Amino acid dipepetide frequency for Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.95AlaAla: 3.95 ± 0.953
1.129AlaCys: 1.129 ± 0.453
2.257AlaAsp: 2.257 ± 0.554
4.515AlaGlu: 4.515 ± 0.514
1.129AlaPhe: 1.129 ± 0.594
4.138AlaGly: 4.138 ± 0.838
0.564AlaHis: 0.564 ± 0.335
4.891AlaIle: 4.891 ± 1.107
2.445AlaLys: 2.445 ± 0.506
5.079AlaLeu: 5.079 ± 1.011
3.01AlaMet: 3.01 ± 0.674
2.445AlaAsn: 2.445 ± 0.466
2.634AlaPro: 2.634 ± 0.412
1.505AlaGln: 1.505 ± 0.409
2.822AlaArg: 2.822 ± 0.5
5.455AlaSer: 5.455 ± 1.124
4.891AlaThr: 4.891 ± 0.763
3.386AlaVal: 3.386 ± 0.812
0.941AlaTrp: 0.941 ± 0.406
1.505AlaTyr: 1.505 ± 0.356
0.0AlaXaa: 0.0 ± 0.0
Cys
0.752CysAla: 0.752 ± 0.327
0.188CysCys: 0.188 ± 0.163
0.752CysAsp: 0.752 ± 0.516
0.752CysGlu: 0.752 ± 0.399
1.317CysPhe: 1.317 ± 0.542
0.376CysGly: 0.376 ± 0.313
0.941CysHis: 0.941 ± 0.247
0.941CysIle: 0.941 ± 0.397
1.317CysLys: 1.317 ± 0.42
0.564CysLeu: 0.564 ± 0.241
1.129CysMet: 1.129 ± 0.273
1.317CysAsn: 1.317 ± 0.349
0.941CysPro: 0.941 ± 0.432
0.188CysGln: 0.188 ± 0.153
1.693CysArg: 1.693 ± 0.721
1.881CysSer: 1.881 ± 0.545
0.564CysThr: 0.564 ± 0.282
0.941CysVal: 0.941 ± 0.349
0.376CysTrp: 0.376 ± 0.246
0.564CysTyr: 0.564 ± 0.296
0.0CysXaa: 0.0 ± 0.0
Asp
3.386AspAla: 3.386 ± 0.374
1.693AspCys: 1.693 ± 0.37
1.317AspAsp: 1.317 ± 0.287
3.198AspGlu: 3.198 ± 0.538
2.445AspPhe: 2.445 ± 0.729
2.634AspGly: 2.634 ± 0.74
0.564AspHis: 0.564 ± 0.314
2.069AspIle: 2.069 ± 0.652
2.257AspLys: 2.257 ± 0.506
4.138AspLeu: 4.138 ± 0.531
1.693AspMet: 1.693 ± 0.488
3.198AspAsn: 3.198 ± 0.642
3.386AspPro: 3.386 ± 0.776
1.693AspGln: 1.693 ± 0.676
2.069AspArg: 2.069 ± 0.343
2.822AspSer: 2.822 ± 0.672
1.693AspThr: 1.693 ± 0.51
3.198AspVal: 3.198 ± 0.431
0.376AspTrp: 0.376 ± 0.212
1.693AspTyr: 1.693 ± 0.525
0.0AspXaa: 0.0 ± 0.0
Glu
3.01GluAla: 3.01 ± 0.546
1.693GluCys: 1.693 ± 0.613
4.327GluAsp: 4.327 ± 0.743
6.208GluGlu: 6.208 ± 0.826
2.257GluPhe: 2.257 ± 0.578
3.574GluGly: 3.574 ± 1.066
0.752GluHis: 0.752 ± 0.489
4.703GluIle: 4.703 ± 0.743
6.584GluLys: 6.584 ± 1.346
6.02GluLeu: 6.02 ± 0.584
3.01GluMet: 3.01 ± 0.605
3.574GluAsn: 3.574 ± 0.968
2.445GluPro: 2.445 ± 0.919
4.138GluGln: 4.138 ± 1.006
4.891GluArg: 4.891 ± 1.152
7.148GluSer: 7.148 ± 1.176
2.822GluThr: 2.822 ± 0.677
4.891GluVal: 4.891 ± 1.117
1.317GluTrp: 1.317 ± 0.586
2.069GluTyr: 2.069 ± 0.315
0.0GluXaa: 0.0 ± 0.0
Phe
1.317PheAla: 1.317 ± 0.409
0.188PheCys: 0.188 ± 0.156
1.129PheAsp: 1.129 ± 0.557
5.079PheGlu: 5.079 ± 0.854
1.693PhePhe: 1.693 ± 0.453
1.881PheGly: 1.881 ± 0.324
0.941PheHis: 0.941 ± 0.364
1.881PheIle: 1.881 ± 0.546
1.129PheLys: 1.129 ± 0.438
4.138PheLeu: 4.138 ± 0.857
0.376PheMet: 0.376 ± 0.248
2.069PheAsn: 2.069 ± 0.65
0.941PhePro: 0.941 ± 0.346
2.634PheGln: 2.634 ± 0.655
1.505PheArg: 1.505 ± 0.288
3.762PheSer: 3.762 ± 0.553
3.198PheThr: 3.198 ± 0.479
3.01PheVal: 3.01 ± 0.716
0.564PheTrp: 0.564 ± 0.267
0.752PheTyr: 0.752 ± 0.311
0.0PheXaa: 0.0 ± 0.0
Gly
2.634GlyAla: 2.634 ± 0.66
0.376GlyCys: 0.376 ± 0.202
3.01GlyAsp: 3.01 ± 0.327
4.138GlyGlu: 4.138 ± 1.206
2.634GlyPhe: 2.634 ± 0.452
3.574GlyGly: 3.574 ± 1.008
0.752GlyHis: 0.752 ± 0.358
4.891GlyIle: 4.891 ± 0.677
2.634GlyLys: 2.634 ± 0.61
4.891GlyLeu: 4.891 ± 1.075
2.069GlyMet: 2.069 ± 0.445
3.386GlyAsn: 3.386 ± 0.877
3.386GlyPro: 3.386 ± 0.625
1.693GlyGln: 1.693 ± 0.333
5.267GlyArg: 5.267 ± 0.692
3.95GlySer: 3.95 ± 1.116
5.267GlyThr: 5.267 ± 0.646
5.267GlyVal: 5.267 ± 0.51
1.317GlyTrp: 1.317 ± 0.638
2.257GlyTyr: 2.257 ± 0.535
0.0GlyXaa: 0.0 ± 0.0
His
0.941HisAla: 0.941 ± 0.332
0.188HisCys: 0.188 ± 0.17
0.752HisAsp: 0.752 ± 0.402
1.129HisGlu: 1.129 ± 0.315
1.881HisPhe: 1.881 ± 0.408
1.317HisGly: 1.317 ± 0.339
0.376HisHis: 0.376 ± 0.305
1.505HisIle: 1.505 ± 0.672
0.941HisLys: 0.941 ± 0.41
1.693HisLeu: 1.693 ± 0.459
0.564HisMet: 0.564 ± 0.279
0.376HisAsn: 0.376 ± 0.305
1.317HisPro: 1.317 ± 0.417
0.752HisGln: 0.752 ± 0.26
1.505HisArg: 1.505 ± 0.516
1.881HisSer: 1.881 ± 0.497
0.376HisThr: 0.376 ± 0.248
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.752HisTyr: 0.752 ± 0.325
0.0HisXaa: 0.0 ± 0.0
Ile
3.574IleAla: 3.574 ± 0.723
2.257IleCys: 2.257 ± 0.483
2.822IleAsp: 2.822 ± 0.741
6.02IleGlu: 6.02 ± 1.983
1.129IlePhe: 1.129 ± 0.321
4.891IleGly: 4.891 ± 0.964
0.941IleHis: 0.941 ± 0.378
4.327IleIle: 4.327 ± 0.875
4.327IleLys: 4.327 ± 0.782
6.396IleLeu: 6.396 ± 1.568
3.01IleMet: 3.01 ± 0.611
3.01IleAsn: 3.01 ± 0.597
1.881IlePro: 1.881 ± 0.531
2.069IleGln: 2.069 ± 0.371
5.455IleArg: 5.455 ± 1.069
3.198IleSer: 3.198 ± 1.004
4.327IleThr: 4.327 ± 0.943
3.95IleVal: 3.95 ± 0.615
0.941IleTrp: 0.941 ± 0.549
0.941IleTyr: 0.941 ± 0.428
0.0IleXaa: 0.0 ± 0.0
Lys
4.891LysAla: 4.891 ± 0.75
1.505LysCys: 1.505 ± 0.547
2.445LysAsp: 2.445 ± 0.435
4.891LysGlu: 4.891 ± 0.966
1.693LysPhe: 1.693 ± 0.777
3.01LysGly: 3.01 ± 0.695
1.129LysHis: 1.129 ± 0.284
4.703LysIle: 4.703 ± 0.631
4.327LysLys: 4.327 ± 1.209
3.762LysLeu: 3.762 ± 1.008
2.822LysMet: 2.822 ± 0.525
2.445LysAsn: 2.445 ± 0.598
1.129LysPro: 1.129 ± 0.545
1.505LysGln: 1.505 ± 0.676
5.267LysArg: 5.267 ± 1.214
3.386LysSer: 3.386 ± 0.775
4.327LysThr: 4.327 ± 1.008
3.01LysVal: 3.01 ± 0.819
1.505LysTrp: 1.505 ± 0.451
2.069LysTyr: 2.069 ± 0.402
0.0LysXaa: 0.0 ± 0.0
Leu
4.891LeuAla: 4.891 ± 0.688
0.941LeuCys: 0.941 ± 0.345
1.505LeuAsp: 1.505 ± 0.496
6.584LeuGlu: 6.584 ± 0.909
2.257LeuPhe: 2.257 ± 0.456
2.822LeuGly: 2.822 ± 0.778
0.941LeuHis: 0.941 ± 0.352
6.02LeuIle: 6.02 ± 0.736
7.336LeuLys: 7.336 ± 1.487
6.396LeuLeu: 6.396 ± 1.068
2.822LeuMet: 2.822 ± 0.578
3.95LeuAsn: 3.95 ± 0.738
3.386LeuPro: 3.386 ± 0.527
3.386LeuGln: 3.386 ± 0.73
6.772LeuArg: 6.772 ± 1.442
4.515LeuSer: 4.515 ± 0.774
6.02LeuThr: 6.02 ± 1.397
3.574LeuVal: 3.574 ± 1.039
1.693LeuTrp: 1.693 ± 0.35
2.257LeuTyr: 2.257 ± 0.918
0.0LeuXaa: 0.0 ± 0.0
Met
3.95MetAla: 3.95 ± 0.726
1.693MetCys: 1.693 ± 0.609
3.198MetAsp: 3.198 ± 1.049
6.02MetGlu: 6.02 ± 0.693
0.941MetPhe: 0.941 ± 0.673
2.445MetGly: 2.445 ± 0.825
0.564MetHis: 0.564 ± 0.314
2.822MetIle: 2.822 ± 0.562
2.445MetLys: 2.445 ± 0.612
1.505MetLeu: 1.505 ± 0.341
2.069MetMet: 2.069 ± 0.654
0.376MetAsn: 0.376 ± 0.217
0.564MetPro: 0.564 ± 0.271
1.129MetGln: 1.129 ± 0.41
1.881MetArg: 1.881 ± 0.602
2.634MetSer: 2.634 ± 0.555
1.505MetThr: 1.505 ± 0.595
4.138MetVal: 4.138 ± 1.034
0.376MetTrp: 0.376 ± 0.252
0.941MetTyr: 0.941 ± 0.28
0.0MetXaa: 0.0 ± 0.0
Asn
3.198AsnAla: 3.198 ± 0.767
0.188AsnCys: 0.188 ± 0.153
3.01AsnAsp: 3.01 ± 0.599
3.95AsnGlu: 3.95 ± 0.738
1.881AsnPhe: 1.881 ± 0.303
5.831AsnGly: 5.831 ± 1.499
0.564AsnHis: 0.564 ± 0.303
2.445AsnIle: 2.445 ± 0.477
2.445AsnLys: 2.445 ± 0.658
3.386AsnLeu: 3.386 ± 0.389
1.693AsnMet: 1.693 ± 0.656
1.693AsnAsn: 1.693 ± 0.558
4.891AsnPro: 4.891 ± 0.682
2.822AsnGln: 2.822 ± 0.795
3.01AsnArg: 3.01 ± 0.571
3.762AsnSer: 3.762 ± 0.724
3.762AsnThr: 3.762 ± 0.712
2.069AsnVal: 2.069 ± 0.792
0.752AsnTrp: 0.752 ± 0.387
0.752AsnTyr: 0.752 ± 0.347
0.0AsnXaa: 0.0 ± 0.0
Pro
2.634ProAla: 2.634 ± 0.789
0.564ProCys: 0.564 ± 0.344
1.693ProAsp: 1.693 ± 0.546
2.822ProGlu: 2.822 ± 0.572
1.881ProPhe: 1.881 ± 0.422
2.069ProGly: 2.069 ± 0.398
0.752ProHis: 0.752 ± 0.366
2.445ProIle: 2.445 ± 0.329
3.198ProLys: 3.198 ± 0.665
3.198ProLeu: 3.198 ± 0.665
1.693ProMet: 1.693 ± 0.548
3.762ProAsn: 3.762 ± 0.9
0.941ProPro: 0.941 ± 0.37
0.752ProGln: 0.752 ± 0.313
2.069ProArg: 2.069 ± 0.726
3.198ProSer: 3.198 ± 0.745
2.257ProThr: 2.257 ± 0.603
1.693ProVal: 1.693 ± 0.599
0.564ProTrp: 0.564 ± 0.3
1.129ProTyr: 1.129 ± 0.626
0.0ProXaa: 0.0 ± 0.0
Gln
2.257GlnAla: 2.257 ± 0.838
0.564GlnCys: 0.564 ± 0.253
2.069GlnAsp: 2.069 ± 0.504
2.069GlnGlu: 2.069 ± 0.595
0.564GlnPhe: 0.564 ± 0.27
3.198GlnGly: 3.198 ± 0.828
0.564GlnHis: 0.564 ± 0.372
3.198GlnIle: 3.198 ± 0.425
2.445GlnLys: 2.445 ± 0.727
3.574GlnLeu: 3.574 ± 0.639
2.445GlnMet: 2.445 ± 0.734
2.445GlnAsn: 2.445 ± 0.533
0.752GlnPro: 0.752 ± 0.338
1.129GlnGln: 1.129 ± 0.369
3.762GlnArg: 3.762 ± 0.944
3.198GlnSer: 3.198 ± 0.68
2.822GlnThr: 2.822 ± 0.696
1.505GlnVal: 1.505 ± 0.429
0.564GlnTrp: 0.564 ± 0.405
0.752GlnTyr: 0.752 ± 0.218
0.0GlnXaa: 0.0 ± 0.0
Arg
4.327ArgAla: 4.327 ± 0.856
0.376ArgCys: 0.376 ± 0.235
3.386ArgAsp: 3.386 ± 0.693
3.386ArgGlu: 3.386 ± 0.766
2.634ArgPhe: 2.634 ± 0.524
5.455ArgGly: 5.455 ± 0.976
0.564ArgHis: 0.564 ± 0.282
4.515ArgIle: 4.515 ± 0.738
2.634ArgLys: 2.634 ± 0.518
5.455ArgLeu: 5.455 ± 0.647
3.762ArgMet: 3.762 ± 1.132
5.267ArgAsn: 5.267 ± 1.02
2.257ArgPro: 2.257 ± 0.691
3.574ArgGln: 3.574 ± 0.72
6.02ArgArg: 6.02 ± 0.866
3.95ArgSer: 3.95 ± 0.868
6.02ArgThr: 6.02 ± 0.805
3.198ArgVal: 3.198 ± 1.069
0.564ArgTrp: 0.564 ± 0.323
1.317ArgTyr: 1.317 ± 0.562
0.0ArgXaa: 0.0 ± 0.0
Ser
3.95SerAla: 3.95 ± 0.959
1.693SerCys: 1.693 ± 0.786
2.822SerAsp: 2.822 ± 0.568
3.386SerGlu: 3.386 ± 0.726
5.455SerPhe: 5.455 ± 0.787
5.455SerGly: 5.455 ± 0.945
1.881SerHis: 1.881 ± 0.749
5.267SerIle: 5.267 ± 0.767
2.634SerLys: 2.634 ± 0.659
6.02SerLeu: 6.02 ± 0.864
2.822SerMet: 2.822 ± 0.871
3.574SerAsn: 3.574 ± 1.028
2.822SerPro: 2.822 ± 0.529
3.95SerGln: 3.95 ± 0.846
3.574SerArg: 3.574 ± 0.608
7.336SerSer: 7.336 ± 1.027
4.891SerThr: 4.891 ± 0.612
4.138SerVal: 4.138 ± 0.806
1.505SerTrp: 1.505 ± 0.65
1.693SerTyr: 1.693 ± 0.532
0.0SerXaa: 0.0 ± 0.0
Thr
3.01ThrAla: 3.01 ± 0.621
1.129ThrCys: 1.129 ± 0.36
2.069ThrAsp: 2.069 ± 0.717
4.515ThrGlu: 4.515 ± 0.833
2.445ThrPhe: 2.445 ± 0.481
4.515ThrGly: 4.515 ± 0.89
2.257ThrHis: 2.257 ± 0.683
4.703ThrIle: 4.703 ± 0.689
4.515ThrLys: 4.515 ± 0.625
3.95ThrLeu: 3.95 ± 0.335
2.257ThrMet: 2.257 ± 0.441
3.574ThrAsn: 3.574 ± 0.314
1.881ThrPro: 1.881 ± 0.474
3.198ThrGln: 3.198 ± 0.87
4.327ThrArg: 4.327 ± 0.824
3.386ThrSer: 3.386 ± 0.657
3.01ThrThr: 3.01 ± 0.828
4.327ThrVal: 4.327 ± 0.955
0.941ThrTrp: 0.941 ± 0.274
3.198ThrTyr: 3.198 ± 0.502
0.0ThrXaa: 0.0 ± 0.0
Val
4.703ValAla: 4.703 ± 0.922
0.941ValCys: 0.941 ± 0.424
4.138ValAsp: 4.138 ± 1.232
3.574ValGlu: 3.574 ± 0.623
2.445ValPhe: 2.445 ± 0.55
3.198ValGly: 3.198 ± 0.716
1.693ValHis: 1.693 ± 0.678
0.752ValIle: 0.752 ± 0.26
4.138ValLys: 4.138 ± 1.178
5.455ValLeu: 5.455 ± 1.312
1.881ValMet: 1.881 ± 0.521
3.574ValAsn: 3.574 ± 0.693
1.693ValPro: 1.693 ± 0.585
2.069ValGln: 2.069 ± 0.677
4.327ValArg: 4.327 ± 1.454
5.455ValSer: 5.455 ± 0.664
2.069ValThr: 2.069 ± 0.401
3.01ValVal: 3.01 ± 0.572
0.752ValTrp: 0.752 ± 0.376
1.505ValTyr: 1.505 ± 0.43
0.0ValXaa: 0.0 ± 0.0
Trp
0.564TrpAla: 0.564 ± 0.251
0.0TrpCys: 0.0 ± 0.0
0.752TrpAsp: 0.752 ± 0.314
1.505TrpGlu: 1.505 ± 0.496
0.376TrpPhe: 0.376 ± 0.235
0.941TrpGly: 0.941 ± 0.285
0.564TrpHis: 0.564 ± 0.303
1.317TrpIle: 1.317 ± 0.423
0.752TrpLys: 0.752 ± 0.553
1.129TrpLeu: 1.129 ± 0.442
0.941TrpMet: 0.941 ± 0.332
0.752TrpAsn: 0.752 ± 0.278
0.376TrpPro: 0.376 ± 0.221
0.188TrpGln: 0.188 ± 0.153
0.752TrpArg: 0.752 ± 0.378
1.505TrpSer: 1.505 ± 0.606
1.693TrpThr: 1.693 ± 0.497
1.129TrpVal: 1.129 ± 0.63
0.564TrpTrp: 0.564 ± 0.245
0.376TrpTyr: 0.376 ± 0.266
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.752TyrAla: 0.752 ± 0.313
0.188TyrCys: 0.188 ± 0.17
2.069TyrAsp: 2.069 ± 0.649
1.693TyrGlu: 1.693 ± 0.54
1.129TyrPhe: 1.129 ± 0.276
2.069TyrGly: 2.069 ± 0.412
0.941TyrHis: 0.941 ± 0.628
2.069TyrIle: 2.069 ± 0.287
1.317TyrLys: 1.317 ± 0.293
1.317TyrLeu: 1.317 ± 0.478
0.941TyrMet: 0.941 ± 0.424
1.505TyrAsn: 1.505 ± 0.469
1.693TyrPro: 1.693 ± 0.584
1.505TyrGln: 1.505 ± 0.365
1.693TyrArg: 1.693 ± 0.862
2.445TyrSer: 2.445 ± 0.343
1.693TyrThr: 1.693 ± 0.542
0.941TyrVal: 0.941 ± 0.387
0.564TyrTrp: 0.564 ± 0.297
0.376TyrTyr: 0.376 ± 0.248
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (5317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski