Amino acid dipepetide frequency for Listeria phage A500 (Bacteriophage A500)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.498AlaAla: 6.498 ± 2.617
0.422AlaCys: 0.422 ± 0.196
5.316AlaAsp: 5.316 ± 0.891
6.751AlaGlu: 6.751 ± 0.736
3.291AlaPhe: 3.291 ± 0.941
6.582AlaGly: 6.582 ± 1.239
0.844AlaHis: 0.844 ± 0.329
6.16AlaIle: 6.16 ± 1.167
8.776AlaLys: 8.776 ± 1.65
7.764AlaLeu: 7.764 ± 1.361
2.11AlaMet: 2.11 ± 0.39
4.979AlaAsn: 4.979 ± 0.98
1.772AlaPro: 1.772 ± 0.384
2.7AlaGln: 2.7 ± 0.489
2.447AlaArg: 2.447 ± 0.522
5.063AlaSer: 5.063 ± 0.844
3.46AlaThr: 3.46 ± 0.437
5.401AlaVal: 5.401 ± 1.146
0.928AlaTrp: 0.928 ± 0.284
2.278AlaTyr: 2.278 ± 0.386
0.0AlaXaa: 0.0 ± 0.0
Cys
0.253CysAla: 0.253 ± 0.158
0.0CysCys: 0.0 ± 0.0
0.591CysAsp: 0.591 ± 0.283
0.506CysGlu: 0.506 ± 0.239
0.422CysPhe: 0.422 ± 0.23
0.675CysGly: 0.675 ± 0.247
0.169CysHis: 0.169 ± 0.145
0.169CysIle: 0.169 ± 0.126
0.253CysLys: 0.253 ± 0.178
0.506CysLeu: 0.506 ± 0.205
0.084CysMet: 0.084 ± 0.075
0.422CysAsn: 0.422 ± 0.212
0.084CysPro: 0.084 ± 0.072
0.084CysGln: 0.084 ± 0.075
0.591CysArg: 0.591 ± 0.24
0.169CysSer: 0.169 ± 0.107
0.169CysThr: 0.169 ± 0.118
0.506CysVal: 0.506 ± 0.204
0.084CysTrp: 0.084 ± 0.077
0.422CysTyr: 0.422 ± 0.201
0.0CysXaa: 0.0 ± 0.0
Asp
4.219AspAla: 4.219 ± 0.76
0.253AspCys: 0.253 ± 0.138
4.051AspAsp: 4.051 ± 0.679
4.81AspGlu: 4.81 ± 0.913
2.616AspPhe: 2.616 ± 0.443
3.966AspGly: 3.966 ± 0.58
0.506AspHis: 0.506 ± 0.216
5.232AspIle: 5.232 ± 0.615
5.738AspLys: 5.738 ± 0.743
5.401AspLeu: 5.401 ± 0.698
2.194AspMet: 2.194 ± 0.539
3.122AspAsn: 3.122 ± 0.462
1.519AspPro: 1.519 ± 0.41
0.759AspGln: 0.759 ± 0.224
0.759AspArg: 0.759 ± 0.253
4.051AspSer: 4.051 ± 0.723
3.207AspThr: 3.207 ± 0.518
3.207AspVal: 3.207 ± 0.438
0.506AspTrp: 0.506 ± 0.214
3.376AspTyr: 3.376 ± 0.742
0.0AspXaa: 0.0 ± 0.0
Glu
6.414GluAla: 6.414 ± 0.771
0.422GluCys: 0.422 ± 0.167
3.122GluAsp: 3.122 ± 0.665
6.076GluGlu: 6.076 ± 1.133
3.376GluPhe: 3.376 ± 0.608
3.46GluGly: 3.46 ± 0.519
1.097GluHis: 1.097 ± 0.286
5.148GluIle: 5.148 ± 0.99
8.101GluLys: 8.101 ± 0.968
7.426GluLeu: 7.426 ± 0.934
2.7GluMet: 2.7 ± 0.512
4.557GluAsn: 4.557 ± 0.641
1.181GluPro: 1.181 ± 0.384
3.376GluGln: 3.376 ± 0.556
3.291GluArg: 3.291 ± 0.692
4.473GluSer: 4.473 ± 0.581
4.557GluThr: 4.557 ± 0.548
4.219GluVal: 4.219 ± 0.817
1.013GluTrp: 1.013 ± 0.354
2.447GluTyr: 2.447 ± 0.529
0.0GluXaa: 0.0 ± 0.0
Phe
3.122PheAla: 3.122 ± 0.346
0.422PheCys: 0.422 ± 0.219
2.954PheAsp: 2.954 ± 0.668
2.785PheGlu: 2.785 ± 0.533
1.435PhePhe: 1.435 ± 0.371
2.025PheGly: 2.025 ± 0.329
0.591PheHis: 0.591 ± 0.229
3.713PheIle: 3.713 ± 0.862
3.122PheLys: 3.122 ± 0.446
3.207PheLeu: 3.207 ± 0.417
0.844PheMet: 0.844 ± 0.262
2.532PheAsn: 2.532 ± 0.336
0.675PhePro: 0.675 ± 0.248
1.013PheGln: 1.013 ± 0.402
0.759PheArg: 0.759 ± 0.266
3.122PheSer: 3.122 ± 0.543
2.278PheThr: 2.278 ± 0.437
3.376PheVal: 3.376 ± 0.448
0.169PheTrp: 0.169 ± 0.12
0.928PheTyr: 0.928 ± 0.411
0.0PheXaa: 0.0 ± 0.0
Gly
4.81GlyAla: 4.81 ± 1.259
0.591GlyCys: 0.591 ± 0.199
2.869GlyAsp: 2.869 ± 0.509
3.797GlyGlu: 3.797 ± 0.526
2.7GlyPhe: 2.7 ± 0.484
3.122GlyGly: 3.122 ± 0.551
0.506GlyHis: 0.506 ± 0.18
4.135GlyIle: 4.135 ± 0.518
5.401GlyLys: 5.401 ± 0.586
5.823GlyLeu: 5.823 ± 0.736
1.603GlyMet: 1.603 ± 0.488
3.713GlyAsn: 3.713 ± 0.635
0.338GlyPro: 0.338 ± 0.154
1.688GlyGln: 1.688 ± 0.394
1.772GlyArg: 1.772 ± 0.386
4.388GlySer: 4.388 ± 1.047
3.629GlyThr: 3.629 ± 0.62
3.966GlyVal: 3.966 ± 0.573
0.422GlyTrp: 0.422 ± 0.209
2.532GlyTyr: 2.532 ± 0.555
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.311
0.084HisCys: 0.084 ± 0.072
0.844HisAsp: 0.844 ± 0.285
0.844HisGlu: 0.844 ± 0.279
0.253HisPhe: 0.253 ± 0.162
0.506HisGly: 0.506 ± 0.204
0.506HisHis: 0.506 ± 0.217
0.928HisIle: 0.928 ± 0.313
1.181HisLys: 1.181 ± 0.412
0.338HisLeu: 0.338 ± 0.17
0.169HisMet: 0.169 ± 0.122
1.266HisAsn: 1.266 ± 0.405
0.253HisPro: 0.253 ± 0.135
0.338HisGln: 0.338 ± 0.167
0.591HisArg: 0.591 ± 0.23
0.591HisSer: 0.591 ± 0.187
1.266HisThr: 1.266 ± 0.311
0.844HisVal: 0.844 ± 0.32
0.338HisTrp: 0.338 ± 0.155
0.422HisTyr: 0.422 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.401IleAla: 5.401 ± 0.503
0.591IleCys: 0.591 ± 0.262
5.823IleAsp: 5.823 ± 0.689
6.329IleGlu: 6.329 ± 0.939
2.869IlePhe: 2.869 ± 0.622
2.278IleGly: 2.278 ± 0.396
1.603IleHis: 1.603 ± 0.512
3.882IleIle: 3.882 ± 0.566
6.667IleLys: 6.667 ± 1.055
4.219IleLeu: 4.219 ± 0.543
1.435IleMet: 1.435 ± 0.384
4.388IleAsn: 4.388 ± 0.559
1.941IlePro: 1.941 ± 0.317
2.785IleGln: 2.785 ± 0.513
2.532IleArg: 2.532 ± 0.609
4.726IleSer: 4.726 ± 0.678
3.797IleThr: 3.797 ± 0.517
4.051IleVal: 4.051 ± 0.616
1.097IleTrp: 1.097 ± 0.375
2.616IleTyr: 2.616 ± 0.561
0.0IleXaa: 0.0 ± 0.0
Lys
7.932LysAla: 7.932 ± 1.488
0.675LysCys: 0.675 ± 0.26
4.726LysAsp: 4.726 ± 0.566
6.92LysGlu: 6.92 ± 0.77
2.278LysPhe: 2.278 ± 0.427
5.57LysGly: 5.57 ± 0.489
1.266LysHis: 1.266 ± 0.341
4.81LysIle: 4.81 ± 0.658
7.764LysLys: 7.764 ± 1.138
8.439LysLeu: 8.439 ± 0.863
2.869LysMet: 2.869 ± 0.577
4.895LysAsn: 4.895 ± 0.787
2.363LysPro: 2.363 ± 0.434
4.051LysGln: 4.051 ± 0.602
4.304LysArg: 4.304 ± 0.742
6.245LysSer: 6.245 ± 2.067
6.582LysThr: 6.582 ± 0.724
5.654LysVal: 5.654 ± 0.753
1.35LysTrp: 1.35 ± 0.376
3.46LysTyr: 3.46 ± 0.609
0.0LysXaa: 0.0 ± 0.0
Leu
8.523LeuAla: 8.523 ± 0.866
0.591LeuCys: 0.591 ± 0.316
5.316LeuAsp: 5.316 ± 0.568
6.329LeuGlu: 6.329 ± 0.795
2.785LeuPhe: 2.785 ± 0.543
4.473LeuGly: 4.473 ± 0.884
0.675LeuHis: 0.675 ± 0.238
4.473LeuIle: 4.473 ± 0.448
7.932LeuLys: 7.932 ± 0.96
6.329LeuLeu: 6.329 ± 0.964
1.519LeuMet: 1.519 ± 0.411
4.726LeuAsn: 4.726 ± 0.601
2.785LeuPro: 2.785 ± 0.381
2.616LeuGln: 2.616 ± 0.417
4.051LeuArg: 4.051 ± 0.78
5.485LeuSer: 5.485 ± 0.58
6.076LeuThr: 6.076 ± 0.614
4.388LeuVal: 4.388 ± 0.481
0.591LeuTrp: 0.591 ± 0.257
3.291LeuTyr: 3.291 ± 0.463
0.0LeuXaa: 0.0 ± 0.0
Met
1.603MetAla: 1.603 ± 0.345
0.0MetCys: 0.0 ± 0.0
1.35MetAsp: 1.35 ± 0.416
1.688MetGlu: 1.688 ± 0.368
1.181MetPhe: 1.181 ± 0.294
1.519MetGly: 1.519 ± 0.331
0.422MetHis: 0.422 ± 0.169
1.266MetIle: 1.266 ± 0.315
2.363MetLys: 2.363 ± 0.46
2.194MetLeu: 2.194 ± 0.412
0.422MetMet: 0.422 ± 0.208
1.603MetAsn: 1.603 ± 0.28
0.591MetPro: 0.591 ± 0.252
1.181MetGln: 1.181 ± 0.322
1.266MetArg: 1.266 ± 0.274
1.266MetSer: 1.266 ± 0.324
2.447MetThr: 2.447 ± 0.431
1.097MetVal: 1.097 ± 0.286
0.253MetTrp: 0.253 ± 0.125
0.844MetTyr: 0.844 ± 0.281
0.0MetXaa: 0.0 ± 0.0
Asn
4.979AsnAla: 4.979 ± 0.809
0.338AsnCys: 0.338 ± 0.159
3.122AsnAsp: 3.122 ± 0.606
4.388AsnGlu: 4.388 ± 0.858
1.519AsnPhe: 1.519 ± 0.326
4.473AsnGly: 4.473 ± 0.662
0.591AsnHis: 0.591 ± 0.234
4.473AsnIle: 4.473 ± 0.546
5.654AsnLys: 5.654 ± 0.625
4.895AsnLeu: 4.895 ± 0.614
1.266AsnMet: 1.266 ± 0.282
4.641AsnAsn: 4.641 ± 0.717
1.519AsnPro: 1.519 ± 0.436
3.207AsnGln: 3.207 ± 0.471
2.363AsnArg: 2.363 ± 0.408
3.376AsnSer: 3.376 ± 0.601
3.713AsnThr: 3.713 ± 0.676
3.544AsnVal: 3.544 ± 0.442
0.591AsnTrp: 0.591 ± 0.241
2.869AsnTyr: 2.869 ± 0.52
0.0AsnXaa: 0.0 ± 0.0
Pro
2.11ProAla: 2.11 ± 0.458
0.084ProCys: 0.084 ± 0.091
1.181ProAsp: 1.181 ± 0.318
1.603ProGlu: 1.603 ± 0.415
1.266ProPhe: 1.266 ± 0.455
1.013ProGly: 1.013 ± 0.237
0.253ProHis: 0.253 ± 0.153
1.097ProIle: 1.097 ± 0.265
1.772ProLys: 1.772 ± 0.363
2.532ProLeu: 2.532 ± 0.509
0.422ProMet: 0.422 ± 0.259
1.097ProAsn: 1.097 ± 0.324
1.266ProPro: 1.266 ± 0.461
0.506ProGln: 0.506 ± 0.168
0.759ProArg: 0.759 ± 0.261
1.772ProSer: 1.772 ± 0.346
1.603ProThr: 1.603 ± 0.396
2.785ProVal: 2.785 ± 0.521
0.084ProTrp: 0.084 ± 0.08
0.506ProTyr: 0.506 ± 0.198
0.0ProXaa: 0.0 ± 0.0
Gln
3.207GlnAla: 3.207 ± 0.839
0.253GlnCys: 0.253 ± 0.133
2.194GlnAsp: 2.194 ± 0.519
2.954GlnGlu: 2.954 ± 0.539
1.097GlnPhe: 1.097 ± 0.308
1.941GlnGly: 1.941 ± 0.357
0.338GlnHis: 0.338 ± 0.204
2.785GlnIle: 2.785 ± 0.398
3.038GlnLys: 3.038 ± 0.491
2.7GlnLeu: 2.7 ± 0.576
0.759GlnMet: 0.759 ± 0.252
2.194GlnAsn: 2.194 ± 0.452
0.759GlnPro: 0.759 ± 0.3
2.278GlnGln: 2.278 ± 0.485
1.603GlnArg: 1.603 ± 0.441
2.532GlnSer: 2.532 ± 0.652
2.025GlnThr: 2.025 ± 0.372
2.194GlnVal: 2.194 ± 0.538
0.338GlnTrp: 0.338 ± 0.149
1.519GlnTyr: 1.519 ± 0.363
0.0GlnXaa: 0.0 ± 0.0
Arg
1.857ArgAla: 1.857 ± 0.408
0.253ArgCys: 0.253 ± 0.143
1.857ArgAsp: 1.857 ± 0.476
3.038ArgGlu: 3.038 ± 0.579
1.266ArgPhe: 1.266 ± 0.367
1.857ArgGly: 1.857 ± 0.441
0.928ArgHis: 0.928 ± 0.363
2.7ArgIle: 2.7 ± 0.526
3.629ArgLys: 3.629 ± 0.689
3.038ArgLeu: 3.038 ± 0.433
0.928ArgMet: 0.928 ± 0.284
2.363ArgAsn: 2.363 ± 0.565
0.591ArgPro: 0.591 ± 0.242
1.097ArgGln: 1.097 ± 0.447
1.097ArgArg: 1.097 ± 0.322
2.363ArgSer: 2.363 ± 0.549
1.941ArgThr: 1.941 ± 0.506
2.785ArgVal: 2.785 ± 0.576
0.591ArgTrp: 0.591 ± 0.189
1.603ArgTyr: 1.603 ± 0.369
0.0ArgXaa: 0.0 ± 0.0
Ser
5.992SerAla: 5.992 ± 1.525
0.084SerCys: 0.084 ± 0.072
4.135SerAsp: 4.135 ± 0.486
4.473SerGlu: 4.473 ± 0.687
3.122SerPhe: 3.122 ± 0.54
4.81SerGly: 4.81 ± 1.146
0.253SerHis: 0.253 ± 0.159
5.401SerIle: 5.401 ± 0.901
4.81SerLys: 4.81 ± 0.683
5.654SerLeu: 5.654 ± 0.915
1.181SerMet: 1.181 ± 0.257
4.979SerAsn: 4.979 ± 0.615
1.772SerPro: 1.772 ± 0.287
1.941SerGln: 1.941 ± 0.467
1.435SerArg: 1.435 ± 0.445
3.882SerSer: 3.882 ± 0.663
3.46SerThr: 3.46 ± 0.841
4.388SerVal: 4.388 ± 0.577
0.422SerTrp: 0.422 ± 0.192
2.194SerTyr: 2.194 ± 0.429
0.0SerXaa: 0.0 ± 0.0
Thr
6.076ThrAla: 6.076 ± 1.17
0.591ThrCys: 0.591 ± 0.256
2.869ThrAsp: 2.869 ± 0.439
5.232ThrGlu: 5.232 ± 0.619
2.954ThrPhe: 2.954 ± 0.571
3.713ThrGly: 3.713 ± 0.609
0.928ThrHis: 0.928 ± 0.328
4.388ThrIle: 4.388 ± 0.41
5.148ThrLys: 5.148 ± 0.68
4.81ThrLeu: 4.81 ± 0.651
1.181ThrMet: 1.181 ± 0.321
3.544ThrAsn: 3.544 ± 0.582
1.857ThrPro: 1.857 ± 0.415
2.447ThrGln: 2.447 ± 0.523
1.857ThrArg: 1.857 ± 0.418
3.882ThrSer: 3.882 ± 0.53
4.895ThrThr: 4.895 ± 0.698
3.966ThrVal: 3.966 ± 0.557
0.506ThrTrp: 0.506 ± 0.189
1.941ThrTyr: 1.941 ± 0.5
0.0ThrXaa: 0.0 ± 0.0
Val
5.316ValAla: 5.316 ± 0.719
0.338ValCys: 0.338 ± 0.188
4.81ValAsp: 4.81 ± 0.628
4.557ValGlu: 4.557 ± 0.438
2.11ValPhe: 2.11 ± 0.404
3.46ValGly: 3.46 ± 0.545
0.591ValHis: 0.591 ± 0.212
4.219ValIle: 4.219 ± 0.565
6.414ValLys: 6.414 ± 0.69
4.473ValLeu: 4.473 ± 0.507
1.603ValMet: 1.603 ± 0.361
3.207ValAsn: 3.207 ± 0.454
1.603ValPro: 1.603 ± 0.4
2.025ValGln: 2.025 ± 0.355
2.785ValArg: 2.785 ± 0.719
4.557ValSer: 4.557 ± 0.617
4.135ValThr: 4.135 ± 0.749
4.304ValVal: 4.304 ± 0.654
0.338ValTrp: 0.338 ± 0.164
2.278ValTyr: 2.278 ± 0.598
0.0ValXaa: 0.0 ± 0.0
Trp
1.097TrpAla: 1.097 ± 0.269
0.084TrpCys: 0.084 ± 0.112
0.591TrpAsp: 0.591 ± 0.185
0.759TrpGlu: 0.759 ± 0.305
0.506TrpPhe: 0.506 ± 0.179
0.338TrpGly: 0.338 ± 0.143
0.338TrpHis: 0.338 ± 0.175
0.928TrpIle: 0.928 ± 0.361
0.506TrpLys: 0.506 ± 0.23
0.844TrpLeu: 0.844 ± 0.241
0.169TrpMet: 0.169 ± 0.111
0.675TrpAsn: 0.675 ± 0.29
0.084TrpPro: 0.084 ± 0.08
0.675TrpGln: 0.675 ± 0.168
0.338TrpArg: 0.338 ± 0.189
0.338TrpSer: 0.338 ± 0.16
0.506TrpThr: 0.506 ± 0.221
0.675TrpVal: 0.675 ± 0.192
0.0TrpTrp: 0.0 ± 0.0
0.591TrpTyr: 0.591 ± 0.431
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.038TyrAla: 3.038 ± 0.414
0.084TyrCys: 0.084 ± 0.082
1.772TyrAsp: 1.772 ± 0.502
2.616TyrGlu: 2.616 ± 0.533
2.025TyrPhe: 2.025 ± 0.491
2.025TyrGly: 2.025 ± 0.407
0.253TyrHis: 0.253 ± 0.144
3.122TyrIle: 3.122 ± 0.577
3.882TyrLys: 3.882 ± 0.81
2.363TyrLeu: 2.363 ± 0.594
1.013TyrMet: 1.013 ± 0.234
2.616TyrAsn: 2.616 ± 0.601
0.759TyrPro: 0.759 ± 0.26
1.941TyrGln: 1.941 ± 0.49
1.181TyrArg: 1.181 ± 0.398
2.11TyrSer: 2.11 ± 0.432
3.038TyrThr: 3.038 ± 0.566
1.857TyrVal: 1.857 ± 0.412
0.422TyrTrp: 0.422 ± 0.185
1.941TyrTyr: 1.941 ± 0.52
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (11851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski