Amino acid dipepetide frequency for Paraburkholderia phenazinium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.76AlaAla: 17.76 ± 0.127	1.221AlaCys: 1.221 ± 0.029	6.455AlaAsp: 6.455 ± 0.055	6.043AlaGlu: 6.043 ± 0.062	4.275AlaPhe: 4.275 ± 0.043	10.529AlaGly: 10.529 ± 0.09	2.863AlaHis: 2.863 ± 0.038	5.652AlaIle: 5.652 ± 0.058	3.513AlaLys: 3.513 ± 0.05	14.283AlaLeu: 14.283 ± 0.091	3.093AlaMet: 3.093 ± 0.035	3.308AlaAsn: 3.308 ± 0.05	5.94AlaPro: 5.94 ± 0.072	5.519AlaGln: 5.519 ± 0.058	8.392AlaArg: 8.392 ± 0.08	7.67AlaSer: 7.67 ± 0.073	6.694AlaThr: 6.694 ± 0.063	8.964AlaVal: 8.964 ± 0.068	1.693AlaTrp: 1.693 ± 0.029	2.775AlaTyr: 2.775 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.202CysAla: 1.202 ± 0.024	0.128CysCys: 0.128 ± 0.007	0.512CysAsp: 0.512 ± 0.015	0.478CysGlu: 0.478 ± 0.016	0.32CysPhe: 0.32 ± 0.012	0.949CysGly: 0.949 ± 0.021	0.24CysHis: 0.24 ± 0.01	0.38CysIle: 0.38 ± 0.013	0.211CysLys: 0.211 ± 0.009	0.827CysLeu: 0.827 ± 0.017	0.18CysMet: 0.18 ± 0.009	0.246CysAsn: 0.246 ± 0.008	0.42CysPro: 0.42 ± 0.016	0.227CysGln: 0.227 ± 0.01	0.591CysArg: 0.591 ± 0.016	0.546CysSer: 0.546 ± 0.014	0.463CysThr: 0.463 ± 0.014	0.798CysVal: 0.798 ± 0.02	0.125CysTrp: 0.125 ± 0.007	0.214CysTyr: 0.214 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.378AspAla: 7.378 ± 0.07	0.462AspCys: 0.462 ± 0.014	2.98AspAsp: 2.98 ± 0.041	3.314AspGlu: 3.314 ± 0.04	1.943AspPhe: 1.943 ± 0.028	4.587AspGly: 4.587 ± 0.051	1.163AspHis: 1.163 ± 0.027	2.469AspIle: 2.469 ± 0.035	1.466AspLys: 1.466 ± 0.029	5.233AspLeu: 5.233 ± 0.043	1.108AspMet: 1.108 ± 0.022	1.393AspAsn: 1.393 ± 0.025	2.955AspPro: 2.955 ± 0.034	1.609AspGln: 1.609 ± 0.027	3.174AspArg: 3.174 ± 0.036	2.59AspSer: 2.59 ± 0.035	2.848AspThr: 2.848 ± 0.036	4.167AspVal: 4.167 ± 0.043	0.919AspTrp: 0.919 ± 0.02	1.522AspTyr: 1.522 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.599GluAla: 6.599 ± 0.078	0.392GluCys: 0.392 ± 0.012	2.087GluAsp: 2.087 ± 0.034	2.31GluGlu: 2.31 ± 0.039	1.766GluPhe: 1.766 ± 0.027	3.36GluGly: 3.36 ± 0.043	1.396GluHis: 1.396 ± 0.027	2.72GluIle: 2.72 ± 0.044	1.611GluLys: 1.611 ± 0.031	5.306GluLeu: 5.306 ± 0.059	1.161GluMet: 1.161 ± 0.021	1.317GluAsn: 1.317 ± 0.027	2.494GluPro: 2.494 ± 0.035	2.412GluGln: 2.412 ± 0.037	4.691GluArg: 4.691 ± 0.06	2.625GluSer: 2.625 ± 0.035	2.917GluThr: 2.917 ± 0.039	3.63GluVal: 3.63 ± 0.045	0.704GluTrp: 0.704 ± 0.019	1.182GluTyr: 1.182 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.76PheAla: 4.76 ± 0.049	0.403PheCys: 0.403 ± 0.013	2.702PheAsp: 2.702 ± 0.034	2.046PheGlu: 2.046 ± 0.029	1.436PhePhe: 1.436 ± 0.028	3.701PheGly: 3.701 ± 0.041	0.76PheHis: 0.76 ± 0.017	1.592PheIle: 1.592 ± 0.026	0.983PheLys: 0.983 ± 0.023	3.019PheLeu: 3.019 ± 0.043	0.798PheMet: 0.798 ± 0.018	1.186PheAsn: 1.186 ± 0.019	1.583PhePro: 1.583 ± 0.025	1.033PheGln: 1.033 ± 0.018	2.013PheArg: 2.013 ± 0.032	2.352PheSer: 2.352 ± 0.034	1.978PheThr: 1.978 ± 0.033	3.128PheVal: 3.128 ± 0.039	0.528PheTrp: 0.528 ± 0.018	1.004PheTyr: 1.004 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.414GlyAla: 9.414 ± 0.081	0.827GlyCys: 0.827 ± 0.021	3.869GlyAsp: 3.869 ± 0.04	4.217GlyGlu: 4.217 ± 0.039	3.464GlyPhe: 3.464 ± 0.043	6.934GlyGly: 6.934 ± 0.101	1.932GlyHis: 1.932 ± 0.029	4.251GlyIle: 4.251 ± 0.052	3.113GlyLys: 3.113 ± 0.042	8.205GlyLeu: 8.205 ± 0.059	2.138GlyMet: 2.138 ± 0.03	2.479GlyAsn: 2.479 ± 0.062	2.905GlyPro: 2.905 ± 0.039	2.897GlyGln: 2.897 ± 0.041	5.014GlyArg: 5.014 ± 0.052	4.929GlySer: 4.929 ± 0.081	4.932GlyThr: 4.932 ± 0.08	6.902GlyVal: 6.902 ± 0.063	1.371GlyTrp: 1.371 ± 0.025	2.485GlyTyr: 2.485 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	3.093HisAla: 3.093 ± 0.04	0.257HisCys: 0.257 ± 0.011	1.369HisAsp: 1.369 ± 0.027	1.201HisGlu: 1.201 ± 0.025	0.959HisPhe: 0.959 ± 0.022	2.147HisGly: 2.147 ± 0.038	0.66HisHis: 0.66 ± 0.019	0.94HisIle: 0.94 ± 0.019	0.493HisLys: 0.493 ± 0.013	2.232HisLeu: 2.232 ± 0.035	0.543HisMet: 0.543 ± 0.015	0.574HisAsn: 0.574 ± 0.017	1.481HisPro: 1.481 ± 0.022	0.638HisGln: 0.638 ± 0.014	1.468HisArg: 1.468 ± 0.028	1.134HisSer: 1.134 ± 0.022	1.119HisThr: 1.119 ± 0.021	1.705HisVal: 1.705 ± 0.026	0.402HisTrp: 0.402 ± 0.012	0.68HisTyr: 0.68 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.827IleAla: 6.827 ± 0.062	0.441IleCys: 0.441 ± 0.014	3.357IleAsp: 3.357 ± 0.035	3.181IleGlu: 3.181 ± 0.04	1.472IlePhe: 1.472 ± 0.025	4.661IleGly: 4.661 ± 0.05	0.892IleHis: 0.892 ± 0.019	1.569IleIle: 1.569 ± 0.031	1.334IleLys: 1.334 ± 0.023	3.526IleLeu: 3.526 ± 0.04	0.741IleMet: 0.741 ± 0.019	1.432IleAsn: 1.432 ± 0.026	2.115IlePro: 2.115 ± 0.029	1.302IleGln: 1.302 ± 0.021	2.798IleArg: 2.798 ± 0.032	2.578IleSer: 2.578 ± 0.039	2.421IleThr: 2.421 ± 0.036	4.33IleVal: 4.33 ± 0.042	0.526IleTrp: 0.526 ± 0.015	1.067IleTyr: 1.067 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.441LysAla: 3.441 ± 0.043	0.157LysCys: 0.157 ± 0.007	1.424LysAsp: 1.424 ± 0.028	1.331LysGlu: 1.331 ± 0.027	0.884LysPhe: 0.884 ± 0.02	2.063LysGly: 2.063 ± 0.03	0.641LysHis: 0.641 ± 0.014	1.513LysIle: 1.513 ± 0.03	1.143LysLys: 1.143 ± 0.031	3.256LysLeu: 3.256 ± 0.037	0.695LysMet: 0.695 ± 0.018	0.833LysAsn: 0.833 ± 0.02	1.857LysPro: 1.857 ± 0.032	1.23LysGln: 1.23 ± 0.028	2.206LysArg: 2.206 ± 0.027	1.68LysSer: 1.68 ± 0.03	1.789LysThr: 1.789 ± 0.031	2.278LysVal: 2.278 ± 0.038	0.362LysTrp: 0.362 ± 0.013	0.688LysTyr: 0.688 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.031LeuAla: 14.031 ± 0.086	1.044LeuCys: 1.044 ± 0.022	5.944LeuAsp: 5.944 ± 0.056	5.112LeuGlu: 5.112 ± 0.056	3.643LeuPhe: 3.643 ± 0.041	8.309LeuGly: 8.309 ± 0.08	2.292LeuHis: 2.292 ± 0.035	4.772LeuIle: 4.772 ± 0.05	3.317LeuLys: 3.317 ± 0.042	10.296LeuLeu: 10.296 ± 0.111	2.232LeuMet: 2.232 ± 0.033	2.942LeuAsn: 2.942 ± 0.04	5.765LeuPro: 5.765 ± 0.054	3.567LeuGln: 3.567 ± 0.04	6.988LeuArg: 6.988 ± 0.069	6.621LeuSer: 6.621 ± 0.068	5.926LeuThr: 5.926 ± 0.06	7.426LeuVal: 7.426 ± 0.058	1.137LeuTrp: 1.137 ± 0.023	2.226LeuTyr: 2.226 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.438MetAla: 2.438 ± 0.031	0.169MetCys: 0.169 ± 0.009	0.897MetAsp: 0.897 ± 0.021	0.89MetGlu: 0.89 ± 0.019	0.75MetPhe: 0.75 ± 0.018	1.528MetGly: 1.528 ± 0.027	0.528MetHis: 0.528 ± 0.015	1.08MetIle: 1.08 ± 0.021	0.95MetLys: 0.95 ± 0.021	2.538MetLeu: 2.538 ± 0.034	0.569MetMet: 0.569 ± 0.018	0.904MetAsn: 0.904 ± 0.019	1.393MetPro: 1.393 ± 0.026	0.98MetGln: 0.98 ± 0.022	1.695MetArg: 1.695 ± 0.03	1.708MetSer: 1.708 ± 0.021	1.594MetThr: 1.594 ± 0.026	1.488MetVal: 1.488 ± 0.029	0.205MetTrp: 0.205 ± 0.009	0.391MetTyr: 0.391 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.589AsnAla: 3.589 ± 0.05	0.26AsnCys: 0.26 ± 0.01	1.456AsnAsp: 1.456 ± 0.027	1.328AsnGlu: 1.328 ± 0.026	1.045AsnPhe: 1.045 ± 0.022	2.742AsnGly: 2.742 ± 0.055	0.532AsnHis: 0.532 ± 0.015	1.275AsnIle: 1.275 ± 0.025	0.644AsnLys: 0.644 ± 0.019	2.936AsnLeu: 2.936 ± 0.044	0.581AsnMet: 0.581 ± 0.016	0.93AsnAsn: 0.93 ± 0.03	1.917AsnPro: 1.917 ± 0.037	1.005AsnGln: 1.005 ± 0.024	1.789AsnArg: 1.789 ± 0.028	1.517AsnSer: 1.517 ± 0.04	1.636AsnThr: 1.636 ± 0.039	2.31AsnVal: 2.31 ± 0.038	0.425AsnTrp: 0.425 ± 0.014	0.765AsnTyr: 0.765 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.692ProAla: 6.692 ± 0.065	0.346ProCys: 0.346 ± 0.015	3.258ProAsp: 3.258 ± 0.035	2.935ProGlu: 2.935 ± 0.039	1.945ProPhe: 1.945 ± 0.031	4.173ProGly: 4.173 ± 0.047	1.269ProHis: 1.269 ± 0.027	2.01ProIle: 2.01 ± 0.029	1.378ProLys: 1.378 ± 0.025	5.29ProLeu: 5.29 ± 0.056	1.09ProMet: 1.09 ± 0.02	1.457ProAsn: 1.457 ± 0.025	2.453ProPro: 2.453 ± 0.041	2.036ProGln: 2.036 ± 0.034	2.776ProArg: 2.776 ± 0.037	2.97ProSer: 2.97 ± 0.034	2.664ProThr: 2.664 ± 0.039	4.356ProVal: 4.356 ± 0.049	0.647ProTrp: 0.647 ± 0.016	1.274ProTyr: 1.274 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.653GlnAla: 4.653 ± 0.045	0.281GlnCys: 0.281 ± 0.013	1.46GlnAsp: 1.46 ± 0.023	1.357GlnGlu: 1.357 ± 0.024	1.351GlnPhe: 1.351 ± 0.023	2.563GlnGly: 2.563 ± 0.036	1.011GlnHis: 1.011 ± 0.02	2.05GlnIle: 2.05 ± 0.03	1.065GlnLys: 1.065 ± 0.023	3.88GlnLeu: 3.88 ± 0.047	1.004GlnMet: 1.004 ± 0.024	1.007GlnAsn: 1.007 ± 0.024	2.121GlnPro: 2.121 ± 0.029	2.019GlnGln: 2.019 ± 0.042	2.933GlnArg: 2.933 ± 0.039	2.21GlnSer: 2.21 ± 0.035	2.222GlnThr: 2.222 ± 0.037	2.627GlnVal: 2.627 ± 0.032	0.586GlnTrp: 0.586 ± 0.016	1.005GlnTyr: 1.005 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.657ArgAla: 7.657 ± 0.066	0.552ArgCys: 0.552 ± 0.015	3.558ArgAsp: 3.558 ± 0.043	3.993ArgGlu: 3.993 ± 0.05	2.893ArgPhe: 2.893 ± 0.037	4.353ArgGly: 4.353 ± 0.047	1.819ArgHis: 1.819 ± 0.03	3.534ArgIle: 3.534 ± 0.045	1.949ArgLys: 1.949 ± 0.03	7.187ArgLeu: 7.187 ± 0.072	1.677ArgMet: 1.677 ± 0.027	1.861ArgAsn: 1.861 ± 0.032	3.024ArgPro: 3.024 ± 0.04	2.511ArgGln: 2.511 ± 0.036	4.99ArgArg: 4.99 ± 0.06	3.609ArgSer: 3.609 ± 0.04	3.424ArgThr: 3.424 ± 0.046	5.121ArgVal: 5.121 ± 0.057	1.029ArgTrp: 1.029 ± 0.019	1.987ArgTyr: 1.987 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.153SerAla: 7.153 ± 0.055	0.437SerCys: 0.437 ± 0.014	2.908SerAsp: 2.908 ± 0.037	2.632SerGlu: 2.632 ± 0.037	2.301SerPhe: 2.301 ± 0.031	5.795SerGly: 5.795 ± 0.09	1.274SerHis: 1.274 ± 0.023	2.866SerIle: 2.866 ± 0.037	1.63SerLys: 1.63 ± 0.029	6.09SerLeu: 6.09 ± 0.059	1.39SerMet: 1.39 ± 0.025	1.831SerAsn: 1.831 ± 0.038	2.939SerPro: 2.939 ± 0.038	2.063SerGln: 2.063 ± 0.037	3.555SerArg: 3.555 ± 0.042	3.817SerSer: 3.817 ± 0.057	3.575SerThr: 3.575 ± 0.069	4.622SerVal: 4.622 ± 0.047	0.754SerTrp: 0.754 ± 0.017	1.466SerTyr: 1.466 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.271ThrAla: 6.271 ± 0.066	0.434ThrCys: 0.434 ± 0.014	2.696ThrAsp: 2.696 ± 0.041	2.361ThrGlu: 2.361 ± 0.036	2.074ThrPhe: 2.074 ± 0.032	5.05ThrGly: 5.05 ± 0.075	1.342ThrHis: 1.342 ± 0.024	2.628ThrIle: 2.628 ± 0.043	1.222ThrLys: 1.222 ± 0.022	6.837ThrLeu: 6.837 ± 0.062	1.131ThrMet: 1.131 ± 0.024	1.504ThrAsn: 1.504 ± 0.041	3.702ThrPro: 3.702 ± 0.044	2.149ThrGln: 2.149 ± 0.041	3.552ThrArg: 3.552 ± 0.045	3.373ThrSer: 3.373 ± 0.058	3.221ThrThr: 3.221 ± 0.053	4.649ThrVal: 4.649 ± 0.049	0.729ThrTrp: 0.729 ± 0.018	1.366ThrTyr: 1.366 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.716ValAla: 9.716 ± 0.077	0.833ValCys: 0.833 ± 0.019	4.262ValAsp: 4.262 ± 0.04	4.225ValGlu: 4.225 ± 0.045	2.859ValPhe: 2.859 ± 0.04	5.711ValGly: 5.711 ± 0.059	1.538ValHis: 1.538 ± 0.027	3.7ValIle: 3.7 ± 0.045	2.414ValLys: 2.414 ± 0.039	8.065ValLeu: 8.065 ± 0.067	1.774ValMet: 1.774 ± 0.028	2.31ValAsn: 2.31 ± 0.036	3.983ValPro: 3.983 ± 0.05	2.558ValGln: 2.558 ± 0.034	5.034ValArg: 5.034 ± 0.049	4.971ValSer: 4.971 ± 0.054	4.741ValThr: 4.741 ± 0.047	6.439ValVal: 6.439 ± 0.072	0.988ValTrp: 0.988 ± 0.018	1.705ValTyr: 1.705 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.178TrpAla: 1.178 ± 0.023	0.145TrpCys: 0.145 ± 0.007	0.635TrpAsp: 0.635 ± 0.017	0.482TrpGlu: 0.482 ± 0.015	0.589TrpPhe: 0.589 ± 0.017	0.861TrpGly: 0.861 ± 0.019	0.401TrpHis: 0.401 ± 0.013	0.703TrpIle: 0.703 ± 0.017	0.41TrpLys: 0.41 ± 0.013	1.959TrpLeu: 1.959 ± 0.035	0.363TrpMet: 0.363 ± 0.013	0.469TrpAsn: 0.469 ± 0.015	0.649TrpPro: 0.649 ± 0.014	0.715TrpGln: 0.715 ± 0.019	1.145TrpArg: 1.145 ± 0.022	0.838TrpSer: 0.838 ± 0.02	0.729TrpThr: 0.729 ± 0.018	0.93TrpVal: 0.93 ± 0.017	0.224TrpTrp: 0.224 ± 0.01	0.334TrpTyr: 0.334 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.79TyrAla: 2.79 ± 0.037	0.27TyrCys: 0.27 ± 0.011	1.451TyrAsp: 1.451 ± 0.028	1.243TyrGlu: 1.243 ± 0.023	1.035TyrPhe: 1.035 ± 0.021	2.261TyrGly: 2.261 ± 0.036	0.544TyrHis: 0.544 ± 0.016	0.864TyrIle: 0.864 ± 0.021	0.627TyrLys: 0.627 ± 0.018	2.625TyrLeu: 2.625 ± 0.036	0.428TyrMet: 0.428 ± 0.014	0.697TyrAsn: 0.697 ± 0.019	1.322TyrPro: 1.322 ± 0.024	0.936TyrGln: 0.936 ± 0.02	1.926TyrArg: 1.926 ± 0.031	1.36TyrSer: 1.36 ± 0.023	1.396TyrThr: 1.396 ± 0.028	1.954TyrVal: 1.954 ± 0.032	0.405TyrTrp: 0.405 ± 0.011	0.693TyrTyr: 0.693 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7404 proteins (2444871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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