Amino acid dipepetide frequency for Leishmania infantum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.36AlaAla: 21.36 ± 0.156	1.775AlaCys: 1.775 ± 0.025	5.513AlaAsp: 5.513 ± 0.047	7.526AlaGlu: 7.526 ± 0.071	3.011AlaPhe: 3.011 ± 0.028	7.127AlaGly: 7.127 ± 0.055	2.781AlaHis: 2.781 ± 0.028	2.949AlaIle: 2.949 ± 0.026	3.809AlaLys: 3.809 ± 0.049	10.292AlaLeu: 10.292 ± 0.067	2.565AlaMet: 2.565 ± 0.027	2.716AlaAsn: 2.716 ± 0.025	7.242AlaPro: 7.242 ± 0.15	4.498AlaGln: 4.498 ± 0.044	6.937AlaArg: 6.937 ± 0.055	11.159AlaSer: 11.159 ± 0.09	7.812AlaThr: 7.812 ± 0.063	8.956AlaVal: 8.956 ± 0.158	1.005AlaTrp: 1.005 ± 0.016	2.275AlaTyr: 2.275 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	2.271CysAla: 2.271 ± 0.084	0.533CysCys: 0.533 ± 0.013	0.926CysAsp: 0.926 ± 0.019	0.924CysGlu: 0.924 ± 0.015	0.684CysPhe: 0.684 ± 0.012	1.574CysGly: 1.574 ± 0.023	0.44CysHis: 0.44 ± 0.01	0.711CysIle: 0.711 ± 0.014	0.492CysLys: 0.492 ± 0.009	1.544CysLeu: 1.544 ± 0.02	0.408CysMet: 0.408 ± 0.009	0.476CysAsn: 0.476 ± 0.011	0.88CysPro: 0.88 ± 0.017	0.487CysGln: 0.487 ± 0.01	1.284CysArg: 1.284 ± 0.018	1.565CysSer: 1.565 ± 0.021	1.211CysThr: 1.211 ± 0.019	1.659CysVal: 1.659 ± 0.025	0.208CysTrp: 0.208 ± 0.007	0.461CysTyr: 0.461 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.69AspAla: 6.69 ± 0.04	0.752AspCys: 0.752 ± 0.013	3.54AspAsp: 3.54 ± 0.037	3.568AspGlu: 3.568 ± 0.038	1.427AspPhe: 1.427 ± 0.019	4.312AspGly: 4.312 ± 0.034	0.946AspHis: 0.946 ± 0.014	1.716AspIle: 1.716 ± 0.022	1.456AspLys: 1.456 ± 0.022	3.599AspLeu: 3.599 ± 0.035	1.158AspMet: 1.158 ± 0.016	1.252AspAsn: 1.252 ± 0.017	2.319AspPro: 2.319 ± 0.035	1.096AspGln: 1.096 ± 0.014	2.739AspArg: 2.739 ± 0.042	3.508AspSer: 3.508 ± 0.035	2.739AspThr: 2.739 ± 0.032	4.197AspVal: 4.197 ± 0.037	0.482AspTrp: 0.482 ± 0.011	1.178AspTyr: 1.178 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	7.631GluAla: 7.631 ± 0.075	0.908GluCys: 0.908 ± 0.017	3.534GluAsp: 3.534 ± 0.041	5.834GluGlu: 5.834 ± 0.071	1.298GluPhe: 1.298 ± 0.022	3.731GluGly: 3.731 ± 0.031	1.44GluHis: 1.44 ± 0.019	1.449GluIle: 1.449 ± 0.019	2.698GluLys: 2.698 ± 0.038	5.674GluLeu: 5.674 ± 0.056	1.533GluMet: 1.533 ± 0.02	1.55GluAsn: 1.55 ± 0.02	2.177GluPro: 2.177 ± 0.029	2.68GluGln: 2.68 ± 0.04	4.694GluArg: 4.694 ± 0.048	3.819GluSer: 3.819 ± 0.034	2.801GluThr: 2.801 ± 0.058	4.444GluVal: 4.444 ± 0.032	0.736GluTrp: 0.736 ± 0.017	1.322GluTyr: 1.322 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.861PheAla: 2.861 ± 0.028	0.641PheCys: 0.641 ± 0.013	1.554PheAsp: 1.554 ± 0.022	1.447PheGlu: 1.447 ± 0.017	1.445PhePhe: 1.445 ± 0.019	1.909PheGly: 1.909 ± 0.027	0.833PheHis: 0.833 ± 0.013	1.074PheIle: 1.074 ± 0.017	0.845PheLys: 0.845 ± 0.015	2.988PheLeu: 2.988 ± 0.031	0.709PheMet: 0.709 ± 0.012	0.87PheAsn: 0.87 ± 0.016	1.463PhePro: 1.463 ± 0.016	1.007PheGln: 1.007 ± 0.014	1.746PheArg: 1.746 ± 0.021	2.673PheSer: 2.673 ± 0.026	1.856PheThr: 1.856 ± 0.024	2.316PheVal: 2.316 ± 0.023	0.302PheTrp: 0.302 ± 0.008	0.919PheTyr: 0.919 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	8.006GlyAla: 8.006 ± 0.066	1.267GlyCys: 1.267 ± 0.018	3.78GlyAsp: 3.78 ± 0.031	3.645GlyGlu: 3.645 ± 0.032	1.853GlyPhe: 1.853 ± 0.026	6.943GlyGly: 6.943 ± 0.075	1.52GlyHis: 1.52 ± 0.019	2.095GlyIle: 2.095 ± 0.022	2.339GlyLys: 2.339 ± 0.025	4.43GlyLeu: 4.43 ± 0.035	1.382GlyMet: 1.382 ± 0.019	1.977GlyAsn: 1.977 ± 0.022	2.455GlyPro: 2.455 ± 0.035	1.839GlyGln: 1.839 ± 0.02	4.193GlyArg: 4.193 ± 0.036	6.113GlySer: 6.113 ± 0.045	3.975GlyThr: 3.975 ± 0.032	4.939GlyVal: 4.939 ± 0.081	0.63GlyTrp: 0.63 ± 0.011	1.486GlyTyr: 1.486 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	2.785HisAla: 2.785 ± 0.027	0.553HisCys: 0.553 ± 0.011	1.2HisAsp: 1.2 ± 0.019	1.349HisGlu: 1.349 ± 0.019	0.839HisPhe: 0.839 ± 0.013	1.818HisGly: 1.818 ± 0.024	1.119HisHis: 1.119 ± 0.041	0.932HisIle: 0.932 ± 0.014	0.75HisLys: 0.75 ± 0.012	2.461HisLeu: 2.461 ± 0.024	0.566HisMet: 0.566 ± 0.011	0.775HisAsn: 0.775 ± 0.015	1.627HisPro: 1.627 ± 0.02	1.119HisGln: 1.119 ± 0.016	2.345HisArg: 2.345 ± 0.024	2.133HisSer: 2.133 ± 0.026	1.618HisThr: 1.618 ± 0.019	1.9HisVal: 1.9 ± 0.02	0.296HisTrp: 0.296 ± 0.008	0.75HisTyr: 0.75 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.273IleAla: 3.273 ± 0.032	0.563IleCys: 0.563 ± 0.012	1.691IleAsp: 1.691 ± 0.022	1.786IleGlu: 1.786 ± 0.025	1.116IlePhe: 1.116 ± 0.02	1.943IleGly: 1.943 ± 0.023	0.774IleHis: 0.774 ± 0.013	1.201IleIle: 1.201 ± 0.017	1.002IleLys: 1.002 ± 0.017	2.551IleLeu: 2.551 ± 0.029	0.711IleMet: 0.711 ± 0.013	0.862IleAsn: 0.862 ± 0.015	1.785IlePro: 1.785 ± 0.02	1.055IleGln: 1.055 ± 0.015	1.941IleArg: 1.941 ± 0.022	2.359IleSer: 2.359 ± 0.025	1.894IleThr: 1.894 ± 0.023	2.26IleVal: 2.26 ± 0.026	0.24IleTrp: 0.24 ± 0.007	0.732IleTyr: 0.732 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.698LysAla: 3.698 ± 0.041	0.495LysCys: 0.495 ± 0.01	1.825LysAsp: 1.825 ± 0.026	2.592LysGlu: 2.592 ± 0.038	0.705LysPhe: 0.705 ± 0.015	2.108LysGly: 2.108 ± 0.024	0.83LysHis: 0.83 ± 0.014	0.942LysIle: 0.942 ± 0.018	1.963LysLys: 1.963 ± 0.032	2.809LysLeu: 2.809 ± 0.035	0.881LysMet: 0.881 ± 0.017	0.954LysAsn: 0.954 ± 0.017	1.673LysPro: 1.673 ± 0.026	1.458LysGln: 1.458 ± 0.023	2.772LysArg: 2.772 ± 0.03	2.311LysSer: 2.311 ± 0.025	1.859LysThr: 1.859 ± 0.021	2.179LysVal: 2.179 ± 0.026	0.369LysTrp: 0.369 ± 0.012	0.862LysTyr: 0.862 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.549LeuAla: 8.549 ± 0.062	2.11LeuCys: 2.11 ± 0.025	4.006LeuAsp: 4.006 ± 0.037	5.272LeuGlu: 5.272 ± 0.055	3.15LeuPhe: 3.15 ± 0.032	4.42LeuGly: 4.42 ± 0.032	3.006LeuHis: 3.006 ± 0.027	2.571LeuIle: 2.571 ± 0.027	3.007LeuLys: 3.007 ± 0.036	10.283LeuLeu: 10.283 ± 0.08	2.004LeuMet: 2.004 ± 0.02	2.329LeuAsn: 2.329 ± 0.027	5.931LeuPro: 5.931 ± 0.041	4.987LeuGln: 4.987 ± 0.049	8.168LeuArg: 8.168 ± 0.096	7.895LeuSer: 7.895 ± 0.047	4.912LeuThr: 4.912 ± 0.034	5.762LeuVal: 5.762 ± 0.059	1.125LeuTrp: 1.125 ± 0.017	2.373LeuTyr: 2.373 ± 0.024	0.001LeuXaa: 0.001 ± 0.0
Met	2.264MetAla: 2.264 ± 0.023	0.418MetCys: 0.418 ± 0.01	1.108MetAsp: 1.108 ± 0.015	1.564MetGlu: 1.564 ± 0.018	0.582MetPhe: 0.582 ± 0.012	1.191MetGly: 1.191 ± 0.019	0.626MetHis: 0.626 ± 0.011	0.659MetIle: 0.659 ± 0.014	0.892MetLys: 0.892 ± 0.014	2.123MetLeu: 2.123 ± 0.024	0.688MetMet: 0.688 ± 0.016	0.738MetAsn: 0.738 ± 0.018	1.42MetPro: 1.42 ± 0.02	1.142MetGln: 1.142 ± 0.016	1.797MetArg: 1.797 ± 0.018	1.868MetSer: 1.868 ± 0.019	1.27MetThr: 1.27 ± 0.016	1.305MetVal: 1.305 ± 0.016	0.294MetTrp: 0.294 ± 0.008	0.573MetTyr: 0.573 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.239AsnAla: 3.239 ± 0.03	0.472AsnCys: 0.472 ± 0.011	1.39AsnAsp: 1.39 ± 0.02	1.505AsnGlu: 1.505 ± 0.02	0.819AsnPhe: 0.819 ± 0.015	2.232AsnGly: 2.232 ± 0.026	0.58AsnHis: 0.58 ± 0.01	1.025AsnIle: 1.025 ± 0.015	0.863AsnLys: 0.863 ± 0.015	1.906AsnLeu: 1.906 ± 0.023	0.619AsnMet: 0.619 ± 0.012	0.863AsnAsn: 0.863 ± 0.016	1.451AsnPro: 1.451 ± 0.021	0.706AsnGln: 0.706 ± 0.014	1.619AsnArg: 1.619 ± 0.021	2.161AsnSer: 2.161 ± 0.025	1.758AsnThr: 1.758 ± 0.021	1.977AsnVal: 1.977 ± 0.021	0.249AsnTrp: 0.249 ± 0.008	0.736AsnTyr: 0.736 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.744ProAla: 6.744 ± 0.066	0.906ProCys: 0.906 ± 0.017	2.015ProAsp: 2.015 ± 0.02	2.569ProGlu: 2.569 ± 0.029	1.798ProPhe: 1.798 ± 0.023	2.777ProGly: 2.777 ± 0.032	1.724ProHis: 1.724 ± 0.021	1.528ProIle: 1.528 ± 0.018	1.568ProLys: 1.568 ± 0.023	5.977ProLeu: 5.977 ± 0.05	1.112ProMet: 1.112 ± 0.015	1.351ProAsn: 1.351 ± 0.019	5.841ProPro: 5.841 ± 0.077	2.492ProGln: 2.492 ± 0.037	3.745ProArg: 3.745 ± 0.051	6.76ProSer: 6.76 ± 0.143	3.767ProThr: 3.767 ± 0.036	3.692ProVal: 3.692 ± 0.033	0.549ProTrp: 0.549 ± 0.01	1.316ProTyr: 1.316 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.669GlnAla: 3.669 ± 0.042	0.737GlnCys: 0.737 ± 0.014	1.448GlnAsp: 1.448 ± 0.023	2.53GlnGlu: 2.53 ± 0.043	0.914GlnPhe: 0.914 ± 0.016	1.851GlnGly: 1.851 ± 0.02	1.551GlnHis: 1.551 ± 0.021	0.929GlnIle: 0.929 ± 0.015	1.377GlnLys: 1.377 ± 0.021	4.994GlnLeu: 4.994 ± 0.091	0.891GlnMet: 0.891 ± 0.014	0.919GlnAsn: 0.919 ± 0.013	2.371GlnPro: 2.371 ± 0.03	4.301GlnGln: 4.301 ± 0.185	4.544GlnArg: 4.544 ± 0.035	2.691GlnSer: 2.691 ± 0.025	1.801GlnThr: 1.801 ± 0.021	2.298GlnVal: 2.298 ± 0.025	0.57GlnTrp: 0.57 ± 0.01	1.026GlnTyr: 1.026 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.24ArgAla: 7.24 ± 0.088	1.644ArgCys: 1.644 ± 0.022	3.441ArgAsp: 3.441 ± 0.034	4.454ArgGlu: 4.454 ± 0.044	2.008ArgPhe: 2.008 ± 0.023	4.673ArgGly: 4.673 ± 0.041	2.439ArgHis: 2.439 ± 0.027	2.27ArgIle: 2.27 ± 0.021	2.561ArgLys: 2.561 ± 0.026	6.908ArgLeu: 6.908 ± 0.058	1.569ArgMet: 1.569 ± 0.022	1.894ArgAsn: 1.894 ± 0.022	3.331ArgPro: 3.331 ± 0.052	3.567ArgGln: 3.567 ± 0.035	7.517ArgArg: 7.517 ± 0.169	5.786ArgSer: 5.786 ± 0.042	3.745ArgThr: 3.745 ± 0.032	4.774ArgVal: 4.774 ± 0.033	0.965ArgTrp: 0.965 ± 0.015	1.902ArgTyr: 1.902 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	11.312SerAla: 11.312 ± 0.202	1.533SerCys: 1.533 ± 0.02	3.75SerAsp: 3.75 ± 0.032	3.894SerGlu: 3.894 ± 0.044	2.614SerPhe: 2.614 ± 0.024	6.25SerGly: 6.25 ± 0.049	2.002SerHis: 2.002 ± 0.024	2.638SerIle: 2.638 ± 0.027	2.414SerLys: 2.414 ± 0.025	7.606SerLeu: 7.606 ± 0.041	1.86SerMet: 1.86 ± 0.022	2.176SerAsn: 2.176 ± 0.024	6.133SerPro: 6.133 ± 0.059	2.597SerGln: 2.597 ± 0.026	5.523SerArg: 5.523 ± 0.039	11.703SerSer: 11.703 ± 0.484	6.107SerThr: 6.107 ± 0.041	5.862SerVal: 5.862 ± 0.037	0.826SerTrp: 0.826 ± 0.014	1.671SerTyr: 1.671 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.272ThrAla: 8.272 ± 0.057	0.962ThrCys: 0.962 ± 0.014	2.495ThrAsp: 2.495 ± 0.023	3.164ThrGlu: 3.164 ± 0.037	1.714ThrPhe: 1.714 ± 0.019	3.622ThrGly: 3.622 ± 0.029	1.464ThrHis: 1.464 ± 0.018	1.792ThrIle: 1.792 ± 0.021	1.747ThrLys: 1.747 ± 0.024	5.359ThrLeu: 5.359 ± 0.038	1.237ThrMet: 1.237 ± 0.016	1.475ThrAsn: 1.475 ± 0.016	4.319ThrPro: 4.319 ± 0.04	2.036ThrGln: 2.036 ± 0.022	3.529ThrArg: 3.529 ± 0.028	5.781ThrSer: 5.781 ± 0.047	4.448ThrThr: 4.448 ± 0.051	4.367ThrVal: 4.367 ± 0.038	0.56ThrTrp: 0.56 ± 0.012	1.307ThrTyr: 1.307 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	8.101ValAla: 8.101 ± 0.054	1.665ValCys: 1.665 ± 0.091	3.684ValAsp: 3.684 ± 0.029	4.386ValGlu: 4.386 ± 0.031	2.291ValPhe: 2.291 ± 0.023	4.149ValGly: 4.149 ± 0.072	1.897ValHis: 1.897 ± 0.022	2.02ValIle: 2.02 ± 0.027	2.316ValLys: 2.316 ± 0.027	7.121ValLeu: 7.121 ± 0.062	1.67ValMet: 1.67 ± 0.02	1.828ValAsn: 1.828 ± 0.02	4.242ValPro: 4.242 ± 0.038	3.041ValGln: 3.041 ± 0.086	4.819ValArg: 4.819 ± 0.034	5.692ValSer: 5.692 ± 0.04	4.023ValThr: 4.023 ± 0.03	5.887ValVal: 5.887 ± 0.16	0.78ValTrp: 0.78 ± 0.013	1.82ValTyr: 1.82 ± 0.023	0.001ValXaa: 0.001 ± 0.0
Trp	0.951TrpAla: 0.951 ± 0.017	0.309TrpCys: 0.309 ± 0.007	0.481TrpAsp: 0.481 ± 0.011	0.574TrpGlu: 0.574 ± 0.013	0.295TrpPhe: 0.295 ± 0.007	0.611TrpGly: 0.611 ± 0.013	0.288TrpHis: 0.288 ± 0.007	0.351TrpIle: 0.351 ± 0.008	0.451TrpLys: 0.451 ± 0.009	1.028TrpLeu: 1.028 ± 0.017	0.351TrpMet: 0.351 ± 0.01	0.361TrpAsn: 0.361 ± 0.008	0.44TrpPro: 0.44 ± 0.01	0.467TrpGln: 0.467 ± 0.011	1.078TrpArg: 1.078 ± 0.018	0.856TrpSer: 0.856 ± 0.015	0.581TrpThr: 0.581 ± 0.011	0.684TrpVal: 0.684 ± 0.013	0.231TrpTrp: 0.231 ± 0.008	0.311TrpTyr: 0.311 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.026	0.495TyrCys: 0.495 ± 0.01	1.292TyrAsp: 1.292 ± 0.017	1.368TyrGlu: 1.368 ± 0.023	0.897TyrPhe: 0.897 ± 0.014	1.627TyrGly: 1.627 ± 0.023	0.675TyrHis: 0.675 ± 0.013	0.891TyrIle: 0.891 ± 0.017	0.738TyrLys: 0.738 ± 0.015	2.211TyrLeu: 2.211 ± 0.028	0.605TyrMet: 0.605 ± 0.013	0.803TyrAsn: 0.803 ± 0.017	1.132TyrPro: 1.132 ± 0.018	0.836TyrGln: 0.836 ± 0.013	1.696TyrArg: 1.696 ± 0.023	1.636TyrSer: 1.636 ± 0.024	1.473TyrThr: 1.473 ± 0.022	1.974TyrVal: 1.974 ± 0.025	0.281TyrTrp: 0.281 ± 0.008	0.875TyrTyr: 0.875 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.006

Statistics based on 8045 proteins (5116451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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