Amino acid dipepetide frequency for Rhizobium phage RHEph10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.103AlaAla: 13.103 ± 0.759
0.796AlaCys: 0.796 ± 0.162
7.589AlaAsp: 7.589 ± 0.471
7.22AlaGlu: 7.22 ± 0.457
3.354AlaPhe: 3.354 ± 0.315
8.186AlaGly: 8.186 ± 0.499
2.274AlaHis: 2.274 ± 0.284
6.31AlaIle: 6.31 ± 0.434
5.543AlaLys: 5.543 ± 0.586
9.039AlaLeu: 9.039 ± 0.519
3.297AlaMet: 3.297 ± 0.282
3.61AlaAsn: 3.61 ± 0.35
4.15AlaPro: 4.15 ± 0.35
4.093AlaGln: 4.093 ± 0.45
6.054AlaArg: 6.054 ± 0.412
4.86AlaSer: 4.86 ± 0.392
5.457AlaThr: 5.457 ± 0.43
6.168AlaVal: 6.168 ± 0.379
1.563AlaTrp: 1.563 ± 0.223
2.757AlaTyr: 2.757 ± 0.259
0.0AlaXaa: 0.0 ± 0.0
Cys
1.08CysAla: 1.08 ± 0.166
0.142CysCys: 0.142 ± 0.069
0.682CysAsp: 0.682 ± 0.12
0.625CysGlu: 0.625 ± 0.113
0.256CysPhe: 0.256 ± 0.095
0.739CysGly: 0.739 ± 0.125
0.171CysHis: 0.171 ± 0.084
0.256CysIle: 0.256 ± 0.096
0.398CysLys: 0.398 ± 0.132
0.739CysLeu: 0.739 ± 0.17
0.114CysMet: 0.114 ± 0.056
0.426CysAsn: 0.426 ± 0.106
0.455CysPro: 0.455 ± 0.129
0.256CysGln: 0.256 ± 0.091
0.881CysArg: 0.881 ± 0.192
0.739CysSer: 0.739 ± 0.153
0.313CysThr: 0.313 ± 0.09
0.654CysVal: 0.654 ± 0.152
0.227CysTrp: 0.227 ± 0.084
0.085CysTyr: 0.085 ± 0.056
0.0CysXaa: 0.0 ± 0.0
Asp
6.736AspAla: 6.736 ± 0.46
0.767AspCys: 0.767 ± 0.149
4.576AspAsp: 4.576 ± 0.801
4.804AspGlu: 4.804 ± 0.493
2.871AspPhe: 2.871 ± 0.268
5.429AspGly: 5.429 ± 0.482
1.307AspHis: 1.307 ± 0.211
3.127AspIle: 3.127 ± 0.295
3.07AspLys: 3.07 ± 0.348
6.907AspLeu: 6.907 ± 0.47
1.506AspMet: 1.506 ± 0.199
2.047AspAsn: 2.047 ± 0.312
3.326AspPro: 3.326 ± 0.357
2.501AspGln: 2.501 ± 0.299
3.951AspArg: 3.951 ± 0.348
2.331AspSer: 2.331 ± 0.277
3.297AspThr: 3.297 ± 0.312
3.866AspVal: 3.866 ± 0.321
1.109AspTrp: 1.109 ± 0.174
1.848AspTyr: 1.848 ± 0.255
0.0AspXaa: 0.0 ± 0.0
Glu
6.765GluAla: 6.765 ± 0.505
0.654GluCys: 0.654 ± 0.142
4.804GluAsp: 4.804 ± 0.477
4.718GluGlu: 4.718 ± 0.456
2.16GluPhe: 2.16 ± 0.253
3.695GluGly: 3.695 ± 0.358
1.535GluHis: 1.535 ± 0.232
4.548GluIle: 4.548 ± 0.384
4.15GluLys: 4.15 ± 0.378
6.481GluLeu: 6.481 ± 0.464
1.791GluMet: 1.791 ± 0.231
2.7GluAsn: 2.7 ± 0.29
2.587GluPro: 2.587 ± 0.292
3.354GluGln: 3.354 ± 0.352
4.917GluArg: 4.917 ± 0.511
2.757GluSer: 2.757 ± 0.277
3.866GluThr: 3.866 ± 0.322
3.866GluVal: 3.866 ± 0.357
1.165GluTrp: 1.165 ± 0.176
1.819GluTyr: 1.819 ± 0.213
0.0GluXaa: 0.0 ± 0.0
Phe
3.269PheAla: 3.269 ± 0.31
0.37PheCys: 0.37 ± 0.099
2.643PheAsp: 2.643 ± 0.255
2.16PheGlu: 2.16 ± 0.258
0.881PhePhe: 0.881 ± 0.148
3.78PheGly: 3.78 ± 0.387
1.08PheHis: 1.08 ± 0.165
1.762PheIle: 1.762 ± 0.215
1.961PheLys: 1.961 ± 0.223
2.814PheLeu: 2.814 ± 0.256
1.052PheMet: 1.052 ± 0.199
1.563PheAsn: 1.563 ± 0.189
1.649PhePro: 1.649 ± 0.24
1.222PheGln: 1.222 ± 0.166
1.876PheArg: 1.876 ± 0.274
2.189PheSer: 2.189 ± 0.251
2.302PheThr: 2.302 ± 0.279
2.331PheVal: 2.331 ± 0.267
0.597PheTrp: 0.597 ± 0.139
1.194PheTyr: 1.194 ± 0.192
0.0PheXaa: 0.0 ± 0.0
Gly
6.509GlyAla: 6.509 ± 0.484
0.711GlyCys: 0.711 ± 0.135
4.718GlyAsp: 4.718 ± 0.428
5.145GlyGlu: 5.145 ± 0.512
3.07GlyPhe: 3.07 ± 0.333
4.633GlyGly: 4.633 ± 0.605
1.194GlyHis: 1.194 ± 0.187
3.468GlyIle: 3.468 ± 0.31
4.519GlyLys: 4.519 ± 0.365
5.486GlyLeu: 5.486 ± 0.487
2.018GlyMet: 2.018 ± 0.237
2.984GlyAsn: 2.984 ± 0.317
2.473GlyPro: 2.473 ± 0.247
2.615GlyGln: 2.615 ± 0.273
4.178GlyArg: 4.178 ± 0.379
4.491GlySer: 4.491 ± 0.397
3.894GlyThr: 3.894 ± 0.316
5.599GlyVal: 5.599 ± 0.426
1.08GlyTrp: 1.08 ± 0.177
2.7GlyTyr: 2.7 ± 0.223
0.0GlyXaa: 0.0 ± 0.0
His
2.245HisAla: 2.245 ± 0.3
0.114HisCys: 0.114 ± 0.058
1.251HisAsp: 1.251 ± 0.246
1.45HisGlu: 1.45 ± 0.202
1.251HisPhe: 1.251 ± 0.197
1.393HisGly: 1.393 ± 0.224
0.512HisHis: 0.512 ± 0.142
1.279HisIle: 1.279 ± 0.186
1.165HisLys: 1.165 ± 0.237
1.734HisLeu: 1.734 ± 0.238
0.398HisMet: 0.398 ± 0.117
0.881HisAsn: 0.881 ± 0.143
1.62HisPro: 1.62 ± 0.214
0.767HisGln: 0.767 ± 0.163
1.506HisArg: 1.506 ± 0.233
1.165HisSer: 1.165 ± 0.184
1.052HisThr: 1.052 ± 0.18
1.023HisVal: 1.023 ± 0.18
0.199HisTrp: 0.199 ± 0.067
0.654HisTyr: 0.654 ± 0.125
0.0HisXaa: 0.0 ± 0.0
Ile
5.827IleAla: 5.827 ± 0.464
0.767IleCys: 0.767 ± 0.182
4.576IleAsp: 4.576 ± 0.334
4.605IleGlu: 4.605 ± 0.341
1.506IlePhe: 1.506 ± 0.189
3.752IleGly: 3.752 ± 0.313
1.251IleHis: 1.251 ± 0.233
2.842IleIle: 2.842 ± 0.227
3.07IleLys: 3.07 ± 0.324
4.008IleLeu: 4.008 ± 0.329
1.279IleMet: 1.279 ± 0.184
2.501IleAsn: 2.501 ± 0.271
2.359IlePro: 2.359 ± 0.284
1.762IleGln: 1.762 ± 0.242
3.439IleArg: 3.439 ± 0.279
2.928IleSer: 2.928 ± 0.335
3.496IleThr: 3.496 ± 0.341
3.922IleVal: 3.922 ± 0.264
0.597IleTrp: 0.597 ± 0.127
1.62IleTyr: 1.62 ± 0.208
0.0IleXaa: 0.0 ± 0.0
Lys
6.879LysAla: 6.879 ± 0.633
0.313LysCys: 0.313 ± 0.09
2.786LysAsp: 2.786 ± 0.366
3.894LysGlu: 3.894 ± 0.313
1.933LysPhe: 1.933 ± 0.184
3.837LysGly: 3.837 ± 0.42
1.45LysHis: 1.45 ± 0.204
3.183LysIle: 3.183 ± 0.282
3.155LysLys: 3.155 ± 0.356
5.116LysLeu: 5.116 ± 0.484
1.62LysMet: 1.62 ± 0.205
1.848LysAsn: 1.848 ± 0.198
2.132LysPro: 2.132 ± 0.263
1.762LysGln: 1.762 ± 0.214
3.581LysArg: 3.581 ± 0.347
2.501LysSer: 2.501 ± 0.274
3.269LysThr: 3.269 ± 0.302
3.24LysVal: 3.24 ± 0.319
0.682LysTrp: 0.682 ± 0.158
0.881LysTyr: 0.881 ± 0.159
0.0LysXaa: 0.0 ± 0.0
Leu
8.385LeuAla: 8.385 ± 0.483
0.767LeuCys: 0.767 ± 0.178
5.77LeuAsp: 5.77 ± 0.519
5.599LeuGlu: 5.599 ± 0.389
2.444LeuPhe: 2.444 ± 0.287
5.543LeuGly: 5.543 ± 0.447
1.791LeuHis: 1.791 ± 0.265
4.463LeuIle: 4.463 ± 0.367
5.145LeuLys: 5.145 ± 0.429
5.912LeuLeu: 5.912 ± 0.5
1.762LeuMet: 1.762 ± 0.212
2.786LeuAsn: 2.786 ± 0.26
4.548LeuPro: 4.548 ± 0.402
2.842LeuGln: 2.842 ± 0.389
5.543LeuArg: 5.543 ± 0.396
4.86LeuSer: 4.86 ± 0.352
5.088LeuThr: 5.088 ± 0.38
5.997LeuVal: 5.997 ± 0.47
1.023LeuTrp: 1.023 ± 0.15
1.933LeuTyr: 1.933 ± 0.206
0.0LeuXaa: 0.0 ± 0.0
Met
2.53MetAla: 2.53 ± 0.302
0.114MetCys: 0.114 ± 0.059
1.194MetAsp: 1.194 ± 0.17
1.364MetGlu: 1.364 ± 0.196
0.739MetPhe: 0.739 ± 0.123
1.563MetGly: 1.563 ± 0.208
0.455MetHis: 0.455 ± 0.114
1.535MetIle: 1.535 ± 0.21
1.734MetLys: 1.734 ± 0.204
1.563MetLeu: 1.563 ± 0.218
0.739MetMet: 0.739 ± 0.161
1.279MetAsn: 1.279 ± 0.182
1.705MetPro: 1.705 ± 0.211
0.966MetGln: 0.966 ± 0.155
2.217MetArg: 2.217 ± 0.223
2.217MetSer: 2.217 ± 0.293
2.331MetThr: 2.331 ± 0.228
1.336MetVal: 1.336 ± 0.206
0.284MetTrp: 0.284 ± 0.079
0.199MetTyr: 0.199 ± 0.085
0.0MetXaa: 0.0 ± 0.0
Asn
4.235AsnAla: 4.235 ± 0.409
0.256AsnCys: 0.256 ± 0.081
2.473AsnAsp: 2.473 ± 0.206
2.643AsnGlu: 2.643 ± 0.242
1.592AsnPhe: 1.592 ± 0.188
2.871AsnGly: 2.871 ± 0.263
0.711AsnHis: 0.711 ± 0.145
2.245AsnIle: 2.245 ± 0.26
1.762AsnLys: 1.762 ± 0.261
2.814AsnLeu: 2.814 ± 0.266
1.165AsnMet: 1.165 ± 0.182
1.62AsnAsn: 1.62 ± 0.226
2.331AsnPro: 2.331 ± 0.285
1.307AsnGln: 1.307 ± 0.173
2.075AsnArg: 2.075 ± 0.244
1.848AsnSer: 1.848 ± 0.267
1.791AsnThr: 1.791 ± 0.209
2.53AsnVal: 2.53 ± 0.233
0.37AsnTrp: 0.37 ± 0.083
0.796AsnTyr: 0.796 ± 0.138
0.0AsnXaa: 0.0 ± 0.0
Pro
5.372ProAla: 5.372 ± 0.459
0.341ProCys: 0.341 ± 0.106
2.928ProAsp: 2.928 ± 0.28
3.013ProGlu: 3.013 ± 0.319
1.848ProPhe: 1.848 ± 0.216
3.297ProGly: 3.297 ± 0.337
0.853ProHis: 0.853 ± 0.143
2.473ProIle: 2.473 ± 0.237
2.444ProLys: 2.444 ± 0.344
2.984ProLeu: 2.984 ± 0.362
0.853ProMet: 0.853 ± 0.159
1.876ProAsn: 1.876 ± 0.236
1.421ProPro: 1.421 ± 0.235
1.251ProGln: 1.251 ± 0.185
2.501ProArg: 2.501 ± 0.315
2.757ProSer: 2.757 ± 0.274
2.757ProThr: 2.757 ± 0.341
3.837ProVal: 3.837 ± 0.404
0.625ProTrp: 0.625 ± 0.139
1.364ProTyr: 1.364 ± 0.21
0.0ProXaa: 0.0 ± 0.0
Gln
4.377GlnAla: 4.377 ± 0.404
0.227GlnCys: 0.227 ± 0.073
1.45GlnAsp: 1.45 ± 0.219
2.615GlnGlu: 2.615 ± 0.272
1.393GlnPhe: 1.393 ± 0.226
2.473GlnGly: 2.473 ± 0.315
0.91GlnHis: 0.91 ± 0.179
2.587GlnIle: 2.587 ± 0.327
1.961GlnLys: 1.961 ± 0.238
2.786GlnLeu: 2.786 ± 0.314
1.364GlnMet: 1.364 ± 0.198
1.279GlnAsn: 1.279 ± 0.206
2.075GlnPro: 2.075 ± 0.283
1.478GlnGln: 1.478 ± 0.279
2.7GlnArg: 2.7 ± 0.349
1.592GlnSer: 1.592 ± 0.188
2.302GlnThr: 2.302 ± 0.251
2.814GlnVal: 2.814 ± 0.274
0.455GlnTrp: 0.455 ± 0.158
0.654GlnTyr: 0.654 ± 0.145
0.0GlnXaa: 0.0 ± 0.0
Arg
6.054ArgAla: 6.054 ± 0.435
0.739ArgCys: 0.739 ± 0.162
3.439ArgAsp: 3.439 ± 0.321
3.979ArgGlu: 3.979 ± 0.382
3.24ArgPhe: 3.24 ± 0.378
4.377ArgGly: 4.377 ± 0.348
1.677ArgHis: 1.677 ± 0.24
3.269ArgIle: 3.269 ± 0.307
3.098ArgLys: 3.098 ± 0.339
5.571ArgLeu: 5.571 ± 0.457
1.933ArgMet: 1.933 ± 0.272
2.018ArgAsn: 2.018 ± 0.234
2.899ArgPro: 2.899 ± 0.301
2.814ArgGln: 2.814 ± 0.379
4.349ArgArg: 4.349 ± 0.536
4.178ArgSer: 4.178 ± 0.378
2.928ArgThr: 2.928 ± 0.248
4.349ArgVal: 4.349 ± 0.371
0.796ArgTrp: 0.796 ± 0.155
2.274ArgTyr: 2.274 ± 0.275
0.0ArgXaa: 0.0 ± 0.0
Ser
4.463SerAla: 4.463 ± 0.414
0.568SerCys: 0.568 ± 0.162
3.183SerAsp: 3.183 ± 0.403
2.871SerGlu: 2.871 ± 0.274
2.16SerPhe: 2.16 ± 0.23
4.804SerGly: 4.804 ± 0.454
1.251SerHis: 1.251 ± 0.187
2.672SerIle: 2.672 ± 0.277
2.672SerLys: 2.672 ± 0.23
4.15SerLeu: 4.15 ± 0.376
1.307SerMet: 1.307 ± 0.198
2.217SerAsn: 2.217 ± 0.317
2.274SerPro: 2.274 ± 0.262
2.16SerGln: 2.16 ± 0.231
3.581SerArg: 3.581 ± 0.314
3.07SerSer: 3.07 ± 0.33
2.928SerThr: 2.928 ± 0.293
4.519SerVal: 4.519 ± 0.396
0.796SerTrp: 0.796 ± 0.16
1.819SerTyr: 1.819 ± 0.253
0.0SerXaa: 0.0 ± 0.0
Thr
6.651ThrAla: 6.651 ± 0.623
0.483ThrCys: 0.483 ± 0.137
3.695ThrAsp: 3.695 ± 0.291
3.78ThrGlu: 3.78 ± 0.332
2.132ThrPhe: 2.132 ± 0.271
4.576ThrGly: 4.576 ± 0.409
1.023ThrHis: 1.023 ± 0.176
4.008ThrIle: 4.008 ± 0.338
2.956ThrLys: 2.956 ± 0.349
4.86ThrLeu: 4.86 ± 0.464
1.165ThrMet: 1.165 ± 0.183
1.791ThrAsn: 1.791 ± 0.24
3.013ThrPro: 3.013 ± 0.313
1.904ThrGln: 1.904 ± 0.252
2.956ThrArg: 2.956 ± 0.313
3.468ThrSer: 3.468 ± 0.38
3.525ThrThr: 3.525 ± 0.392
3.922ThrVal: 3.922 ± 0.357
0.739ThrTrp: 0.739 ± 0.149
1.535ThrTyr: 1.535 ± 0.275
0.0ThrXaa: 0.0 ± 0.0
Val
7.419ValAla: 7.419 ± 0.46
0.625ValCys: 0.625 ± 0.13
4.377ValAsp: 4.377 ± 0.342
4.917ValGlu: 4.917 ± 0.425
2.615ValPhe: 2.615 ± 0.252
4.121ValGly: 4.121 ± 0.366
1.364ValHis: 1.364 ± 0.201
4.178ValIle: 4.178 ± 0.322
3.354ValLys: 3.354 ± 0.325
5.344ValLeu: 5.344 ± 0.426
1.762ValMet: 1.762 ± 0.207
2.444ValAsn: 2.444 ± 0.277
2.473ValPro: 2.473 ± 0.268
2.444ValGln: 2.444 ± 0.267
3.638ValArg: 3.638 ± 0.299
3.411ValSer: 3.411 ± 0.419
5.059ValThr: 5.059 ± 0.456
4.633ValVal: 4.633 ± 0.403
0.853ValTrp: 0.853 ± 0.169
2.075ValTyr: 2.075 ± 0.216
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.191
0.142TrpCys: 0.142 ± 0.084
1.023TrpAsp: 1.023 ± 0.191
0.966TrpGlu: 0.966 ± 0.176
0.455TrpPhe: 0.455 ± 0.123
0.597TrpGly: 0.597 ± 0.121
0.256TrpHis: 0.256 ± 0.086
0.824TrpIle: 0.824 ± 0.174
0.767TrpLys: 0.767 ± 0.153
0.938TrpLeu: 0.938 ± 0.191
0.284TrpMet: 0.284 ± 0.092
0.512TrpAsn: 0.512 ± 0.123
0.341TrpPro: 0.341 ± 0.11
0.739TrpGln: 0.739 ± 0.143
1.45TrpArg: 1.45 ± 0.205
0.881TrpSer: 0.881 ± 0.169
0.938TrpThr: 0.938 ± 0.132
0.881TrpVal: 0.881 ± 0.144
0.142TrpTrp: 0.142 ± 0.061
0.284TrpTyr: 0.284 ± 0.097
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.388TyrAla: 2.388 ± 0.261
0.341TyrCys: 0.341 ± 0.094
2.217TyrAsp: 2.217 ± 0.329
1.961TyrGlu: 1.961 ± 0.283
0.796TyrPhe: 0.796 ± 0.167
1.819TyrGly: 1.819 ± 0.209
0.597TyrHis: 0.597 ± 0.124
1.08TyrIle: 1.08 ± 0.183
1.137TyrLys: 1.137 ± 0.169
2.956TyrLeu: 2.956 ± 0.276
0.625TyrMet: 0.625 ± 0.126
1.052TyrAsn: 1.052 ± 0.152
0.966TyrPro: 0.966 ± 0.178
1.251TyrGln: 1.251 ± 0.183
2.615TyrArg: 2.615 ± 0.251
1.222TyrSer: 1.222 ± 0.211
1.592TyrThr: 1.592 ± 0.242
1.62TyrVal: 1.62 ± 0.217
0.256TyrTrp: 0.256 ± 0.075
0.853TyrTyr: 0.853 ± 0.162
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 171 proteins (35183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski