Amino acid dipepetide frequency for Ureibacillus thermophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.436AlaAla: 5.436 ± 0.115	0.645AlaCys: 0.645 ± 0.028	3.035AlaAsp: 3.035 ± 0.069	4.904AlaGlu: 4.904 ± 0.082	3.251AlaPhe: 3.251 ± 0.07	4.693AlaGly: 4.693 ± 0.09	1.24AlaHis: 1.24 ± 0.036	6.434AlaIle: 6.434 ± 0.103	5.336AlaLys: 5.336 ± 0.086	7.075AlaLeu: 7.075 ± 0.104	1.991AlaMet: 1.991 ± 0.051	2.912AlaAsn: 2.912 ± 0.064	2.038AlaPro: 2.038 ± 0.057	2.36AlaGln: 2.36 ± 0.064	3.018AlaArg: 3.018 ± 0.105	3.836AlaSer: 3.836 ± 0.066	3.548AlaThr: 3.548 ± 0.067	5.34AlaVal: 5.34 ± 0.105	0.492AlaTrp: 0.492 ± 0.024	2.326AlaTyr: 2.326 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.507CysAla: 0.507 ± 0.023	0.112CysCys: 0.112 ± 0.013	0.412CysAsp: 0.412 ± 0.023	0.498CysGlu: 0.498 ± 0.024	0.338CysPhe: 0.338 ± 0.019	0.723CysGly: 0.723 ± 0.035	0.207CysHis: 0.207 ± 0.016	0.683CysIle: 0.683 ± 0.03	0.439CysLys: 0.439 ± 0.026	0.693CysLeu: 0.693 ± 0.023	0.17CysMet: 0.17 ± 0.014	0.331CysAsn: 0.331 ± 0.023	0.416CysPro: 0.416 ± 0.026	0.217CysGln: 0.217 ± 0.015	0.273CysArg: 0.273 ± 0.023	0.464CysSer: 0.464 ± 0.025	0.432CysThr: 0.432 ± 0.024	0.437CysVal: 0.437 ± 0.022	0.067CysTrp: 0.067 ± 0.008	0.292CysTyr: 0.292 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.358AspAla: 3.358 ± 0.062	0.417AspCys: 0.417 ± 0.022	2.323AspAsp: 2.323 ± 0.053	5.134AspGlu: 5.134 ± 0.096	2.424AspPhe: 2.424 ± 0.049	3.366AspGly: 3.366 ± 0.073	0.918AspHis: 0.918 ± 0.03	3.936AspIle: 3.936 ± 0.077	2.665AspLys: 2.665 ± 0.07	4.612AspLeu: 4.612 ± 0.076	1.163AspMet: 1.163 ± 0.039	1.537AspAsn: 1.537 ± 0.049	1.826AspPro: 1.826 ± 0.049	1.537AspGln: 1.537 ± 0.045	2.002AspArg: 2.002 ± 0.049	2.359AspSer: 2.359 ± 0.058	2.069AspThr: 2.069 ± 0.054	3.721AspVal: 3.721 ± 0.07	0.553AspTrp: 0.553 ± 0.023	2.186AspTyr: 2.186 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.919GluAla: 5.919 ± 0.097	0.427GluCys: 0.427 ± 0.026	3.685GluAsp: 3.685 ± 0.063	8.563GluGlu: 8.563 ± 0.161	2.798GluPhe: 2.798 ± 0.07	4.403GluGly: 4.403 ± 0.084	1.661GluHis: 1.661 ± 0.043	6.642GluIle: 6.642 ± 0.099	7.933GluLys: 7.933 ± 0.13	7.702GluLeu: 7.702 ± 0.11	2.653GluMet: 2.653 ± 0.059	4.013GluAsn: 4.013 ± 0.068	2.095GluPro: 2.095 ± 0.057	3.736GluGln: 3.736 ± 0.076	3.854GluArg: 3.854 ± 0.08	3.441GluSer: 3.441 ± 0.068	3.849GluThr: 3.849 ± 0.074	5.551GluVal: 5.551 ± 0.094	0.814GluTrp: 0.814 ± 0.027	