Amino acid dipepetide frequency for Pustulibacterium marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.82AlaAla: 4.82 ± 0.085
0.583AlaCys: 0.583 ± 0.025
3.558AlaAsp: 3.558 ± 0.058
4.334AlaGlu: 4.334 ± 0.073
3.307AlaPhe: 3.307 ± 0.049
4.13AlaGly: 4.13 ± 0.064
1.215AlaHis: 1.215 ± 0.035
5.355AlaIle: 5.355 ± 0.076
4.704AlaLys: 4.704 ± 0.069
6.194AlaLeu: 6.194 ± 0.07
1.758AlaMet: 1.758 ± 0.038
3.579AlaAsn: 3.579 ± 0.053
1.956AlaPro: 1.956 ± 0.042
2.647AlaGln: 2.647 ± 0.054
1.894AlaArg: 1.894 ± 0.044
4.365AlaSer: 4.365 ± 0.064
4.444AlaThr: 4.444 ± 0.078
4.34AlaVal: 4.34 ± 0.06
0.634AlaTrp: 0.634 ± 0.02
2.945AlaTyr: 2.945 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.46CysAla: 0.46 ± 0.02
0.119CysCys: 0.119 ± 0.009
0.496CysAsp: 0.496 ± 0.027
0.524CysGlu: 0.524 ± 0.023
0.429CysPhe: 0.429 ± 0.02
0.601CysGly: 0.601 ± 0.024
0.165CysHis: 0.165 ± 0.013
0.586CysIle: 0.586 ± 0.025
0.474CysLys: 0.474 ± 0.02
0.665CysLeu: 0.665 ± 0.023
0.167CysMet: 0.167 ± 0.011
0.379CysAsn: 0.379 ± 0.017
0.314CysPro: 0.314 ± 0.022
0.216CysGln: 0.216 ± 0.011
0.174CysArg: 0.174 ± 0.012
0.578CysSer: 0.578 ± 0.024
0.48CysThr: 0.48 ± 0.021
0.439CysVal: 0.439 ± 0.019
0.097CysTrp: 0.097 ± 0.009
0.366CysTyr: 0.366 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.107AspAla: 4.107 ± 0.079
0.445AspCys: 0.445 ± 0.022
3.225AspAsp: 3.225 ± 0.068
4.0AspGlu: 4.0 ± 0.072
3.728AspPhe: 3.728 ± 0.055
3.902AspGly: 3.902 ± 0.083
0.982AspHis: 0.982 ± 0.031
4.187AspIle: 4.187 ± 0.058
3.656AspLys: 3.656 ± 0.062
5.002AspLeu: 5.002 ± 0.077
1.164AspMet: 1.164 ± 0.034
2.823AspAsn: 2.823 ± 0.051
1.676AspPro: 1.676 ± 0.04
1.598AspGln: 1.598 ± 0.035
1.74AspArg: 1.74 ± 0.034
3.184AspSer: 3.184 ± 0.063
3.111AspThr: 3.111 ± 0.051
3.869AspVal: 3.869 ± 0.063
0.841AspTrp: 0.841 ± 0.028
2.909AspTyr: 2.909 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.89GluAla: 4.89 ± 0.074
0.347GluCys: 0.347 ± 0.017
3.984GluAsp: 3.984 ± 0.058
5.495GluGlu: 5.495 ± 0.09
3.034GluPhe: 3.034 ± 0.05
3.993GluGly: 3.993 ± 0.06
1.244GluHis: 1.244 ± 0.038
5.296GluIle: 5.296 ± 0.072
5.881GluLys: 5.881 ± 0.086
6.263GluLeu: 6.263 ± 0.07
1.668GluMet: 1.668 ± 0.039
4.823GluAsn: 4.823 ± 0.069
1.589GluPro: 1.589 ± 0.042
2.446GluGln: 2.446 ± 0.05
2.449GluArg: 2.449 ± 0.048
3.457GluSer: 3.457 ± 0.057
4.178GluThr: 4.178 ± 0.058
4.69GluVal: 4.69 ± 0.064
0.666GluTrp: 0.666 ± 0.025
2.586GluTyr: 2.586 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.038PheAla: 3.038 ± 0.05
0.463PheCys: 0.463 ± 0.02
3.247PheAsp: 3.247 ± 0.052
3.523PheGlu: 3.523 ± 0.057
2.704PhePhe: 2.704 ± 0.067
3.518PheGly: 3.518 ± 0.065
0.921PheHis: 0.921 ± 0.03
3.647PheIle: 3.647 ± 0.069
3.462PheLys: 3.462 ± 0.064
4.537PheLeu: 4.537 ± 0.072
1.212PheMet: 1.212 ± 0.029
2.981PheAsn: 2.981 ± 0.05
1.701PhePro: 1.701 ± 0.033
1.876PheGln: 1.876 ± 0.042
1.556PheArg: 1.556 ± 0.039
3.937PheSer: 3.937 ± 0.057
3.386PheThr: 3.386 ± 0.061
3.016PheVal: 3.016 ± 0.052
0.616PheTrp: 0.616 ± 0.028
2.292PheTyr: 2.292 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.158GlyAla: 4.158 ± 0.066
0.625GlyCys: 0.625 ± 0.03
3.389GlyAsp: 3.389 ± 0.062
3.732GlyGlu: 3.732 ± 0.064
3.556GlyPhe: 3.556 ± 0.058
4.276GlyGly: 4.276 ± 0.076
1.084GlyHis: 1.084 ± 0.033
5.242GlyIle: 5.242 ± 0.076
4.668GlyLys: 4.668 ± 0.075
5.266GlyLeu: 5.266 ± 0.075
1.672GlyMet: 1.672 ± 0.037
3.764GlyAsn: 3.764 ± 0.07
1.282GlyPro: 1.282 ± 0.036
1.7GlyGln: 1.7 ± 0.045
1.909GlyArg: 1.909 ± 0.039
4.039GlySer: 4.039 ± 0.076
4.28GlyThr: 4.28 ± 0.089
4.467GlyVal: 4.467 ± 0.058
0.814GlyTrp: 0.814 ± 0.027
3.104GlyTyr: 3.104 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.013HisAla: 1.013 ± 0.029
0.183HisCys: 0.183 ± 0.012
0.871HisAsp: 0.871 ± 0.026
1.076HisGlu: 1.076 ± 0.03
1.203HisPhe: 1.203 ± 0.034
1.055HisGly: 1.055 ± 0.032
0.525HisHis: 0.525 ± 0.023
1.491HisIle: 1.491 ± 0.035
1.24HisLys: 1.24 ± 0.037
1.781HisLeu: 1.781 ± 0.038
0.401HisMet: 0.401 ± 0.018
0.932HisAsn: 0.932 ± 0.025
0.92HisPro: 0.92 ± 0.03
0.841HisGln: 0.841 ± 0.028
0.652HisArg: 0.652 ± 0.023
1.036HisSer: 1.036 ± 0.028
1.115HisThr: 1.115 ± 0.037
1.013HisVal: 1.013 ± 0.03
0.249HisTrp: 0.249 ± 0.016
0.909HisTyr: 0.909 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.653IleAla: 5.653 ± 0.077
0.656IleCys: 0.656 ± 0.024
4.657IleAsp: 4.657 ± 0.063
5.133IleGlu: 5.133 ± 0.06
3.441IlePhe: 3.441 ± 0.065
4.588IleGly: 4.588 ± 0.072
1.43IleHis: 1.43 ± 0.037
5.162IleIle: 5.162 ± 0.082
4.923IleLys: 4.923 ± 0.072
6.361IleLeu: 6.361 ± 0.094
1.313IleMet: 1.313 ± 0.034
4.113IleAsn: 4.113 ± 0.064
3.301IlePro: 3.301 ± 0.048
2.949IleGln: 2.949 ± 0.045
2.246IleArg: 2.246 ± 0.042
5.347IleSer: 5.347 ± 0.073
4.993IleThr: 4.993 ± 0.071
4.429IleVal: 4.429 ± 0.078
0.669IleTrp: 0.669 ± 0.025
2.855IleTyr: 2.855 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.928LysAla: 4.928 ± 0.065
0.307LysCys: 0.307 ± 0.014
4.317LysAsp: 4.317 ± 0.07
6.304LysGlu: 6.304 ± 0.095
2.797LysPhe: 2.797 ± 0.046
4.214LysGly: 4.214 ± 0.061
1.382LysHis: 1.382 ± 0.035
5.361LysIle: 5.361 ± 0.077
6.307LysLys: 6.307 ± 0.094
6.221LysLeu: 6.221 ± 0.073
1.896LysMet: 1.896 ± 0.04
4.665LysAsn: 4.665 ± 0.069
2.33LysPro: 2.33 ± 0.049
2.683LysGln: 2.683 ± 0.045
2.744LysArg: 2.744 ± 0.059
4.094LysSer: 4.094 ± 0.064
4.432LysThr: 4.432 ± 0.071
4.572LysVal: 4.572 ± 0.069
0.711LysTrp: 0.711 ± 0.024
2.962LysTyr: 2.962 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
5.952LeuAla: 5.952 ± 0.079
0.712LeuCys: 0.712 ± 0.027
4.908LeuAsp: 4.908 ± 0.068
6.118LeuGlu: 6.118 ± 0.075
4.573LeuPhe: 4.573 ± 0.078
5.617LeuGly: 5.617 ± 0.064
1.699LeuHis: 1.699 ± 0.038
6.103LeuIle: 6.103 ± 0.085
7.145LeuLys: 7.145 ± 0.093
8.696LeuLeu: 8.696 ± 0.113
2.134LeuMet: 2.134 ± 0.038
5.204LeuAsn: 5.204 ± 0.068
3.412LeuPro: 3.412 ± 0.053
3.935LeuGln: 3.935 ± 0.066
2.982LeuArg: 2.982 ± 0.046
6.368LeuSer: 6.368 ± 0.072
5.062LeuThr: 5.062 ± 0.069
5.395LeuVal: 5.395 ± 0.063
0.924LeuTrp: 0.924 ± 0.03
3.376LeuTyr: 3.376 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.631MetAla: 1.631 ± 0.039
0.124MetCys: 0.124 ± 0.009
1.102MetAsp: 1.102 ± 0.026
1.535MetGlu: 1.535 ± 0.037
0.906MetPhe: 0.906 ± 0.028
1.374MetGly: 1.374 ± 0.033
0.46MetHis: 0.46 ± 0.021
1.594MetIle: 1.594 ± 0.042
2.348MetLys: 2.348 ± 0.041
2.113MetLeu: 2.113 ± 0.044
0.627MetMet: 0.627 ± 0.025
1.454MetAsn: 1.454 ± 0.037
0.951MetPro: 0.951 ± 0.032
0.942MetGln: 0.942 ± 0.028
0.836MetArg: 0.836 ± 0.022
1.417MetSer: 1.417 ± 0.034
1.136MetThr: 1.136 ± 0.032
1.407MetVal: 1.407 ± 0.034
0.169MetTrp: 0.169 ± 0.013
0.853MetTyr: 0.853 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.004AsnAla: 4.004 ± 0.062
0.423AsnCys: 0.423 ± 0.02
3.121AsnAsp: 3.121 ± 0.068
3.673AsnGlu: 3.673 ± 0.061
2.991AsnPhe: 2.991 ± 0.055
4.084AsnGly: 4.084 ± 0.07
1.108AsnHis: 1.108 ± 0.031
4.256AsnIle: 4.256 ± 0.059
3.694AsnLys: 3.694 ± 0.055
4.999AsnLeu: 4.999 ± 0.063
1.279AsnMet: 1.279 ± 0.035
3.39AsnAsn: 3.39 ± 0.076
2.662AsnPro: 2.662 ± 0.057
2.221AsnGln: 2.221 ± 0.044
2.01AsnArg: 2.01 ± 0.038
3.742AsnSer: 3.742 ± 0.071
3.888AsnThr: 3.888 ± 0.078
3.544AsnVal: 3.544 ± 0.059
0.773AsnTrp: 0.773 ± 0.025
2.954AsnTyr: 2.954 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.961ProAla: 1.961 ± 0.042
0.223ProCys: 0.223 ± 0.015
2.066ProAsp: 2.066 ± 0.038
3.11ProGlu: 3.11 ± 0.058
1.836ProPhe: 1.836 ± 0.043
1.903ProGly: 1.903 ± 0.043
0.587ProHis: 0.587 ± 0.023
2.497ProIle: 2.497 ± 0.051
2.469ProLys: 2.469 ± 0.053
2.903ProLeu: 2.903 ± 0.053
0.79ProMet: 0.79 ± 0.025
2.144ProAsn: 2.144 ± 0.04
0.801ProPro: 0.801 ± 0.026
1.19ProGln: 1.19 ± 0.036
0.837ProArg: 0.837 ± 0.027
2.132ProSer: 2.132 ± 0.041
2.128ProThr: 2.128 ± 0.044
2.431ProVal: 2.431 ± 0.042
0.407ProTrp: 0.407 ± 0.02
1.528ProTyr: 1.528 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.177GlnAla: 2.177 ± 0.052
0.193GlnCys: 0.193 ± 0.012
1.71GlnAsp: 1.71 ± 0.041
2.697GlnGlu: 2.697 ± 0.044
1.839GlnPhe: 1.839 ± 0.036
1.833GlnGly: 1.833 ± 0.037
0.783GlnHis: 0.783 ± 0.03
2.594GlnIle: 2.594 ± 0.049
3.088GlnLys: 3.088 ± 0.059
3.917GlnLeu: 3.917 ± 0.059
0.848GlnMet: 0.848 ± 0.028
2.257GlnAsn: 2.257 ± 0.051
1.264GlnPro: 1.264 ± 0.033
1.985GlnGln: 1.985 ± 0.056
1.264GlnArg: 1.264 ± 0.032
1.939GlnSer: 1.939 ± 0.038
2.231GlnThr: 2.231 ± 0.046
2.072GlnVal: 2.072 ± 0.045
0.419GlnTrp: 0.419 ± 0.018
1.553GlnTyr: 1.553 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
1.989ArgAla: 1.989 ± 0.04
0.183ArgCys: 0.183 ± 0.012
1.572ArgAsp: 1.572 ± 0.037
1.998ArgGlu: 1.998 ± 0.042
1.759ArgPhe: 1.759 ± 0.042
1.804ArgGly: 1.804 ± 0.042
0.518ArgHis: 0.518 ± 0.021
2.664ArgIle: 2.664 ± 0.052
2.791ArgLys: 2.791 ± 0.052
3.023ArgLeu: 3.023 ± 0.055
0.877ArgMet: 0.877 ± 0.024
2.022ArgAsn: 2.022 ± 0.037
1.016ArgPro: 1.016 ± 0.028
0.931ArgGln: 0.931 ± 0.03
1.208ArgArg: 1.208 ± 0.033
1.803ArgSer: 1.803 ± 0.039
1.81ArgThr: 1.81 ± 0.039
2.006ArgVal: 2.006 ± 0.038
0.402ArgTrp: 0.402 ± 0.017
1.486ArgTyr: 1.486 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.737SerAla: 3.737 ± 0.062
0.696SerCys: 0.696 ± 0.027
3.493SerAsp: 3.493 ± 0.052
4.416SerGlu: 4.416 ± 0.056
3.801SerPhe: 3.801 ± 0.066
4.546SerGly: 4.546 ± 0.07
1.04SerHis: 1.04 ± 0.027
4.921SerIle: 4.921 ± 0.068
4.414SerLys: 4.414 ± 0.07
5.956SerLeu: 5.956 ± 0.077
1.428SerMet: 1.428 ± 0.035
3.728SerAsn: 3.728 ± 0.07
1.993SerPro: 1.993 ± 0.04
2.023SerGln: 2.023 ± 0.047
1.845SerArg: 1.845 ± 0.039
4.238SerSer: 4.238 ± 0.075
3.632SerThr: 3.632 ± 0.068
4.152SerVal: 4.152 ± 0.063
0.793SerTrp: 0.793 ± 0.027
3.085SerTyr: 3.085 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.204ThrAla: 4.204 ± 0.064
0.4ThrCys: 0.4 ± 0.021
3.598ThrAsp: 3.598 ± 0.073
4.042ThrGlu: 4.042 ± 0.061
3.276ThrPhe: 3.276 ± 0.068
4.136ThrGly: 4.136 ± 0.062
1.049ThrHis: 1.049 ± 0.028
5.041ThrIle: 5.041 ± 0.07
3.803ThrLys: 3.803 ± 0.053
5.599ThrLeu: 5.599 ± 0.071
1.113ThrMet: 1.113 ± 0.028
3.445ThrAsn: 3.445 ± 0.069
2.678ThrPro: 2.678 ± 0.052
2.104ThrGln: 2.104 ± 0.047
1.642ThrArg: 1.642 ± 0.045
4.215ThrSer: 4.215 ± 0.079
4.184ThrThr: 4.184 ± 0.079
4.223ThrVal: 4.223 ± 0.069
0.609ThrTrp: 0.609 ± 0.025
2.952ThrTyr: 2.952 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
4.679ValAla: 4.679 ± 0.062
0.559ValCys: 0.559 ± 0.022
3.598ValAsp: 3.598 ± 0.058
3.814ValGlu: 3.814 ± 0.057
3.306ValPhe: 3.306 ± 0.06
3.857ValGly: 3.857 ± 0.067
1.146ValHis: 1.146 ± 0.033
4.648ValIle: 4.648 ± 0.061
4.28ValLys: 4.28 ± 0.062
5.874ValLeu: 5.874 ± 0.07
1.418ValMet: 1.418 ± 0.036
3.638ValAsn: 3.638 ± 0.058
2.237ValPro: 2.237 ± 0.044
2.081ValGln: 2.081 ± 0.04
1.924ValArg: 1.924 ± 0.047
4.599ValSer: 4.599 ± 0.065
4.275ValThr: 4.275 ± 0.075
4.351ValVal: 4.351 ± 0.066
0.682ValTrp: 0.682 ± 0.021
2.685ValTyr: 2.685 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.626TrpAla: 0.626 ± 0.021
0.102TrpCys: 0.102 ± 0.009
0.708TrpAsp: 0.708 ± 0.028
0.719TrpGlu: 0.719 ± 0.025
0.615TrpPhe: 0.615 ± 0.026
0.727TrpGly: 0.727 ± 0.028
0.243TrpHis: 0.243 ± 0.012
0.746TrpIle: 0.746 ± 0.029
0.873TrpLys: 0.873 ± 0.026
1.01TrpLeu: 1.01 ± 0.032
0.32TrpMet: 0.32 ± 0.015
0.775TrpAsn: 0.775 ± 0.029
0.267TrpPro: 0.267 ± 0.015
0.433TrpGln: 0.433 ± 0.02
0.4TrpArg: 0.4 ± 0.018
0.689TrpSer: 0.689 ± 0.021
0.617TrpThr: 0.617 ± 0.025
0.656TrpVal: 0.656 ± 0.023
0.187TrpTrp: 0.187 ± 0.011
0.497TrpTyr: 0.497 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.736TyrAla: 2.736 ± 0.051
0.386TyrCys: 0.386 ± 0.018
2.53TyrAsp: 2.53 ± 0.044
2.736TyrGlu: 2.736 ± 0.048
2.533TyrPhe: 2.533 ± 0.041
2.868TyrGly: 2.868 ± 0.048
0.922TyrHis: 0.922 ± 0.028
2.831TyrIle: 2.831 ± 0.042
3.006TyrLys: 3.006 ± 0.053
3.937TyrLeu: 3.937 ± 0.052
0.893TyrMet: 0.893 ± 0.028
2.703TyrAsn: 2.703 ± 0.05
1.591TyrPro: 1.591 ± 0.038
1.861TyrGln: 1.861 ± 0.042
1.552TyrArg: 1.552 ± 0.035
2.757TyrSer: 2.757 ± 0.055
2.932TyrThr: 2.932 ± 0.063
2.577TyrVal: 2.577 ± 0.045
0.547TyrTrp: 0.547 ± 0.022
2.176TyrTyr: 2.176 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3719 proteins (1275365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski