Amino acid dipepetide frequency for Rickettsiales bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.178AlaAla: 3.178 ± 0.106
0.538AlaCys: 0.538 ± 0.046
1.987AlaAsp: 1.987 ± 0.074
2.278AlaGlu: 2.278 ± 0.095
3.464AlaPhe: 3.464 ± 0.123
3.198AlaGly: 3.198 ± 0.12
1.007AlaHis: 1.007 ± 0.062
5.612AlaIle: 5.612 ± 0.131
2.918AlaLys: 2.918 ± 0.087
6.118AlaLeu: 6.118 ± 0.156
1.531AlaMet: 1.531 ± 0.075
2.836AlaAsn: 2.836 ± 0.107
1.571AlaPro: 1.571 ± 0.07
1.254AlaGln: 1.254 ± 0.06
1.551AlaArg: 1.551 ± 0.087
3.798AlaSer: 3.798 ± 0.119
2.768AlaThr: 2.768 ± 0.103
3.62AlaVal: 3.62 ± 0.178
0.314AlaTrp: 0.314 ± 0.033
2.301AlaTyr: 2.301 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.495CysAla: 0.495 ± 0.035
0.158CysCys: 0.158 ± 0.025
0.631CysAsp: 0.631 ± 0.045
0.45CysGlu: 0.45 ± 0.04
0.77CysPhe: 0.77 ± 0.047
0.869CysGly: 0.869 ± 0.06
0.178CysHis: 0.178 ± 0.023
1.022CysIle: 1.022 ± 0.063
0.719CysLys: 0.719 ± 0.045
1.234CysLeu: 1.234 ± 0.061
0.195CysMet: 0.195 ± 0.025
0.702CysAsn: 0.702 ± 0.053
0.396CysPro: 0.396 ± 0.035
0.181CysGln: 0.181 ± 0.027
0.317CysArg: 0.317 ± 0.031
1.005CysSer: 1.005 ± 0.058
0.62CysThr: 0.62 ± 0.039
0.645CysVal: 0.645 ± 0.051
0.099CysTrp: 0.099 ± 0.016
0.552CysTyr: 0.552 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
2.1AspAla: 2.1 ± 0.084
0.512AspCys: 0.512 ± 0.041
2.482AspAsp: 2.482 ± 0.128
2.108AspGlu: 2.108 ± 0.087
2.321AspPhe: 2.321 ± 0.083
2.111AspGly: 2.111 ± 0.079
0.849AspHis: 0.849 ± 0.054
4.78AspIle: 4.78 ± 0.129
3.744AspLys: 3.744 ± 0.109
4.783AspLeu: 4.783 ± 0.115
1.005AspMet: 1.005 ± 0.059
3.973AspAsn: 3.973 ± 0.106
1.412AspPro: 1.412 ± 0.088
1.358AspGln: 1.358 ± 0.063
1.814AspArg: 1.814 ± 0.081
3.549AspSer: 3.549 ± 0.1
2.363AspThr: 2.363 ± 0.103
2.638AspVal: 2.638 ± 0.097
0.393AspTrp: 0.393 ± 0.035
2.154AspTyr: 2.154 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
2.219GluAla: 2.219 ± 0.097
0.532GluCys: 0.532 ± 0.042
2.154GluAsp: 2.154 ± 0.095
2.621GluGlu: 2.621 ± 0.117
2.377GluPhe: 2.377 ± 0.086
2.185GluGly: 2.185 ± 0.091
0.897GluHis: 0.897 ± 0.054
4.474GluIle: 4.474 ± 0.137
3.99GluLys: 3.99 ± 0.138
5.003GluLeu: 5.003 ± 0.118
1.03GluMet: 1.03 ± 0.064
3.438GluAsn: 3.438 ± 0.11
0.951GluPro: 0.951 ± 0.051
1.61GluGln: 1.61 ± 0.067
1.579GluArg: 1.579 ± 0.073
3.385GluSer: 3.385 ± 0.101
2.193GluThr: 2.193 ± 0.085
2.244GluVal: 2.244 ± 0.089
0.365GluTrp: 0.365 ± 0.034
2.471GluTyr: 2.471 ± 0.089
0.0GluXaa: 0.0 ± 0.0
Phe
3.189PheAla: 3.189 ± 0.083
0.637PheCys: 0.637 ± 0.049
2.745PheAsp: 2.745 ± 0.091
2.256PheGlu: 2.256 ± 0.092
4.454PhePhe: 4.454 ± 0.131
3.02PheGly: 3.02 ± 0.089
0.948PheHis: 0.948 ± 0.056
6.789PheIle: 6.789 ± 0.143
3.283PheLys: 3.283 ± 0.097
6.495PheLeu: 6.495 ± 0.157
1.531PheMet: 1.531 ± 0.072
3.625PheAsn: 3.625 ± 0.1
1.373PhePro: 1.373 ± 0.067
1.01PheGln: 1.01 ± 0.05
1.639PheArg: 1.639 ± 0.075
5.405PheSer: 5.405 ± 0.147
3.472PheThr: 3.472 ± 0.121
3.628PheVal: 3.628 ± 0.111
0.49PheTrp: 0.49 ± 0.047
3.212PheTyr: 3.212 ± 0.113
0.0PheXaa: 0.0 ± 0.0
Gly
3.371GlyAla: 3.371 ± 0.108
0.736GlyCys: 0.736 ± 0.052
2.309GlyAsp: 2.309 ± 0.087
1.919GlyGlu: 1.919 ± 0.072
3.509GlyPhe: 3.509 ± 0.111
3.011GlyGly: 3.011 ± 0.099
0.951GlyHis: 0.951 ± 0.059
5.335GlyIle: 5.335 ± 0.134
2.878GlyLys: 2.878 ± 0.098
6.617GlyLeu: 6.617 ± 0.149
1.307GlyMet: 1.307 ± 0.059
2.997GlyAsn: 2.997 ± 0.11
1.231GlyPro: 1.231 ± 0.068
1.661GlyGln: 1.661 ± 0.071
1.542GlyArg: 1.542 ± 0.072
4.304GlySer: 4.304 ± 0.121
2.785GlyThr: 2.785 ± 0.091
3.736GlyVal: 3.736 ± 0.116
0.45GlyTrp: 0.45 ± 0.038
2.612GlyTyr: 2.612 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
1.067HisAla: 1.067 ± 0.059
0.184HisCys: 0.184 ± 0.021
0.874HisAsp: 0.874 ± 0.049
0.841HisGlu: 0.841 ± 0.054
1.036HisPhe: 1.036 ± 0.058
0.968HisGly: 0.968 ± 0.05
0.574HisHis: 0.574 ± 0.047
1.871HisIle: 1.871 ± 0.075
1.129HisLys: 1.129 ± 0.063
1.777HisLeu: 1.777 ± 0.082
0.566HisMet: 0.566 ± 0.039
1.307HisAsn: 1.307 ± 0.064
0.784HisPro: 0.784 ± 0.05
0.487HisGln: 0.487 ± 0.038
0.611HisArg: 0.611 ± 0.041
1.755HisSer: 1.755 ± 0.07
0.951HisThr: 0.951 ± 0.056
1.18HisVal: 1.18 ± 0.057
0.108HisTrp: 0.108 ± 0.017
0.957HisTyr: 0.957 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
5.567IleAla: 5.567 ± 0.152
1.268IleCys: 1.268 ± 0.057
5.156IleAsp: 5.156 ± 0.144
5.487IleGlu: 5.487 ± 0.124
6.172IlePhe: 6.172 ± 0.147
6.025IleGly: 6.025 ± 0.145
1.848IleHis: 1.848 ± 0.07
9.882IleIle: 9.882 ± 0.208
6.667IleLys: 6.667 ± 0.14
11.671IleLeu: 11.671 ± 0.226
2.326IleMet: 2.326 ± 0.073
6.52IleAsn: 6.52 ± 0.174
3.099IlePro: 3.099 ± 0.105
2.4IleGln: 2.4 ± 0.09
2.878IleArg: 2.878 ± 0.097
8.705IleSer: 8.705 ± 0.169
5.694IleThr: 5.694 ± 0.13
5.785IleVal: 5.785 ± 0.14
0.603IleTrp: 0.603 ± 0.046
4.788IleTyr: 4.788 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
3.028LysAla: 3.028 ± 0.089
0.623LysCys: 0.623 ± 0.042
3.806LysAsp: 3.806 ± 0.131
3.897LysGlu: 3.897 ± 0.131
2.807LysPhe: 2.807 ± 0.107
2.881LysGly: 2.881 ± 0.096
1.514LysHis: 1.514 ± 0.063
6.733LysIle: 6.733 ± 0.189
5.38LysLys: 5.38 ± 0.174
6.345LysLeu: 6.345 ± 0.151
1.556LysMet: 1.556 ± 0.07
5.473LysAsn: 5.473 ± 0.157
1.763LysPro: 1.763 ± 0.063
2.281LysGln: 2.281 ± 0.098
2.482LysArg: 2.482 ± 0.09
4.669LysSer: 4.669 ± 0.105
3.413LysThr: 3.413 ± 0.115
3.153LysVal: 3.153 ± 0.097
0.538LysTrp: 0.538 ± 0.046
3.586LysTyr: 3.586 ± 0.112
0.0LysXaa: 0.0 ± 0.0
Leu
6.54LeuAla: 6.54 ± 0.159
1.174LeuCys: 1.174 ± 0.059
4.624LeuAsp: 4.624 ± 0.114
4.582LeuGlu: 4.582 ± 0.094
7.698LeuPhe: 7.698 ± 0.18
6.696LeuGly: 6.696 ± 0.155
2.332LeuHis: 2.332 ± 0.096
11.246LeuIle: 11.246 ± 0.213
6.401LeuLys: 6.401 ± 0.157
13.394LeuLeu: 13.394 ± 0.261
2.578LeuMet: 2.578 ± 0.084
6.84LeuAsn: 6.84 ± 0.163
3.965LeuPro: 3.965 ± 0.127
2.618LeuGln: 2.618 ± 0.078
3.297LeuArg: 3.297 ± 0.1
9.732LeuSer: 9.732 ± 0.217
6.328LeuThr: 6.328 ± 0.199
6.336LeuVal: 6.336 ± 0.146
0.62LeuTrp: 0.62 ± 0.051
5.088LeuTyr: 5.088 ± 0.127
0.0LeuXaa: 0.0 ± 0.0
Met
1.293MetAla: 1.293 ± 0.048
0.291MetCys: 0.291 ± 0.031
0.787MetAsp: 0.787 ± 0.048
0.954MetGlu: 0.954 ± 0.06
1.494MetPhe: 1.494 ± 0.067
1.061MetGly: 1.061 ± 0.057
0.529MetHis: 0.529 ± 0.042
2.236MetIle: 2.236 ± 0.085
1.251MetLys: 1.251 ± 0.067
3.005MetLeu: 3.005 ± 0.089
0.651MetMet: 0.651 ± 0.041
1.375MetAsn: 1.375 ± 0.059
1.208MetPro: 1.208 ± 0.063
0.807MetGln: 0.807 ± 0.043
0.841MetArg: 0.841 ± 0.046
1.865MetSer: 1.865 ± 0.075
1.262MetThr: 1.262 ± 0.055
1.336MetVal: 1.336 ± 0.065
0.125MetTrp: 0.125 ± 0.02
1.155MetTyr: 1.155 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
2.64AsnAla: 2.64 ± 0.081
0.758AsnCys: 0.758 ± 0.055
3.096AsnAsp: 3.096 ± 0.098
2.672AsnGlu: 2.672 ± 0.102
3.382AsnPhe: 3.382 ± 0.094
2.904AsnGly: 2.904 ± 0.093
1.37AsnHis: 1.37 ± 0.065
7.726AsnIle: 7.726 ± 0.185
5.428AsnLys: 5.428 ± 0.164
7.075AsnLeu: 7.075 ± 0.151
1.37AsnMet: 1.37 ± 0.064
6.039AsnAsn: 6.039 ± 0.164
2.394AsnPro: 2.394 ± 0.109
2.272AsnGln: 2.272 ± 0.086
2.688AsnArg: 2.688 ± 0.081
5.453AsnSer: 5.453 ± 0.121
3.84AsnThr: 3.84 ± 0.116
3.351AsnVal: 3.351 ± 0.126
0.546AsnTrp: 0.546 ± 0.043
3.478AsnTyr: 3.478 ± 0.118
0.0AsnXaa: 0.0 ± 0.0
Pro
1.573ProAla: 1.573 ± 0.105
0.249ProCys: 0.249 ± 0.031
1.228ProAsp: 1.228 ± 0.054
1.65ProGlu: 1.65 ± 0.064
1.967ProPhe: 1.967 ± 0.088
1.477ProGly: 1.477 ± 0.077
0.546ProHis: 0.546 ± 0.039
3.039ProIle: 3.039 ± 0.096
1.709ProLys: 1.709 ± 0.066
4.146ProLeu: 4.146 ± 0.181
0.696ProMet: 0.696 ± 0.043
2.066ProAsn: 2.066 ± 0.09
0.889ProPro: 0.889 ± 0.071
0.818ProGln: 0.818 ± 0.051
0.849ProArg: 0.849 ± 0.055
2.352ProSer: 2.352 ± 0.092
1.675ProThr: 1.675 ± 0.086
1.958ProVal: 1.958 ± 0.13
0.255ProTrp: 0.255 ± 0.027
1.837ProTyr: 1.837 ± 0.067
0.0ProXaa: 0.0 ± 0.0
Gln
1.486GlnAla: 1.486 ± 0.063
0.325GlnCys: 0.325 ± 0.029
1.378GlnAsp: 1.378 ± 0.066
1.395GlnGlu: 1.395 ± 0.07
1.523GlnPhe: 1.523 ± 0.06
1.2GlnGly: 1.2 ± 0.059
0.501GlnHis: 0.501 ± 0.036
2.635GlnIle: 2.635 ± 0.088
1.888GlnLys: 1.888 ± 0.076
2.745GlnLeu: 2.745 ± 0.101
0.589GlnMet: 0.589 ± 0.04
1.913GlnAsn: 1.913 ± 0.076
0.753GlnPro: 0.753 ± 0.061
0.891GlnGln: 0.891 ± 0.054
1.146GlnArg: 1.146 ± 0.046
2.057GlnSer: 2.057 ± 0.08
1.593GlnThr: 1.593 ± 0.073
1.339GlnVal: 1.339 ± 0.063
0.175GlnTrp: 0.175 ± 0.023
1.347GlnTyr: 1.347 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
1.718ArgAla: 1.718 ± 0.136
0.342ArgCys: 0.342 ± 0.035
1.743ArgAsp: 1.743 ± 0.067
1.885ArgGlu: 1.885 ± 0.077
1.789ArgPhe: 1.789 ± 0.063
1.729ArgGly: 1.729 ± 0.074
0.512ArgHis: 0.512 ± 0.042
3.141ArgIle: 3.141 ± 0.084
2.539ArgLys: 2.539 ± 0.095
3.532ArgLeu: 3.532 ± 0.104
0.784ArgMet: 0.784 ± 0.043
2.182ArgAsn: 2.182 ± 0.069
1.01ArgPro: 1.01 ± 0.053
0.852ArgGln: 0.852 ± 0.046
1.327ArgArg: 1.327 ± 0.064
2.471ArgSer: 2.471 ± 0.089
1.523ArgThr: 1.523 ± 0.064
1.738ArgVal: 1.738 ± 0.071
0.232ArgTrp: 0.232 ± 0.026
1.551ArgTyr: 1.551 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
3.835SerAla: 3.835 ± 0.118
0.957SerCys: 0.957 ± 0.052
3.713SerAsp: 3.713 ± 0.112
3.804SerGlu: 3.804 ± 0.113
4.627SerPhe: 4.627 ± 0.106
4.463SerGly: 4.463 ± 0.132
1.585SerHis: 1.585 ± 0.066
8.739SerIle: 8.739 ± 0.179
5.332SerLys: 5.332 ± 0.125
9.322SerLeu: 9.322 ± 0.218
1.814SerMet: 1.814 ± 0.072
5.64SerAsn: 5.64 ± 0.166
2.284SerPro: 2.284 ± 0.086
2.089SerGln: 2.089 ± 0.084
2.572SerArg: 2.572 ± 0.088
7.531SerSer: 7.531 ± 0.157
4.457SerThr: 4.457 ± 0.119
4.786SerVal: 4.786 ± 0.122
0.569SerTrp: 0.569 ± 0.042
3.945SerTyr: 3.945 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
2.708ThrAla: 2.708 ± 0.095
0.637ThrCys: 0.637 ± 0.044
2.663ThrAsp: 2.663 ± 0.133
2.355ThrGlu: 2.355 ± 0.082
2.827ThrPhe: 2.827 ± 0.084
3.073ThrGly: 3.073 ± 0.106
1.01ThrHis: 1.01 ± 0.055
5.79ThrIle: 5.79 ± 0.106
3.628ThrLys: 3.628 ± 0.112
5.589ThrLeu: 5.589 ± 0.134
1.251ThrMet: 1.251 ± 0.051
3.685ThrAsn: 3.685 ± 0.128
2.029ThrPro: 2.029 ± 0.08
1.616ThrGln: 1.616 ± 0.074
1.859ThrArg: 1.859 ± 0.081
4.29ThrSer: 4.29 ± 0.12
3.566ThrThr: 3.566 ± 0.142
3.424ThrVal: 3.424 ± 0.099
0.328ThrTrp: 0.328 ± 0.032
2.448ThrTyr: 2.448 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
3.133ValAla: 3.133 ± 0.111
0.552ValCys: 0.552 ± 0.039
2.572ValAsp: 2.572 ± 0.088
2.567ValGlu: 2.567 ± 0.089
3.495ValPhe: 3.495 ± 0.109
3.348ValGly: 3.348 ± 0.109
0.826ValHis: 0.826 ± 0.046
5.872ValIle: 5.872 ± 0.131
3.506ValLys: 3.506 ± 0.109
6.704ValLeu: 6.704 ± 0.163
1.307ValMet: 1.307 ± 0.066
3.424ValAsn: 3.424 ± 0.107
2.125ValPro: 2.125 ± 0.159
1.35ValGln: 1.35 ± 0.065
1.746ValArg: 1.746 ± 0.077
4.822ValSer: 4.822 ± 0.143
3.345ValThr: 3.345 ± 0.101
3.481ValVal: 3.481 ± 0.157
0.405ValTrp: 0.405 ± 0.038
2.731ValTyr: 2.731 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.314TrpAla: 0.314 ± 0.038
0.105TrpCys: 0.105 ± 0.017
0.275TrpAsp: 0.275 ± 0.032
0.294TrpGlu: 0.294 ± 0.031
0.461TrpPhe: 0.461 ± 0.039
0.427TrpGly: 0.427 ± 0.045
0.147TrpHis: 0.147 ± 0.022
0.651TrpIle: 0.651 ± 0.049
0.311TrpLys: 0.311 ± 0.027
0.957TrpLeu: 0.957 ± 0.055
0.144TrpMet: 0.144 ± 0.028
0.49TrpAsn: 0.49 ± 0.041
0.246TrpPro: 0.246 ± 0.027
0.255TrpGln: 0.255 ± 0.031
0.286TrpArg: 0.286 ± 0.028
0.583TrpSer: 0.583 ± 0.044
0.328TrpThr: 0.328 ± 0.029
0.365TrpVal: 0.365 ± 0.04
0.091TrpTrp: 0.091 ± 0.019
0.331TrpTyr: 0.331 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.081
0.659TyrCys: 0.659 ± 0.046
2.224TyrAsp: 2.224 ± 0.087
1.706TyrGlu: 1.706 ± 0.074
3.028TyrPhe: 3.028 ± 0.093
2.615TyrGly: 2.615 ± 0.1
0.9TyrHis: 0.9 ± 0.044
4.969TyrIle: 4.969 ± 0.127
3.226TyrLys: 3.226 ± 0.105
5.578TyrLeu: 5.578 ± 0.145
1.29TyrMet: 1.29 ± 0.053
3.954TyrAsn: 3.954 ± 0.124
1.497TyrPro: 1.497 ± 0.064
1.07TyrGln: 1.07 ± 0.059
1.573TyrArg: 1.573 ± 0.072
4.33TyrSer: 4.33 ± 0.107
2.601TyrThr: 2.601 ± 0.093
2.575TyrVal: 2.575 ± 0.085
0.357TyrTrp: 0.357 ± 0.036
2.476TyrTyr: 2.476 ± 0.087
0.003TyrXaa: 0.003 ± 0.003
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.003XaaAsn: 0.003 ± 0.003
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.006
Statistics based on 2001 proteins (353358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski