Amino acid dipepetide frequency for Halovirus HVTV-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.039AlaAla: 5.039 ± 0.516
0.804AlaCys: 0.804 ± 0.174
6.059AlaAsp: 6.059 ± 0.376
6.554AlaGlu: 6.554 ± 0.382
1.886AlaPhe: 1.886 ± 0.243
5.564AlaGly: 5.564 ± 0.416
1.484AlaHis: 1.484 ± 0.249
2.782AlaIle: 2.782 ± 0.3
2.844AlaLys: 2.844 ± 0.33
4.884AlaLeu: 4.884 ± 0.419
1.577AlaMet: 1.577 ± 0.215
2.38AlaAsn: 2.38 ± 0.269
2.195AlaPro: 2.195 ± 0.317
2.937AlaGln: 2.937 ± 0.292
4.483AlaArg: 4.483 ± 0.322
4.204AlaSer: 4.204 ± 0.404
3.586AlaThr: 3.586 ± 0.454
4.915AlaVal: 4.915 ± 0.435
1.206AlaTrp: 1.206 ± 0.227
2.628AlaTyr: 2.628 ± 0.26
0.0AlaXaa: 0.0 ± 0.0
Cys
0.804CysAla: 0.804 ± 0.144
0.062CysCys: 0.062 ± 0.043
1.267CysAsp: 1.267 ± 0.222
1.237CysGlu: 1.237 ± 0.19
0.247CysPhe: 0.247 ± 0.091
1.608CysGly: 1.608 ± 0.272
0.216CysHis: 0.216 ± 0.097
0.155CysIle: 0.155 ± 0.059
0.464CysLys: 0.464 ± 0.111
0.464CysLeu: 0.464 ± 0.125
0.247CysMet: 0.247 ± 0.088
0.34CysAsn: 0.34 ± 0.099
0.989CysPro: 0.989 ± 0.203
0.402CysGln: 0.402 ± 0.108
0.742CysArg: 0.742 ± 0.149
0.556CysSer: 0.556 ± 0.168
0.34CysThr: 0.34 ± 0.099
0.587CysVal: 0.587 ± 0.133
0.309CysTrp: 0.309 ± 0.112
0.309CysTyr: 0.309 ± 0.108
0.0CysXaa: 0.0 ± 0.0
Asp
7.698AspAla: 7.698 ± 0.441
0.989AspCys: 0.989 ± 0.211
11.84AspAsp: 11.84 ± 1.039
13.386AspGlu: 13.386 ± 1.009
3.493AspPhe: 3.493 ± 0.325
7.543AspGly: 7.543 ± 0.547
1.638AspHis: 1.638 ± 0.25
3.926AspIle: 3.926 ± 0.45
3.06AspLys: 3.06 ± 0.334
7.357AspLeu: 7.357 ± 0.553
2.257AspMet: 2.257 ± 0.283
4.05AspAsn: 4.05 ± 0.389
4.235AspPro: 4.235 ± 0.382
2.319AspGln: 2.319 ± 0.272
4.483AspArg: 4.483 ± 0.41
4.483AspSer: 4.483 ± 0.411
5.008AspThr: 5.008 ± 0.454
7.296AspVal: 7.296 ± 0.477
1.7AspTrp: 1.7 ± 0.211
2.597AspTyr: 2.597 ± 0.288
0.0AspXaa: 0.0 ± 0.0
Glu
7.388GluAla: 7.388 ± 0.609
1.298GluCys: 1.298 ± 0.211
10.48GluAsp: 10.48 ± 0.706
11.407GluGlu: 11.407 ± 0.732
3.06GluPhe: 3.06 ± 0.316
6.245GluGly: 6.245 ± 0.492
3.122GluHis: 3.122 ± 0.392
4.483GluIle: 4.483 ± 0.423
4.483GluLys: 4.483 ± 0.374
5.874GluLeu: 5.874 ± 0.356
2.844GluMet: 2.844 ± 0.315
3.802GluAsn: 3.802 ± 0.326
3.741GluPro: 3.741 ± 0.419
4.142GluGln: 4.142 ± 0.372
6.616GluArg: 6.616 ± 0.549
5.348GluSer: 5.348 ± 0.431
5.472GluThr: 5.472 ± 0.38
9.15GluVal: 9.15 ± 0.524
2.349GluTrp: 2.349 ± 0.281
4.112GluTyr: 4.112 ± 0.396
0.0GluXaa: 0.0 ± 0.0
Phe
1.978PheAla: 1.978 ± 0.204
0.464PheCys: 0.464 ± 0.126
3.246PheAsp: 3.246 ± 0.294
3.277PheGlu: 3.277 ± 0.336
0.742PhePhe: 0.742 ± 0.149
2.69PheGly: 2.69 ± 0.278
0.587PheHis: 0.587 ± 0.153
1.175PheIle: 1.175 ± 0.207
1.391PheLys: 1.391 ± 0.197
1.978PheLeu: 1.978 ± 0.313
0.897PheMet: 0.897 ± 0.153
1.113PheAsn: 1.113 ± 0.168
0.835PhePro: 0.835 ± 0.173
1.175PheGln: 1.175 ± 0.191
1.267PheArg: 1.267 ± 0.19
2.133PheSer: 2.133 ± 0.258
1.608PheThr: 1.608 ± 0.224
2.195PheVal: 2.195 ± 0.27
1.206PheTrp: 1.206 ± 0.216
1.298PheTyr: 1.298 ± 0.247
0.0PheXaa: 0.0 ± 0.0
Gly
4.915GlyAla: 4.915 ± 0.39
0.649GlyCys: 0.649 ± 0.154
7.759GlyAsp: 7.759 ± 0.757
7.296GlyGlu: 7.296 ± 0.512
2.102GlyPhe: 2.102 ± 0.29
6.43GlyGly: 6.43 ± 0.631
1.824GlyHis: 1.824 ± 0.198
2.782GlyIle: 2.782 ± 0.293
3.06GlyLys: 3.06 ± 0.309
4.112GlyLeu: 4.112 ± 0.404
1.824GlyMet: 1.824 ± 0.293
2.999GlyAsn: 2.999 ± 0.312
1.886GlyPro: 1.886 ± 0.245
2.628GlyGln: 2.628 ± 0.266
4.823GlyArg: 4.823 ± 0.325
3.895GlySer: 3.895 ± 0.396
4.39GlyThr: 4.39 ± 0.406
5.688GlyVal: 5.688 ± 0.365
1.453GlyTrp: 1.453 ± 0.192
2.782GlyTyr: 2.782 ± 0.284
0.0GlyXaa: 0.0 ± 0.0
His
1.329HisAla: 1.329 ± 0.196
0.464HisCys: 0.464 ± 0.113
1.546HisAsp: 1.546 ± 0.249
2.257HisGlu: 2.257 ± 0.253
0.742HisPhe: 0.742 ± 0.148
2.071HisGly: 2.071 ± 0.313
0.773HisHis: 0.773 ± 0.168
1.206HisIle: 1.206 ± 0.197
0.526HisLys: 0.526 ± 0.12
1.917HisLeu: 1.917 ± 0.234
0.402HisMet: 0.402 ± 0.092
0.927HisAsn: 0.927 ± 0.168
1.298HisPro: 1.298 ± 0.189
0.773HisGln: 0.773 ± 0.155
1.824HisArg: 1.824 ± 0.262
0.989HisSer: 0.989 ± 0.184
0.958HisThr: 0.958 ± 0.152
1.762HisVal: 1.762 ± 0.254
0.34HisTrp: 0.34 ± 0.09
0.897HisTyr: 0.897 ± 0.203
0.0HisXaa: 0.0 ± 0.0
Ile
2.411IleAla: 2.411 ± 0.224
0.247IleCys: 0.247 ± 0.087
3.308IleAsp: 3.308 ± 0.34
4.452IleGlu: 4.452 ± 0.426
1.144IlePhe: 1.144 ± 0.175
2.659IleGly: 2.659 ± 0.359
1.051IleHis: 1.051 ± 0.182
1.484IleIle: 1.484 ± 0.188
1.731IleLys: 1.731 ± 0.246
3.122IleLeu: 3.122 ± 0.298
0.835IleMet: 0.835 ± 0.158
1.608IleAsn: 1.608 ± 0.21
2.009IlePro: 2.009 ± 0.285
1.484IleGln: 1.484 ± 0.23
2.319IleArg: 2.319 ± 0.31
2.906IleSer: 2.906 ± 0.31
2.597IleThr: 2.597 ± 0.266
2.72IleVal: 2.72 ± 0.29
0.742IleTrp: 0.742 ± 0.136
1.113IleTyr: 1.113 ± 0.197
0.0IleXaa: 0.0 ± 0.0
Lys
2.628LysAla: 2.628 ± 0.299
0.309LysCys: 0.309 ± 0.098
2.473LysAsp: 2.473 ± 0.276
3.679LysGlu: 3.679 ± 0.34
1.515LysPhe: 1.515 ± 0.242
2.164LysGly: 2.164 ± 0.24
1.515LysHis: 1.515 ± 0.193
1.453LysIle: 1.453 ± 0.178
1.948LysLys: 1.948 ± 0.235
2.782LysLeu: 2.782 ± 0.305
1.206LysMet: 1.206 ± 0.213
1.886LysAsn: 1.886 ± 0.251
1.175LysPro: 1.175 ± 0.193
1.484LysGln: 1.484 ± 0.191
3.246LysArg: 3.246 ± 0.338
2.349LysSer: 2.349 ± 0.279
2.38LysThr: 2.38 ± 0.28
3.431LysVal: 3.431 ± 0.329
0.711LysTrp: 0.711 ± 0.148
1.546LysTyr: 1.546 ± 0.223
0.0LysXaa: 0.0 ± 0.0
Leu
5.564LeuAla: 5.564 ± 0.506
0.711LeuCys: 0.711 ± 0.14
7.45LeuAsp: 7.45 ± 0.51
6.646LeuGlu: 6.646 ± 0.486
1.793LeuPhe: 1.793 ± 0.214
4.112LeuGly: 4.112 ± 0.33
1.608LeuHis: 1.608 ± 0.228
2.226LeuIle: 2.226 ± 0.273
2.72LeuLys: 2.72 ± 0.351
4.823LeuLeu: 4.823 ± 0.455
1.886LeuMet: 1.886 ± 0.249
2.04LeuAsn: 2.04 ± 0.241
2.473LeuPro: 2.473 ± 0.312
2.133LeuGln: 2.133 ± 0.296
4.606LeuArg: 4.606 ± 0.371
4.483LeuSer: 4.483 ± 0.395
4.359LeuThr: 4.359 ± 0.369
4.946LeuVal: 4.946 ± 0.441
0.649LeuTrp: 0.649 ± 0.12
2.04LeuTyr: 2.04 ± 0.279
0.0LeuXaa: 0.0 ± 0.0
Met
1.762MetAla: 1.762 ± 0.231
0.155MetCys: 0.155 ± 0.063
2.226MetAsp: 2.226 ± 0.249
2.38MetGlu: 2.38 ± 0.279
0.526MetPhe: 0.526 ± 0.127
2.009MetGly: 2.009 ± 0.246
0.309MetHis: 0.309 ± 0.092
0.711MetIle: 0.711 ± 0.128
1.206MetLys: 1.206 ± 0.158
1.546MetLeu: 1.546 ± 0.215
0.587MetMet: 0.587 ± 0.136
0.958MetAsn: 0.958 ± 0.148
1.329MetPro: 1.329 ± 0.194
0.649MetGln: 0.649 ± 0.146
1.484MetArg: 1.484 ± 0.244
2.535MetSer: 2.535 ± 0.294
2.411MetThr: 2.411 ± 0.272
1.391MetVal: 1.391 ± 0.198
0.247MetTrp: 0.247 ± 0.075
0.587MetTyr: 0.587 ± 0.154
0.0MetXaa: 0.0 ± 0.0
Asn
2.875AsnAla: 2.875 ± 0.267
0.587AsnCys: 0.587 ± 0.14
3.555AsnAsp: 3.555 ± 0.317
3.184AsnGlu: 3.184 ± 0.251
0.927AsnPhe: 0.927 ± 0.136
2.782AsnGly: 2.782 ± 0.314
0.495AsnHis: 0.495 ± 0.126
1.608AsnIle: 1.608 ± 0.259
1.051AsnLys: 1.051 ± 0.166
2.782AsnLeu: 2.782 ± 0.245
0.927AsnMet: 0.927 ± 0.149
1.669AsnAsn: 1.669 ± 0.261
2.69AsnPro: 2.69 ± 0.276
1.391AsnGln: 1.391 ± 0.185
1.917AsnArg: 1.917 ± 0.277
2.257AsnSer: 2.257 ± 0.27
1.917AsnThr: 1.917 ± 0.246
2.999AsnVal: 2.999 ± 0.342
0.773AsnTrp: 0.773 ± 0.137
1.267AsnTyr: 1.267 ± 0.217
0.0AsnXaa: 0.0 ± 0.0
Pro
2.906ProAla: 2.906 ± 0.294
0.34ProCys: 0.34 ± 0.1
5.224ProAsp: 5.224 ± 0.37
5.101ProGlu: 5.101 ± 0.425
1.515ProPhe: 1.515 ± 0.207
2.751ProGly: 2.751 ± 0.234
0.866ProHis: 0.866 ± 0.189
1.36ProIle: 1.36 ± 0.187
1.02ProLys: 1.02 ± 0.188
1.948ProLeu: 1.948 ± 0.252
0.927ProMet: 0.927 ± 0.167
1.329ProAsn: 1.329 ± 0.178
1.206ProPro: 1.206 ± 0.197
1.206ProGln: 1.206 ± 0.244
2.288ProArg: 2.288 ± 0.325
2.813ProSer: 2.813 ± 0.328
2.38ProThr: 2.38 ± 0.295
2.226ProVal: 2.226 ± 0.259
0.587ProTrp: 0.587 ± 0.129
0.989ProTyr: 0.989 ± 0.179
0.0ProXaa: 0.0 ± 0.0
Gln
2.751GlnAla: 2.751 ± 0.33
0.402GlnCys: 0.402 ± 0.115
3.122GlnAsp: 3.122 ± 0.345
3.648GlnGlu: 3.648 ± 0.298
1.453GlnPhe: 1.453 ± 0.226
1.917GlnGly: 1.917 ± 0.226
0.618GlnHis: 0.618 ± 0.137
1.608GlnIle: 1.608 ± 0.226
2.164GlnLys: 2.164 ± 0.265
2.782GlnLeu: 2.782 ± 0.26
1.082GlnMet: 1.082 ± 0.194
1.329GlnAsn: 1.329 ± 0.19
1.02GlnPro: 1.02 ± 0.186
1.298GlnGln: 1.298 ± 0.189
1.546GlnArg: 1.546 ± 0.205
2.504GlnSer: 2.504 ± 0.327
1.608GlnThr: 1.608 ± 0.254
2.782GlnVal: 2.782 ± 0.319
0.742GlnTrp: 0.742 ± 0.139
0.927GlnTyr: 0.927 ± 0.175
0.0GlnXaa: 0.0 ± 0.0
Arg
3.988ArgAla: 3.988 ± 0.3
0.68ArgCys: 0.68 ± 0.164
4.575ArgAsp: 4.575 ± 0.442
6.028ArgGlu: 6.028 ± 0.44
2.319ArgPhe: 2.319 ± 0.268
4.019ArgGly: 4.019 ± 0.416
1.267ArgHis: 1.267 ± 0.213
2.411ArgIle: 2.411 ± 0.294
2.968ArgLys: 2.968 ± 0.313
4.235ArgLeu: 4.235 ± 0.401
1.917ArgMet: 1.917 ± 0.259
1.948ArgAsn: 1.948 ± 0.256
1.886ArgPro: 1.886 ± 0.252
2.226ArgGln: 2.226 ± 0.263
4.575ArgArg: 4.575 ± 0.431
3.586ArgSer: 3.586 ± 0.359
3.122ArgThr: 3.122 ± 0.296
4.761ArgVal: 4.761 ± 0.368
0.958ArgTrp: 0.958 ± 0.174
2.72ArgTyr: 2.72 ± 0.231
0.0ArgXaa: 0.0 ± 0.0
Ser
2.937SerAla: 2.937 ± 0.363
0.618SerCys: 0.618 ± 0.144
6.121SerAsp: 6.121 ± 0.572
5.564SerGlu: 5.564 ± 0.471
2.473SerPhe: 2.473 ± 0.28
5.41SerGly: 5.41 ± 0.379
1.267SerHis: 1.267 ± 0.187
2.782SerIle: 2.782 ± 0.269
2.442SerLys: 2.442 ± 0.325
4.513SerLeu: 4.513 ± 0.333
1.329SerMet: 1.329 ± 0.172
2.659SerAsn: 2.659 ± 0.364
2.411SerPro: 2.411 ± 0.286
1.978SerGln: 1.978 ± 0.217
2.968SerArg: 2.968 ± 0.305
4.853SerSer: 4.853 ± 0.491
4.05SerThr: 4.05 ± 0.351
4.112SerVal: 4.112 ± 0.342
0.927SerTrp: 0.927 ± 0.176
1.793SerTyr: 1.793 ± 0.239
0.0SerXaa: 0.0 ± 0.0
Thr
3.802ThrAla: 3.802 ± 0.376
0.618ThrCys: 0.618 ± 0.152
5.503ThrAsp: 5.503 ± 0.439
5.101ThrGlu: 5.101 ± 0.513
2.319ThrPhe: 2.319 ± 0.333
4.513ThrGly: 4.513 ± 0.333
1.144ThrHis: 1.144 ± 0.184
2.597ThrIle: 2.597 ± 0.313
2.195ThrLys: 2.195 ± 0.255
3.988ThrLeu: 3.988 ± 0.388
1.237ThrMet: 1.237 ± 0.199
1.762ThrAsn: 1.762 ± 0.193
2.751ThrPro: 2.751 ± 0.287
2.411ThrGln: 2.411 ± 0.293
3.153ThrArg: 3.153 ± 0.267
3.215ThrSer: 3.215 ± 0.352
4.266ThrThr: 4.266 ± 0.377
3.71ThrVal: 3.71 ± 0.319
1.206ThrTrp: 1.206 ± 0.188
1.731ThrTyr: 1.731 ± 0.199
0.0ThrXaa: 0.0 ± 0.0
Val
4.421ValAla: 4.421 ± 0.4
1.051ValCys: 1.051 ± 0.205
7.203ValAsp: 7.203 ± 0.494
8.285ValGlu: 8.285 ± 0.483
1.515ValPhe: 1.515 ± 0.189
5.07ValGly: 5.07 ± 0.335
2.071ValHis: 2.071 ± 0.301
2.782ValIle: 2.782 ± 0.285
2.504ValLys: 2.504 ± 0.288
4.915ValLeu: 4.915 ± 0.373
1.793ValMet: 1.793 ± 0.292
2.937ValAsn: 2.937 ± 0.269
3.03ValPro: 3.03 ± 0.342
2.968ValGln: 2.968 ± 0.309
4.421ValArg: 4.421 ± 0.322
5.472ValSer: 5.472 ± 0.355
4.112ValThr: 4.112 ± 0.344
5.41ValVal: 5.41 ± 0.423
1.051ValTrp: 1.051 ± 0.16
2.535ValTyr: 2.535 ± 0.243
0.0ValXaa: 0.0 ± 0.0
Trp
0.927TrpAla: 0.927 ± 0.172
0.309TrpCys: 0.309 ± 0.088
2.473TrpAsp: 2.473 ± 0.28
1.917TrpGlu: 1.917 ± 0.224
0.649TrpPhe: 0.649 ± 0.14
0.835TrpGly: 0.835 ± 0.168
0.371TrpHis: 0.371 ± 0.105
0.556TrpIle: 0.556 ± 0.138
0.804TrpLys: 0.804 ± 0.144
0.897TrpLeu: 0.897 ± 0.165
0.556TrpMet: 0.556 ± 0.144
0.742TrpAsn: 0.742 ± 0.13
0.371TrpPro: 0.371 ± 0.102
0.804TrpGln: 0.804 ± 0.162
1.144TrpArg: 1.144 ± 0.203
1.144TrpSer: 1.144 ± 0.179
1.02TrpThr: 1.02 ± 0.206
1.391TrpVal: 1.391 ± 0.205
0.402TrpTrp: 0.402 ± 0.102
0.68TrpTyr: 0.68 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.886TyrAla: 1.886 ± 0.251
0.587TyrCys: 0.587 ± 0.128
3.926TyrAsp: 3.926 ± 0.322
4.019TyrGlu: 4.019 ± 0.331
0.835TyrPhe: 0.835 ± 0.159
2.906TyrGly: 2.906 ± 0.305
0.773TyrHis: 0.773 ± 0.168
1.855TyrIle: 1.855 ± 0.245
1.298TyrLys: 1.298 ± 0.208
2.349TyrLeu: 2.349 ± 0.286
0.649TyrMet: 0.649 ± 0.153
1.175TyrAsn: 1.175 ± 0.189
1.453TyrPro: 1.453 ± 0.206
0.897TyrGln: 0.897 ± 0.15
2.319TyrArg: 2.319 ± 0.23
1.484TyrSer: 1.484 ± 0.189
1.638TyrThr: 1.638 ± 0.241
2.071TyrVal: 2.071 ± 0.264
0.433TyrTrp: 0.433 ± 0.107
1.577TyrTyr: 1.577 ± 0.305
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 173 proteins (32349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski