Amino acid dipepetide frequency for Tessaracoccus sp. ZS01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.228AlaAla: 17.228 ± 0.22	0.886AlaCys: 0.886 ± 0.033	7.78AlaAsp: 7.78 ± 0.098	8.247AlaGlu: 8.247 ± 0.12	3.583AlaPhe: 3.583 ± 0.069	10.914AlaGly: 10.914 ± 0.128	2.442AlaHis: 2.442 ± 0.064	5.098AlaIle: 5.098 ± 0.078	3.109AlaLys: 3.109 ± 0.069	12.833AlaLeu: 12.833 ± 0.162	2.953AlaMet: 2.953 ± 0.066	2.551AlaAsn: 2.551 ± 0.056	5.73AlaPro: 5.73 ± 0.103	4.073AlaGln: 4.073 ± 0.066	7.829AlaArg: 7.829 ± 0.11	6.278AlaSer: 6.278 ± 0.081	7.379AlaThr: 7.379 ± 0.137	10.689AlaVal: 10.689 ± 0.113	1.955AlaTrp: 1.955 ± 0.049	2.285AlaTyr: 2.285 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.692CysAla: 0.692 ± 0.028	0.066CysCys: 0.066 ± 0.009	0.427CysAsp: 0.427 ± 0.024	0.396CysGlu: 0.396 ± 0.023	0.195CysPhe: 0.195 ± 0.014	0.709CysGly: 0.709 ± 0.03	0.174CysHis: 0.174 ± 0.014	0.224CysIle: 0.224 ± 0.015	0.086CysLys: 0.086 ± 0.009	0.579CysLeu: 0.579 ± 0.023	0.118CysMet: 0.118 ± 0.012	0.152CysAsn: 0.152 ± 0.012	0.419CysPro: 0.419 ± 0.025	0.171CysGln: 0.171 ± 0.013	0.517CysArg: 0.517 ± 0.027	0.387CysSer: 0.387 ± 0.023	0.427CysThr: 0.427 ± 0.026	0.494CysVal: 0.494 ± 0.024	0.088CysTrp: 0.088 ± 0.01	0.14CysTyr: 0.14 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.451AspAla: 7.451 ± 0.111	0.333AspCys: 0.333 ± 0.018	4.345AspAsp: 4.345 ± 0.103	4.514AspGlu: 4.514 ± 0.083	1.828AspPhe: 1.828 ± 0.044	6.289AspGly: 6.289 ± 0.103	1.284AspHis: 1.284 ± 0.033	2.485AspIle: 2.485 ± 0.059	1.258AspLys: 1.258 ± 0.039	6.511AspLeu: 6.511 ± 0.078	1.011AspMet: 1.011 ± 0.029	1.257AspAsn: 1.257 ± 0.047	3.982AspPro: 3.982 ± 0.069	1.714AspGln: 1.714 ± 0.047	3.823AspArg: 3.823 ± 0.069	2.662AspSer: 2.662 ± 0.049	2.918AspThr: 2.918 ± 0.062	5.454AspVal: 5.454 ± 0.1	0.957AspTrp: 0.957 ± 0.035	1.363AspTyr: 1.363 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.658GluAla: 7.658 ± 0.109	0.391GluCys: 0.391 ± 0.024	3.017GluAsp: 3.017 ± 0.063	3.682GluGlu: 3.682 ± 0.076	1.909GluPhe: 1.909 ± 0.04	4.577GluGly: 4.577 ± 0.076	1.451GluHis: 1.451 ± 0.041	2.659GluIle: 2.659 ± 0.057	1.49GluLys: 1.49 ± 0.05	6.819GluLeu: 6.819 ± 0.099	1.238GluMet: 1.238 ± 0.042	1.262GluAsn: 1.262 ± 0.037	3.169GluPro: 3.169 ± 0.063	2.326GluGln: 2.326 ± 0.054	4.729GluArg: 4.729 ± 0.086	2.915GluSer: 2.915 ± 0.062	2.994GluThr: 2.994 ± 0.061	5.319GluVal: 5.319 ± 0.079	0.9GluTrp: 0.9 ± 0.033	1.172GluTyr: 1.172 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.778PheAla: 3.778 ± 0.065	0.236PheCys: 0.236 ± 0.015	2.338PheAsp: 2.338 ± 0.052	1.79PheGlu: 1.79 ± 0.043	1.09PhePhe: 1.09 ± 0.039	3.292PheGly: 3.292 ± 0.064	0.667PheHis: 0.667 ± 0.028	1.334PheIle: 1.334 ± 0.041	0.636PheLys: 0.636 ± 0.028	2.837PheLeu: 2.837 ± 0.062	0.592PheMet: 0.592 ± 0.026	0.97PheAsn: 0.97 ± 0.037	1.456PhePro: 1.456 ± 0.04	0.878PheGln: 0.878 ± 0.031	1.762PheArg: 1.762 ± 0.051	1.816PheSer: 1.816 ± 0.042	2.248PheThr: 2.248 ± 0.067	2.789PheVal: 2.789 ± 0.053	0.501PheTrp: 0.501 ± 0.026	0.679PheTyr: 0.679 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.709GlyAla: 9.709 ± 0.123	0.679GlyCys: 0.679 ± 0.029	5.177GlyAsp: 5.177 ± 0.088	5.087GlyGlu: 5.087 ± 0.075	3.213GlyPhe: 3.213 ± 0.058	7.519GlyGly: 7.519 ± 0.13	2.02GlyHis: 2.02 ± 0.054	4.205GlyIle: 4.205 ± 0.074	2.338GlyLys: 2.338 ± 0.054	9.095GlyLeu: 9.095 ± 0.129	2.246GlyMet: 2.246 ± 0.045	2.142GlyAsn: 2.142 ± 0.059	3.801GlyPro: 3.801 ± 0.07	2.843GlyGln: 2.843 ± 0.064	6.37GlyArg: 6.37 ± 0.103	5.076GlySer: 5.076 ± 0.088	5.502GlyThr: 5.502 ± 0.12	7.723GlyVal: 7.723 ± 0.107	1.904GlyTrp: 1.904 ± 0.053	2.333GlyTyr: 2.333 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.195HisAla: 2.195 ± 0.055	0.158HisCys: 0.158 ± 0.013	1.383HisAsp: 1.383 ± 0.039	1.227HisGlu: 1.227 ± 0.035	0.639HisPhe: 0.639 ± 0.025	1.986HisGly: 1.986 ± 0.051	0.638HisHis: 0.638 ± 0.029	0.803HisIle: 0.803 ± 0.03	0.376HisLys: 0.376 ± 0.019	2.362HisLeu: 2.362 ± 0.058	0.353HisMet: 0.353 ± 0.018	0.503HisAsn: 0.503 ± 0.027	1.487HisPro: 1.487 ± 0.042	0.674HisGln: 0.674 ± 0.028	1.688HisArg: 1.688 ± 0.052	0.974HisSer: 0.974 ± 0.034	1.171HisThr: 1.171 ± 0.035	1.705HisVal: 1.705 ± 0.046	0.327HisTrp: 0.327 ± 0.017	0.446HisTyr: 0.446 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.725IleAla: 5.725 ± 0.092	0.304IleCys: 0.304 ± 0.017	3.128IleAsp: 3.128 ± 0.061	2.736IleGlu: 2.736 ± 0.06	1.176IlePhe: 1.176 ± 0.042	4.175IleGly: 4.175 ± 0.073	0.757IleHis: 0.757 ± 0.029	1.914IleIle: 1.914 ± 0.051	0.938IleLys: 0.938 ± 0.037	3.445IleLeu: 3.445 ± 0.07	0.792IleMet: 0.792 ± 0.031	1.166IleAsn: 1.166 ± 0.038	2.139IlePro: 2.139 ± 0.051	1.059IleGln: 1.059 ± 0.028	2.479IleArg: 2.479 ± 0.055	2.447IleSer: 2.447 ± 0.062	2.887IleThr: 2.887 ± 0.064	3.966IleVal: 3.966 ± 0.069	0.595IleTrp: 0.595 ± 0.026	0.822IleTyr: 0.822 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.953LysAla: 2.953 ± 0.061	0.115LysCys: 0.115 ± 0.013	1.248LysAsp: 1.248 ± 0.043	1.156LysGlu: 1.156 ± 0.045	0.678LysPhe: 0.678 ± 0.026	1.899LysGly: 1.899 ± 0.042	0.52LysHis: 0.52 ± 0.024	0.985LysIle: 0.985 ± 0.035	0.818LysLys: 0.818 ± 0.033	2.434LysLeu: 2.434 ± 0.052	0.538LysMet: 0.538 ± 0.027	0.545LysAsn: 0.545 ± 0.026	1.398LysPro: 1.398 ± 0.039	0.761LysGln: 0.761 ± 0.035	1.675LysArg: 1.675 ± 0.039	1.197LysSer: 1.197 ± 0.035	1.303LysThr: 1.303 ± 0.04	2.217LysVal: 2.217 ± 0.053	0.305LysTrp: 0.305 ± 0.018	0.517LysTyr: 0.517 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.597LeuAla: 13.597 ± 0.155	0.559LeuCys: 0.559 ± 0.028	6.371LeuAsp: 6.371 ± 0.099	5.337LeuGlu: 5.337 ± 0.083	2.904LeuPhe: 2.904 ± 0.065	9.434LeuGly: 9.434 ± 0.125	1.939LeuHis: 1.939 ± 0.043	4.352LeuIle: 4.352 ± 0.09	2.188LeuLys: 2.188 ± 0.049	10.094LeuLeu: 10.094 ± 0.167	2.024LeuMet: 2.024 ± 0.051	2.235LeuAsn: 2.235 ± 0.054	5.867LeuPro: 5.867 ± 0.08	2.764LeuGln: 2.764 ± 0.061	7.205LeuArg: 7.205 ± 0.108	5.81LeuSer: 5.81 ± 0.08	6.873LeuThr: 6.873 ± 0.099	8.81LeuVal: 8.81 ± 0.125	1.293LeuTrp: 1.293 ± 0.043	1.768LeuTyr: 1.768 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.761MetAla: 2.761 ± 0.056	0.117MetCys: 0.117 ± 0.01	1.036MetAsp: 1.036 ± 0.032	0.956MetGlu: 0.956 ± 0.036	0.674MetPhe: 0.674 ± 0.023	1.792MetGly: 1.792 ± 0.053	0.402MetHis: 0.402 ± 0.022	0.927MetIle: 0.927 ± 0.033	0.587MetLys: 0.587 ± 0.027	2.156MetLeu: 2.156 ± 0.045	0.483MetMet: 0.483 ± 0.027	0.613MetAsn: 0.613 ± 0.022	1.109MetPro: 1.109 ± 0.031	0.578MetGln: 0.578 ± 0.024	1.447MetArg: 1.447 ± 0.04	1.494MetSer: 1.494 ± 0.037	1.773MetThr: 1.773 ± 0.04	1.787MetVal: 1.787 ± 0.042	0.275MetTrp: 0.275 ± 0.019	0.331MetTyr: 0.331 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.605AsnAla: 2.605 ± 0.053	0.158AsnCys: 0.158 ± 0.015	1.251AsnAsp: 1.251 ± 0.042	1.246AsnGlu: 1.246 ± 0.038	0.747AsnPhe: 0.747 ± 0.026	2.159AsnGly: 2.159 ± 0.064	0.484AsnHis: 0.484 ± 0.023	0.981AsnIle: 0.981 ± 0.035	0.5AsnLys: 0.5 ± 0.026	2.376AsnLeu: 2.376 ± 0.054	0.477AsnMet: 0.477 ± 0.023	0.723AsnAsn: 0.723 ± 0.031	1.738AsnPro: 1.738 ± 0.042	0.754AsnGln: 0.754 ± 0.033	1.515AsnArg: 1.515 ± 0.045	1.17AsnSer: 1.17 ± 0.038	1.344AsnThr: 1.344 ± 0.055	1.868AsnVal: 1.868 ± 0.052	0.416AsnTrp: 0.416 ± 0.023	0.643AsnTyr: 0.643 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.582ProAla: 6.582 ± 0.107	0.259ProCys: 0.259 ± 0.017	3.8ProAsp: 3.8 ± 0.065	4.125ProGlu: 4.125 ± 0.066	1.56ProPhe: 1.56 ± 0.045	5.179ProGly: 5.179 ± 0.091	1.15ProHis: 1.15 ± 0.035	1.859ProIle: 1.859 ± 0.044	1.278ProLys: 1.278 ± 0.039	4.781ProLeu: 4.781 ± 0.068	1.141ProMet: 1.141 ± 0.034	1.178ProAsn: 1.178 ± 0.036	2.38ProPro: 2.38 ± 0.058	1.712ProGln: 1.712 ± 0.045	2.976ProArg: 2.976 ± 0.066	3.377ProSer: 3.377 ± 0.101	3.663ProThr: 3.663 ± 0.073	4.813ProVal: 4.813 ± 0.08	0.88ProTrp: 0.88 ± 0.033	1.169ProTyr: 1.169 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.795GlnAla: 3.795 ± 0.068	0.163GlnCys: 0.163 ± 0.013	1.343GlnAsp: 1.343 ± 0.039	1.582GlnGlu: 1.582 ± 0.043	1.042GlnPhe: 1.042 ± 0.036	2.324GlnGly: 2.324 ± 0.049	0.711GlnHis: 0.711 ± 0.026	1.409GlnIle: 1.409 ± 0.039	0.699GlnLys: 0.699 ± 0.025	3.554GlnLeu: 3.554 ± 0.07	0.637GlnMet: 0.637 ± 0.026	0.634GlnAsn: 0.634 ± 0.028	1.887GlnPro: 1.887 ± 0.046	1.398GlnGln: 1.398 ± 0.058	2.551GlnArg: 2.551 ± 0.061	1.524GlnSer: 1.524 ± 0.044	1.554GlnThr: 1.554 ± 0.039	2.741GlnVal: 2.741 ± 0.053	0.623GlnTrp: 0.623 ± 0.031	0.668GlnTyr: 0.668 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.635ArgAla: 7.635 ± 0.114	0.439ArgCys: 0.439 ± 0.023	4.014ArgAsp: 4.014 ± 0.076	4.123ArgGlu: 4.123 ± 0.084	2.317ArgPhe: 2.317 ± 0.05	5.075ArgGly: 5.075 ± 0.081	1.603ArgHis: 1.603 ± 0.046	3.278ArgIle: 3.278 ± 0.055	1.587ArgLys: 1.587 ± 0.039	6.974ArgLeu: 6.974 ± 0.113	1.573ArgMet: 1.573 ± 0.041	1.594ArgAsn: 1.594 ± 0.04	3.605ArgPro: 3.605 ± 0.067	2.264ArgGln: 2.264 ± 0.059	5.999ArgArg: 5.999 ± 0.096	3.827ArgSer: 3.827 ± 0.07	3.972ArgThr: 3.972 ± 0.066	5.536ArgVal: 5.536 ± 0.087	1.259ArgTrp: 1.259 ± 0.042	1.661ArgTyr: 1.661 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.275SerAla: 6.275 ± 0.092	0.339SerCys: 0.339 ± 0.02	2.957SerAsp: 2.957 ± 0.058	2.83SerGlu: 2.83 ± 0.057	1.951SerPhe: 1.951 ± 0.045	5.395SerGly: 5.395 ± 0.086	1.102SerHis: 1.102 ± 0.036	2.323SerIle: 2.323 ± 0.055	1.24SerLys: 1.24 ± 0.033	5.375SerLeu: 5.375 ± 0.068	1.437SerMet: 1.437 ± 0.04	1.183SerAsn: 1.183 ± 0.04	3.275SerPro: 3.275 ± 0.085	1.575SerGln: 1.575 ± 0.039	3.623SerArg: 3.623 ± 0.065	3.118SerSer: 3.118 ± 0.066	3.415SerThr: 3.415 ± 0.065	4.655SerVal: 4.655 ± 0.084	0.904SerTrp: 0.904 ± 0.03	1.369SerTyr: 1.369 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.461ThrAla: 7.461 ± 0.131	0.439ThrCys: 0.439 ± 0.03	3.715ThrAsp: 3.715 ± 0.08	3.265ThrGlu: 3.265 ± 0.06	2.1ThrPhe: 2.1 ± 0.05	5.672ThrGly: 5.672 ± 0.095	1.218ThrHis: 1.218 ± 0.037	2.596ThrIle: 2.596 ± 0.058	1.364ThrLys: 1.364 ± 0.036	5.958ThrLeu: 5.958 ± 0.084	1.326ThrMet: 1.326 ± 0.039	1.429ThrAsn: 1.429 ± 0.056	3.942ThrPro: 3.942 ± 0.08	1.797ThrGln: 1.797 ± 0.05	3.556ThrArg: 3.556 ± 0.067	3.307ThrSer: 3.307 ± 0.068	4.176ThrThr: 4.176 ± 0.122	6.153ThrVal: 6.153 ± 0.113	1.072ThrTrp: 1.072 ± 0.037	1.447ThrTyr: 1.447 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	11.55ValAla: 11.55 ± 0.134	0.555ValCys: 0.555 ± 0.027	5.856ValAsp: 5.856 ± 0.084	5.397ValGlu: 5.397 ± 0.089	2.675ValPhe: 2.675 ± 0.068	7.491ValGly: 7.491 ± 0.086	1.702ValHis: 1.702 ± 0.047	3.923ValIle: 3.923 ± 0.07	1.949ValLys: 1.949 ± 0.049	8.916ValLeu: 8.916 ± 0.123	1.73ValMet: 1.73 ± 0.047	2.042ValAsn: 2.042 ± 0.042	4.565ValPro: 4.565 ± 0.068	2.2ValGln: 2.2 ± 0.047	5.632ValArg: 5.632 ± 0.086	4.789ValSer: 4.789 ± 0.082	6.125ValThr: 6.125 ± 0.118	8.624ValVal: 8.624 ± 0.112	1.165ValTrp: 1.165 ± 0.034	1.486ValTyr: 1.486 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.811TrpAla: 1.811 ± 0.048	0.115TrpCys: 0.115 ± 0.012	0.882TrpAsp: 0.882 ± 0.031	0.759TrpGlu: 0.759 ± 0.03	0.633TrpPhe: 0.633 ± 0.027	1.19TrpGly: 1.19 ± 0.036	0.413TrpHis: 0.413 ± 0.022	0.603TrpIle: 0.603 ± 0.028	0.412TrpLys: 0.412 ± 0.023	1.951TrpLeu: 1.951 ± 0.057	0.336TrpMet: 0.336 ± 0.023	0.441TrpAsn: 0.441 ± 0.024	0.773TrpPro: 0.773 ± 0.032	0.626TrpGln: 0.626 ± 0.027	1.316TrpArg: 1.316 ± 0.041	0.926TrpSer: 0.926 ± 0.037	0.95TrpThr: 0.95 ± 0.031	1.3TrpVal: 1.3 ± 0.04	0.38TrpTrp: 0.38 ± 0.023	0.325TrpTyr: 0.325 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.381TyrAla: 2.381 ± 0.051	0.152TyrCys: 0.152 ± 0.012	1.373TyrAsp: 1.373 ± 0.043	1.223TyrGlu: 1.223 ± 0.039	0.776TyrPhe: 0.776 ± 0.035	1.912TyrGly: 1.912 ± 0.051	0.417TyrHis: 0.417 ± 0.022	0.692TyrIle: 0.692 ± 0.027	0.411TyrLys: 0.411 ± 0.021	2.374TyrLeu: 2.374 ± 0.056	0.29TyrMet: 0.29 ± 0.016	0.534TyrAsn: 0.534 ± 0.023	1.141TyrPro: 1.141 ± 0.037	0.672TyrGln: 0.672 ± 0.025	1.643TyrArg: 1.643 ± 0.042	1.249TyrSer: 1.249 ± 0.038	1.318TyrThr: 1.318 ± 0.054	1.728TyrVal: 1.728 ± 0.04	0.339TyrTrp: 0.339 ± 0.02	0.526TyrTyr: 0.526 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2773 proteins (964266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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