlu: 0.446 ± 0.015	0.309CysPhe: 0.309 ± 0.012	0.882CysGly: 0.882 ± 0.026	0.275CysHis: 0.275 ± 0.012	0.347CysIle: 0.347 ± 0.016	0.146CysLys: 0.146 ± 0.01	0.879CysLeu: 0.879 ± 0.024	0.15CysMet: 0.15 ± 0.01	0.199CysAsn: 0.199 ± 0.012	0.491CysPro: 0.491 ± 0.019	0.186CysGln: 0.186 ± 0.01	0.603CysArg: 0.603 ± 0.022	0.404CysSer: 0.404 ± 0.018	0.424CysThr: 0.424 ± 0.018	0.568CysVal: 0.568 ± 0.018	0.134CysTrp: 0.134 ± 0.01	0.188CysTyr: 0.188 ± 0.012	0.003CysXaa: 0.003 ± 0.001
Asp	7.004AspAla: 7.004 ± 0.081	0.494AspCys: 0.494 ± 0.019	3.326AspAsp: 3.326 ± 0.073	4.021AspGlu: 4.021 ± 0.064	2.261AspPhe: 2.261 ± 0.043	5.497AspGly: 5.497 ± 0.072	1.391AspHis: 1.391 ± 0.032	2.672AspIle: 2.672 ± 0.047	1.475AspLys: 1.475 ± 0.038	6.391AspLeu: 6.391 ± 0.065	1.628AspMet: 1.628 ± 0.033	1.151AspAsn: 1.151 ± 0.033	4.035AspPro: 4.035 ± 0.059	1.658AspGln: 1.658 ± 0.036	5.031AspArg: 5.031 ± 0.068	2.302AspSer: 2.302 ± 0.045	2.703AspThr: 2.703 ± 0.054	4.073AspVal: 4.073 ± 0.053	1.207AspTrp: 1.207 ± 0.028	1.519AspTyr: 1.519 ± 0.031	0.016AspXaa: 0.016 ± 0.005
Glu	9.594GluAla: 9.594 ± 0.099	0.363GluCys: 0.363 ± 0.017	3.876GluAsp: 3.876 ± 0.071	4.725GluGlu: 4.725 ± 0.083	1.765GluPhe: 1.765 ± 0.037	6.054GluGly: 6.054 ± 0.083	1.226GluHis: 1.226 ± 0.03	3.494GluIle: 3.494 ± 0.053	2.076GluLys: 2.076 ± 0.049	5.859GluLeu: 5.859 ± 0.061	2.016GluMet: 2.016 ± 0.037	1.617GluAsn: 1.617 ± 0.036	2.931GluPro: 2.931 ± 0.046	2.075GluGln: 2.075 ± 0.045	5.05GluArg: 5.05 ± 0.063	2.528GluSer: 2.528 ± 0.04	4.012GluThr: 4.012 ± 0.06	4.92GluVal: 4.92 ± 0.057	0.8GluTrp: 0.8 ± 0.025	1.127GluTyr: 1.127 ± 0.028	0.014GluXaa: 0.014 ± 0.003
Phe	4.278PheAla: 4.278 ± 0.056	0.394PheCys: 0.394 ± 0.016	2.671PheAsp: 2.671 ± 0.047	2.114PheGlu: 2.114 ± 0.045	1.343PhePhe: 1.343 ± 0.032	3.531PheGly: 3.531 ± 0.05	0.747PheHis: 0.747 ± 0.022	1.409PheIle: 1.409 ± 0.032	0.732PheLys: 0.732 ± 0.025	3.443PheLeu: 3.443 ± 0.054	0.767PheMet: 0.767 ± 0.025	0.857PheAsn: 0.857 ± 0.027	1.574PhePro: 1.574 ± 0.033	0.911PheGln: 0.911 ± 0.025	2.383PheArg: 2.383 ± 0.043	1.906PheSer: 1.906 ± 0.037	1.95PheThr: 1.95 ± 0.039	2.576PheVal: 2.576 ± 0.04	0.53PheTrp: 0.53 ± 0.023	0.842PheTyr: 0.842 ± 0.027	0.009PheXaa: 0.009 ± 0.002
Gly	10.455GlyAla: 10.455 ± 0.129	0.786GlyCys: 0.786 ± 0.025	4.858GlyAsp: 4.858 ± 0.082	5.579GlyGlu: 5.579 ± 0.058	3.457GlyPhe: 3.457 ± 0.052	7.898GlyGly: 7.898 ± 0.112	2.069GlyHis: 2.069 ± 0.036	4.228GlyIle: 4.228 ± 0.055	2.681GlyLys: 2.681 ± 0.051	9.678GlyLeu: 9.678 ± 0.102	2.73GlyMet: 2.73 ± 0.051	1.934GlyAsn: 1.934 ± 0.048	4.152GlyPro: 4.152 ± 0.048	3.008GlyGln: 3.008 ± 0.044	6.878GlyArg: 6.878 ± 0.078	4.257GlySer: 4.257 ± 0.054	4.977GlyThr: 4.977 ± 0.069	6.413GlyVal: 6.413 ± 0.069	1.561GlyTrp: 1.561 ± 0.034	2.335GlyTyr: 2.335 ± 0.038	0.01GlyXaa: 0.01 ± 0.003
His	2.378HisAla: 2.378 ± 0.038	0.249HisCys: 0.249 ± 0.014	1.303HisAsp: 1.303 ± 0.032	1.176HisGlu: 1.176 ± 0.03	0.858HisPhe: 0.858 ± 0.024	2.053HisGly: 2.053 ± 0.041	0.571HisHis: 0.571 ± 0.022	0.819HisIle: 0.819 ± 0.02	0.409HisLys: 0.409 ± 0.018	2.192HisLeu: 2.192 ± 0.045	0.501HisMet: 0.501 ± 0.017	0.394HisAsn: 0.394 ± 0.015	1.455HisPro: 1.455 ± 0.035	0.546HisGln: 0.546 ± 0.02	1.579HisArg: 1.579 ± 0.032	0.933HisSer: 0.933 ± 0.026	0.738HisThr: 0.738 ± 0.022	1.632HisVal: 1.632 ± 0.03	0.382HisTrp: 0.382 ± 0.017	0.581HisTyr: 0.581 ± 0.021	0.006HisXaa: 0.006 ± 0.002
Ile	6.325IleAla: 6.325 ± 0.073	0.551IleCys: 0.551 ± 0.02	3.072IleAsp: 3.072 ± 0.049	3.159IleGlu: 3.159 ± 0.053	1.636IlePhe: 1.636 ± 0.039	4.331IleGly: 4.331 ± 0.057	0.863IleHis: 0.863 ± 0.024	1.781IleIle: 1.781 ± 0.038	1.07IleLys: 1.07 ± 0.031	4.492IleLeu: 4.492 ± 0.061	0.964IleMet: 0.964 ± 0.022	1.079IleAsn: 1.079 ± 0.029	2.218IlePro: 2.218 ± 0.034	1.025IleGln: 1.025 ± 0.028	3.334IleArg: 3.334 ± 0.053	2.542IleSer: 2.542 ± 0.042	2.599IleThr: 2.599 ± 0.039	3.345IleVal: 3.345 ± 0.051	0.649IleTrp: 0.649 ± 0.022	1.062IleTyr: 1.062 ± 0.028	0.016IleXaa: 0.016 ± 0.004
Lys	3.3LysAla: 3.3 ± 0.057	0.148LysCys: 0.148 ± 0.01	1.506LysAsp: 1.506 ± 0.039	1.501LysGlu: 1.501 ± 0.035	0.712LysPhe: 0.712 ± 0.024	2.271LysGly: 2.271 ± 0.045	0.527LysHis: 0.527 ± 0.016	1.266LysIle: 1.266 ± 0.031	1.001LysLys: 1.001 ± 0.036	2.578LysLeu: 2.578 ± 0.046	0.7LysMet: 0.7 ± 0.022	0.656LysAsn: 0.656 ± 0.023	1.56LysPro: 1.56 ± 0.034	0.794LysGln: 0.794 ± 0.024	1.991LysArg: 1.991 ± 0.044	1.491LysSer: 1.491 ± 0.033	1.604LysThr: 1.604 ± 0.033	2.122LysVal: 2.122 ± 0.046	0.295LysTrp: 0.295 ± 0.014	0.573LysTyr: 0.573 ± 0.023	0.01LysXaa: 0.01 ± 0.003
Leu	13.69LeuAla: 13.69 ± 0.138	0.93LeuCys: 0.93 ± 0.026	6.406LeuAsp: 6.406 ± 0.068	6.041LeuGlu: 6.041 ± 0.068	3.461LeuPhe: 3.461 ± 0.062	8.974LeuGly: 8.974 ± 0.099	2.016LeuHis: 2.016 ± 0.041	4.701LeuIle: 4.701 ± 0.064	2.847LeuLys: 2.847 ± 0.047	9.741LeuLeu: 9.741 ± 0.118	2.549LeuMet: 2.549 ± 0.045	2.315LeuAsn: 2.315 ± 0.037	5.873LeuPro: 5.873 ± 0.065	2.648LeuGln: 2.648 ± 0.046	7.937LeuArg: 7.937 ± 0.08	6.342LeuSer: 6.342 ± 0.078	5.754LeuThr: 5.754 ± 0.066	7.511LeuVal: 7.511 ± 0.081	1.336LeuTrp: 1.336 ± 0.032	1.995LeuTyr: 1.995 ± 0.044	0.019LeuXaa: 0.019 ± 0.005
Met	3.481MetAla: 3.481 ± 0.053	0.165MetCys: 0.165 ± 0.01	1.376MetAsp: 1.376 ± 0.033	1.554MetGlu: 1.554 ± 0.032	0.734MetPhe: 0.734 ± 0.024	2.228MetGly: 2.228 ± 0.041	0.42MetHis: 0.42 ± 0.018	1.441MetIle: 1.441 ± 0.031	0.938MetLys: 0.938 ± 0.025	2.613MetLeu: 2.613 ± 0.043	0.802MetMet: 0.802 ± 0.026	0.75MetAsn: 0.75 ± 0.022	1.487MetPro: 1.487 ± 0.031	0.915MetGln: 0.915 ± 0.022	1.94MetArg: 1.94 ± 0.038	1.719MetSer: 1.719 ± 0.034	1.983MetThr: 1.983 ± 0.041	1.821MetVal: 1.821 ± 0.04	0.221MetTrp: 0.221 ± 0.014	0.313MetTyr: 0.313 ± 0.014	0.005MetXaa: 0.005 ± 0.002
Asn	2.697AsnAla: 2.697 ± 0.041	0.198AsnCys: 0.198 ± 0.013	1.232AsnAsp: 1.232 ± 0.036	1.154AsnGlu: 1.154 ± 0.033	0.841AsnPhe: 0.841 ± 0.026	2.037AsnGly: 2.037 ± 0.035	0.462AsnHis: 0.462 ± 0.018	1.127AsnIle: 1.127 ± 0.028	0.492AsnLys: 0.492 ± 0.022	2.222AsnLeu: 2.222 ± 0.042	0.607AsnMet: 0.607 ± 0.019	0.54AsnAsn: 0.54 ± 0.021	1.582AsnPro: 1.582 ± 0.034	0.613AsnGln: 0.613 ± 0.022	1.64AsnArg: 1.64 ± 0.036	1.006AsnSer: 1.006 ± 0.027	1.121AsnThr: 1.121 ± 0.027	1.644AsnVal: 1.644 ± 0.039	0.357AsnTrp: 0.357 ± 0.017	0.53AsnTyr: 0.53 ± 0.021	0.009AsnXaa: 0.009 ± 0.003
Pro	6.488ProAla: 6.488 ± 0.073	0.343ProCys: 0.343 ± 0.014	4.047ProAsp: 4.047 ± 0.062	5.025ProGlu: 5.025 ± 0.064	1.912ProPhe: 1.912 ± 0.032	5.284ProGly: 5.284 ± 0.072	1.064ProHis: 1.064 ± 0.028	1.95ProIle: 1.95 ± 0.04	1.352ProLys: 1.352 ± 0.033	4.844ProLeu: 4.844 ± 0.063	1.268ProMet: 1.268 ± 0.032	1.058ProAsn: 1.058 ± 0.026	2.617ProPro: 2.617 ± 0.051	1.616ProGln: 1.616 ± 0.035	3.417ProArg: 3.417 ± 0.052	2.573ProSer: 2.573 ± 0.049	2.201ProThr: 2.201 ± 0.038	4.558ProVal: 4.558 ± 0.054	0.724ProTrp: 0.724 ± 0.027	1.147ProTyr: 1.147 ± 0.028	0.011ProXaa: 0.011 ± 0.003
Gln	3.938GlnAla: 3.938 ± 0.061	0.18GlnCys: 0.18 ± 0.011	1.64GlnAsp: 1.64 ± 0.033	1.801GlnGlu: 1.801 ± 0.037	0.872GlnPhe: 0.872 ± 0.021	2.546GlnGly: 2.546 ± 0.041	0.557GlnHis: 0.557 ± 0.019	1.655GlnIle: 1.655 ± 0.034	0.952GlnLys: 0.952 ± 0.029	2.671GlnLeu: 2.671 ± 0.044	0.915GlnMet: 0.915 ± 0.027	0.711GlnAsn: 0.711 ± 0.022	1.637GlnPro: 1.637 ± 0.035	1.044GlnGln: 1.044 ± 0.031	2.244GlnArg: 2.244 ± 0.045	1.594GlnSer: 1.594 ± 0.033	1.552GlnThr: 1.552 ± 0.032	2.357GlnVal: 2.357 ± 0.037	0.384GlnTrp: 0.384 ± 0.015	0.553GlnTyr: 0.553 ± 0.021	0.009GlnXaa: 0.009 ± 0.003
Arg	9.089ArgAla: 9.089 ± 0.089	0.496ArgCys: 0.496 ± 0.02	4.836ArgAsp: 4.836 ± 0.067	4.874ArgGlu: 4.874 ± 0.063	2.788ArgPhe: 2.788 ± 0.047	5.352ArgGly: 5.352 ± 0.068	1.824ArgHis: 1.824 ± 0.037	4.014ArgIle: 4.014 ± 0.056	2.073ArgLys: 2.073 ± 0.044	8.457ArgLeu: 8.457 ± 0.097	2.096ArgMet: 2.096 ± 0.043	1.705ArgAsn: 1.705 ± 0.035	3.988ArgPro: 3.988 ± 0.062	2.488ArgGln: 2.488 ± 0.042	6.336ArgArg: 6.336 ± 0.079	3.503ArgSer: 3.503 ± 0.046	3.241ArgThr: 3.241 ± 0.046	5.074ArgVal: 5.074 ± 0.055	1.025ArgTrp: 1.025 ± 0.025	1.667ArgTyr: 1.667 ± 0.034	0.009ArgXaa: 0.009 ± 0.003
Ser	5.689SerAla: 5.689 ± 0.063	0.439SerCys: 0.439 ± 0.016	3.106SerAsp: 3.106 ± 0.055	2.955SerGlu: 2.955 ± 0.046	2.099SerPhe: 2.099 ± 0.036	5.319SerGly: 5.319 ± 0.077	1.084SerHis: 1.084 ± 0.029	2.14SerIle: 2.14 ± 0.038	1.202SerLys: 1.202 ± 0.029	4.922SerLeu: 4.922 ± 0.063	1.314SerMet: 1.314 ± 0.03	1.12SerAsn: 1.12 ± 0.029	2.542SerPro: 2.542 ± 0.046	1.479SerGln: 1.479 ± 0.032	3.547SerArg: 3.547 ± 0.058	2.554SerSer: 2.554 ± 0.049	2.379SerThr: 2.379 ± 0.045	3.718SerVal: 3.718 ± 0.051	0.692SerTrp: 0.692 ± 0.024	1.265SerTyr: 1.265 ± 0.03	0.012SerXaa: 0.012 ± 0.004
Thr	6.003ThrAla: 6.003 ± 0.077	0.446ThrCys: 0.446 ± 0.018	3.048ThrAsp: 3.048 ± 0.051	3.294ThrGlu: 3.294 ± 0.046	1.826ThrPhe: 1.826 ± 0.036	5.613ThrGly: 5.613 ± 0.08	1.05ThrHis: 1.05 ± 0.025	2.37ThrIle: 2.37 ± 0.043	1.167ThrLys: 1.167 ± 0.031	5.909ThrLeu: 5.909 ± 0.081	1.232ThrMet: 1.232 ± 0.029	1.058ThrAsn: 1.058 ± 0.033	3.403ThrPro: 3.403 ± 0.04	1.375ThrGln: 1.375 ± 0.028	3.732ThrArg: 3.732 ± 0.047	2.499ThrSer: 2.499 ± 0.047	2.684ThrThr: 2.684 ± 0.045	3.962ThrVal: 3.962 ± 0.054	0.693ThrTrp: 0.693 ± 0.02	1.191ThrTyr: 1.191 ± 0.032	0.009ThrXaa: 0.009 ± 0.002
Val	9.098ValAla: 9.098 ± 0.085	0.625ValCys: 0.625 ± 0.024	3.976ValAsp: 3.976 ± 0.055	5.003ValGlu: 5.003 ± 0.059	2.643ValPhe: 2.643 ± 0.045	5.38ValGly: 5.38 ± 0.06	1.382ValHis: 1.382 ± 0.03	3.912ValIle: 3.912 ± 0.051	1.954ValLys: 1.954 ± 0.042	7.833ValLeu: 7.833 ± 0.079	2.097ValMet: 2.097 ± 0.036	1.776ValAsn: 1.776 ± 0.038	3.859ValPro: 3.859 ± 0.055	1.986ValGln: 1.986 ± 0.037	4.472ValArg: 4.472 ± 0.063	4.079ValSer: 4.079 ± 0.057	4.88ValThr: 4.88 ± 0.061	5.732ValVal: 5.732 ± 0.069	0.931ValTrp: 0.931 ± 0.027	1.407ValTyr: 1.407 ± 0.033	0.01ValXaa: 0.01 ± 0.003
Trp	1.394TrpAla: 1.394 ± 0.035	0.137TrpCys: 0.137 ± 0.01	0.779TrpAsp: 0.779 ± 0.023	0.702TrpGlu: 0.702 ± 0.022	0.517TrpPhe: 0.517 ± 0.017	1.031TrpGly: 1.031 ± 0.029	0.364TrpHis: 0.364 ± 0.017	0.655TrpIle: 0.655 ± 0.02	0.423TrpLys: 0.423 ± 0.018	1.757TrpLeu: 1.757 ± 0.04	0.389TrpMet: 0.389 ± 0.015	0.378TrpAsn: 0.378 ± 0.017	0.73TrpPro: 0.73 ± 0.024	0.628TrpGln: 0.628 ± 0.022	1.197TrpArg: 1.197 ± 0.027	0.796TrpSer: 0.796 ± 0.025	0.826TrpThr: 0.826 ± 0.029	0.908TrpVal: 0.908 ± 0.027	0.237TrpTrp: 0.237 ± 0.012	0.28TrpTyr: 0.28 ± 0.014	0.003TrpXaa: 0.003 ± 0.001
Tyr	2.474TyrAla: 2.474 ± 0.04	0.25TyrCys: 0.25 ± 0.013	1.562TyrAsp: 1.562 ± 0.032	1.365TyrGlu: 1.365 ± 0.035	0.825TyrPhe: 0.825 ± 0.023	2.075TyrGly: 2.075 ± 0.044	0.518TyrHis: 0.518 ± 0.017	0.835TyrIle: 0.835 ± 0.022	0.48TyrLys: 0.48 ± 0.019	2.311TyrLeu: 2.311 ± 0.044	0.46TyrMet: 0.46 ± 0.019	0.545TyrAsn: 0.545 ± 0.021	1.05TyrPro: 1.05 ± 0.027	0.598TyrGln: 0.598 ± 0.023	1.744TyrArg: 1.744 ± 0.038	1.11TyrSer: 1.11 ± 0.031	0.988TyrThr: 0.988 ± 0.024	1.519TyrVal: 1.519 ± 0.034	0.373TyrTrp: 0.373 ± 0.018	0.593TyrTyr: 0.593 ± 0.022	0.008TyrXaa: 0.008 ± 0.002
Xaa	0.013XaaAla: 0.013 ± 0.003	0.001XaaCys: 0.001 ± 0.001	0.015XaaAsp: 0.015 ± 0.004	0.017XaaGlu: 0.017 ± 0.004	0.01XaaPhe: 0.01 ± 0.003	0.011XaaGly: 0.011 ± 0.003	0.005XaaHis: 0.005 ± 0.002	0.014XaaIle: 0.014 ± 0.003	0.02XaaLys: 0.02 ± 0.005	0.013XaaLeu: 0.013 ± 0.004	0.004XaaMet: 0.004 ± 0.002	0.012XaaAsn: 0.012 ± 0.004	0.004XaaPro: 0.004 ± 0.002	0.012XaaGln: 0.012 ± 0.003	0.012XaaArg: 0.012 ± 0.003	0.015XaaSer: 0.015 ± 0.004	0.005XaaThr: 0.005 ± 0.002	0.013XaaVal: 0.013 ± 0.004	0.001XaaTrp: 0.001 ± 0.001	0.007XaaTyr: 0.007 ± 0.003	0.015XaaXaa: 0.015 ± 0.005

Statistics based on 5316 proteins (1503426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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