Amino acid dipepetide frequency for Tessaracoccus aquimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.665AlaAla: 17.665 ± 0.177
0.965AlaCys: 0.965 ± 0.033
8.111AlaAsp: 8.111 ± 0.102
7.844AlaGlu: 7.844 ± 0.106
3.71AlaPhe: 3.71 ± 0.063
10.905AlaGly: 10.905 ± 0.113
2.161AlaHis: 2.161 ± 0.05
5.597AlaIle: 5.597 ± 0.07
3.432AlaLys: 3.432 ± 0.073
13.235AlaLeu: 13.235 ± 0.142
3.061AlaMet: 3.061 ± 0.056
2.562AlaAsn: 2.562 ± 0.054
5.914AlaPro: 5.914 ± 0.092
3.695AlaGln: 3.695 ± 0.059
8.234AlaArg: 8.234 ± 0.121
7.145AlaSer: 7.145 ± 0.09
7.573AlaThr: 7.573 ± 0.093
10.646AlaVal: 10.646 ± 0.124
2.03AlaTrp: 2.03 ± 0.046
2.31AlaTyr: 2.31 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.808CysAla: 0.808 ± 0.028
0.082CysCys: 0.082 ± 0.009
0.392CysAsp: 0.392 ± 0.021
0.34CysGlu: 0.34 ± 0.019
0.218CysPhe: 0.218 ± 0.015
0.746CysGly: 0.746 ± 0.03
0.159CysHis: 0.159 ± 0.013
0.233CysIle: 0.233 ± 0.013
0.09CysLys: 0.09 ± 0.01
0.604CysLeu: 0.604 ± 0.023
0.112CysMet: 0.112 ± 0.011
0.126CysAsn: 0.126 ± 0.013
0.392CysPro: 0.392 ± 0.021
0.17CysGln: 0.17 ± 0.012
0.429CysArg: 0.429 ± 0.02
0.437CysSer: 0.437 ± 0.022
0.414CysThr: 0.414 ± 0.025
0.551CysVal: 0.551 ± 0.023
0.109CysTrp: 0.109 ± 0.01
0.163CysTyr: 0.163 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
8.245AspAla: 8.245 ± 0.126
0.335AspCys: 0.335 ± 0.019
4.313AspAsp: 4.313 ± 0.074
4.46AspGlu: 4.46 ± 0.077
1.828AspPhe: 1.828 ± 0.042
6.377AspGly: 6.377 ± 0.108
1.209AspHis: 1.209 ± 0.034
2.241AspIle: 2.241 ± 0.048
1.429AspLys: 1.429 ± 0.042
7.041AspLeu: 7.041 ± 0.095
0.935AspMet: 0.935 ± 0.03
1.101AspAsn: 1.101 ± 0.029
4.422AspPro: 4.422 ± 0.075
1.891AspGln: 1.891 ± 0.044
4.206AspArg: 4.206 ± 0.076
2.756AspSer: 2.756 ± 0.052
2.82AspThr: 2.82 ± 0.051
5.313AspVal: 5.313 ± 0.079
1.031AspTrp: 1.031 ± 0.032
1.39AspTyr: 1.39 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.843GluAla: 7.843 ± 0.104
0.335GluCys: 0.335 ± 0.018
2.97GluAsp: 2.97 ± 0.064
3.097GluGlu: 3.097 ± 0.061
1.78GluPhe: 1.78 ± 0.046
4.436GluGly: 4.436 ± 0.067
1.334GluHis: 1.334 ± 0.037
2.546GluIle: 2.546 ± 0.047
1.414GluLys: 1.414 ± 0.044
6.068GluLeu: 6.068 ± 0.083
1.041GluMet: 1.041 ± 0.033
1.076GluAsn: 1.076 ± 0.035
3.161GluPro: 3.161 ± 0.064
2.147GluGln: 2.147 ± 0.049
4.86GluArg: 4.86 ± 0.074
2.835GluSer: 2.835 ± 0.053
2.9GluThr: 2.9 ± 0.056
5.041GluVal: 5.041 ± 0.08
0.768GluTrp: 0.768 ± 0.03
1.057GluTyr: 1.057 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.932PheAla: 3.932 ± 0.059
0.234PheCys: 0.234 ± 0.015
2.478PheAsp: 2.478 ± 0.052
1.712PheGlu: 1.712 ± 0.037
1.034PhePhe: 1.034 ± 0.035
3.332PheGly: 3.332 ± 0.059
0.573PheHis: 0.573 ± 0.027
1.196PheIle: 1.196 ± 0.036
0.61PheLys: 0.61 ± 0.026
2.877PheLeu: 2.877 ± 0.061
0.564PheMet: 0.564 ± 0.026
0.767PheAsn: 0.767 ± 0.031
1.431PhePro: 1.431 ± 0.034
0.83PheGln: 0.83 ± 0.026
1.711PheArg: 1.711 ± 0.04
1.785PheSer: 1.785 ± 0.044
2.108PheThr: 2.108 ± 0.048
2.764PheVal: 2.764 ± 0.055
0.49PheTrp: 0.49 ± 0.02
0.635PheTyr: 0.635 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.914GlyAla: 9.914 ± 0.101
0.7GlyCys: 0.7 ± 0.026
5.343GlyAsp: 5.343 ± 0.073
4.937GlyGlu: 4.937 ± 0.074
3.163GlyPhe: 3.163 ± 0.055
7.471GlyGly: 7.471 ± 0.129
1.832GlyHis: 1.832 ± 0.044
4.422GlyIle: 4.422 ± 0.075
2.504GlyLys: 2.504 ± 0.064
9.256GlyLeu: 9.256 ± 0.109
2.141GlyMet: 2.141 ± 0.045
1.88GlyAsn: 1.88 ± 0.044
3.9GlyPro: 3.9 ± 0.076
2.842GlyGln: 2.842 ± 0.057
6.238GlyArg: 6.238 ± 0.095
5.33GlySer: 5.33 ± 0.074
5.407GlyThr: 5.407 ± 0.087
7.854GlyVal: 7.854 ± 0.096
1.84GlyTrp: 1.84 ± 0.046
2.437GlyTyr: 2.437 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.09HisAla: 2.09 ± 0.048
0.123HisCys: 0.123 ± 0.011
1.265HisAsp: 1.265 ± 0.038
1.115HisGlu: 1.115 ± 0.032
0.556HisPhe: 0.556 ± 0.025
1.85HisGly: 1.85 ± 0.039
0.517HisHis: 0.517 ± 0.024
0.71HisIle: 0.71 ± 0.024
0.354HisLys: 0.354 ± 0.019
2.218HisLeu: 2.218 ± 0.055
0.312HisMet: 0.312 ± 0.019
0.39HisAsn: 0.39 ± 0.017
1.378HisPro: 1.378 ± 0.038
0.568HisGln: 0.568 ± 0.023
1.491HisArg: 1.491 ± 0.041
0.901HisSer: 0.901 ± 0.029
1.01HisThr: 1.01 ± 0.03
1.527HisVal: 1.527 ± 0.039
0.297HisTrp: 0.297 ± 0.017
0.435HisTyr: 0.435 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.362IleAla: 6.362 ± 0.071
0.343IleCys: 0.343 ± 0.018
3.359IleAsp: 3.359 ± 0.055
2.686IleGlu: 2.686 ± 0.054
1.269IlePhe: 1.269 ± 0.039
4.474IleGly: 4.474 ± 0.074
0.694IleHis: 0.694 ± 0.024
1.723IleIle: 1.723 ± 0.055
0.959IleLys: 0.959 ± 0.033
3.541IleLeu: 3.541 ± 0.072
0.676IleMet: 0.676 ± 0.027
1.096IleAsn: 1.096 ± 0.033
2.238IlePro: 2.238 ± 0.045
1.016IleGln: 1.016 ± 0.034
2.382IleArg: 2.382 ± 0.049
2.428IleSer: 2.428 ± 0.049
2.818IleThr: 2.818 ± 0.063
4.385IleVal: 4.385 ± 0.076
0.562IleTrp: 0.562 ± 0.025
0.869IleTyr: 0.869 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.144LysAla: 3.144 ± 0.073
0.109LysCys: 0.109 ± 0.011
1.39LysAsp: 1.39 ± 0.042
1.26LysGlu: 1.26 ± 0.047
0.654LysPhe: 0.654 ± 0.028
2.048LysGly: 2.048 ± 0.048
0.467LysHis: 0.467 ± 0.02
1.052LysIle: 1.052 ± 0.04
0.912LysLys: 0.912 ± 0.041
2.315LysLeu: 2.315 ± 0.058
0.505LysMet: 0.505 ± 0.02
0.553LysAsn: 0.553 ± 0.024
1.412LysPro: 1.412 ± 0.049
0.797LysGln: 0.797 ± 0.029
1.608LysArg: 1.608 ± 0.042
1.305LysSer: 1.305 ± 0.037
1.429LysThr: 1.429 ± 0.042
2.362LysVal: 2.362 ± 0.058
0.333LysTrp: 0.333 ± 0.015
0.508LysTyr: 0.508 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.078LeuAla: 14.078 ± 0.15
0.592LeuCys: 0.592 ± 0.024
6.775LeuAsp: 6.775 ± 0.097
5.097LeuGlu: 5.097 ± 0.075
2.813LeuPhe: 2.813 ± 0.06
9.576LeuGly: 9.576 ± 0.126
1.802LeuHis: 1.802 ± 0.049
4.87LeuIle: 4.87 ± 0.086
2.161LeuLys: 2.161 ± 0.053
10.666LeuLeu: 10.666 ± 0.138
1.945LeuMet: 1.945 ± 0.045
2.206LeuAsn: 2.206 ± 0.053
5.723LeuPro: 5.723 ± 0.082
2.544LeuGln: 2.544 ± 0.05
7.384LeuArg: 7.384 ± 0.095
5.852LeuSer: 5.852 ± 0.081
6.697LeuThr: 6.697 ± 0.086
8.899LeuVal: 8.899 ± 0.109
1.339LeuTrp: 1.339 ± 0.04
1.583LeuTyr: 1.583 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.491MetAla: 2.491 ± 0.053
0.136MetCys: 0.136 ± 0.012
0.96MetAsp: 0.96 ± 0.032
0.783MetGlu: 0.783 ± 0.025
0.637MetPhe: 0.637 ± 0.027
1.707MetGly: 1.707 ± 0.044
0.354MetHis: 0.354 ± 0.018
0.947MetIle: 0.947 ± 0.033
0.513MetLys: 0.513 ± 0.023
2.071MetLeu: 2.071 ± 0.05
0.412MetMet: 0.412 ± 0.022
0.551MetAsn: 0.551 ± 0.023
1.134MetPro: 1.134 ± 0.037
0.587MetGln: 0.587 ± 0.023
1.531MetArg: 1.531 ± 0.038
1.604MetSer: 1.604 ± 0.039
1.674MetThr: 1.674 ± 0.039
1.639MetVal: 1.639 ± 0.039
0.279MetTrp: 0.279 ± 0.016
0.333MetTyr: 0.333 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.484AsnAla: 2.484 ± 0.047
0.155AsnCys: 0.155 ± 0.011
1.297AsnAsp: 1.297 ± 0.038
1.134AsnGlu: 1.134 ± 0.04
0.702AsnPhe: 0.702 ± 0.026
1.944AsnGly: 1.944 ± 0.049
0.451AsnHis: 0.451 ± 0.022
0.89AsnIle: 0.89 ± 0.031
0.513AsnLys: 0.513 ± 0.024
2.208AsnLeu: 2.208 ± 0.048
0.436AsnMet: 0.436 ± 0.024
0.552AsnAsn: 0.552 ± 0.028
1.621AsnPro: 1.621 ± 0.042
0.776AsnGln: 0.776 ± 0.031
1.368AsnArg: 1.368 ± 0.038
1.122AsnSer: 1.122 ± 0.036
1.204AsnThr: 1.204 ± 0.04
1.71AsnVal: 1.71 ± 0.044
0.395AsnTrp: 0.395 ± 0.02
0.597AsnTyr: 0.597 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
6.43ProAla: 6.43 ± 0.087
0.238ProCys: 0.238 ± 0.015
3.978ProAsp: 3.978 ± 0.072
3.99ProGlu: 3.99 ± 0.063
1.585ProPhe: 1.585 ± 0.04
5.266ProGly: 5.266 ± 0.085
1.053ProHis: 1.053 ± 0.027
2.141ProIle: 2.141 ± 0.047
1.349ProLys: 1.349 ± 0.04
4.618ProLeu: 4.618 ± 0.075
1.099ProMet: 1.099 ± 0.034
1.239ProAsn: 1.239 ± 0.038
2.391ProPro: 2.391 ± 0.068
1.629ProGln: 1.629 ± 0.045
3.262ProArg: 3.262 ± 0.057
3.454ProSer: 3.454 ± 0.062
3.916ProThr: 3.916 ± 0.071
4.715ProVal: 4.715 ± 0.068
0.913ProTrp: 0.913 ± 0.031
1.076ProTyr: 1.076 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.849GlnAla: 3.849 ± 0.074
0.143GlnCys: 0.143 ± 0.011
1.33GlnAsp: 1.33 ± 0.034
1.449GlnGlu: 1.449 ± 0.042
0.938GlnPhe: 0.938 ± 0.029
2.323GlnGly: 2.323 ± 0.047
0.614GlnHis: 0.614 ± 0.022
1.427GlnIle: 1.427 ± 0.043
0.665GlnLys: 0.665 ± 0.025
3.186GlnLeu: 3.186 ± 0.073
0.606GlnMet: 0.606 ± 0.026
0.605GlnAsn: 0.605 ± 0.026
1.795GlnPro: 1.795 ± 0.053
1.321GlnGln: 1.321 ± 0.05
2.484GlnArg: 2.484 ± 0.053
1.533GlnSer: 1.533 ± 0.04
1.369GlnThr: 1.369 ± 0.032
2.769GlnVal: 2.769 ± 0.057
0.559GlnTrp: 0.559 ± 0.024
0.606GlnTyr: 0.606 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
7.745ArgAla: 7.745 ± 0.094
0.427ArgCys: 0.427 ± 0.023
4.273ArgAsp: 4.273 ± 0.067
3.981ArgGlu: 3.981 ± 0.073
2.363ArgPhe: 2.363 ± 0.054
5.198ArgGly: 5.198 ± 0.079
1.502ArgHis: 1.502 ± 0.046
3.283ArgIle: 3.283 ± 0.059
1.492ArgLys: 1.492 ± 0.045
7.632ArgLeu: 7.632 ± 0.103
1.611ArgMet: 1.611 ± 0.038
1.415ArgAsn: 1.415 ± 0.04
3.83ArgPro: 3.83 ± 0.079
2.229ArgGln: 2.229 ± 0.055
6.385ArgArg: 6.385 ± 0.115
3.808ArgSer: 3.808 ± 0.061
3.758ArgThr: 3.758 ± 0.066
5.593ArgVal: 5.593 ± 0.076
1.274ArgTrp: 1.274 ± 0.038
1.599ArgTyr: 1.599 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.572SerAla: 6.572 ± 0.091
0.353SerCys: 0.353 ± 0.02
3.259SerAsp: 3.259 ± 0.063
2.957SerGlu: 2.957 ± 0.06
1.906SerPhe: 1.906 ± 0.045
5.461SerGly: 5.461 ± 0.073
1.054SerHis: 1.054 ± 0.033
2.479SerIle: 2.479 ± 0.052
1.441SerLys: 1.441 ± 0.045
5.662SerLeu: 5.662 ± 0.077
1.423SerMet: 1.423 ± 0.034
1.263SerAsn: 1.263 ± 0.034
3.194SerPro: 3.194 ± 0.065
1.533SerGln: 1.533 ± 0.041
3.722SerArg: 3.722 ± 0.065
3.397SerSer: 3.397 ± 0.06
3.501SerThr: 3.501 ± 0.06
4.783SerVal: 4.783 ± 0.081
0.955SerTrp: 0.955 ± 0.032
1.286SerTyr: 1.286 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
7.044ThrAla: 7.044 ± 0.094
0.408ThrCys: 0.408 ± 0.024
3.535ThrAsp: 3.535 ± 0.075
2.883ThrGlu: 2.883 ± 0.052
1.982ThrPhe: 1.982 ± 0.047
5.637ThrGly: 5.637 ± 0.088
1.116ThrHis: 1.116 ± 0.033
2.822ThrIle: 2.822 ± 0.058
1.568ThrLys: 1.568 ± 0.047
6.206ThrLeu: 6.206 ± 0.08
1.237ThrMet: 1.237 ± 0.034
1.336ThrAsn: 1.336 ± 0.044
4.063ThrPro: 4.063 ± 0.072
1.693ThrGln: 1.693 ± 0.04
3.723ThrArg: 3.723 ± 0.064
3.508ThrSer: 3.508 ± 0.06
3.829ThrThr: 3.829 ± 0.072
5.676ThrVal: 5.676 ± 0.099
1.075ThrTrp: 1.075 ± 0.034
1.284ThrTyr: 1.284 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
12.037ValAla: 12.037 ± 0.122
0.578ValCys: 0.578 ± 0.021
6.055ValAsp: 6.055 ± 0.077
5.134ValGlu: 5.134 ± 0.069
2.551ValPhe: 2.551 ± 0.053
7.602ValGly: 7.602 ± 0.111
1.487ValHis: 1.487 ± 0.041
4.02ValIle: 4.02 ± 0.079
1.953ValLys: 1.953 ± 0.051
8.865ValLeu: 8.865 ± 0.115
1.619ValMet: 1.619 ± 0.038
1.908ValAsn: 1.908 ± 0.046
4.375ValPro: 4.375 ± 0.068
1.997ValGln: 1.997 ± 0.045
5.362ValArg: 5.362 ± 0.078
4.89ValSer: 4.89 ± 0.077
6.068ValThr: 6.068 ± 0.097
8.527ValVal: 8.527 ± 0.129
1.217ValTrp: 1.217 ± 0.034
1.436ValTyr: 1.436 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.749TrpAla: 1.749 ± 0.045
0.139TrpCys: 0.139 ± 0.011
0.905TrpAsp: 0.905 ± 0.033
0.734TrpGlu: 0.734 ± 0.025
0.625TrpPhe: 0.625 ± 0.026
1.212TrpGly: 1.212 ± 0.037
0.348TrpHis: 0.348 ± 0.021
0.655TrpIle: 0.655 ± 0.026
0.372TrpLys: 0.372 ± 0.018
1.944TrpLeu: 1.944 ± 0.049
0.34TrpMet: 0.34 ± 0.015
0.447TrpAsn: 0.447 ± 0.023
0.847TrpPro: 0.847 ± 0.029
0.622TrpGln: 0.622 ± 0.024
1.334TrpArg: 1.334 ± 0.041
0.979TrpSer: 0.979 ± 0.035
0.976TrpThr: 0.976 ± 0.034
1.275TrpVal: 1.275 ± 0.035
0.388TrpTrp: 0.388 ± 0.02
0.313TrpTyr: 0.313 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.312TyrAla: 2.312 ± 0.047
0.179TyrCys: 0.179 ± 0.014
1.354TyrAsp: 1.354 ± 0.039
1.12TyrGlu: 1.12 ± 0.035
0.748TyrPhe: 0.748 ± 0.026
1.844TyrGly: 1.844 ± 0.043
0.38TyrHis: 0.38 ± 0.018
0.627TyrIle: 0.627 ± 0.029
0.43TyrLys: 0.43 ± 0.022
2.388TyrLeu: 2.388 ± 0.05
0.267TyrMet: 0.267 ± 0.016
0.489TyrAsn: 0.489 ± 0.026
1.12TyrPro: 1.12 ± 0.04
0.684TyrGln: 0.684 ± 0.028
1.685TyrArg: 1.685 ± 0.045
1.133TyrSer: 1.133 ± 0.033
1.152TyrThr: 1.152 ± 0.037
1.656TyrVal: 1.656 ± 0.042
0.351TyrTrp: 0.351 ± 0.019
0.514TyrTyr: 0.514 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3246 proteins (1049727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski