Amino acid dipepetide frequency for Flavobacterium rivuli WB 3.3-2 = DSM 21788

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.688AlaAla: 6.688 ± 0.105	0.605AlaCys: 0.605 ± 0.025	4.331AlaAsp: 4.331 ± 0.066	4.561AlaGlu: 4.561 ± 0.067	3.578AlaPhe: 3.578 ± 0.054	5.631AlaGly: 5.631 ± 0.086	1.213AlaHis: 1.213 ± 0.034	5.608AlaIle: 5.608 ± 0.081	5.116AlaLys: 5.116 ± 0.089	7.126AlaLeu: 7.126 ± 0.09	1.745AlaMet: 1.745 ± 0.035	4.129AlaAsn: 4.129 ± 0.076	2.476AlaPro: 2.476 ± 0.06	3.102AlaGln: 3.102 ± 0.052	2.248AlaArg: 2.248 ± 0.04	4.359AlaSer: 4.359 ± 0.066	5.082AlaThr: 5.082 ± 0.134	5.295AlaVal: 5.295 ± 0.063	0.761AlaTrp: 0.761 ± 0.026	2.827AlaTyr: 2.827 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.475CysAla: 0.475 ± 0.02	0.1CysCys: 0.1 ± 0.009	0.402CysAsp: 0.402 ± 0.018	0.411CysGlu: 0.411 ± 0.02	0.413CysPhe: 0.413 ± 0.021	0.668CysGly: 0.668 ± 0.032	0.19CysHis: 0.19 ± 0.015	0.617CysIle: 0.617 ± 0.025	0.385CysLys: 0.385 ± 0.019	0.63CysLeu: 0.63 ± 0.026	0.146CysMet: 0.146 ± 0.011	0.447CysAsn: 0.447 ± 0.018	0.303CysPro: 0.303 ± 0.018	0.206CysGln: 0.206 ± 0.013	0.255CysArg: 0.255 ± 0.013	0.539CysSer: 0.539 ± 0.024	0.528CysThr: 0.528 ± 0.023	0.42CysVal: 0.42 ± 0.017	0.059CysTrp: 0.059 ± 0.008	0.33CysTyr: 0.33 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.392AspAla: 4.392 ± 0.064	0.388AspCys: 0.388 ± 0.019	2.874AspAsp: 2.874 ± 0.057	3.392AspGlu: 3.392 ± 0.066	3.328AspPhe: 3.328 ± 0.061	3.906AspGly: 3.906 ± 0.075	0.818AspHis: 0.818 ± 0.027	4.369AspIle: 4.369 ± 0.062	4.193AspLys: 4.193 ± 0.07	4.573AspLeu: 4.573 ± 0.064	1.139AspMet: 1.139 ± 0.034	3.177AspAsn: 3.177 ± 0.053	1.709AspPro: 1.709 ± 0.04	1.203AspGln: 1.203 ± 0.033	1.968AspArg: 1.968 ± 0.039	2.941AspSer: 2.941 ± 0.057	3.129AspThr: 3.129 ± 0.06	3.859AspVal: 3.859 ± 0.06	0.719AspTrp: 0.719 ± 0.024	2.902AspTyr: 2.902 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.609GluAla: 4.609 ± 0.079	0.348GluCys: 0.348 ± 0.017	3.177GluAsp: 3.177 ± 0.063	3.85GluGlu: 3.85 ± 0.074	2.58GluPhe: 2.58 ± 0.047	3.766GluGly: 3.766 ± 0.054	1.113GluHis: 1.113 ± 0.033	4.524GluIle: 4.524 ± 0.07	4.829GluLys: 4.829 ± 0.071	5.471GluLeu: 5.471 ± 0.077	1.474GluMet: 1.474 ± 0.038	3.666GluAsn: 3.666 ± 0.059	1.676GluPro: 1.676 ± 0.039	2.292GluGln: 2.292 ± 0.048	2.382GluArg: 2.382 ± 0.052	2.93GluSer: 2.93 ± 0.052	3.348GluThr: 3.348 ± 0.055	4.021GluVal: 4.021 ± 0.064	0.643GluTrp: 0.643 ± 0.026	2.425GluTyr: 2.425 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.541PheAla: 3.541 ± 0.065	0.463PheCys: 0.463 ± 0.021	2.987PheAsp: 2.987 ± 0.05	2.967PheGlu: 2.967 ± 0.056	2.467PhePhe: 2.467 ± 0.053	3.41PheGly: 3.41 ± 0.062	0.736PheHis: 0.736 ± 0.027	3.69PheIle: 3.69 ± 0.063	3.491PheLys: 3.491 ± 0.062	4.098PheLeu: 4.098 ± 0.067	1.185PheMet: 1.185 ± 0.032	3.148PheAsn: 3.148 ± 0.058	1.66PhePro: 1.66 ± 0.043	1.12PheGln: 1.12 ± 0.033	1.647PheArg: 1.647 ± 0.039	3.591PheSer: 3.591 ± 0.063	3.756PheThr: 3.756 ± 0.066	2.894PheVal: 2.894 ± 0.048	0.486PheTrp: 0.486 ± 0.021	2.271PheTyr: 2.271 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.728GlyAla: 4.728 ± 0.067	0.619GlyCys: 0.619 ± 0.025	3.334GlyAsp: 3.334 ± 0.06	3.523GlyGlu: 3.523 ± 0.058	3.671GlyPhe: 3.671 ± 0.052	4.753GlyGly: 4.753 ± 0.087	1.256GlyHis: 1.256 ± 0.033	5.436GlyIle: 5.436 ± 0.062	5.026GlyLys: 5.026 ± 0.073	5.916GlyLeu: 5.916 ± 0.082	1.647GlyMet: 1.647 ± 0.047	3.908GlyAsn: 3.908 ± 0.069	1.451GlyPro: 1.451 ± 0.038	2.184GlyGln: 2.184 ± 0.043	2.35GlyArg: 2.35 ± 0.048	4.257GlySer: 4.257 ± 0.081	4.939GlyThr: 4.939 ± 0.106	4.408GlyVal: 4.408 ± 0.066	0.838GlyTrp: 0.838 ± 0.029	3.186GlyTyr: 3.186 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.116HisAla: 1.116 ± 0.031	0.158HisCys: 0.158 ± 0.012	0.98HisAsp: 0.98 ± 0.031	1.033HisGlu: 1.033 ± 0.033	1.071HisPhe: 1.071 ± 0.031	1.098HisGly: 1.098 ± 0.035	0.466HisHis: 0.466 ± 0.022	1.357HisIle: 1.357 ± 0.035	1.134HisLys: 1.134 ± 0.034	1.669HisLeu: 1.669 ± 0.038	0.307HisMet: 0.307 ± 0.018	1.104HisAsn: 1.104 ± 0.034	0.841HisPro: 0.841 ± 0.031	0.596HisGln: 0.596 ± 0.02	0.666HisArg: 0.666 ± 0.027	1.009HisSer: 1.009 ± 0.035	1.032HisThr: 1.032 ± 0.03	0.987HisVal: 0.987 ± 0.029	0.202HisTrp: 0.202 ± 0.015	0.883HisTyr: 0.883 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.152IleAla: 6.152 ± 0.08	0.59IleCys: 0.59 ± 0.021	4.456IleAsp: 4.456 ± 0.063	4.501IleGlu: 4.501 ± 0.07	3.244IlePhe: 3.244 ± 0.06	4.572IleGly: 4.572 ± 0.072	1.211IleHis: 1.211 ± 0.036	5.526IleIle: 5.526 ± 0.086	5.34IleLys: 5.34 ± 0.072	6.053IleLeu: 6.053 ± 0.078	1.495IleMet: 1.495 ± 0.04	4.646IleAsn: 4.646 ± 0.06	3.054IlePro: 3.054 ± 0.056	2.296IleGln: 2.296 ± 0.042	2.437IleArg: 2.437 ± 0.047	4.766IleSer: 4.766 ± 0.069	5.445IleThr: 5.445 ± 0.077	4.758IleVal: 4.758 ± 0.06	0.666IleTrp: 0.666 ± 0.026	2.802IleTyr: 2.802 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.266LysAla: 5.266 ± 0.077	0.306LysCys: 0.306 ± 0.018	4.396LysAsp: 4.396 ± 0.081	5.253LysGlu: 5.253 ± 0.076	2.753LysPhe: 2.753 ± 0.045	4.43LysGly: 4.43 ± 0.069	1.208LysHis: 1.208 ± 0.03	5.508LysIle: 5.508 ± 0.078	6.102LysLys: 6.102 ± 0.099	6.133LysLeu: 6.133 ± 0.087	1.927LysMet: 1.927 ± 0.041	4.54LysAsn: 4.54 ± 0.076	2.557LysPro: 2.557 ± 0.05	2.735LysGln: 2.735 ± 0.054	2.527LysArg: 2.527 ± 0.056	3.793LysSer: 3.793 ± 0.06	4.336LysThr: 4.336 ± 0.067	4.531LysVal: 4.531 ± 0.076	0.739LysTrp: 0.739 ± 0.025	2.973LysTyr: 2.973 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.522LeuAla: 6.522 ± 0.077	0.715LeuCys: 0.715 ± 0.025	4.64LeuAsp: 4.64 ± 0.072	5.121LeuGlu: 5.121 ± 0.081	4.525LeuPhe: 4.525 ± 0.075	5.707LeuGly: 5.707 ± 0.073	1.699LeuHis: 1.699 ± 0.045	5.995LeuIle: 5.995 ± 0.093	6.908LeuLys: 6.908 ± 0.098	8.971LeuLeu: 8.971 ± 0.107	2.086LeuMet: 2.086 ± 0.048	5.244LeuAsn: 5.244 ± 0.077	3.819LeuPro: 3.819 ± 0.064	3.629LeuGln: 3.629 ± 0.058	3.196LeuArg: 3.196 ± 0.05	6.164LeuSer: 6.164 ± 0.073	5.664LeuThr: 5.664 ± 0.072	5.195LeuVal: 5.195 ± 0.07	0.864LeuTrp: 0.864 ± 0.028	3.444LeuTyr: 3.444 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.934MetAla: 1.934 ± 0.043	0.126MetCys: 0.126 ± 0.011	1.175MetAsp: 1.175 ± 0.031	1.389MetGlu: 1.389 ± 0.036	0.899MetPhe: 0.899 ± 0.028	1.517MetGly: 1.517 ± 0.039	0.453MetHis: 0.453 ± 0.018	1.378MetIle: 1.378 ± 0.036	2.076MetLys: 2.076 ± 0.042	2.096MetLeu: 2.096 ± 0.039	0.562MetMet: 0.562 ± 0.026	1.127MetAsn: 1.127 ± 0.031	0.992MetPro: 0.992 ± 0.029	0.955MetGln: 0.955 ± 0.033	0.902MetArg: 0.902 ± 0.027	1.298MetSer: 1.298 ± 0.033	1.063MetThr: 1.063 ± 0.031	1.426MetVal: 1.426 ± 0.039	0.175MetTrp: 0.175 ± 0.012	0.79MetTyr: 0.79 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	4.397AsnAla: 4.397 ± 0.07	0.469AsnCys: 0.469 ± 0.023	3.209AsnAsp: 3.209 ± 0.06	3.287AsnGlu: 3.287 ± 0.053	2.989AsnPhe: 2.989 ± 0.053	4.301AsnGly: 4.301 ± 0.081	1.033AsnHis: 1.033 ± 0.029	4.501AsnIle: 4.501 ± 0.069	3.857AsnLys: 3.857 ± 0.063	4.986AsnLeu: 4.986 ± 0.074	1.226AsnMet: 1.226 ± 0.033	3.85AsnAsn: 3.85 ± 0.085	2.864AsnPro: 2.864 ± 0.052	1.725AsnGln: 1.725 ± 0.04	2.143AsnArg: 2.143 ± 0.043	3.429AsnSer: 3.429 ± 0.068	3.817AsnThr: 3.817 ± 0.078	3.736AsnVal: 3.736 ± 0.076	0.719AsnTrp: 0.719 ± 0.028	2.98AsnTyr: 2.98 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	3.12ProAla: 3.12 ± 0.07	0.214ProCys: 0.214 ± 0.015	2.408ProAsp: 2.408 ± 0.049	2.761ProGlu: 2.761 ± 0.045	1.873ProPhe: 1.873 ± 0.039	2.423ProGly: 2.423 ± 0.048	0.663ProHis: 0.663 ± 0.024	2.21ProIle: 2.21 ± 0.049	2.34ProLys: 2.34 ± 0.052	3.254ProLeu: 3.254 ± 0.053	0.686ProMet: 0.686 ± 0.024	2.1ProAsn: 2.1 ± 0.044	1.014ProPro: 1.014 ± 0.041	1.413ProGln: 1.413 ± 0.036	0.928ProArg: 0.928 ± 0.027	1.962ProSer: 1.962 ± 0.044	2.067ProThr: 2.067 ± 0.057	3.157ProVal: 3.157 ± 0.05	0.35ProTrp: 0.35 ± 0.017	1.588ProTyr: 1.588 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.473GlnAla: 2.473 ± 0.053	0.209GlnCys: 0.209 ± 0.015	1.743GlnAsp: 1.743 ± 0.034	2.071GlnGlu: 2.071 ± 0.043	1.659GlnPhe: 1.659 ± 0.038	1.98GlnGly: 1.98 ± 0.038	0.648GlnHis: 0.648 ± 0.026	2.304GlnIle: 2.304 ± 0.049	2.644GlnLys: 2.644 ± 0.058	3.471GlnLeu: 3.471 ± 0.054	0.833GlnMet: 0.833 ± 0.026	2.085GlnAsn: 2.085 ± 0.05	1.312GlnPro: 1.312 ± 0.033	1.667GlnGln: 1.667 ± 0.043	1.252GlnArg: 1.252 ± 0.035	2.016GlnSer: 2.016 ± 0.04	2.008GlnThr: 2.008 ± 0.051	2.081GlnVal: 2.081 ± 0.034	0.414GlnTrp: 0.414 ± 0.021	1.541GlnTyr: 1.541 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.241ArgAla: 2.241 ± 0.042	0.203ArgCys: 0.203 ± 0.012	1.849ArgAsp: 1.849 ± 0.045	2.197ArgGlu: 2.197 ± 0.048	1.827ArgPhe: 1.827 ± 0.042	1.924ArgGly: 1.924 ± 0.044	0.664ArgHis: 0.664 ± 0.026	2.797ArgIle: 2.797 ± 0.05	2.584ArgLys: 2.584 ± 0.053	3.299ArgLeu: 3.299 ± 0.053	0.966ArgMet: 0.966 ± 0.027	2.062ArgAsn: 2.062 ± 0.044	1.162ArgPro: 1.162 ± 0.032	1.291ArgGln: 1.291 ± 0.035	1.303ArgArg: 1.303 ± 0.029	1.869ArgSer: 1.869 ± 0.044	1.898ArgThr: 1.898 ± 0.045	2.29ArgVal: 2.29 ± 0.042	0.4ArgTrp: 0.4 ± 0.019	1.602ArgTyr: 1.602 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.432SerAla: 4.432 ± 0.081	0.586SerCys: 0.586 ± 0.023	3.031SerAsp: 3.031 ± 0.052	3.129SerGlu: 3.129 ± 0.056	3.448SerPhe: 3.448 ± 0.059	4.734SerGly: 4.734 ± 0.073	1.136SerHis: 1.136 ± 0.029	4.416SerIle: 4.416 ± 0.068	3.895SerLys: 3.895 ± 0.054	5.788SerLeu: 5.788 ± 0.075	1.23SerMet: 1.23 ± 0.035	3.163SerAsn: 3.163 ± 0.055	2.268SerPro: 2.268 ± 0.045	2.02SerGln: 2.02 ± 0.045	2.124SerArg: 2.124 ± 0.039	3.448SerSer: 3.448 ± 0.062	3.408SerThr: 3.408 ± 0.069	4.2SerVal: 4.2 ± 0.061	0.679SerTrp: 0.679 ± 0.027	2.686SerTyr: 2.686 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	5.517ThrAla: 5.517 ± 0.116	0.411ThrCys: 0.411 ± 0.024	3.782ThrAsp: 3.782 ± 0.063	3.404ThrGlu: 3.404 ± 0.058	3.149ThrPhe: 3.149 ± 0.056	5.381ThrGly: 5.381 ± 0.1	1.018ThrHis: 1.018 ± 0.031	5.055ThrIle: 5.055 ± 0.073	3.653ThrLys: 3.653 ± 0.06	5.799ThrLeu: 5.799 ± 0.073	1.079ThrMet: 1.079 ± 0.029	3.453ThrAsn: 3.453 ± 0.066	2.909ThrPro: 2.909 ± 0.066	2.085ThrGln: 2.085 ± 0.048	1.827ThrArg: 1.827 ± 0.038	3.759ThrSer: 3.759 ± 0.078	4.542ThrThr: 4.542 ± 0.115	4.757ThrVal: 4.757 ± 0.086	0.604ThrTrp: 0.604 ± 0.023	2.512ThrTyr: 2.512 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.237ValAla: 5.237 ± 0.089	0.548ValCys: 0.548 ± 0.023	3.17ValAsp: 3.17 ± 0.057	3.338ValGlu: 3.338 ± 0.057	3.232ValPhe: 3.232 ± 0.057	3.719ValGly: 3.719 ± 0.064	1.121ValHis: 1.121 ± 0.036	5.057ValIle: 5.057 ± 0.071	4.638ValLys: 4.638 ± 0.079	6.068ValLeu: 6.068 ± 0.075	1.463ValMet: 1.463 ± 0.041	4.073ValAsn: 4.073 ± 0.065	2.562ValPro: 2.562 ± 0.049	2.02ValGln: 2.02 ± 0.046	2.219ValArg: 2.219 ± 0.042	4.3ValSer: 4.3 ± 0.065	5.019ValThr: 5.019 ± 0.092	4.612ValVal: 4.612 ± 0.072	0.657ValTrp: 0.657 ± 0.024	2.628ValTyr: 2.628 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.774TrpAla: 0.774 ± 0.028	0.098TrpCys: 0.098 ± 0.009	0.609TrpAsp: 0.609 ± 0.021	0.663TrpGlu: 0.663 ± 0.027	0.525TrpPhe: 0.525 ± 0.022	0.735TrpGly: 0.735 ± 0.03	0.249TrpHis: 0.249 ± 0.015	0.699TrpIle: 0.699 ± 0.024	0.736TrpLys: 0.736 ± 0.023	1.004TrpLeu: 1.004 ± 0.032	0.3TrpMet: 0.3 ± 0.016	0.672TrpAsn: 0.672 ± 0.027	0.278TrpPro: 0.278 ± 0.017	0.465TrpGln: 0.465 ± 0.02	0.351TrpArg: 0.351 ± 0.016	0.592TrpSer: 0.592 ± 0.022	0.558TrpThr: 0.558 ± 0.021	0.672TrpVal: 0.672 ± 0.023	0.145TrpTrp: 0.145 ± 0.01	0.477TrpTyr: 0.477 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.87TyrAla: 2.87 ± 0.055	0.37TyrCys: 0.37 ± 0.019	2.428TyrAsp: 2.428 ± 0.049	2.271TyrGlu: 2.271 ± 0.049	2.375TyrPhe: 2.375 ± 0.049	2.778TyrGly: 2.778 ± 0.051	0.814TyrHis: 0.814 ± 0.025	2.964TyrIle: 2.964 ± 0.053	3.065TyrLys: 3.065 ± 0.058	3.701TyrLeu: 3.701 ± 0.062	0.838TyrMet: 0.838 ± 0.024	2.925TyrAsn: 2.925 ± 0.057	1.622TyrPro: 1.622 ± 0.036	1.406TyrGln: 1.406 ± 0.039	1.701TyrArg: 1.701 ± 0.041	2.802TyrSer: 2.802 ± 0.057	3.054TyrThr: 3.054 ± 0.062	2.38TyrVal: 2.38 ± 0.048	0.485TyrTrp: 0.485 ± 0.02	2.147TyrTyr: 2.147 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3691 proteins (1210709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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