Amino acid dipepetide frequency for Cetobacterium ceti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.131AlaAla: 3.131 ± 0.096
0.522AlaCys: 0.522 ± 0.027
1.988AlaAsp: 1.988 ± 0.062
2.705AlaGlu: 2.705 ± 0.073
2.452AlaPhe: 2.452 ± 0.077
3.904AlaGly: 3.904 ± 0.097
0.771AlaHis: 0.771 ± 0.036
5.034AlaIle: 5.034 ± 0.094
4.273AlaLys: 4.273 ± 0.083
5.451AlaLeu: 5.451 ± 0.099
1.5AlaMet: 1.5 ± 0.048
2.368AlaAsn: 2.368 ± 0.07
1.477AlaPro: 1.477 ± 0.051
1.378AlaGln: 1.378 ± 0.046
1.74AlaArg: 1.74 ± 0.056
2.62AlaSer: 2.62 ± 0.067
2.705AlaThr: 2.705 ± 0.069
3.099AlaVal: 3.099 ± 0.075
0.316AlaTrp: 0.316 ± 0.022
2.012AlaTyr: 2.012 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.42CysAla: 0.42 ± 0.024
0.086CysCys: 0.086 ± 0.011
0.465CysAsp: 0.465 ± 0.024
0.643CysGlu: 0.643 ± 0.029
0.349CysPhe: 0.349 ± 0.021
0.92CysGly: 0.92 ± 0.041
0.167CysHis: 0.167 ± 0.017
0.659CysIle: 0.659 ± 0.033
0.75CysLys: 0.75 ± 0.033
0.654CysLeu: 0.654 ± 0.033
0.184CysMet: 0.184 ± 0.017
0.451CysAsn: 0.451 ± 0.025
0.421CysPro: 0.421 ± 0.027
0.185CysGln: 0.185 ± 0.015
0.27CysArg: 0.27 ± 0.02
0.529CysSer: 0.529 ± 0.028
0.395CysThr: 0.395 ± 0.024
0.484CysVal: 0.484 ± 0.027
0.042CysTrp: 0.042 ± 0.007
0.26CysTyr: 0.26 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
1.756AspAla: 1.756 ± 0.062
0.42AspCys: 0.42 ± 0.025
1.895AspAsp: 1.895 ± 0.056
3.81AspGlu: 3.81 ± 0.081
2.978AspPhe: 2.978 ± 0.061
3.159AspGly: 3.159 ± 0.083
0.635AspHis: 0.635 ± 0.031
5.659AspIle: 5.659 ± 0.097
4.935AspLys: 4.935 ± 0.09
5.041AspLeu: 5.041 ± 0.091
1.33AspMet: 1.33 ± 0.041
2.856AspAsn: 2.856 ± 0.073
1.325AspPro: 1.325 ± 0.047
0.824AspGln: 0.824 ± 0.035
1.828AspArg: 1.828 ± 0.055
2.734AspSer: 2.734 ± 0.069
2.187AspThr: 2.187 ± 0.053
2.857AspVal: 2.857 ± 0.083
0.376AspTrp: 0.376 ± 0.029
2.69AspTyr: 2.69 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
3.815GluAla: 3.815 ± 0.089
0.466GluCys: 0.466 ± 0.022
4.08GluAsp: 4.08 ± 0.077
7.551GluGlu: 7.551 ± 0.144
3.557GluPhe: 3.557 ± 0.07
3.995GluGly: 3.995 ± 0.079
0.865GluHis: 0.865 ± 0.036
8.945GluIle: 8.945 ± 0.126
10.285GluLys: 10.285 ± 0.159
6.832GluLeu: 6.832 ± 0.119
1.934GluMet: 1.934 ± 0.05
7.408GluAsn: 7.408 ± 0.114
1.318GluPro: 1.318 ± 0.043
1.325GluGln: 1.325 ± 0.045
2.791GluArg: 2.791 ± 0.07
3.146GluSer: 3.146 ± 0.068
3.189GluThr: 3.189 ± 0.055
4.755GluVal: 4.755 ± 0.094
0.398GluTrp: 0.398 ± 0.026
3.373GluTyr: 3.373 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.173PheAla: 2.173 ± 0.061
0.375PheCys: 0.375 ± 0.021
2.232PheAsp: 2.232 ± 0.05
2.959PheGlu: 2.959 ± 0.062
2.716PhePhe: 2.716 ± 0.077
3.333PheGly: 3.333 ± 0.076
0.634PheHis: 0.634 ± 0.033
5.072PheIle: 5.072 ± 0.114
4.593PheLys: 4.593 ± 0.072
5.424PheLeu: 5.424 ± 0.111
1.212PheMet: 1.212 ± 0.041
2.998PheAsn: 2.998 ± 0.069
1.473PhePro: 1.473 ± 0.043
1.392PheGln: 1.392 ± 0.049
1.366PheArg: 1.366 ± 0.037
3.559PheSer: 3.559 ± 0.075
2.559PheThr: 2.559 ± 0.054
2.435PheVal: 2.435 ± 0.059
0.327PheTrp: 0.327 ± 0.021
2.374PheTyr: 2.374 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
4.484GlyAla: 4.484 ± 0.103
0.667GlyCys: 0.667 ± 0.037
3.615GlyAsp: 3.615 ± 0.077
5.31GlyGlu: 5.31 ± 0.111
3.245GlyPhe: 3.245 ± 0.074
5.046GlyGly: 5.046 ± 0.091
0.993GlyHis: 0.993 ± 0.038
7.646GlyIle: 7.646 ± 0.122
6.535GlyLys: 6.535 ± 0.108
5.866GlyLeu: 5.866 ± 0.104
1.855GlyMet: 1.855 ± 0.056
3.682GlyAsn: 3.682 ± 0.091
1.297GlyPro: 1.297 ± 0.052
1.398GlyGln: 1.398 ± 0.045
2.321GlyArg: 2.321 ± 0.055
3.429GlySer: 3.429 ± 0.073
3.817GlyThr: 3.817 ± 0.1
4.964GlyVal: 4.964 ± 0.104
0.442GlyTrp: 0.442 ± 0.024
2.932GlyTyr: 2.932 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.505HisAla: 0.505 ± 0.028
0.16HisCys: 0.16 ± 0.016
0.525HisAsp: 0.525 ± 0.026
0.809HisGlu: 0.809 ± 0.033
0.657HisPhe: 0.657 ± 0.028
1.057HisGly: 1.057 ± 0.035
0.289HisHis: 0.289 ± 0.021
1.278HisIle: 1.278 ± 0.043
1.032HisLys: 1.032 ± 0.038
1.294HisLeu: 1.294 ± 0.036
0.402HisMet: 0.402 ± 0.023
0.761HisAsn: 0.761 ± 0.031
0.6HisPro: 0.6 ± 0.028
0.28HisGln: 0.28 ± 0.018
0.529HisArg: 0.529 ± 0.026
0.797HisSer: 0.797 ± 0.037
0.608HisThr: 0.608 ± 0.031
0.658HisVal: 0.658 ± 0.033
0.11HisTrp: 0.11 ± 0.011
0.494HisTyr: 0.494 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.034IleAla: 5.034 ± 0.102
0.889IleCys: 0.889 ± 0.04
5.422IleAsp: 5.422 ± 0.075
7.988IleGlu: 7.988 ± 0.128
5.65IlePhe: 5.65 ± 0.127
6.884IleGly: 6.884 ± 0.117
1.186IleHis: 1.186 ± 0.035
9.193IleIle: 9.193 ± 0.159
9.389IleLys: 9.389 ± 0.132
10.815IleLeu: 10.815 ± 0.139
2.021IleMet: 2.021 ± 0.048
5.986IleAsn: 5.986 ± 0.104
3.671IlePro: 3.671 ± 0.073
1.881IleGln: 1.881 ± 0.053
2.941IleArg: 2.941 ± 0.067
6.644IleSer: 6.644 ± 0.103
4.662IleThr: 4.662 ± 0.087
5.619IleVal: 5.619 ± 0.089
0.587IleTrp: 0.587 ± 0.03
4.189IleTyr: 4.189 ± 0.094
0.0IleXaa: 0.0 ± 0.0
Lys
4.224LysAla: 4.224 ± 0.09
0.671LysCys: 0.671 ± 0.035
5.643LysAsp: 5.643 ± 0.107
10.023LysGlu: 10.023 ± 0.144
3.985LysPhe: 3.985 ± 0.072
5.49LysGly: 5.49 ± 0.098
1.079LysHis: 1.079 ± 0.039
10.6LysIle: 10.6 ± 0.15
10.54LysLys: 10.54 ± 0.15
8.234LysLeu: 8.234 ± 0.125
2.567LysMet: 2.567 ± 0.058
8.762LysAsn: 8.762 ± 0.154
2.052LysPro: 2.052 ± 0.053
1.548LysGln: 1.548 ± 0.043
3.288LysArg: 3.288 ± 0.066
4.778LysSer: 4.778 ± 0.087
4.363LysThr: 4.363 ± 0.071
5.671LysVal: 5.671 ± 0.105
0.639LysTrp: 0.639 ± 0.033
4.901LysTyr: 4.901 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
5.107LeuAla: 5.107 ± 0.113
0.814LeuCys: 0.814 ± 0.028
5.326LeuAsp: 5.326 ± 0.106
8.727LeuGlu: 8.727 ± 0.131
4.163LeuPhe: 4.163 ± 0.087
7.604LeuGly: 7.604 ± 0.12
1.112LeuHis: 1.112 ± 0.042
8.255LeuIle: 8.255 ± 0.129
10.416LeuLys: 10.416 ± 0.123
8.711LeuLeu: 8.711 ± 0.137
2.305LeuMet: 2.305 ± 0.06
6.619LeuAsn: 6.619 ± 0.108
2.902LeuPro: 2.902 ± 0.055
2.054LeuGln: 2.054 ± 0.045
3.16LeuArg: 3.16 ± 0.07
6.001LeuSer: 6.001 ± 0.115
4.723LeuThr: 4.723 ± 0.084
5.144LeuVal: 5.144 ± 0.098
0.546LeuTrp: 0.546 ± 0.026
3.372LeuTyr: 3.372 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.752MetAla: 1.752 ± 0.057
0.169MetCys: 0.169 ± 0.015
1.449MetAsp: 1.449 ± 0.045
2.312MetGlu: 2.312 ± 0.06
0.97MetPhe: 0.97 ± 0.034
2.128MetGly: 2.128 ± 0.061
0.229MetHis: 0.229 ± 0.017
2.1MetIle: 2.1 ± 0.05
2.787MetLys: 2.787 ± 0.06
1.929MetLeu: 1.929 ± 0.049
0.543MetMet: 0.543 ± 0.028
1.451MetAsn: 1.451 ± 0.042
0.69MetPro: 0.69 ± 0.028
0.351MetGln: 0.351 ± 0.022
0.876MetArg: 0.876 ± 0.037
1.33MetSer: 1.33 ± 0.05
1.176MetThr: 1.176 ± 0.042
1.602MetVal: 1.602 ± 0.045
0.161MetTrp: 0.161 ± 0.016
0.73MetTyr: 0.73 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.021AsnAla: 2.021 ± 0.056
0.541AsnCys: 0.541 ± 0.03
2.388AsnAsp: 2.388 ± 0.055
4.118AsnGlu: 4.118 ± 0.078
3.581AsnPhe: 3.581 ± 0.074
4.015AsnGly: 4.015 ± 0.098
0.825AsnHis: 0.825 ± 0.036
7.955AsnIle: 7.955 ± 0.136
6.699AsnLys: 6.699 ± 0.126
7.087AsnLeu: 7.087 ± 0.135
1.602AsnMet: 1.602 ± 0.047
4.501AsnAsn: 4.501 ± 0.115
2.454AsnPro: 2.454 ± 0.052
1.36AsnGln: 1.36 ± 0.045
2.26AsnArg: 2.26 ± 0.057
4.124AsnSer: 4.124 ± 0.096
2.696AsnThr: 2.696 ± 0.075
2.918AsnVal: 2.918 ± 0.069
0.468AsnTrp: 0.468 ± 0.027
3.082AsnTyr: 3.082 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
1.356ProAla: 1.356 ± 0.052
0.283ProCys: 0.283 ± 0.02
1.222ProAsp: 1.222 ± 0.044
2.633ProGlu: 2.633 ± 0.062
1.491ProPhe: 1.491 ± 0.046
2.116ProGly: 2.116 ± 0.074
0.536ProHis: 0.536 ± 0.029
2.671ProIle: 2.671 ± 0.058
2.45ProLys: 2.45 ± 0.054
2.813ProLeu: 2.813 ± 0.06
0.805ProMet: 0.805 ± 0.029
1.567ProAsn: 1.567 ± 0.045
0.593ProPro: 0.593 ± 0.03
0.729ProGln: 0.729 ± 0.028
0.896ProArg: 0.896 ± 0.034
1.555ProSer: 1.555 ± 0.051
1.498ProThr: 1.498 ± 0.045
2.015ProVal: 2.015 ± 0.056
0.247ProTrp: 0.247 ± 0.017
1.259ProTyr: 1.259 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
0.981GlnAla: 0.981 ± 0.043
0.207GlnCys: 0.207 ± 0.016
0.927GlnAsp: 0.927 ± 0.035
1.881GlnGlu: 1.881 ± 0.051
0.892GlnPhe: 0.892 ± 0.04
1.749GlnGly: 1.749 ± 0.053
0.224GlnHis: 0.224 ± 0.018
1.927GlnIle: 1.927 ± 0.048
1.931GlnLys: 1.931 ± 0.047
1.908GlnLeu: 1.908 ± 0.05
0.605GlnMet: 0.605 ± 0.024
1.396GlnAsn: 1.396 ± 0.04
0.493GlnPro: 0.493 ± 0.03
0.493GlnGln: 0.493 ± 0.032
0.806GlnArg: 0.806 ± 0.037
1.128GlnSer: 1.128 ± 0.047
0.876GlnThr: 0.876 ± 0.039
1.162GlnVal: 1.162 ± 0.038
0.227GlnTrp: 0.227 ± 0.016
0.842GlnTyr: 0.842 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
1.842ArgAla: 1.842 ± 0.047
0.261ArgCys: 0.261 ± 0.018
1.942ArgAsp: 1.942 ± 0.058
3.643ArgGlu: 3.643 ± 0.081
1.408ArgPhe: 1.408 ± 0.043
2.351ArgGly: 2.351 ± 0.06
0.369ArgHis: 0.369 ± 0.021
3.116ArgIle: 3.116 ± 0.064
3.314ArgLys: 3.314 ± 0.074
2.515ArgLeu: 2.515 ± 0.056
0.849ArgMet: 0.849 ± 0.031
2.07ArgAsn: 2.07 ± 0.049
0.74ArgPro: 0.74 ± 0.037
0.653ArgGln: 0.653 ± 0.028
1.337ArgArg: 1.337 ± 0.049
1.451ArgSer: 1.451 ± 0.051
1.524ArgThr: 1.524 ± 0.047
2.32ArgVal: 2.32 ± 0.06
0.202ArgTrp: 0.202 ± 0.015
1.317ArgTyr: 1.317 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
2.639SerAla: 2.639 ± 0.07
0.51SerCys: 0.51 ± 0.028
2.359SerAsp: 2.359 ± 0.055
3.856SerGlu: 3.856 ± 0.079
3.188SerPhe: 3.188 ± 0.071
4.066SerGly: 4.066 ± 0.084
0.815SerHis: 0.815 ± 0.031
5.664SerIle: 5.664 ± 0.086
5.599SerLys: 5.599 ± 0.1
6.398SerLeu: 6.398 ± 0.098
1.36SerMet: 1.36 ± 0.045
3.134SerAsn: 3.134 ± 0.071
1.692SerPro: 1.692 ± 0.05
1.571SerGln: 1.571 ± 0.053
1.851SerArg: 1.851 ± 0.058
3.613SerSer: 3.613 ± 0.078
2.946SerThr: 2.946 ± 0.062
2.974SerVal: 2.974 ± 0.071
0.437SerTrp: 0.437 ± 0.026
2.343SerTyr: 2.343 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
2.58ThrAla: 2.58 ± 0.072
0.402ThrCys: 0.402 ± 0.025
2.109ThrAsp: 2.109 ± 0.056
2.876ThrGlu: 2.876 ± 0.067
2.512ThrPhe: 2.512 ± 0.061
3.822ThrGly: 3.822 ± 0.09
0.72ThrHis: 0.72 ± 0.027
4.661ThrIle: 4.661 ± 0.099
3.687ThrLys: 3.687 ± 0.065
5.432ThrLeu: 5.432 ± 0.095
1.112ThrMet: 1.112 ± 0.039
2.49ThrAsn: 2.49 ± 0.074
2.004ThrPro: 2.004 ± 0.048
0.966ThrGln: 0.966 ± 0.03
1.482ThrArg: 1.482 ± 0.049
2.932ThrSer: 2.932 ± 0.058
2.538ThrThr: 2.538 ± 0.079
3.12ThrVal: 3.12 ± 0.096
0.36ThrTrp: 0.36 ± 0.021
2.151ThrTyr: 2.151 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
3.694ValAla: 3.694 ± 0.091
0.465ValCys: 0.465 ± 0.027
3.109ValAsp: 3.109 ± 0.067
4.561ValGlu: 4.561 ± 0.096
2.535ValPhe: 2.535 ± 0.066
4.324ValGly: 4.324 ± 0.092
0.735ValHis: 0.735 ± 0.037
5.452ValIle: 5.452 ± 0.091
5.16ValLys: 5.16 ± 0.085
5.594ValLeu: 5.594 ± 0.085
1.345ValMet: 1.345 ± 0.041
3.14ValAsn: 3.14 ± 0.079
1.995ValPro: 1.995 ± 0.066
1.252ValGln: 1.252 ± 0.039
1.78ValArg: 1.78 ± 0.053
3.392ValSer: 3.392 ± 0.067
3.211ValThr: 3.211 ± 0.076
4.022ValVal: 4.022 ± 0.093
0.338ValTrp: 0.338 ± 0.023
2.188ValTyr: 2.188 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.359TrpAla: 0.359 ± 0.026
0.076TrpCys: 0.076 ± 0.011
0.411TrpAsp: 0.411 ± 0.025
0.589TrpGlu: 0.589 ± 0.029
0.328TrpPhe: 0.328 ± 0.02
0.511TrpGly: 0.511 ± 0.028
0.094TrpHis: 0.094 ± 0.011
0.611TrpIle: 0.611 ± 0.03
0.558TrpLys: 0.558 ± 0.025
0.546TrpLeu: 0.546 ± 0.026
0.191TrpMet: 0.191 ± 0.016
0.407TrpAsn: 0.407 ± 0.025
0.136TrpPro: 0.136 ± 0.011
0.183TrpGln: 0.183 ± 0.015
0.218TrpArg: 0.218 ± 0.018
0.344TrpSer: 0.344 ± 0.02
0.278TrpThr: 0.278 ± 0.021
0.392TrpVal: 0.392 ± 0.024
0.066TrpTrp: 0.066 ± 0.011
0.264TrpTyr: 0.264 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.574TyrAla: 1.574 ± 0.051
0.352TyrCys: 0.352 ± 0.023
2.185TyrAsp: 2.185 ± 0.056
3.037TyrGlu: 3.037 ± 0.068
2.549TyrPhe: 2.549 ± 0.068
3.068TyrGly: 3.068 ± 0.058
0.565TyrHis: 0.565 ± 0.025
4.154TyrIle: 4.154 ± 0.089
4.124TyrLys: 4.124 ± 0.08
4.515TyrLeu: 4.515 ± 0.097
1.015TyrMet: 1.015 ± 0.035
2.651TyrAsn: 2.651 ± 0.063
1.403TyrPro: 1.403 ± 0.047
0.833TyrGln: 0.833 ± 0.034
1.483TyrArg: 1.483 ± 0.046
2.908TyrSer: 2.908 ± 0.076
2.003TyrThr: 2.003 ± 0.056
2.081TyrVal: 2.081 ± 0.051
0.27TyrTrp: 0.27 ± 0.018
1.898TyrTyr: 1.898 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2511 proteins (788890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski