Amino acid dipepetide frequency for Enterococcus sp. 9E7_DIV0242

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.173AlaAla: 6.173 ± 0.087
0.596AlaCys: 0.596 ± 0.021
3.814AlaAsp: 3.814 ± 0.068
5.42AlaGlu: 5.42 ± 0.078
3.444AlaPhe: 3.444 ± 0.054
5.082AlaGly: 5.082 ± 0.081
1.162AlaHis: 1.162 ± 0.028
5.493AlaIle: 5.493 ± 0.077
4.235AlaLys: 4.235 ± 0.065
7.031AlaLeu: 7.031 ± 0.083
1.992AlaMet: 1.992 ± 0.042
2.767AlaAsn: 2.767 ± 0.051
1.976AlaPro: 1.976 ± 0.044
2.62AlaGln: 2.62 ± 0.054
2.315AlaArg: 2.315 ± 0.044
4.107AlaSer: 4.107 ± 0.06
3.945AlaThr: 3.945 ± 0.073
5.762AlaVal: 5.762 ± 0.061
0.612AlaTrp: 0.612 ± 0.023
2.551AlaTyr: 2.551 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.413CysAla: 0.413 ± 0.02
0.108CysCys: 0.108 ± 0.011
0.355CysAsp: 0.355 ± 0.019
0.441CysGlu: 0.441 ± 0.021
0.373CysPhe: 0.373 ± 0.016
0.675CysGly: 0.675 ± 0.025
0.196CysHis: 0.196 ± 0.013
0.529CysIle: 0.529 ± 0.021
0.325CysLys: 0.325 ± 0.016
0.795CysLeu: 0.795 ± 0.025
0.198CysMet: 0.198 ± 0.012
0.25CysAsn: 0.25 ± 0.015
0.289CysPro: 0.289 ± 0.015
0.266CysGln: 0.266 ± 0.017
0.285CysArg: 0.285 ± 0.015
0.522CysSer: 0.522 ± 0.022
0.375CysThr: 0.375 ± 0.017
0.47CysVal: 0.47 ± 0.02
0.075CysTrp: 0.075 ± 0.007
0.318CysTyr: 0.318 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.274AspAla: 3.274 ± 0.058
0.404AspCys: 0.404 ± 0.018
2.581AspAsp: 2.581 ± 0.064
4.337AspGlu: 4.337 ± 0.073
2.845AspPhe: 2.845 ± 0.053
3.707AspGly: 3.707 ± 0.058
0.98AspHis: 0.98 ± 0.032
3.978AspIle: 3.978 ± 0.05
3.251AspLys: 3.251 ± 0.054
4.75AspLeu: 4.75 ± 0.063
1.339AspMet: 1.339 ± 0.032
2.035AspAsn: 2.035 ± 0.043
1.861AspPro: 1.861 ± 0.04
2.169AspGln: 2.169 ± 0.039
2.166AspArg: 2.166 ± 0.045
3.294AspSer: 3.294 ± 0.059
2.924AspThr: 2.924 ± 0.049
3.536AspVal: 3.536 ± 0.063
0.674AspTrp: 0.674 ± 0.025
2.605AspTyr: 2.605 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.85GluAla: 5.85 ± 0.078
0.397GluCys: 0.397 ± 0.019
3.673GluAsp: 3.673 ± 0.057
7.287GluGlu: 7.287 ± 0.1
2.515GluPhe: 2.515 ± 0.041
4.022GluGly: 4.022 ± 0.069
1.299GluHis: 1.299 ± 0.037
5.508GluIle: 5.508 ± 0.074
6.97GluLys: 6.97 ± 0.081
7.666GluLeu: 7.666 ± 0.1
2.317GluMet: 2.317 ± 0.045
4.132GluAsn: 4.132 ± 0.057
1.935GluPro: 1.935 ± 0.042
3.944GluGln: 3.944 ± 0.066
3.149GluArg: 3.149 ± 0.058
3.591GluSer: 3.591 ± 0.058
4.468GluThr: 4.468 ± 0.064
4.741GluVal: 4.741 ± 0.065
0.76GluTrp: 0.76 ± 0.024
2.517GluTyr: 2.517 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
2.94PheAla: 2.94 ± 0.052
0.385PheCys: 0.385 ± 0.019
2.82PheAsp: 2.82 ± 0.05
2.938PheGlu: 2.938 ± 0.047
2.458PhePhe: 2.458 ± 0.055
3.235PheGly: 3.235 ± 0.053
0.855PheHis: 0.855 ± 0.027
3.451PheIle: 3.451 ± 0.052
2.338PheLys: 2.338 ± 0.047
4.765PheLeu: 4.765 ± 0.084
1.184PheMet: 1.184 ± 0.031
1.987PheAsn: 1.987 ± 0.038
1.645PhePro: 1.645 ± 0.036
1.676PheGln: 1.676 ± 0.033
1.521PheArg: 1.521 ± 0.038
3.852PheSer: 3.852 ± 0.068
2.628PheThr: 2.628 ± 0.053
3.124PheVal: 3.124 ± 0.046
0.494PheTrp: 0.494 ± 0.019
1.867PheTyr: 1.867 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.64GlyAla: 4.64 ± 0.075
0.584GlyCys: 0.584 ± 0.025
3.113GlyAsp: 3.113 ± 0.056
4.457GlyGlu: 4.457 ± 0.065
3.263GlyPhe: 3.263 ± 0.056
4.525GlyGly: 4.525 ± 0.093
1.148GlyHis: 1.148 ± 0.038
5.661GlyIle: 5.661 ± 0.078
4.81GlyLys: 4.81 ± 0.061
6.344GlyLeu: 6.344 ± 0.094
2.086GlyMet: 2.086 ± 0.045
2.929GlyAsn: 2.929 ± 0.061
1.398GlyPro: 1.398 ± 0.034
2.355GlyGln: 2.355 ± 0.044
2.326GlyArg: 2.326 ± 0.043
4.062GlySer: 4.062 ± 0.062
4.182GlyThr: 4.182 ± 0.063
4.715GlyVal: 4.715 ± 0.074
0.754GlyTrp: 0.754 ± 0.03
2.869GlyTyr: 2.869 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.101HisAla: 1.101 ± 0.031
0.199HisCys: 0.199 ± 0.013
0.832HisAsp: 0.832 ± 0.026
1.165HisGlu: 1.165 ± 0.037
1.016HisPhe: 1.016 ± 0.031
1.193HisGly: 1.193 ± 0.03
0.459HisHis: 0.459 ± 0.019
1.184HisIle: 1.184 ± 0.03
0.823HisLys: 0.823 ± 0.024
1.914HisLeu: 1.914 ± 0.041
0.433HisMet: 0.433 ± 0.018
0.585HisAsn: 0.585 ± 0.018
0.86HisPro: 0.86 ± 0.026
0.754HisGln: 0.754 ± 0.029
0.732HisArg: 0.732 ± 0.025
1.116HisSer: 1.116 ± 0.031
1.024HisThr: 1.024 ± 0.034
1.121HisVal: 1.121 ± 0.028
0.204HisTrp: 0.204 ± 0.015
0.854HisTyr: 0.854 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.616IleAla: 5.616 ± 0.066
0.689IleCys: 0.689 ± 0.025
4.695IleAsp: 4.695 ± 0.063
5.507IleGlu: 5.507 ± 0.073
3.251IlePhe: 3.251 ± 0.062
5.307IleGly: 5.307 ± 0.064
1.437IleHis: 1.437 ± 0.033
5.154IleIle: 5.154 ± 0.07
4.239IleLys: 4.239 ± 0.064
6.922IleLeu: 6.922 ± 0.087
1.653IleMet: 1.653 ± 0.038
3.267IleAsn: 3.267 ± 0.054
3.242IlePro: 3.242 ± 0.058
3.025IleGln: 3.025 ± 0.054
3.075IleArg: 3.075 ± 0.047
4.992IleSer: 4.992 ± 0.073
4.312IleThr: 4.312 ± 0.067
5.139IleVal: 5.139 ± 0.07
0.582IleTrp: 0.582 ± 0.023
2.621IleTyr: 2.621 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.477LysAla: 4.477 ± 0.061
0.26LysCys: 0.26 ± 0.016
3.627LysAsp: 3.627 ± 0.06
7.041LysGlu: 7.041 ± 0.088
1.841LysPhe: 1.841 ± 0.037
3.874LysGly: 3.874 ± 0.059
1.051LysHis: 1.051 ± 0.027
4.936LysIle: 4.936 ± 0.061
6.439LysLys: 6.439 ± 0.093
5.491LysLeu: 5.491 ± 0.071
2.13LysMet: 2.13 ± 0.033
3.863LysAsn: 3.863 ± 0.056
1.763LysPro: 1.763 ± 0.039
3.235LysGln: 3.235 ± 0.056
3.298LysArg: 3.298 ± 0.059
3.187LysSer: 3.187 ± 0.054
3.798LysThr: 3.798 ± 0.067
4.054LysVal: 4.054 ± 0.057
0.625LysTrp: 0.625 ± 0.024
2.229LysTyr: 2.229 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
7.738LeuAla: 7.738 ± 0.086
0.709LeuCys: 0.709 ± 0.024
5.087LeuAsp: 5.087 ± 0.062
6.586LeuGlu: 6.586 ± 0.088
5.026LeuPhe: 5.026 ± 0.09
6.286LeuGly: 6.286 ± 0.088
1.546LeuHis: 1.546 ± 0.038
7.112LeuIle: 7.112 ± 0.084
6.365LeuLys: 6.365 ± 0.069
10.832LeuLeu: 10.832 ± 0.152
2.429LeuMet: 2.429 ± 0.047
4.385LeuAsn: 4.385 ± 0.061
3.977LeuPro: 3.977 ± 0.056
3.354LeuGln: 3.354 ± 0.058
3.419LeuArg: 3.419 ± 0.059
7.356LeuSer: 7.356 ± 0.091
6.335LeuThr: 6.335 ± 0.076
6.295LeuVal: 6.295 ± 0.07
0.807LeuTrp: 0.807 ± 0.031
3.167LeuTyr: 3.167 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.971MetAla: 1.971 ± 0.039
0.162MetCys: 0.162 ± 0.011
1.494MetAsp: 1.494 ± 0.037
1.911MetGlu: 1.911 ± 0.042
1.002MetPhe: 1.002 ± 0.031
1.762MetGly: 1.762 ± 0.042
0.378MetHis: 0.378 ± 0.018
2.224MetIle: 2.224 ± 0.046
2.369MetLys: 2.369 ± 0.044
2.4MetLeu: 2.4 ± 0.047
0.85MetMet: 0.85 ± 0.032
1.635MetAsn: 1.635 ± 0.04
0.91MetPro: 0.91 ± 0.026
0.819MetGln: 0.819 ± 0.026
0.966MetArg: 0.966 ± 0.03
1.603MetSer: 1.603 ± 0.04
1.814MetThr: 1.814 ± 0.04
1.714MetVal: 1.714 ± 0.036
0.186MetTrp: 0.186 ± 0.012
0.752MetTyr: 0.752 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.723AsnAla: 2.723 ± 0.051
0.353AsnCys: 0.353 ± 0.018
2.388AsnAsp: 2.388 ± 0.05
3.445AsnGlu: 3.445 ± 0.052
1.872AsnPhe: 1.872 ± 0.042
3.551AsnGly: 3.551 ± 0.061
0.96AsnHis: 0.96 ± 0.03
3.091AsnIle: 3.091 ± 0.05
2.764AsnLys: 2.764 ± 0.052
3.762AsnLeu: 3.762 ± 0.059
1.155AsnMet: 1.155 ± 0.028
2.083AsnAsn: 2.083 ± 0.051
1.903AsnPro: 1.903 ± 0.036
2.317AsnGln: 2.317 ± 0.052
2.04AsnArg: 2.04 ± 0.047
2.605AsnSer: 2.605 ± 0.051
2.416AsnThr: 2.416 ± 0.05
2.828AsnVal: 2.828 ± 0.053
0.533AsnTrp: 0.533 ± 0.021
1.95AsnTyr: 1.95 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.261ProAla: 2.261 ± 0.039
0.19ProCys: 0.19 ± 0.011
1.942ProAsp: 1.942 ± 0.039
3.163ProGlu: 3.163 ± 0.049
1.818ProPhe: 1.818 ± 0.036
1.76ProGly: 1.76 ± 0.04
0.556ProHis: 0.556 ± 0.023
2.632ProIle: 2.632 ± 0.046
2.168ProLys: 2.168 ± 0.044
3.259ProLeu: 3.259 ± 0.06
0.912ProMet: 0.912 ± 0.028
1.491ProAsn: 1.491 ± 0.033
0.702ProPro: 0.702 ± 0.026
1.165ProGln: 1.165 ± 0.029
0.923ProArg: 0.923 ± 0.027
1.971ProSer: 1.971 ± 0.044
2.138ProThr: 2.138 ± 0.044
2.672ProVal: 2.672 ± 0.052
0.298ProTrp: 0.298 ± 0.015
1.338ProTyr: 1.338 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.155GlnAla: 3.155 ± 0.056
0.21GlnCys: 0.21 ± 0.011
1.551GlnAsp: 1.551 ± 0.038
3.347GlnGlu: 3.347 ± 0.063
1.675GlnPhe: 1.675 ± 0.041
2.312GlnGly: 2.312 ± 0.054
0.65GlnHis: 0.65 ± 0.022
2.668GlnIle: 2.668 ± 0.045
3.071GlnLys: 3.071 ± 0.054
4.957GlnLeu: 4.957 ± 0.09
1.146GlnMet: 1.146 ± 0.027
1.629GlnAsn: 1.629 ± 0.034
1.343GlnPro: 1.343 ± 0.036
2.349GlnGln: 2.349 ± 0.07
1.736GlnArg: 1.736 ± 0.042
2.128GlnSer: 2.128 ± 0.046
2.429GlnThr: 2.429 ± 0.045
2.672GlnVal: 2.672 ± 0.055
0.413GlnTrp: 0.413 ± 0.019
1.307GlnTyr: 1.307 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.216ArgAla: 2.216 ± 0.046
0.301ArgCys: 0.301 ± 0.015
1.664ArgAsp: 1.664 ± 0.036
2.889ArgGlu: 2.889 ± 0.048
1.934ArgPhe: 1.934 ± 0.042
2.071ArgGly: 2.071 ± 0.045
0.711ArgHis: 0.711 ± 0.024
2.905ArgIle: 2.905 ± 0.052
3.168ArgLys: 3.168 ± 0.057
3.999ArgLeu: 3.999 ± 0.066
1.164ArgMet: 1.164 ± 0.031
1.836ArgAsn: 1.836 ± 0.039
1.169ArgPro: 1.169 ± 0.04
1.672ArgGln: 1.672 ± 0.038
1.752ArgArg: 1.752 ± 0.044
2.146ArgSer: 2.146 ± 0.039
2.113ArgThr: 2.113 ± 0.044
2.493ArgVal: 2.493 ± 0.054
0.4ArgTrp: 0.4 ± 0.019
1.661ArgTyr: 1.661 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.086SerAla: 4.086 ± 0.062
0.436SerCys: 0.436 ± 0.021
3.311SerAsp: 3.311 ± 0.052
4.49SerGlu: 4.49 ± 0.058
3.495SerPhe: 3.495 ± 0.054
4.748SerGly: 4.748 ± 0.074
1.018SerHis: 1.018 ± 0.032
4.804SerIle: 4.804 ± 0.064
3.798SerLys: 3.798 ± 0.064
6.193SerLeu: 6.193 ± 0.075
1.654SerMet: 1.654 ± 0.04
2.537SerAsn: 2.537 ± 0.044
1.836SerPro: 1.836 ± 0.042
2.229SerGln: 2.229 ± 0.042
2.154SerArg: 2.154 ± 0.037
4.341SerSer: 4.341 ± 0.085
3.501SerThr: 3.501 ± 0.059
4.304SerVal: 4.304 ± 0.061
0.673SerTrp: 0.673 ± 0.024
2.733SerTyr: 2.733 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
4.555ThrAla: 4.555 ± 0.063
0.333ThrCys: 0.333 ± 0.015
3.294ThrAsp: 3.294 ± 0.059
4.288ThrGlu: 4.288 ± 0.06
2.643ThrPhe: 2.643 ± 0.046
4.403ThrGly: 4.403 ± 0.074
1.059ThrHis: 1.059 ± 0.028
5.111ThrIle: 5.111 ± 0.073
3.459ThrLys: 3.459 ± 0.058
5.626ThrLeu: 5.626 ± 0.07
1.367ThrMet: 1.367 ± 0.033
2.563ThrAsn: 2.563 ± 0.054
2.361ThrPro: 2.361 ± 0.049
1.9ThrGln: 1.9 ± 0.04
1.875ThrArg: 1.875 ± 0.036
3.483ThrSer: 3.483 ± 0.063
3.776ThrThr: 3.776 ± 0.082
4.688ThrVal: 4.688 ± 0.07
0.509ThrTrp: 0.509 ± 0.023
2.197ThrTyr: 2.197 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.016ValAla: 5.016 ± 0.07
0.538ValCys: 0.538 ± 0.023
3.705ValAsp: 3.705 ± 0.066
4.689ValGlu: 4.689 ± 0.06
3.211ValPhe: 3.211 ± 0.055
4.485ValGly: 4.485 ± 0.063
1.087ValHis: 1.087 ± 0.029
5.27ValIle: 5.27 ± 0.067
4.078ValLys: 4.078 ± 0.058
6.754ValLeu: 6.754 ± 0.079
1.758ValMet: 1.758 ± 0.036
2.84ValAsn: 2.84 ± 0.054
2.515ValPro: 2.515 ± 0.045
2.298ValGln: 2.298 ± 0.047
2.36ValArg: 2.36 ± 0.047
4.892ValSer: 4.892 ± 0.069
4.421ValThr: 4.421 ± 0.062
4.864ValVal: 4.864 ± 0.075
0.589ValTrp: 0.589 ± 0.022
2.459ValTyr: 2.459 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.601TrpAla: 0.601 ± 0.025
0.081TrpCys: 0.081 ± 0.008
0.495TrpAsp: 0.495 ± 0.021
0.672TrpGlu: 0.672 ± 0.029
0.451TrpPhe: 0.451 ± 0.02
0.666TrpGly: 0.666 ± 0.029
0.207TrpHis: 0.207 ± 0.013
0.644TrpIle: 0.644 ± 0.025
0.575TrpLys: 0.575 ± 0.022
1.231TrpLeu: 1.231 ± 0.032
0.281TrpMet: 0.281 ± 0.016
0.449TrpAsn: 0.449 ± 0.019
0.216TrpPro: 0.216 ± 0.013
0.601TrpGln: 0.601 ± 0.026
0.4TrpArg: 0.4 ± 0.02
0.598TrpSer: 0.598 ± 0.024
0.594TrpThr: 0.594 ± 0.026
0.508TrpVal: 0.508 ± 0.022
0.113TrpTrp: 0.113 ± 0.011
0.361TrpTyr: 0.361 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.292TyrAla: 2.292 ± 0.048
0.325TyrCys: 0.325 ± 0.017
2.269TyrAsp: 2.269 ± 0.061
2.667TyrGlu: 2.667 ± 0.046
2.03TyrPhe: 2.03 ± 0.047
2.554TyrGly: 2.554 ± 0.042
0.812TyrHis: 0.812 ± 0.031
2.373TyrIle: 2.373 ± 0.051
1.972TyrLys: 1.972 ± 0.039
4.12TyrLeu: 4.12 ± 0.06
0.872TyrMet: 0.872 ± 0.031
1.475TyrAsn: 1.475 ± 0.036
1.456TyrPro: 1.456 ± 0.035
2.002TyrGln: 2.002 ± 0.045
1.774TyrArg: 1.774 ± 0.041
2.495TyrSer: 2.495 ± 0.045
2.297TyrThr: 2.297 ± 0.044
2.129TyrVal: 2.129 ± 0.044
0.444TyrTrp: 0.444 ± 0.024
1.7TyrTyr: 1.7 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4171 proteins (1250518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski