Amino acid dipepetide frequency for Clohesyomyces aquaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.311AlaAla: 8.311 ± 0.049	1.184AlaCys: 1.184 ± 0.016	3.879AlaAsp: 3.879 ± 0.026	4.811AlaGlu: 4.811 ± 0.032	3.23AlaPhe: 3.23 ± 0.025	5.743AlaGly: 5.743 ± 0.034	1.823AlaHis: 1.823 ± 0.016	4.292AlaIle: 4.292 ± 0.03	4.127AlaLys: 4.127 ± 0.028	7.696AlaLeu: 7.696 ± 0.039	1.942AlaMet: 1.942 ± 0.017	3.013AlaAsn: 3.013 ± 0.022	4.926AlaPro: 4.926 ± 0.037	3.255AlaGln: 3.255 ± 0.024	4.84AlaArg: 4.84 ± 0.031	7.166AlaSer: 7.166 ± 0.036	5.216AlaThr: 5.216 ± 0.033	5.218AlaVal: 5.218 ± 0.033	1.215AlaTrp: 1.215 ± 0.016	2.17AlaTyr: 2.17 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.048CysAla: 1.048 ± 0.013	0.321CysCys: 0.321 ± 0.008	0.691CysAsp: 0.691 ± 0.011	0.661CysGlu: 0.661 ± 0.011	0.583CysPhe: 0.583 ± 0.01	1.114CysGly: 1.114 ± 0.017	0.364CysHis: 0.364 ± 0.008	0.79CysIle: 0.79 ± 0.011	0.608CysLys: 0.608 ± 0.012	1.356CysLeu: 1.356 ± 0.015	0.299CysMet: 0.299 ± 0.007	0.509CysAsn: 0.509 ± 0.009	0.782CysPro: 0.782 ± 0.012	0.484CysGln: 0.484 ± 0.009	0.88CysArg: 0.88 ± 0.014	1.084CysSer: 1.084 ± 0.016	0.823CysThr: 0.823 ± 0.012	0.872CysVal: 0.872 ± 0.012	0.255CysTrp: 0.255 ± 0.007	0.4CysTyr: 0.4 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.478AspAla: 4.478 ± 0.028	0.684AspCys: 0.684 ± 0.011	3.699AspAsp: 3.699 ± 0.034	4.078AspGlu: 4.078 ± 0.032	2.167AspPhe: 2.167 ± 0.018	3.92AspGly: 3.92 ± 0.029	1.192AspHis: 1.192 ± 0.014	2.978AspIle: 2.978 ± 0.022	2.275AspLys: 2.275 ± 0.02	4.779AspLeu: 4.779 ± 0.031	1.261AspMet: 1.261 ± 0.014	1.723AspAsn: 1.723 ± 0.018	3.31AspPro: 3.31 ± 0.024	1.727AspGln: 1.727 ± 0.018	2.925AspArg: 2.925 ± 0.022	3.892AspSer: 3.892 ± 0.026	2.868AspThr: 2.868 ± 0.023	3.514AspVal: 3.514 ± 0.025	0.928AspTrp: 0.928 ± 0.012	1.5AspTyr: 1.5 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	5.024GluAla: 5.024 ± 0.034	0.694GluCys: 0.694 ± 0.012	4.004GluAsp: 4.004 ± 0.031	5.257GluGlu: 5.257 ± 0.048	1.953GluPhe: 1.953 ± 0.018	3.931GluGly: 3.931 ± 0.031	1.416GluHis: 1.416 ± 0.016	3.026GluIle: 3.026 ± 0.023	3.751GluLys: 3.751 ± 0.028	4.98GluLeu: 4.98 ± 0.034	1.469GluMet: 1.469 ± 0.017	2.229GluAsn: 2.229 ± 0.023	2.725GluPro: 2.725 ± 0.027	2.299GluGln: 2.299 ± 0.022	3.992GluArg: 3.992 ± 0.033	4.013GluSer: 4.013 ± 0.029	3.296GluThr: 3.296 ± 0.025	3.491GluVal: 3.491 ± 0.026	0.941GluTrp: 0.941 ± 0.013	1.662GluTyr: 1.662 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.153PheAla: 3.153 ± 0.027	0.616PheCys: 0.616 ± 0.011	2.201PheAsp: 2.201 ± 0.019	2.163PheGlu: 2.163 ± 0.019	1.637PhePhe: 1.637 ± 0.019	2.976PheGly: 2.976 ± 0.03	0.956PheHis: 0.956 ± 0.013	1.809PheIle: 1.809 ± 0.017	1.585PheLys: 1.585 ± 0.017	3.584PheLeu: 3.584 ± 0.029	0.777PheMet: 0.777 ± 0.01	1.422PheAsn: 1.422 ± 0.018	2.08PhePro: 2.08 ± 0.019	1.452PheGln: 1.452 ± 0.015	2.043PheArg: 2.043 ± 0.018	3.112PheSer: 3.112 ± 0.025	2.225PheThr: 2.225 ± 0.02	2.445PheVal: 2.445 ± 0.02	0.694PheTrp: 0.694 ± 0.012	1.101PheTyr: 1.101 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.393GlyAla: 5.393 ± 0.036	1.024GlyCys: 1.024 ± 0.014	3.534GlyAsp: 3.534 ± 0.028	3.764GlyGlu: 3.764 ± 0.026	2.889GlyPhe: 2.889 ± 0.024	6.035GlyGly: 6.035 ± 0.057	1.696GlyHis: 1.696 ± 0.019	3.644GlyIle: 3.644 ± 0.026	3.693GlyLys: 3.693 ± 0.027	6.056GlyLeu: 6.056 ± 0.032	1.738GlyMet: 1.738 ± 0.018	2.638GlyAsn: 2.638 ± 0.023	3.419GlyPro: 3.419 ± 0.027	2.466GlyGln: 2.466 ± 0.022	4.241GlyArg: 4.241 ± 0.027	5.577GlySer: 5.577 ± 0.034	4.078GlyThr: 4.078 ± 0.027	4.436GlyVal: 4.436 ± 0.031	1.274GlyTrp: 1.274 ± 0.017	2.185GlyTyr: 2.185 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.899HisAla: 1.899 ± 0.017	0.395HisCys: 0.395 ± 0.008	1.29HisAsp: 1.29 ± 0.013	1.338HisGlu: 1.338 ± 0.013	0.987HisPhe: 0.987 ± 0.011	1.743HisGly: 1.743 ± 0.017	0.884HisHis: 0.884 ± 0.014	1.256HisIle: 1.256 ± 0.013	0.951HisLys: 0.951 ± 0.012	2.306HisLeu: 2.306 ± 0.024	0.514HisMet: 0.514 ± 0.01	0.845HisAsn: 0.845 ± 0.012	1.772HisPro: 1.772 ± 0.018	0.989HisGln: 0.989 ± 0.012	1.587HisArg: 1.587 ± 0.017	1.986HisSer: 1.986 ± 0.021	1.359HisThr: 1.359 ± 0.016	1.461HisVal: 1.461 ± 0.016	0.38HisTrp: 0.38 ± 0.008	0.694HisTyr: 0.694 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.237IleAla: 4.237 ± 0.028	0.808IleCys: 0.808 ± 0.013	2.653IleAsp: 2.653 ± 0.019	2.81IleGlu: 2.81 ± 0.021	2.081IlePhe: 2.081 ± 0.019	3.274IleGly: 3.274 ± 0.028	1.214IleHis: 1.214 ± 0.015	2.54IleIle: 2.54 ± 0.023	2.156IleLys: 2.156 ± 0.021	4.674IleLeu: 4.674 ± 0.031	1.016IleMet: 1.016 ± 0.014	1.742IleAsn: 1.742 ± 0.016	3.21IlePro: 3.21 ± 0.021	1.907IleGln: 1.907 ± 0.017	2.847IleArg: 2.847 ± 0.021	4.013IleSer: 4.013 ± 0.025	2.922IleThr: 2.922 ± 0.025	3.175IleVal: 3.175 ± 0.022	0.78IleTrp: 0.78 ± 0.011	1.471IleTyr: 1.471 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.241LysAla: 4.241 ± 0.039	0.598LysCys: 0.598 ± 0.01	2.862LysAsp: 2.862 ± 0.024	3.527LysGlu: 3.527 ± 0.028	1.536LysPhe: 1.536 ± 0.015	3.154LysGly: 3.154 ± 0.026	1.157LysHis: 1.157 ± 0.014	2.336LysIle: 2.336 ± 0.02	3.391LysLys: 3.391 ± 0.036	4.043LysLeu: 4.043 ± 0.027	1.061LysMet: 1.061 ± 0.013	1.793LysAsn: 1.793 ± 0.019	2.826LysPro: 2.826 ± 0.027	1.765LysGln: 1.765 ± 0.018	3.447LysArg: 3.447 ± 0.026	3.567LysSer: 3.567 ± 0.025	2.91LysThr: 2.91 ± 0.022	2.811LysVal: 2.811 ± 0.022	0.746LysTrp: 0.746 ± 0.011	1.396LysTyr: 1.396 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.655LeuAla: 7.655 ± 0.044	1.342LeuCys: 1.342 ± 0.016	4.996LeuAsp: 4.996 ± 0.031	5.433LeuGlu: 5.433 ± 0.034	3.4LeuPhe: 3.4 ± 0.032	6.005LeuGly: 6.005 ± 0.036	2.343LeuHis: 2.343 ± 0.019	3.949LeuIle: 3.949 ± 0.03	4.205LeuLys: 4.205 ± 0.029	8.37LeuLeu: 8.37 ± 0.054	1.739LeuMet: 1.739 ± 0.017	3.114LeuAsn: 3.114 ± 0.023	5.661LeuPro: 5.661 ± 0.033	3.74LeuGln: 3.74 ± 0.028	5.81LeuArg: 5.81 ± 0.033	7.359LeuSer: 7.359 ± 0.037	4.768LeuThr: 4.768 ± 0.031	5.371LeuVal: 5.371 ± 0.032	1.271LeuTrp: 1.271 ± 0.014	2.357LeuTyr: 2.357 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.139MetAla: 2.139 ± 0.017	0.275MetCys: 0.275 ± 0.007	1.246MetAsp: 1.246 ± 0.013	1.32MetGlu: 1.32 ± 0.017	0.784MetPhe: 0.784 ± 0.011	1.526MetGly: 1.526 ± 0.018	0.534MetHis: 0.534 ± 0.01	0.982MetIle: 0.982 ± 0.013	1.076MetLys: 1.076 ± 0.012	1.882MetLeu: 1.882 ± 0.019	0.585MetMet: 0.585 ± 0.01	0.851MetAsn: 0.851 ± 0.014	1.323MetPro: 1.323 ± 0.016	0.857MetGln: 0.857 ± 0.012	1.311MetArg: 1.311 ± 0.016	1.852MetSer: 1.852 ± 0.015	1.277MetThr: 1.277 ± 0.015	1.324MetVal: 1.324 ± 0.015	0.301MetTrp: 0.301 ± 0.007	0.555MetTyr: 0.555 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.159AsnAla: 3.159 ± 0.025	0.517AsnCys: 0.517 ± 0.01	1.86AsnAsp: 1.86 ± 0.017	1.977AsnGlu: 1.977 ± 0.017	1.43AsnPhe: 1.43 ± 0.015	3.083AsnGly: 3.083 ± 0.027	0.854AsnHis: 0.854 ± 0.011	2.023AsnIle: 2.023 ± 0.018	1.558AsnLys: 1.558 ± 0.016	3.252AsnLeu: 3.252 ± 0.024	0.866AsnMet: 0.866 ± 0.012	1.437AsnAsn: 1.437 ± 0.017	2.607AsnPro: 2.607 ± 0.021	1.323AsnGln: 1.323 ± 0.017	1.944AsnArg: 1.944 ± 0.02	2.798AsnSer: 2.798 ± 0.023	2.256AsnThr: 2.256 ± 0.021	2.296AsnVal: 2.296 ± 0.017	0.598AsnTrp: 0.598 ± 0.011	1.041AsnTyr: 1.041 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.203ProAla: 5.203 ± 0.036	0.611ProCys: 0.611 ± 0.011	3.078ProAsp: 3.078 ± 0.02	3.671ProGlu: 3.671 ± 0.026	2.149ProPhe: 2.149 ± 0.02	3.985ProGly: 3.985 ± 0.027	1.519ProHis: 1.519 ± 0.018	2.725ProIle: 2.725 ± 0.023	2.874ProLys: 2.874 ± 0.025	4.914ProLeu: 4.914 ± 0.026	1.135ProMet: 1.135 ± 0.015	2.425ProAsn: 2.425 ± 0.021	5.46ProPro: 5.46 ± 0.066	2.525ProGln: 2.525 ± 0.028	3.612ProArg: 3.612 ± 0.031	6.247ProSer: 6.247 ± 0.041	4.362ProThr: 4.362 ± 0.03	3.452ProVal: 3.452 ± 0.026	0.801ProTrp: 0.801 ± 0.011	1.597ProTyr: 1.597 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.238GlnAla: 3.238 ± 0.024	0.497GlnCys: 0.497 ± 0.008	1.991GlnAsp: 1.991 ± 0.017	2.278GlnGlu: 2.278 ± 0.021	1.301GlnPhe: 1.301 ± 0.013	2.402GlnGly: 2.402 ± 0.023	1.114GlnHis: 1.114 ± 0.015	1.863GlnIle: 1.863 ± 0.018	1.952GlnLys: 1.952 ± 0.02	3.301GlnLeu: 3.301 ± 0.024	0.857GlnMet: 0.857 ± 0.012	1.598GlnAsn: 1.598 ± 0.018	2.481GlnPro: 2.481 ± 0.027	2.151GlnGln: 2.151 ± 0.041	2.549GlnArg: 2.549 ± 0.022	3.0GlnSer: 3.0 ± 0.023	2.286GlnThr: 2.286 ± 0.018	2.058GlnVal: 2.058 ± 0.019	0.593GlnTrp: 0.593 ± 0.008	1.183GlnTyr: 1.183 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.668ArgAla: 4.668 ± 0.027	0.865ArgCys: 0.865 ± 0.013	3.209ArgAsp: 3.209 ± 0.027	3.788ArgGlu: 3.788 ± 0.03	2.194ArgPhe: 2.194 ± 0.02	3.874ArgGly: 3.874 ± 0.028	1.596ArgHis: 1.596 ± 0.015	2.989ArgIle: 2.989 ± 0.02	3.566ArgLys: 3.566 ± 0.026	5.451ArgLeu: 5.451 ± 0.034	1.393ArgMet: 1.393 ± 0.015	2.362ArgAsn: 2.362 ± 0.022	3.607ArgPro: 3.607 ± 0.03	2.487ArgGln: 2.487 ± 0.023	5.158ArgArg: 5.158 ± 0.038	4.819ArgSer: 4.819 ± 0.035	3.413ArgThr: 3.413 ± 0.023	3.406ArgVal: 3.406 ± 0.024	0.989ArgTrp: 0.989 ± 0.013	1.678ArgTyr: 1.678 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.68SerAla: 6.68 ± 0.032	1.01SerCys: 1.01 ± 0.013	3.964SerAsp: 3.964 ± 0.029	4.005SerGlu: 4.005 ± 0.026	3.067SerPhe: 3.067 ± 0.024	5.552SerGly: 5.552 ± 0.035	2.026SerHis: 2.026 ± 0.019	4.055SerIle: 4.055 ± 0.025	3.787SerLys: 3.787 ± 0.025	7.167SerLeu: 7.167 ± 0.039	1.749SerMet: 1.749 ± 0.019	3.026SerAsn: 3.026 ± 0.019	5.771SerPro: 5.771 ± 0.048	3.142SerGln: 3.142 ± 0.026	4.999SerArg: 4.999 ± 0.034	8.702SerSer: 8.702 ± 0.065	5.814SerThr: 5.814 ± 0.038	4.55SerVal: 4.55 ± 0.028	1.207SerTrp: 1.207 ± 0.015	2.102SerTyr: 2.102 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.145ThrAla: 5.145 ± 0.031	0.874ThrCys: 0.874 ± 0.014	2.691ThrAsp: 2.691 ± 0.023	2.946ThrGlu: 2.946 ± 0.025	2.379ThrPhe: 2.379 ± 0.022	4.126ThrGly: 4.126 ± 0.03	1.397ThrHis: 1.397 ± 0.016	3.181ThrIle: 3.181 ± 0.025	2.679ThrLys: 2.679 ± 0.02	5.478ThrLeu: 5.478 ± 0.034	1.234ThrMet: 1.234 ± 0.014	2.204ThrAsn: 2.204 ± 0.018	4.555ThrPro: 4.555 ± 0.037	2.131ThrGln: 2.131 ± 0.018	3.209ThrArg: 3.209 ± 0.023	5.408ThrSer: 5.408 ± 0.035	4.294ThrThr: 4.294 ± 0.034	3.687ThrVal: 3.687 ± 0.027	0.915ThrTrp: 0.915 ± 0.011	1.661ThrTyr: 1.661 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.09ValAla: 5.09 ± 0.029	0.909ValCys: 0.909 ± 0.012	3.555ValAsp: 3.555 ± 0.027	3.876ValGlu: 3.876 ± 0.028	2.478ValPhe: 2.478 ± 0.021	4.164ValGly: 4.164 ± 0.026	1.409ValHis: 1.409 ± 0.016	2.828ValIle: 2.828 ± 0.021	2.914ValLys: 2.914 ± 0.023	5.555ValLeu: 5.555 ± 0.032	1.327ValMet: 1.327 ± 0.015	2.145ValAsn: 2.145 ± 0.019	3.578ValPro: 3.578 ± 0.024	2.338ValGln: 2.338 ± 0.017	3.448ValArg: 3.448 ± 0.027	4.528ValSer: 4.528 ± 0.028	3.329ValThr: 3.329 ± 0.024	4.231ValVal: 4.231 ± 0.028	0.963ValTrp: 0.963 ± 0.012	1.728ValTyr: 1.728 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.155TrpAla: 1.155 ± 0.013	0.234TrpCys: 0.234 ± 0.007	0.927TrpAsp: 0.927 ± 0.013	0.894TrpGlu: 0.894 ± 0.012	0.582TrpPhe: 0.582 ± 0.011	1.069TrpGly: 1.069 ± 0.016	0.384TrpHis: 0.384 ± 0.008	0.852TrpIle: 0.852 ± 0.012	0.891TrpLys: 0.891 ± 0.012	1.391TrpLeu: 1.391 ± 0.017	0.406TrpMet: 0.406 ± 0.008	0.695TrpAsn: 0.695 ± 0.011	0.661TrpPro: 0.661 ± 0.011	0.558TrpGln: 0.558 ± 0.009	1.053TrpArg: 1.053 ± 0.013	1.135TrpSer: 1.135 ± 0.014	0.998TrpThr: 0.998 ± 0.014	0.966TrpVal: 0.966 ± 0.012	0.301TrpTrp: 0.301 ± 0.008	0.472TrpTyr: 0.472 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.14TyrAla: 2.14 ± 0.019	0.468TyrCys: 0.468 ± 0.008	1.571TyrAsp: 1.571 ± 0.016	1.554TyrGlu: 1.554 ± 0.018	1.206TyrPhe: 1.206 ± 0.014	2.106TyrGly: 2.106 ± 0.02	0.758TyrHis: 0.758 ± 0.01	1.415TyrIle: 1.415 ± 0.015	1.127TyrLys: 1.127 ± 0.014	2.654TyrLeu: 2.654 ± 0.025	0.632TyrMet: 0.632 ± 0.01	1.108TyrAsn: 1.108 ± 0.013	1.59TyrPro: 1.59 ± 0.018	1.097TyrGln: 1.097 ± 0.016	1.617TyrArg: 1.617 ± 0.017	2.115TyrSer: 2.115 ± 0.022	1.698TyrThr: 1.698 ± 0.017	1.626TyrVal: 1.626 ± 0.018	0.473TyrTrp: 0.473 ± 0.011	0.972TyrTyr: 0.972 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 15806 proteins (6750781 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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