2.546GluTyr: 2.546 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.049PheAla: 3.049 ± 0.062	0.427PheCys: 0.427 ± 0.024	2.349PheAsp: 2.349 ± 0.055	3.346PheGlu: 3.346 ± 0.059	2.338PhePhe: 2.338 ± 0.067	3.146PheGly: 3.146 ± 0.075	1.077PheHis: 1.077 ± 0.038	4.151PheIle: 4.151 ± 0.086	2.507PheLys: 2.507 ± 0.048	4.259PheLeu: 4.259 ± 0.092	1.152PheMet: 1.152 ± 0.037	1.821PheAsn: 1.821 ± 0.048	1.64PhePro: 1.64 ± 0.046	1.68PheGln: 1.68 ± 0.044	1.704PheArg: 1.704 ± 0.05	2.875PheSer: 2.875 ± 0.061	2.507PheThr: 2.507 ± 0.056	3.209PheVal: 3.209 ± 0.069	0.439PheTrp: 0.439 ± 0.026	1.725PheTyr: 1.725 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.681GlyAla: 4.681 ± 0.094	0.617GlyCys: 0.617 ± 0.026	3.066GlyAsp: 3.066 ± 0.067	4.575GlyGlu: 4.575 ± 0.083	3.119GlyPhe: 3.119 ± 0.067	4.361GlyGly: 4.361 ± 0.092	1.263GlyHis: 1.263 ± 0.042	5.816GlyIle: 5.816 ± 0.091	5.275GlyLys: 5.275 ± 0.082	5.853GlyLeu: 5.853 ± 0.091	1.907GlyMet: 1.907 ± 0.049	2.604GlyAsn: 2.604 ± 0.06	1.657GlyPro: 1.657 ± 0.052	1.979GlyGln: 1.979 ± 0.049	2.692GlyArg: 2.692 ± 0.057	3.408GlySer: 3.408 ± 0.074	3.712GlyThr: 3.712 ± 0.077	4.865GlyVal: 4.865 ± 0.082	0.686GlyTrp: 0.686 ± 0.033	2.74GlyTyr: 2.74 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.241HisAla: 1.241 ± 0.039	0.242HisCys: 0.242 ± 0.018	0.938HisAsp: 0.938 ± 0.035	1.5HisGlu: 1.5 ± 0.038	1.112HisPhe: 1.112 ± 0.042	1.363HisGly: 1.363 ± 0.036	0.717HisHis: 0.717 ± 0.039	1.627HisIle: 1.627 ± 0.047	1.088HisLys: 1.088 ± 0.034	2.174HisLeu: 2.174 ± 0.044	0.473HisMet: 0.473 ± 0.023	0.718HisAsn: 0.718 ± 0.029	1.239HisPro: 1.239 ± 0.039	0.906HisGln: 0.906 ± 0.034	0.871HisArg: 0.871 ± 0.034	1.133HisSer: 1.133 ± 0.04	0.95HisThr: 0.95 ± 0.037	1.342HisVal: 1.342 ± 0.045	0.202HisTrp: 0.202 ± 0.015	0.925HisTyr: 0.925 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.404IleAla: 6.404 ± 0.098	0.712IleCys: 0.712 ± 0.033	4.518IleAsp: 4.518 ± 0.074	6.798IleGlu: 6.798 ± 0.095	3.475IlePhe: 3.475 ± 0.084	5.884IleGly: 5.884 ± 0.106	1.895IleHis: 1.895 ± 0.053	6.373IleIle: 6.373 ± 0.117	4.697IleLys: 4.697 ± 0.091	7.575IleLeu: 7.575 ± 0.12	1.769IleMet: 1.769 ± 0.045	3.184IleAsn: 3.184 ± 0.062	3.644IlePro: 3.644 ± 0.079	3.495IleGln: 3.495 ± 0.061	3.489IleArg: 3.489 ± 0.069	4.953IleSer: 4.953 ± 0.087	4.242IleThr: 4.242 ± 0.075	6.195IleVal: 6.195 ± 0.084	0.632IleTrp: 0.632 ± 0.026	2.799IleTyr: 2.799 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.828LysAla: 4.828 ± 0.078	0.405LysCys: 0.405 ± 0.025	3.626LysAsp: 3.626 ± 0.073	8.057LysGlu: 8.057 ± 0.104	2.326LysPhe: 2.326 ± 0.059	4.51LysGly: 4.51 ± 0.076	1.474LysHis: 1.474 ± 0.048	5.567LysIle: 5.567 ± 0.075	6.422LysLys: 6.422 ± 0.097	6.128LysLeu: 6.128 ± 0.1	2.307LysMet: 2.307 ± 0.057	3.833LysAsn: 3.833 ± 0.076	2.356LysPro: 2.356 ± 0.059	3.071LysGln: 3.071 ± 0.068	3.498LysArg: 3.498 ± 0.066	3.437LysSer: 3.437 ± 0.068	3.87LysThr: 3.87 ± 0.076	5.088LysVal: 5.088 ± 0.088	0.882LysTrp: 0.882 ± 0.032	2.58LysTyr: 2.58 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	7.106LeuAla: 7.106 ± 0.119	0.706LeuCys: 0.706 ± 0.028	4.654LeuAsp: 4.654 ± 0.074	7.163LeuGlu: 7.163 ± 0.118	4.651LeuPhe: 4.651 ± 0.095	5.786LeuGly: 5.786 ± 0.089	2.001LeuHis: 2.001 ± 0.045	7.047LeuIle: 7.047 ± 0.116	7.479LeuLys: 7.479 ± 0.108	9.609LeuLeu: 9.609 ± 0.146	2.381LeuMet: 2.381 ± 0.058	4.461LeuAsn: 4.461 ± 0.077	3.842LeuPro: 3.842 ± 0.075	3.517LeuGln: 3.517 ± 0.071	3.759LeuArg: 3.759 ± 0.069	6.217LeuSer: 6.217 ± 0.102	5.127LeuThr: 5.127 ± 0.073	5.869LeuVal: 5.869 ± 0.094	0.766LeuTrp: 0.766 ± 0.031	3.221LeuTyr: 3.221 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.899MetAla: 1.899 ± 0.046	0.158MetCys: 0.158 ± 0.014	1.372MetAsp: 1.372 ± 0.041	2.229MetGlu: 2.229 ± 0.056	1.014MetPhe: 1.014 ± 0.039	1.575MetGly: 1.575 ± 0.047	0.469MetHis: 0.469 ± 0.022	2.068MetIle: 2.068 ± 0.06	2.606MetLys: 2.606 ± 0.054	2.518MetLeu: 2.518 ± 0.058	0.881MetMet: 0.881 ± 0.032	1.509MetAsn: 1.509 ± 0.044	1.031MetPro: 1.031 ± 0.038	0.882MetGln: 0.882 ± 0.035	1.157MetArg: 1.157 ± 0.038	1.421MetSer: 1.421 ± 0.041	1.58MetThr: 1.58 ± 0.046	1.616MetVal: 1.616 ± 0.045	0.167MetTrp: 0.167 ± 0.014	0.727MetTyr: 0.727 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.185AsnAla: 3.185 ± 0.075	0.296AsnCys: 0.296 ± 0.02	1.931AsnAsp: 1.931 ± 0.049	3.91AsnGlu: 3.91 ± 0.089	1.774AsnPhe: 1.774 ± 0.045	3.263AsnGly: 3.263 ± 0.073	1.044AsnHis: 1.044 ± 0.034	3.612AsnIle: 3.612 ± 0.067	2.942AsnLys: 2.942 ± 0.071	3.92AsnLeu: 3.92 ± 0.073	1.128AsnMet: 1.128 ± 0.041	1.894AsnAsn: 1.894 ± 0.057	2.236AsnPro: 2.236 ± 0.061	1.857AsnGln: 1.857 ± 0.05	2.103AsnArg: 2.103 ± 0.054	2.185AsnSer: 2.185 ± 0.054	2.102AsnThr: 2.102 ± 0.051	3.052AsnVal: 3.052 ± 0.06	0.469AsnTrp: 0.469 ± 0.029	1.566AsnTyr: 1.566 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.118ProAla: 2.118 ± 0.06	0.241ProCys: 0.241 ± 0.018	1.895ProAsp: 1.895 ± 0.048	3.034ProGlu: 3.034 ± 0.063	2.075ProPhe: 2.075 ± 0.054	2.234ProGly: 2.234 ± 0.059	0.815ProHis: 0.815 ± 0.03	3.218ProIle: 3.218 ± 0.058	2.71ProLys: 2.71 ± 0.065	3.392ProLeu: 3.392 ± 0.061	0.854ProMet: 0.854 ± 0.032	1.88ProAsn: 1.88 ± 0.05	1.035ProPro: 1.035 ± 0.039	1.125ProGln: 1.125 ± 0.044	1.089ProArg: 1.089 ± 0.037	2.194ProSer: 2.194 ± 0.053	1.967ProThr: 1.967 ± 0.053	2.68ProVal: 2.68 ± 0.061	0.358ProTrp: 0.358 ± 0.022	1.589ProTyr: 1.589 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.471GlnAla: 2.471 ± 0.055	0.228GlnCys: 0.228 ± 0.018	1.348GlnAsp: 1.348 ± 0.046	2.873GlnGlu: 2.873 ± 0.06	1.711GlnPhe: 1.711 ± 0.043	1.953GlnGly: 1.953 ± 0.053	0.767GlnHis: 0.767 ± 0.028	2.894GlnIle: 2.894 ± 0.061	2.913GlnLys: 2.913 ± 0.064	4.271GlnLeu: 4.271 ± 0.081	1.179GlnMet: 1.179 ± 0.037	1.746GlnAsn: 1.746 ± 0.053	1.192GlnPro: 1.192 ± 0.041	1.769GlnGln: 1.769 ± 0.057	1.43GlnArg: 1.43 ± 0.044	2.05GlnSer: 2.05 ± 0.051	1.883GlnThr: 1.883 ± 0.05	2.313GlnVal: 2.313 ± 0.054	0.397GlnTrp: 0.397 ± 0.025	1.499GlnTyr: 1.499 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.617ArgAla: 2.617 ± 0.061	0.29ArgCys: 0.29 ± 0.018	1.938ArgAsp: 1.938 ± 0.045	3.536ArgGlu: 3.536 ± 0.063	1.997ArgPhe: 1.997 ± 0.05	2.368ArgGly: 2.368 ± 0.049	0.82ArgHis: 0.82 ± 0.034	3.512ArgIle: 3.512 ± 0.078	3.598ArgLys: 3.598 ± 0.076	3.99ArgLeu: 3.99 ± 0.073	1.246ArgMet: 1.246 ± 0.037	2.226ArgAsn: 2.226 ± 0.076	1.384ArgPro: 1.384 ± 0.045	1.501ArgGln: 1.501 ± 0.041	1.864ArgArg: 1.864 ± 0.055	1.974ArgSer: 1.974 ± 0.056	2.083ArgThr: 2.083 ± 0.05	2.608ArgVal: 2.608 ± 0.058	0.41ArgTrp: 0.41 ± 0.023	1.61ArgTyr: 1.61 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.649SerAla: 3.649 ± 0.1	0.422SerCys: 0.422 ± 0.022	2.492SerAsp: 2.492 ± 0.053	3.615SerGlu: 3.615 ± 0.077	3.016SerPhe: 3.016 ± 0.064	3.913SerGly: 3.913 ± 0.08	1.088SerHis: 1.088 ± 0.032	5.09SerIle: 5.09 ± 0.088	4.015SerLys: 4.015 ± 0.086	5.409SerLeu: 5.409 ± 0.082	1.488SerMet: 1.488 ± 0.037	2.4SerAsn: 2.4 ± 0.063	2.113SerPro: 2.113 ± 0.05	1.778SerGln: 1.778 ± 0.058	2.1SerArg: 2.1 ± 0.051	3.416SerSer: 3.416 ± 0.081	2.809SerThr: 2.809 ± 0.061	3.628SerVal: 3.628 ± 0.071	0.481SerTrp: 0.481 ± 0.024	2.047SerTyr: 2.047 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.638ThrAla: 3.638 ± 0.07	0.374ThrCys: 0.374 ± 0.022	2.358ThrAsp: 2.358 ± 0.057	3.419ThrGlu: 3.419 ± 0.07	2.574ThrPhe: 2.574 ± 0.049	3.833ThrGly: 3.833 ± 0.081	0.947ThrHis: 0.947 ± 0.034	4.815ThrIle: 4.815 ± 0.084	3.547ThrLys: 3.547 ± 0.072	4.982ThrLeu: 4.982 ± 0.083	1.22ThrMet: 1.22 ± 0.035	2.365ThrAsn: 2.365 ± 0.061	2.249ThrPro: 2.249 ± 0.049	1.313ThrGln: 1.313 ± 0.043	1.752ThrArg: 1.752 ± 0.042	2.892ThrSer: 2.892 ± 0.054	2.9ThrThr: 2.9 ± 0.059	4.107ThrVal: 4.107 ± 0.084	0.458ThrTrp: 0.458 ± 0.027	1.918ThrTyr: 1.918 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.99ValAla: 4.99 ± 0.088	0.57ValCys: 0.57 ± 0.025	3.702ValAsp: 3.702 ± 0.07	5.527ValGlu: 5.527 ± 0.092	3.01ValPhe: 3.01 ± 0.06	4.466ValGly: 4.466 ± 0.081	1.351ValHis: 1.351 ± 0.039	5.543ValIle: 5.543 ± 0.08	5.037ValLys: 5.037 ± 0.083	6.546ValLeu: 6.546 ± 0.092	1.732ValMet: 1.732 ± 0.043	3.062ValAsn: 3.062 ± 0.064	2.828ValPro: 2.828 ± 0.055	2.392ValGln: 2.392 ± 0.065	2.889ValArg: 2.889 ± 0.054	4.197ValSer: 4.197 ± 0.099	3.829ValThr: 3.829 ± 0.074	5.278ValVal: 5.278 ± 0.085	0.556ValTrp: 0.556 ± 0.026	2.374ValTyr: 2.374 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.531TrpAla: 0.531 ± 0.024	0.083TrpCys: 0.083 ± 0.009	0.436TrpAsp: 0.436 ± 0.023	0.635TrpGlu: 0.635 ± 0.029	0.445TrpPhe: 0.445 ± 0.02	0.59TrpGly: 0.59 ± 0.028	0.207TrpHis: 0.207 ± 0.018	0.901TrpIle: 0.901 ± 0.039	0.796TrpLys: 0.796 ± 0.031	1.078TrpLeu: 1.078 ± 0.038	0.321TrpMet: 0.321 ± 0.019	0.482TrpAsn: 0.482 ± 0.024	0.231TrpPro: 0.231 ± 0.019	0.302TrpGln: 0.302 ± 0.018	0.357TrpArg: 0.357 ± 0.02	0.476TrpSer: 0.476 ± 0.024	0.46TrpThr: 0.46 ± 0.026	0.586TrpVal: 0.586 ± 0.027	0.104TrpTrp: 0.104 ± 0.013	0.29TrpTyr: 0.29 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.057	0.342TyrCys: 0.342 ± 0.021	2.028TyrAsp: 2.028 ± 0.056	2.97TyrGlu: 2.97 ± 0.056	1.951TyrPhe: 1.951 ± 0.049	2.444TyrGly: 2.444 ± 0.051	0.797TyrHis: 0.797 ± 0.033	2.803TyrIle: 2.803 ± 0.065	2.261TyrLys: 2.261 ± 0.06	3.578TyrLeu: 3.578 ± 0.064	0.862TyrMet: 0.862 ± 0.032	1.49TyrAsn: 1.49 ± 0.047	1.451TyrPro: 1.451 ± 0.041	1.472TyrGln: 1.472 ± 0.042	1.67TyrArg: 1.67 ± 0.043	2.043TyrSer: 2.043 ± 0.049	1.741TyrThr: 1.741 ± 0.04	2.398TyrVal: 2.398 ± 0.062	0.378TyrTrp: 0.378 ± 0.021	1.5TyrTyr: 1.5 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2797 proteins (810556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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