Amino acid dipepetide frequency for Jeotgalibaca sp. PTS2502

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.636AlaAla: 5.636 ± 0.135
0.477AlaCys: 0.477 ± 0.029
4.4AlaAsp: 4.4 ± 0.091
5.085AlaGlu: 5.085 ± 0.109
3.244AlaPhe: 3.244 ± 0.075
4.85AlaGly: 4.85 ± 0.119
1.26AlaHis: 1.26 ± 0.043
6.384AlaIle: 6.384 ± 0.091
4.417AlaLys: 4.417 ± 0.094
7.063AlaLeu: 7.063 ± 0.128
2.074AlaMet: 2.074 ± 0.062
3.115AlaAsn: 3.115 ± 0.078
1.738AlaPro: 1.738 ± 0.068
2.43AlaGln: 2.43 ± 0.067
2.751AlaArg: 2.751 ± 0.067
4.274AlaSer: 4.274 ± 0.089
3.874AlaThr: 3.874 ± 0.081
5.551AlaVal: 5.551 ± 0.1
0.504AlaTrp: 0.504 ± 0.03
2.79AlaTyr: 2.79 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.344CysAla: 0.344 ± 0.03
0.078CysCys: 0.078 ± 0.013
0.358CysAsp: 0.358 ± 0.027
0.325CysGlu: 0.325 ± 0.023
0.26CysPhe: 0.26 ± 0.022
0.5CysGly: 0.5 ± 0.029
0.204CysHis: 0.204 ± 0.018
0.365CysIle: 0.365 ± 0.025
0.235CysLys: 0.235 ± 0.02
0.552CysLeu: 0.552 ± 0.03
0.127CysMet: 0.127 ± 0.014
0.196CysAsn: 0.196 ± 0.021
0.26CysPro: 0.26 ± 0.024
0.325CysGln: 0.325 ± 0.022
0.249CysArg: 0.249 ± 0.02
0.381CysSer: 0.381 ± 0.024
0.229CysThr: 0.229 ± 0.019
0.32CysVal: 0.32 ± 0.021
0.036CysTrp: 0.036 ± 0.008
0.242CysTyr: 0.242 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.794AspAla: 3.794 ± 0.095
0.387AspCys: 0.387 ± 0.024
3.338AspAsp: 3.338 ± 0.082
4.577AspGlu: 4.577 ± 0.095
3.018AspPhe: 3.018 ± 0.071
3.67AspGly: 3.67 ± 0.083
1.319AspHis: 1.319 ± 0.048
4.701AspIle: 4.701 ± 0.081
3.361AspLys: 3.361 ± 0.078
5.628AspLeu: 5.628 ± 0.089
1.63AspMet: 1.63 ± 0.055
2.442AspAsn: 2.442 ± 0.075
1.82AspPro: 1.82 ± 0.059
2.508AspGln: 2.508 ± 0.069
2.478AspArg: 2.478 ± 0.067
3.283AspSer: 3.283 ± 0.068
2.896AspThr: 2.896 ± 0.075
4.265AspVal: 4.265 ± 0.086
0.637AspTrp: 0.637 ± 0.035
3.107AspTyr: 3.107 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
6.056GluAla: 6.056 ± 0.121
0.275GluCys: 0.275 ± 0.022
4.408GluAsp: 4.408 ± 0.099
7.288GluGlu: 7.288 ± 0.146
2.412GluPhe: 2.412 ± 0.062
4.26GluGly: 4.26 ± 0.087
1.282GluHis: 1.282 ± 0.043
5.245GluIle: 5.245 ± 0.097
6.157GluLys: 6.157 ± 0.102
7.066GluLeu: 7.066 ± 0.116
2.29GluMet: 2.29 ± 0.057
3.846GluAsn: 3.846 ± 0.074
1.78GluPro: 1.78 ± 0.063
2.994GluGln: 2.994 ± 0.073
3.41GluArg: 3.41 ± 0.083
4.075GluSer: 4.075 ± 0.084
4.58GluThr: 4.58 ± 0.089
4.938GluVal: 4.938 ± 0.107
0.745GluTrp: 0.745 ± 0.04
2.078GluTyr: 2.078 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
2.652PheAla: 2.652 ± 0.075
0.276PheCys: 0.276 ± 0.021
2.847PheAsp: 2.847 ± 0.075
3.082PheGlu: 3.082 ± 0.076
2.232PhePhe: 2.232 ± 0.067
3.015PheGly: 3.015 ± 0.064
0.888PheHis: 0.888 ± 0.038
3.631PheIle: 3.631 ± 0.098
2.452PheLys: 2.452 ± 0.062
4.268PheLeu: 4.268 ± 0.099
1.14PheMet: 1.14 ± 0.048
1.942PheAsn: 1.942 ± 0.058
1.512PhePro: 1.512 ± 0.052
1.638PheGln: 1.638 ± 0.058
1.614PheArg: 1.614 ± 0.056
3.504PheSer: 3.504 ± 0.08
2.48PheThr: 2.48 ± 0.068
2.91PheVal: 2.91 ± 0.069
0.427PheTrp: 0.427 ± 0.021
1.845PheTyr: 1.845 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.174GlyAla: 4.174 ± 0.092
0.389GlyCys: 0.389 ± 0.028
3.387GlyAsp: 3.387 ± 0.077
4.163GlyGlu: 4.163 ± 0.087
3.114GlyPhe: 3.114 ± 0.074
4.146GlyGly: 4.146 ± 0.117
1.325GlyHis: 1.325 ± 0.047
5.487GlyIle: 5.487 ± 0.1
4.483GlyLys: 4.483 ± 0.099
6.144GlyLeu: 6.144 ± 0.116
1.962GlyMet: 1.962 ± 0.061
2.612GlyAsn: 2.612 ± 0.075
1.506GlyPro: 1.506 ± 0.055
2.48GlyGln: 2.48 ± 0.07
2.58GlyArg: 2.58 ± 0.066
3.978GlySer: 3.978 ± 0.076
3.647GlyThr: 3.647 ± 0.071
4.714GlyVal: 4.714 ± 0.104
0.569GlyTrp: 0.569 ± 0.036
2.776GlyTyr: 2.776 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.369HisAla: 1.369 ± 0.047
0.152HisCys: 0.152 ± 0.015
1.093HisAsp: 1.093 ± 0.043
1.133HisGlu: 1.133 ± 0.046
1.065HisPhe: 1.065 ± 0.046
1.214HisGly: 1.214 ± 0.044
0.585HisHis: 0.585 ± 0.036
1.543HisIle: 1.543 ± 0.051
0.899HisLys: 0.899 ± 0.041
2.183HisLeu: 2.183 ± 0.06
0.508HisMet: 0.508 ± 0.025
0.767HisAsn: 0.767 ± 0.033
1.065HisPro: 1.065 ± 0.04
0.973HisGln: 0.973 ± 0.041
0.798HisArg: 0.798 ± 0.04
1.181HisSer: 1.181 ± 0.045
1.005HisThr: 1.005 ± 0.033
1.363HisVal: 1.363 ± 0.048
0.173HisTrp: 0.173 ± 0.017
1.078HisTyr: 1.078 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.055IleAla: 6.055 ± 0.115
0.522IleCys: 0.522 ± 0.032
4.753IleAsp: 4.753 ± 0.084
5.989IleGlu: 5.989 ± 0.117
3.17IlePhe: 3.17 ± 0.076
5.443IleGly: 5.443 ± 0.111
1.532IleHis: 1.532 ± 0.052
5.747IleIle: 5.747 ± 0.113
4.505IleLys: 4.505 ± 0.088
6.988IleLeu: 6.988 ± 0.138
1.827IleMet: 1.827 ± 0.057
3.551IleAsn: 3.551 ± 0.078
3.026IlePro: 3.026 ± 0.08
3.299IleGln: 3.299 ± 0.08
3.156IleArg: 3.156 ± 0.064
5.12IleSer: 5.12 ± 0.095
4.198IleThr: 4.198 ± 0.085
5.419IleVal: 5.419 ± 0.091
0.574IleTrp: 0.574 ± 0.03
2.563IleTyr: 2.563 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.42LysAla: 4.42 ± 0.089
0.232LysCys: 0.232 ± 0.02
3.907LysAsp: 3.907 ± 0.082
6.389LysGlu: 6.389 ± 0.116
1.614LysPhe: 1.614 ± 0.047
3.951LysGly: 3.951 ± 0.076
1.17LysHis: 1.17 ± 0.041
4.263LysIle: 4.263 ± 0.084
5.355LysLys: 5.355 ± 0.121
5.134LysLeu: 5.134 ± 0.092
2.088LysMet: 2.088 ± 0.06
3.297LysAsn: 3.297 ± 0.078
1.758LysPro: 1.758 ± 0.055
3.041LysGln: 3.041 ± 0.084
3.192LysArg: 3.192 ± 0.073
3.128LysSer: 3.128 ± 0.085
3.841LysThr: 3.841 ± 0.091
4.149LysVal: 4.149 ± 0.088
0.678LysTrp: 0.678 ± 0.036
1.895LysTyr: 1.895 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
7.967LeuAla: 7.967 ± 0.125
0.518LeuCys: 0.518 ± 0.028
5.612LeuAsp: 5.612 ± 0.098
6.93LeuGlu: 6.93 ± 0.109
4.632LeuPhe: 4.632 ± 0.117
5.722LeuGly: 5.722 ± 0.112
1.562LeuHis: 1.562 ± 0.045
7.048LeuIle: 7.048 ± 0.134
6.23LeuLys: 6.23 ± 0.11
10.084LeuLeu: 10.084 ± 0.193
2.587LeuMet: 2.587 ± 0.067
4.605LeuAsn: 4.605 ± 0.073
3.641LeuPro: 3.641 ± 0.074
3.423LeuGln: 3.423 ± 0.071
3.536LeuArg: 3.536 ± 0.084
6.977LeuSer: 6.977 ± 0.123
5.965LeuThr: 5.965 ± 0.106
6.321LeuVal: 6.321 ± 0.12
0.676LeuTrp: 0.676 ± 0.036
3.352LeuTyr: 3.352 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.257MetAla: 2.257 ± 0.064
0.155MetCys: 0.155 ± 0.018
1.628MetAsp: 1.628 ± 0.055
1.918MetGlu: 1.918 ± 0.052
0.841MetPhe: 0.841 ± 0.038
1.782MetGly: 1.782 ± 0.056
0.392MetHis: 0.392 ± 0.025
2.212MetIle: 2.212 ± 0.069
2.088MetLys: 2.088 ± 0.062
2.281MetLeu: 2.281 ± 0.069
0.886MetMet: 0.886 ± 0.045
1.495MetAsn: 1.495 ± 0.05
0.969MetPro: 0.969 ± 0.036
0.875MetGln: 0.875 ± 0.035
1.107MetArg: 1.107 ± 0.046
1.749MetSer: 1.749 ± 0.056
2.05MetThr: 2.05 ± 0.056
1.9MetVal: 1.9 ± 0.058
0.19MetTrp: 0.19 ± 0.02
0.736MetTyr: 0.736 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.737AsnAla: 2.737 ± 0.072
0.275AsnCys: 0.275 ± 0.02
2.676AsnAsp: 2.676 ± 0.067
3.398AsnGlu: 3.398 ± 0.083
1.804AsnPhe: 1.804 ± 0.056
3.211AsnGly: 3.211 ± 0.073
1.322AsnHis: 1.322 ± 0.05
3.186AsnIle: 3.186 ± 0.062
2.941AsnLys: 2.941 ± 0.067
3.914AsnLeu: 3.914 ± 0.081
1.244AsnMet: 1.244 ± 0.041
2.251AsnAsn: 2.251 ± 0.069
2.055AsnPro: 2.055 ± 0.056
2.69AsnGln: 2.69 ± 0.062
2.416AsnArg: 2.416 ± 0.063
2.356AsnSer: 2.356 ± 0.059
2.06AsnThr: 2.06 ± 0.056
2.748AsnVal: 2.748 ± 0.069
0.483AsnTrp: 0.483 ± 0.025
1.931AsnTyr: 1.931 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.29ProAla: 2.29 ± 0.069
0.163ProCys: 0.163 ± 0.016
1.981ProAsp: 1.981 ± 0.055
2.712ProGlu: 2.712 ± 0.069
1.735ProPhe: 1.735 ± 0.052
1.87ProGly: 1.87 ± 0.06
0.745ProHis: 0.745 ± 0.037
2.712ProIle: 2.712 ± 0.059
1.794ProLys: 1.794 ± 0.051
3.165ProLeu: 3.165 ± 0.07
0.833ProMet: 0.833 ± 0.04
1.493ProAsn: 1.493 ± 0.044
0.704ProPro: 0.704 ± 0.039
1.227ProGln: 1.227 ± 0.047
0.954ProArg: 0.954 ± 0.042
2.121ProSer: 2.121 ± 0.059
2.055ProThr: 2.055 ± 0.057
2.351ProVal: 2.351 ± 0.074
0.246ProTrp: 0.246 ± 0.023
1.454ProTyr: 1.454 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.633GlnAla: 3.633 ± 0.091
0.14GlnCys: 0.14 ± 0.015
2.091GlnAsp: 2.091 ± 0.061
3.054GlnGlu: 3.054 ± 0.081
1.835GlnPhe: 1.835 ± 0.047
1.939GlnGly: 1.939 ± 0.056
0.742GlnHis: 0.742 ± 0.032
2.878GlnIle: 2.878 ± 0.073
2.667GlnLys: 2.667 ± 0.068
4.88GlnLeu: 4.88 ± 0.087
1.261GlnMet: 1.261 ± 0.045
1.699GlnAsn: 1.699 ± 0.049
1.341GlnPro: 1.341 ± 0.049
1.939GlnGln: 1.939 ± 0.065
1.589GlnArg: 1.589 ± 0.056
2.477GlnSer: 2.477 ± 0.056
2.682GlnThr: 2.682 ± 0.065
2.67GlnVal: 2.67 ± 0.079
0.37GlnTrp: 0.37 ± 0.025
1.3GlnTyr: 1.3 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.441ArgAla: 2.441 ± 0.067
0.198ArgCys: 0.198 ± 0.02
2.246ArgAsp: 2.246 ± 0.057
2.86ArgGlu: 2.86 ± 0.074
2.016ArgPhe: 2.016 ± 0.063
2.196ArgGly: 2.196 ± 0.062
0.922ArgHis: 0.922 ± 0.04
3.302ArgIle: 3.302 ± 0.069
2.861ArgLys: 2.861 ± 0.074
4.372ArgLeu: 4.372 ± 0.095
1.263ArgMet: 1.263 ± 0.043
1.978ArgAsn: 1.978 ± 0.066
1.336ArgPro: 1.336 ± 0.049
1.987ArgGln: 1.987 ± 0.062
1.912ArgArg: 1.912 ± 0.07
2.259ArgSer: 2.259 ± 0.06
2.034ArgThr: 2.034 ± 0.058
2.627ArgVal: 2.627 ± 0.063
0.307ArgTrp: 0.307 ± 0.021
1.925ArgTyr: 1.925 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
3.719SerAla: 3.719 ± 0.081
0.358SerCys: 0.358 ± 0.023
3.641SerAsp: 3.641 ± 0.073
4.282SerGlu: 4.282 ± 0.082
3.33SerPhe: 3.33 ± 0.068
4.328SerGly: 4.328 ± 0.085
1.319SerHis: 1.319 ± 0.047
4.836SerIle: 4.836 ± 0.095
3.595SerLys: 3.595 ± 0.078
6.552SerLeu: 6.552 ± 0.113
1.487SerMet: 1.487 ± 0.044
2.732SerAsn: 2.732 ± 0.064
1.958SerPro: 1.958 ± 0.057
2.654SerGln: 2.654 ± 0.073
2.616SerArg: 2.616 ± 0.068
3.906SerSer: 3.906 ± 0.1
3.074SerThr: 3.074 ± 0.067
4.268SerVal: 4.268 ± 0.092
0.56SerTrp: 0.56 ± 0.03
2.516SerTyr: 2.516 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.334ThrAla: 4.334 ± 0.088
0.226ThrCys: 0.226 ± 0.018
3.435ThrAsp: 3.435 ± 0.076
3.834ThrGlu: 3.834 ± 0.087
2.638ThrPhe: 2.638 ± 0.057
3.903ThrGly: 3.903 ± 0.081
1.186ThrHis: 1.186 ± 0.045
5.195ThrIle: 5.195 ± 0.09
3.076ThrLys: 3.076 ± 0.064
5.357ThrLeu: 5.357 ± 0.091
1.399ThrMet: 1.399 ± 0.045
2.582ThrAsn: 2.582 ± 0.066
2.133ThrPro: 2.133 ± 0.065
1.813ThrGln: 1.813 ± 0.046
1.878ThrArg: 1.878 ± 0.058
3.307ThrSer: 3.307 ± 0.079
3.407ThrThr: 3.407 ± 0.092
4.372ThrVal: 4.372 ± 0.093
0.427ThrTrp: 0.427 ± 0.024
2.136ThrTyr: 2.136 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.164ValAla: 5.164 ± 0.105
0.46ValCys: 0.46 ± 0.029
4.124ValAsp: 4.124 ± 0.086
5.023ValGlu: 5.023 ± 0.095
3.056ValPhe: 3.056 ± 0.083
4.565ValGly: 4.565 ± 0.105
1.241ValHis: 1.241 ± 0.05
5.565ValIle: 5.565 ± 0.102
3.965ValLys: 3.965 ± 0.087
6.739ValLeu: 6.739 ± 0.112
1.81ValMet: 1.81 ± 0.048
3.007ValAsn: 3.007 ± 0.068
2.328ValPro: 2.328 ± 0.066
2.224ValGln: 2.224 ± 0.056
2.59ValArg: 2.59 ± 0.074
4.779ValSer: 4.779 ± 0.084
4.221ValThr: 4.221 ± 0.081
5.319ValVal: 5.319 ± 0.105
0.511ValTrp: 0.511 ± 0.03
2.343ValTyr: 2.343 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.482TrpAla: 0.482 ± 0.028
0.053TrpCys: 0.053 ± 0.01
0.5TrpAsp: 0.5 ± 0.027
0.626TrpGlu: 0.626 ± 0.037
0.419TrpPhe: 0.419 ± 0.028
0.551TrpGly: 0.551 ± 0.034
0.184TrpHis: 0.184 ± 0.019
0.579TrpIle: 0.579 ± 0.03
0.519TrpLys: 0.519 ± 0.031
1.034TrpLeu: 1.034 ± 0.043
0.22TrpMet: 0.22 ± 0.018
0.452TrpAsn: 0.452 ± 0.025
0.198TrpPro: 0.198 ± 0.017
0.514TrpGln: 0.514 ± 0.03
0.375TrpArg: 0.375 ± 0.025
0.464TrpSer: 0.464 ± 0.026
0.431TrpThr: 0.431 ± 0.03
0.518TrpVal: 0.518 ± 0.026
0.067TrpTrp: 0.067 ± 0.011
0.314TrpTyr: 0.314 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.394TyrAla: 2.394 ± 0.052
0.254TyrCys: 0.254 ± 0.021
2.436TyrAsp: 2.436 ± 0.072
2.522TyrGlu: 2.522 ± 0.065
1.92TyrPhe: 1.92 ± 0.061
2.521TyrGly: 2.521 ± 0.07
0.968TyrHis: 0.968 ± 0.041
2.557TyrIle: 2.557 ± 0.08
1.903TyrLys: 1.903 ± 0.059
3.984TyrLeu: 3.984 ± 0.062
0.874TyrMet: 0.874 ± 0.035
1.633TyrAsn: 1.633 ± 0.047
1.478TyrPro: 1.478 ± 0.047
2.152TyrGln: 2.152 ± 0.062
1.84TyrArg: 1.84 ± 0.06
2.412TyrSer: 2.412 ± 0.069
1.906TyrThr: 1.906 ± 0.059
2.311TyrVal: 2.311 ± 0.062
0.318TyrTrp: 0.318 ± 0.023
1.658TyrTyr: 1.658 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2116 proteins (637522 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski