Amino acid dipepetide frequency for Desulfuromonas acetexigens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.161AlaAla: 12.161 ± 0.169	1.352AlaCys: 1.352 ± 0.047	5.46AlaAsp: 5.46 ± 0.079	7.954AlaGlu: 7.954 ± 0.102	3.752AlaPhe: 3.752 ± 0.062	8.928AlaGly: 8.928 ± 0.094	1.846AlaHis: 1.846 ± 0.041	5.022AlaIle: 5.022 ± 0.073	3.683AlaLys: 3.683 ± 0.067	12.16AlaLeu: 12.16 ± 0.139	2.397AlaMet: 2.397 ± 0.053	2.417AlaAsn: 2.417 ± 0.055	4.525AlaPro: 4.525 ± 0.088	3.327AlaGln: 3.327 ± 0.055	7.183AlaArg: 7.183 ± 0.1	4.423AlaSer: 4.423 ± 0.064	4.798AlaThr: 4.798 ± 0.082	7.441AlaVal: 7.441 ± 0.105	1.055AlaTrp: 1.055 ± 0.032	2.274AlaTyr: 2.274 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.247CysAla: 1.247 ± 0.051	0.193CysCys: 0.193 ± 0.015	0.606CysAsp: 0.606 ± 0.025	0.614CysGlu: 0.614 ± 0.029	0.414CysPhe: 0.414 ± 0.02	1.245CysGly: 1.245 ± 0.038	0.924CysHis: 0.924 ± 0.123	0.454CysIle: 0.454 ± 0.017	0.354CysLys: 0.354 ± 0.017	1.295CysLeu: 1.295 ± 0.035	0.209CysMet: 0.209 ± 0.013	0.292CysAsn: 0.292 ± 0.017	0.749CysPro: 0.749 ± 0.032	0.361CysGln: 0.361 ± 0.018	1.049CysArg: 1.049 ± 0.031	0.641CysSer: 0.641 ± 0.029	0.507CysThr: 0.507 ± 0.027	0.681CysVal: 0.681 ± 0.024	0.122CysTrp: 0.122 ± 0.01	0.277CysTyr: 0.277 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.693AspAla: 4.693 ± 0.078	0.823AspCys: 0.823 ± 0.057	2.783AspAsp: 2.783 ± 0.057	3.849AspGlu: 3.849 ± 0.056	2.639AspPhe: 2.639 ± 0.05	4.697AspGly: 4.697 ± 0.09	1.117AspHis: 1.117 ± 0.03	2.882AspIle: 2.882 ± 0.054	1.935AspLys: 1.935 ± 0.05	6.64AspLeu: 6.64 ± 0.093	1.032AspMet: 1.032 ± 0.035	1.5AspAsn: 1.5 ± 0.043	3.03AspPro: 3.03 ± 0.061	1.761AspGln: 1.761 ± 0.048	3.799AspArg: 3.799 ± 0.065	2.511AspSer: 2.511 ± 0.049	2.072AspThr: 2.072 ± 0.042	3.144AspVal: 3.144 ± 0.06	0.739AspTrp: 0.739 ± 0.03	1.884AspTyr: 1.884 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.127GluAla: 7.127 ± 0.098	0.596GluCys: 0.596 ± 0.029	3.097GluAsp: 3.097 ± 0.057	5.65GluGlu: 5.65 ± 0.094	2.388GluPhe: 2.388 ± 0.045	4.965GluGly: 4.965 ± 0.076	1.27GluHis: 1.27 ± 0.033	4.445GluIle: 4.445 ± 0.075	3.836GluLys: 3.836 ± 0.068	7.909GluLeu: 7.909 ± 0.095	1.739GluMet: 1.739 ± 0.043	2.23GluAsn: 2.23 ± 0.05	2.518GluPro: 2.518 ± 0.049	2.878GluGln: 2.878 ± 0.053	5.461GluArg: 5.461 ± 0.083	3.324GluSer: 3.324 ± 0.059	3.694GluThr: 3.694 ± 0.061	5.106GluVal: 5.106 ± 0.08	0.633GluTrp: 0.633 ± 0.023	1.391GluTyr: 1.391 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.13PheAla: 4.13 ± 0.059	0.581PheCys: 0.581 ± 0.019	2.556PheAsp: 2.556 ± 0.057	2.233PheGlu: 2.233 ± 0.046	2.038PhePhe: 2.038 ± 0.046	3.399PheGly: 3.399 ± 0.061	0.822PheHis: 0.822 ± 0.029	1.948PheIle: 1.948 ± 0.042	1.364PheLys: 1.364 ± 0.036	4.297PheLeu: 4.297 ± 0.074	0.832PheMet: 0.832 ± 0.029	1.252PheAsn: 1.252 ± 0.038	1.85PhePro: 1.85 ± 0.045	1.117PheGln: 1.117 ± 0.029	2.449PheArg: 2.449 ± 0.054	2.718PheSer: 2.718 ± 0.052	2.112PheThr: 2.112 ± 0.048	2.669PheVal: 2.669 ± 0.05	0.506PheTrp: 0.506 ± 0.024	1.119PheTyr: 1.119 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.314GlyAla: 7.314 ± 0.099	1.259GlyCys: 1.259 ± 0.043	4.31GlyAsp: 4.31 ± 0.073	6.078GlyGlu: 6.078 ± 0.079	3.374GlyPhe: 3.374 ± 0.055	6.602GlyGly: 6.602 ± 0.092	1.787GlyHis: 1.787 ± 0.041	4.77GlyIle: 4.77 ± 0.072	4.13GlyLys: 4.13 ± 0.07	8.808GlyLeu: 8.808 ± 0.107	2.272GlyMet: 2.272 ± 0.044	2.344GlyAsn: 2.344 ± 0.053	2.535GlyPro: 2.535 ± 0.049	2.821GlyGln: 2.821 ± 0.048	5.917GlyArg: 5.917 ± 0.078	4.138GlySer: 4.138 ± 0.066	4.056GlyThr: 4.056 ± 0.068	5.775GlyVal: 5.775 ± 0.077	0.983GlyTrp: 0.983 ± 0.031	2.427GlyTyr: 2.427 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.854HisAla: 1.854 ± 0.058	0.324HisCys: 0.324 ± 0.018	1.097HisAsp: 1.097 ± 0.035	1.201HisGlu: 1.201 ± 0.037	1.006HisPhe: 1.006 ± 0.032	1.907HisGly: 1.907 ± 0.047	0.592HisHis: 0.592 ± 0.045	0.982HisIle: 0.982 ± 0.03	0.702HisLys: 0.702 ± 0.031	2.539HisLeu: 2.539 ± 0.051	0.367HisMet: 0.367 ± 0.019	0.656HisAsn: 0.656 ± 0.025	1.54HisPro: 1.54 ± 0.048	0.807HisGln: 0.807 ± 0.027	1.535HisArg: 1.535 ± 0.043	1.071HisSer: 1.071 ± 0.037	0.878HisThr: 0.878 ± 0.035	1.125HisVal: 1.125 ± 0.039	0.295HisTrp: 0.295 ± 0.017	0.659HisTyr: 0.659 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.413IleAla: 5.413 ± 0.085	0.645IleCys: 0.645 ± 0.025	3.653IleAsp: 3.653 ± 0.051	3.753IleGlu: 3.753 ± 0.062	2.244IlePhe: 2.244 ± 0.043	4.248IleGly: 4.248 ± 0.071	1.231IleHis: 1.231 ± 0.034	2.514IleIle: 2.514 ± 0.058	1.948IleLys: 1.948 ± 0.05	5.678IleLeu: 5.678 ± 0.091	0.916IleMet: 0.916 ± 0.031	1.636IleAsn: 1.636 ± 0.045	2.886IlePro: 2.886 ± 0.055	1.49IleGln: 1.49 ± 0.04	3.428IleArg: 3.428 ± 0.057	2.942IleSer: 2.942 ± 0.057	2.489IleThr: 2.489 ± 0.052	3.57IleVal: 3.57 ± 0.073	0.458IleTrp: 0.458 ± 0.019	1.316IleTyr: 1.316 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.873LysAla: 3.873 ± 0.064	0.362LysCys: 0.362 ± 0.02	2.09LysAsp: 2.09 ± 0.05	3.031LysGlu: 3.031 ± 0.08	1.22LysPhe: 1.22 ± 0.034	3.25LysGly: 3.25 ± 0.061	0.725LysHis: 0.725 ± 0.028	2.622LysIle: 2.622 ± 0.057	2.493LysLys: 2.493 ± 0.066	3.863LysLeu: 3.863 ± 0.056	1.007LysMet: 1.007 ± 0.033	1.434LysAsn: 1.434 ± 0.04	1.761LysPro: 1.761 ± 0.045	1.306LysGln: 1.306 ± 0.039	2.535LysArg: 2.535 ± 0.052	2.237LysSer: 2.237 ± 0.046	2.346LysThr: 2.346 ± 0.049	2.926LysVal: 2.926 ± 0.077	0.308LysTrp: 0.308 ± 0.02	1.007LysTyr: 1.007 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.625LeuAla: 13.625 ± 0.14	1.383LeuCys: 1.383 ± 0.039	6.438LeuAsp: 6.438 ± 0.089	7.365LeuGlu: 7.365 ± 0.09	4.577LeuPhe: 4.577 ± 0.068	8.918LeuGly: 8.918 ± 0.108	2.276LeuHis: 2.276 ± 0.045	5.502LeuIle: 5.502 ± 0.092	4.742LeuLys: 4.742 ± 0.071	14.085LeuLeu: 14.085 ± 0.178	2.152LeuMet: 2.152 ± 0.04	3.001LeuAsn: 3.001 ± 0.053	6.285LeuPro: 6.285 ± 0.082	3.397LeuGln: 3.397 ± 0.059	8.422LeuArg: 8.422 ± 0.122	6.473LeuSer: 6.473 ± 0.093	5.887LeuThr: 5.887 ± 0.078	7.808LeuVal: 7.808 ± 0.101	1.114LeuTrp: 1.114 ± 0.038	2.66LeuTyr: 2.66 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.494MetAla: 2.494 ± 0.049	0.139MetCys: 0.139 ± 0.012	1.06MetAsp: 1.06 ± 0.027	1.472MetGlu: 1.472 ± 0.036	0.579MetPhe: 0.579 ± 0.028	1.659MetGly: 1.659 ± 0.043	0.385MetHis: 0.385 ± 0.021	1.161MetIle: 1.161 ± 0.031	1.249MetLys: 1.249 ± 0.032	2.252MetLeu: 2.252 ± 0.044	0.45MetMet: 0.45 ± 0.022	0.83MetAsn: 0.83 ± 0.029	1.143MetPro: 1.143 ± 0.04	0.7MetGln: 0.7 ± 0.025	1.292MetArg: 1.292 ± 0.033	1.257MetSer: 1.257 ± 0.035	1.396MetThr: 1.396 ± 0.038	1.599MetVal: 1.599 ± 0.042	0.105MetTrp: 0.105 ± 0.011	0.358MetTyr: 0.358 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.389AsnAla: 2.389 ± 0.05	0.362AsnCys: 0.362 ± 0.021	1.457AsnAsp: 1.457 ± 0.043	1.493AsnGlu: 1.493 ± 0.037	1.222AsnPhe: 1.222 ± 0.037	2.074AsnGly: 2.074 ± 0.05	0.639AsnHis: 0.639 ± 0.022	1.658AsnIle: 1.658 ± 0.044	1.003AsnLys: 1.003 ± 0.033	3.638AsnLeu: 3.638 ± 0.056	0.547AsnMet: 0.547 ± 0.027	0.901AsnAsn: 0.901 ± 0.03	2.008AsnPro: 2.008 ± 0.043	0.975AsnGln: 0.975 ± 0.03	2.273AsnArg: 2.273 ± 0.043	1.378AsnSer: 1.378 ± 0.042	1.247AsnThr: 1.247 ± 0.043	1.762AsnVal: 1.762 ± 0.044	0.348AsnTrp: 0.348 ± 0.016	0.869AsnTyr: 0.869 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.08ProAla: 5.08 ± 0.091	0.459ProCys: 0.459 ± 0.026	2.739ProAsp: 2.739 ± 0.05	4.589ProGlu: 4.589 ± 0.069	2.032ProPhe: 2.032 ± 0.044	4.24ProGly: 4.24 ± 0.076	1.022ProHis: 1.022 ± 0.042	1.976ProIle: 1.976 ± 0.048	1.64ProLys: 1.64 ± 0.037	5.691ProLeu: 5.691 ± 0.085	1.088ProMet: 1.088 ± 0.031	1.079ProAsn: 1.079 ± 0.034	2.653ProPro: 2.653 ± 0.067	1.547ProGln: 1.547 ± 0.046	2.877ProArg: 2.877 ± 0.059	2.283ProSer: 2.283 ± 0.048	2.373ProThr: 2.373 ± 0.055	3.945ProVal: 3.945 ± 0.062	0.612ProTrp: 0.612 ± 0.024	1.239ProTyr: 1.239 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.882GlnAla: 3.882 ± 0.065	0.314GlnCys: 0.314 ± 0.018	1.411GlnAsp: 1.411 ± 0.04	2.344GlnGlu: 2.344 ± 0.052	1.036GlnPhe: 1.036 ± 0.035	3.092GlnGly: 3.092 ± 0.051	0.579GlnHis: 0.579 ± 0.024	1.764GlnIle: 1.764 ± 0.041	1.46GlnLys: 1.46 ± 0.043	3.57GlnLeu: 3.57 ± 0.057	0.744GlnMet: 0.744 ± 0.027	0.905GlnAsn: 0.905 ± 0.031	1.487GlnPro: 1.487 ± 0.044	1.348GlnGln: 1.348 ± 0.046	2.412GlnArg: 2.412 ± 0.054	1.618GlnSer: 1.618 ± 0.037	1.626GlnThr: 1.626 ± 0.041	2.919GlnVal: 2.919 ± 0.059	0.376GlnTrp: 0.376 ± 0.019	0.634GlnTyr: 0.634 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.909ArgAla: 5.909 ± 0.083	0.789ArgCys: 0.789 ± 0.032	3.694ArgAsp: 3.694 ± 0.054	5.775ArgGlu: 5.775 ± 0.084	3.048ArgPhe: 3.048 ± 0.048	4.681ArgGly: 4.681 ± 0.075	1.765ArgHis: 1.765 ± 0.046	4.376ArgIle: 4.376 ± 0.058	2.907ArgLys: 2.907 ± 0.06	8.927ArgLeu: 8.927 ± 0.119	1.73ArgMet: 1.73 ± 0.041	1.916ArgAsn: 1.916 ± 0.042	3.231ArgPro: 3.231 ± 0.069	3.247ArgGln: 3.247 ± 0.059	5.947ArgArg: 5.947 ± 0.114	3.144ArgSer: 3.144 ± 0.058	2.802ArgThr: 2.802 ± 0.05	4.684ArgVal: 4.684 ± 0.062	0.863ArgTrp: 0.863 ± 0.035	2.13ArgTyr: 2.13 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.042SerAla: 5.042 ± 0.069	0.769SerCys: 0.769 ± 0.048	2.549SerAsp: 2.549 ± 0.055	2.967SerGlu: 2.967 ± 0.059	2.27SerPhe: 2.27 ± 0.049	5.04SerGly: 5.04 ± 0.079	1.104SerHis: 1.104 ± 0.03	2.432SerIle: 2.432 ± 0.049	1.601SerLys: 1.601 ± 0.042	6.26SerLeu: 6.26 ± 0.089	1.028SerMet: 1.028 ± 0.033	1.371SerAsn: 1.371 ± 0.042	2.882SerPro: 2.882 ± 0.058	1.63SerGln: 1.63 ± 0.047	3.753SerArg: 3.753 ± 0.064	2.8SerSer: 2.8 ± 0.066	2.41SerThr: 2.41 ± 0.057	3.235SerVal: 3.235 ± 0.052	0.676SerTrp: 0.676 ± 0.03	1.324SerTyr: 1.324 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.325ThrAla: 5.325 ± 0.076	0.59ThrCys: 0.59 ± 0.026	2.383ThrAsp: 2.383 ± 0.059	2.88ThrGlu: 2.88 ± 0.045	1.901ThrPhe: 1.901 ± 0.045	4.475ThrGly: 4.475 ± 0.073	0.918ThrHis: 0.918 ± 0.031	2.543ThrIle: 2.543 ± 0.053	1.377ThrLys: 1.377 ± 0.041	6.318ThrLeu: 6.318 ± 0.081	0.888ThrMet: 0.888 ± 0.032	1.24ThrAsn: 1.24 ± 0.043	2.937ThrPro: 2.937 ± 0.056	1.317ThrGln: 1.317 ± 0.035	3.021ThrArg: 3.021 ± 0.058	2.515ThrSer: 2.515 ± 0.057	2.546ThrThr: 2.546 ± 0.074	3.813ThrVal: 3.813 ± 0.063	0.479ThrTrp: 0.479 ± 0.021	1.183ThrTyr: 1.183 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.552ValAla: 7.552 ± 0.087	0.852ValCys: 0.852 ± 0.03	4.111ValAsp: 4.111 ± 0.064	5.027ValGlu: 5.027 ± 0.07	2.628ValPhe: 2.628 ± 0.053	5.36ValGly: 5.36 ± 0.082	1.253ValHis: 1.253 ± 0.029	3.843ValIle: 3.843 ± 0.071	2.79ValLys: 2.79 ± 0.061	7.511ValLeu: 7.511 ± 0.102	1.528ValMet: 1.528 ± 0.038	2.136ValAsn: 2.136 ± 0.05	3.27ValPro: 3.27 ± 0.057	1.866ValGln: 1.866 ± 0.043	4.817ValArg: 4.817 ± 0.074	3.756ValSer: 3.756 ± 0.063	3.811ValThr: 3.811 ± 0.063	5.463ValVal: 5.463 ± 0.086	0.658ValTrp: 0.658 ± 0.025	1.643ValTyr: 1.643 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.792TrpAla: 0.792 ± 0.03	0.129TrpCys: 0.129 ± 0.011	0.516TrpAsp: 0.516 ± 0.022	0.666TrpGlu: 0.666 ± 0.024	0.453TrpPhe: 0.453 ± 0.021	0.853TrpGly: 0.853 ± 0.033	0.252TrpHis: 0.252 ± 0.016	0.515TrpIle: 0.515 ± 0.02	0.435TrpLys: 0.435 ± 0.019	1.402TrpLeu: 1.402 ± 0.039	0.239TrpMet: 0.239 ± 0.015	0.374TrpAsn: 0.374 ± 0.019	0.519TrpPro: 0.519 ± 0.025	0.479TrpGln: 0.479 ± 0.024	0.965TrpArg: 0.965 ± 0.028	0.631TrpSer: 0.631 ± 0.024	0.489TrpThr: 0.489 ± 0.023	0.662TrpVal: 0.662 ± 0.024	0.153TrpTrp: 0.153 ± 0.013	0.272TrpTyr: 0.272 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.259TyrAla: 2.259 ± 0.051	0.314TyrCys: 0.314 ± 0.018	1.519TyrAsp: 1.519 ± 0.04	1.317TyrGlu: 1.317 ± 0.037	1.172TyrPhe: 1.172 ± 0.035	2.063TyrGly: 2.063 ± 0.043	0.628TyrHis: 0.628 ± 0.022	1.053TyrIle: 1.053 ± 0.027	0.745TyrLys: 0.745 ± 0.029	3.268TyrLeu: 3.268 ± 0.058	0.415TyrMet: 0.415 ± 0.019	0.729TyrAsn: 0.729 ± 0.029	1.357TyrPro: 1.357 ± 0.039	1.146TyrGln: 1.146 ± 0.033	2.432TyrArg: 2.432 ± 0.055	1.281TyrSer: 1.281 ± 0.041	1.107TyrThr: 1.107 ± 0.039	1.55TyrVal: 1.55 ± 0.047	0.313TyrTrp: 0.313 ± 0.015	0.827TyrTyr: 0.827 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3347 proteins (1093803 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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