Amino acid dipepetide frequency for Noviherbaspirillum galbum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.413AlaAla: 16.413 ± 0.154	1.359AlaCys: 1.359 ± 0.031	6.22AlaAsp: 6.22 ± 0.073	6.411AlaGlu: 6.411 ± 0.097	4.142AlaPhe: 4.142 ± 0.047	10.677AlaGly: 10.677 ± 0.096	2.329AlaHis: 2.329 ± 0.04	5.966AlaIle: 5.966 ± 0.066	4.124AlaLys: 4.124 ± 0.062	12.996AlaLeu: 12.996 ± 0.141	3.758AlaMet: 3.758 ± 0.047	3.257AlaAsn: 3.257 ± 0.048	5.423AlaPro: 5.423 ± 0.081	4.763AlaGln: 4.763 ± 0.072	8.238AlaArg: 8.238 ± 0.101	7.489AlaSer: 7.489 ± 0.08	5.623AlaThr: 5.623 ± 0.063	8.214AlaVal: 8.214 ± 0.084	1.587AlaTrp: 1.587 ± 0.035	2.657AlaTyr: 2.657 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.114CysAla: 1.114 ± 0.026	0.136CysCys: 0.136 ± 0.009	0.558CysAsp: 0.558 ± 0.021	0.523CysGlu: 0.523 ± 0.017	0.324CysPhe: 0.324 ± 0.014	0.989CysGly: 0.989 ± 0.028	0.267CysHis: 0.267 ± 0.015	0.426CysIle: 0.426 ± 0.016	0.289CysLys: 0.289 ± 0.014	0.897CysLeu: 0.897 ± 0.024	0.242CysMet: 0.242 ± 0.011	0.274CysAsn: 0.274 ± 0.013	0.464CysPro: 0.464 ± 0.016	0.271CysGln: 0.271 ± 0.013	0.615CysArg: 0.615 ± 0.02	0.535CysSer: 0.535 ± 0.019	0.449CysThr: 0.449 ± 0.019	0.615CysVal: 0.615 ± 0.021	0.123CysTrp: 0.123 ± 0.009	0.23CysTyr: 0.23 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.077AspAla: 7.077 ± 0.089	0.495AspCys: 0.495 ± 0.018	2.998AspAsp: 2.998 ± 0.047	3.17AspGlu: 3.17 ± 0.047	2.056AspPhe: 2.056 ± 0.032	4.747AspGly: 4.747 ± 0.055	1.122AspHis: 1.122 ± 0.025	2.989AspIle: 2.989 ± 0.037	2.172AspLys: 2.172 ± 0.04	5.427AspLeu: 5.427 ± 0.061	1.522AspMet: 1.522 ± 0.027	1.405AspAsn: 1.405 ± 0.033	2.86AspPro: 2.86 ± 0.042	1.736AspGln: 1.736 ± 0.039	3.396AspArg: 3.396 ± 0.044	2.349AspSer: 2.349 ± 0.034	2.532AspThr: 2.532 ± 0.048	3.985AspVal: 3.985 ± 0.045	0.86AspTrp: 0.86 ± 0.023	1.455AspTyr: 1.455 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.561GluAla: 6.561 ± 0.08	0.438GluCys: 0.438 ± 0.017	2.487GluAsp: 2.487 ± 0.041	3.287GluGlu: 3.287 ± 0.048	1.899GluPhe: 1.899 ± 0.034	3.647GluGly: 3.647 ± 0.047	1.368GluHis: 1.368 ± 0.031	2.935GluIle: 2.935 ± 0.044	2.433GluLys: 2.433 ± 0.043	5.62GluLeu: 5.62 ± 0.068	1.416GluMet: 1.416 ± 0.03	1.586GluAsn: 1.586 ± 0.029	2.271GluPro: 2.271 ± 0.044	2.756GluGln: 2.756 ± 0.049	4.688GluArg: 4.688 ± 0.064	2.906GluSer: 2.906 ± 0.038	2.764GluThr: 2.764 ± 0.046	3.912GluVal: 3.912 ± 0.047	0.717GluTrp: 0.717 ± 0.022	1.133GluTyr: 1.133 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.088PheAla: 4.088 ± 0.048	0.434PheCys: 0.434 ± 0.016	2.355PheAsp: 2.355 ± 0.037	1.884PheGlu: 1.884 ± 0.03	1.446PhePhe: 1.446 ± 0.033	3.362PheGly: 3.362 ± 0.051	0.811PheHis: 0.811 ± 0.02	1.783PheIle: 1.783 ± 0.035	1.277PheLys: 1.277 ± 0.028	3.288PheLeu: 3.288 ± 0.045	0.853PheMet: 0.853 ± 0.023	1.239PheAsn: 1.239 ± 0.026	1.628PhePro: 1.628 ± 0.032	1.107PheGln: 1.107 ± 0.026	2.172PheArg: 2.172 ± 0.039	2.445PheSer: 2.445 ± 0.039	1.911PheThr: 1.911 ± 0.031	2.526PheVal: 2.526 ± 0.04	0.477PheTrp: 0.477 ± 0.016	0.963PheTyr: 0.963 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.373GlyAla: 8.373 ± 0.076	0.814GlyCys: 0.814 ± 0.025	4.087GlyAsp: 4.087 ± 0.062	4.339GlyGlu: 4.339 ± 0.063	3.284GlyPhe: 3.284 ± 0.049	6.64GlyGly: 6.64 ± 0.097	1.828GlyHis: 1.828 ± 0.037	4.564GlyIle: 4.564 ± 0.052	4.18GlyLys: 4.18 ± 0.049	7.941GlyLeu: 7.941 ± 0.081	2.862GlyMet: 2.862 ± 0.04	2.697GlyAsn: 2.697 ± 0.049	2.719GlyPro: 2.719 ± 0.037	3.103GlyGln: 3.103 ± 0.044	5.222GlyArg: 5.222 ± 0.059	4.63GlySer: 4.63 ± 0.057	4.646GlyThr: 4.646 ± 0.064	5.888GlyVal: 5.888 ± 0.057	1.282GlyTrp: 1.282 ± 0.031	2.295GlyTyr: 2.295 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	3.105HisAla: 3.105 ± 0.046	0.261HisCys: 0.261 ± 0.013	1.332HisAsp: 1.332 ± 0.03	1.19HisGlu: 1.19 ± 0.027	0.883HisPhe: 0.883 ± 0.024	2.095HisGly: 2.095 ± 0.04	0.696HisHis: 0.696 ± 0.022	0.923HisIle: 0.923 ± 0.024	0.59HisLys: 0.59 ± 0.018	2.131HisLeu: 2.131 ± 0.041	0.509HisMet: 0.509 ± 0.016	0.5HisAsn: 0.5 ± 0.017	1.52HisPro: 1.52 ± 0.032	0.727HisGln: 0.727 ± 0.021	1.425HisArg: 1.425 ± 0.03	1.027HisSer: 1.027 ± 0.024	0.864HisThr: 0.864 ± 0.024	1.637HisVal: 1.637 ± 0.03	0.326HisTrp: 0.326 ± 0.015	0.616HisTyr: 0.616 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.718IleAla: 6.718 ± 0.074	0.456IleCys: 0.456 ± 0.017	3.476IleAsp: 3.476 ± 0.046	3.156IleGlu: 3.156 ± 0.045	1.446IlePhe: 1.446 ± 0.032	4.534IleGly: 4.534 ± 0.063	1.024IleHis: 1.024 ± 0.024	2.093IleIle: 2.093 ± 0.039	1.774IleLys: 1.774 ± 0.035	4.168IleLeu: 4.168 ± 0.053	1.013IleMet: 1.013 ± 0.027	1.683IleAsn: 1.683 ± 0.033	2.313IlePro: 2.313 ± 0.04	1.422IleGln: 1.422 ± 0.03	3.055IleArg: 3.055 ± 0.04	2.907IleSer: 2.907 ± 0.043	2.602IleThr: 2.602 ± 0.045	3.857IleVal: 3.857 ± 0.052	0.499IleTrp: 0.499 ± 0.015	1.055IleTyr: 1.055 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.351LysAla: 4.351 ± 0.062	0.205LysCys: 0.205 ± 0.011	2.003LysAsp: 2.003 ± 0.033	2.167LysGlu: 2.167 ± 0.04	1.04LysPhe: 1.04 ± 0.025	2.637LysGly: 2.637 ± 0.041	0.771LysHis: 0.771 ± 0.021	1.864LysIle: 1.864 ± 0.037	1.684LysLys: 1.684 ± 0.042	3.912LysLeu: 3.912 ± 0.05	1.059LysMet: 1.059 ± 0.027	1.236LysAsn: 1.236 ± 0.028	2.3LysPro: 2.3 ± 0.04	1.531LysGln: 1.531 ± 0.032	2.521LysArg: 2.521 ± 0.04	2.064LysSer: 2.064 ± 0.034	2.25LysThr: 2.25 ± 0.039	2.749LysVal: 2.749 ± 0.053	0.424LysTrp: 0.424 ± 0.014	0.768LysTyr: 0.768 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.454LeuAla: 13.454 ± 0.114	1.008LeuCys: 1.008 ± 0.026	5.804LeuAsp: 5.804 ± 0.063	5.351LeuGlu: 5.351 ± 0.071	3.541LeuPhe: 3.541 ± 0.051	7.972LeuGly: 7.972 ± 0.071	2.341LeuHis: 2.341 ± 0.038	4.367LeuIle: 4.367 ± 0.059	3.902LeuLys: 3.902 ± 0.057	10.573LeuLeu: 10.573 ± 0.109	2.473LeuMet: 2.473 ± 0.039	3.023LeuAsn: 3.023 ± 0.04	5.802LeuPro: 5.802 ± 0.058	3.842LeuGln: 3.842 ± 0.048	7.22LeuArg: 7.22 ± 0.077	6.437LeuSer: 6.437 ± 0.077	5.178LeuThr: 5.178 ± 0.087	7.201LeuVal: 7.201 ± 0.071	1.027LeuTrp: 1.027 ± 0.03	2.157LeuTyr: 2.157 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.098MetAla: 3.098 ± 0.048	0.172MetCys: 0.172 ± 0.01	1.284MetAsp: 1.284 ± 0.026	1.404MetGlu: 1.404 ± 0.027	0.771MetPhe: 0.771 ± 0.023	1.732MetGly: 1.732 ± 0.033	0.652MetHis: 0.652 ± 0.022	1.221MetIle: 1.221 ± 0.032	1.227MetLys: 1.227 ± 0.029	3.032MetLeu: 3.032 ± 0.045	0.731MetMet: 0.731 ± 0.021	0.968MetAsn: 0.968 ± 0.02	1.642MetPro: 1.642 ± 0.031	1.353MetGln: 1.353 ± 0.029	1.938MetArg: 1.938 ± 0.034	1.754MetSer: 1.754 ± 0.033	1.742MetThr: 1.742 ± 0.031	1.739MetVal: 1.739 ± 0.035	0.207MetTrp: 0.207 ± 0.011	0.453MetTyr: 0.453 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.742AsnAla: 3.742 ± 0.058	0.304AsnCys: 0.304 ± 0.013	1.685AsnAsp: 1.685 ± 0.033	1.433AsnGlu: 1.433 ± 0.03	1.051AsnPhe: 1.051 ± 0.025	2.833AsnGly: 2.833 ± 0.046	0.581AsnHis: 0.581 ± 0.019	1.498AsnIle: 1.498 ± 0.027	1.018AsnLys: 1.018 ± 0.026	2.979AsnLeu: 2.979 ± 0.04	0.713AsnMet: 0.713 ± 0.021	0.971AsnAsn: 0.971 ± 0.03	1.886AsnPro: 1.886 ± 0.033	1.062AsnGln: 1.062 ± 0.024	1.877AsnArg: 1.877 ± 0.036	1.361AsnSer: 1.361 ± 0.029	1.541AsnThr: 1.541 ± 0.037	2.291AsnVal: 2.291 ± 0.045	0.4AsnTrp: 0.4 ± 0.014	0.801AsnTyr: 0.801 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.79ProAla: 6.79 ± 0.078	0.344ProCys: 0.344 ± 0.015	3.32ProAsp: 3.32 ± 0.044	3.261ProGlu: 3.261 ± 0.05	1.78ProPhe: 1.78 ± 0.032	4.31ProGly: 4.31 ± 0.051	1.044ProHis: 1.044 ± 0.026	1.938ProIle: 1.938 ± 0.034	1.595ProLys: 1.595 ± 0.03	4.733ProLeu: 4.733 ± 0.054	1.182ProMet: 1.182 ± 0.026	1.387ProAsn: 1.387 ± 0.028	2.431ProPro: 2.431 ± 0.049	1.914ProGln: 1.914 ± 0.036	2.781ProArg: 2.781 ± 0.046	2.821ProSer: 2.821 ± 0.04	2.159ProThr: 2.159 ± 0.039	4.216ProVal: 4.216 ± 0.05	0.623ProTrp: 0.623 ± 0.02	1.153ProTyr: 1.153 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.267GlnAla: 5.267 ± 0.067	0.306GlnCys: 0.306 ± 0.015	1.78GlnAsp: 1.78 ± 0.029	2.123GlnGlu: 2.123 ± 0.042	1.35GlnPhe: 1.35 ± 0.029	2.874GlnGly: 2.874 ± 0.04	0.898GlnHis: 0.898 ± 0.023	1.935GlnIle: 1.935 ± 0.072	1.295GlnLys: 1.295 ± 0.029	3.751GlnLeu: 3.751 ± 0.058	0.991GlnMet: 0.991 ± 0.025	1.006GlnAsn: 1.006 ± 0.023	1.999GlnPro: 1.999 ± 0.035	1.887GlnGln: 1.887 ± 0.04	2.946GlnArg: 2.946 ± 0.042	2.066GlnSer: 2.066 ± 0.034	1.79GlnThr: 1.79 ± 0.032	2.996GlnVal: 2.996 ± 0.054	0.515GlnTrp: 0.515 ± 0.018	0.825GlnTyr: 0.825 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.995ArgAla: 6.995 ± 0.079	0.564ArgCys: 0.564 ± 0.019	3.654ArgAsp: 3.654 ± 0.045	4.123ArgGlu: 4.123 ± 0.058	2.868ArgPhe: 2.868 ± 0.038	4.243ArgGly: 4.243 ± 0.053	1.917ArgHis: 1.917 ± 0.034	3.909ArgIle: 3.909 ± 0.046	2.595ArgLys: 2.595 ± 0.039	7.563ArgLeu: 7.563 ± 0.076	2.084ArgMet: 2.084 ± 0.033	2.157ArgAsn: 2.157 ± 0.034	3.026ArgPro: 3.026 ± 0.041	3.195ArgGln: 3.195 ± 0.041	5.058ArgArg: 5.058 ± 0.061	3.453ArgSer: 3.453 ± 0.045	3.191ArgThr: 3.191 ± 0.039	4.437ArgVal: 4.437 ± 0.057	0.995ArgTrp: 0.995 ± 0.026	1.881ArgTyr: 1.881 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.516SerAla: 6.516 ± 0.081	0.526SerCys: 0.526 ± 0.019	2.863SerAsp: 2.863 ± 0.047	2.751SerGlu: 2.751 ± 0.038	2.213SerPhe: 2.213 ± 0.037	5.5SerGly: 5.5 ± 0.067	1.281SerHis: 1.281 ± 0.03	2.726SerIle: 2.726 ± 0.04	1.861SerLys: 1.861 ± 0.038	6.225SerLeu: 6.225 ± 0.071	1.622SerMet: 1.622 ± 0.035	1.705SerAsn: 1.705 ± 0.037	2.872SerPro: 2.872 ± 0.044	2.062SerGln: 2.062 ± 0.043	3.914SerArg: 3.914 ± 0.05	3.613SerSer: 3.613 ± 0.061	2.978SerThr: 2.978 ± 0.06	3.913SerVal: 3.913 ± 0.047	0.713SerTrp: 0.713 ± 0.021	1.37SerTyr: 1.37 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.854ThrAla: 5.854 ± 0.082	0.43ThrCys: 0.43 ± 0.018	2.571ThrAsp: 2.571 ± 0.047	2.397ThrGlu: 2.397 ± 0.036	1.737ThrPhe: 1.737 ± 0.033	4.796ThrGly: 4.796 ± 0.059	1.021ThrHis: 1.021 ± 0.022	2.601ThrIle: 2.601 ± 0.04	1.411ThrLys: 1.411 ± 0.028	5.719ThrLeu: 5.719 ± 0.061	1.263ThrMet: 1.263 ± 0.03	1.408ThrAsn: 1.408 ± 0.036	3.128ThrPro: 3.128 ± 0.046	1.747ThrGln: 1.747 ± 0.038	3.109ThrArg: 3.109 ± 0.042	2.943ThrSer: 2.943 ± 0.055	2.874ThrThr: 2.874 ± 0.072	4.088ThrVal: 4.088 ± 0.058	0.681ThrTrp: 0.681 ± 0.019	1.19ThrTyr: 1.19 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.579ValAla: 8.579 ± 0.071	0.665ValCys: 0.665 ± 0.02	3.98ValAsp: 3.98 ± 0.055	4.09ValGlu: 4.09 ± 0.055	2.645ValPhe: 2.645 ± 0.043	5.013ValGly: 5.013 ± 0.055	1.528ValHis: 1.528 ± 0.029	3.876ValIle: 3.876 ± 0.048	2.757ValLys: 2.757 ± 0.042	7.432ValLeu: 7.432 ± 0.074	1.923ValMet: 1.923 ± 0.037	2.402ValAsn: 2.402 ± 0.038	3.766ValPro: 3.766 ± 0.049	2.468ValGln: 2.468 ± 0.038	4.835ValArg: 4.835 ± 0.056	4.378ValSer: 4.378 ± 0.055	4.015ValThr: 4.015 ± 0.065	5.726ValVal: 5.726 ± 0.067	0.814ValTrp: 0.814 ± 0.023	1.596ValTyr: 1.596 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.986TrpAla: 0.986 ± 0.026	0.143TrpCys: 0.143 ± 0.008	0.563TrpAsp: 0.563 ± 0.018	0.611TrpGlu: 0.611 ± 0.02	0.54TrpPhe: 0.54 ± 0.019	0.784TrpGly: 0.784 ± 0.021	0.356TrpHis: 0.356 ± 0.016	0.696TrpIle: 0.696 ± 0.021	0.537TrpLys: 0.537 ± 0.018	1.7TrpLeu: 1.7 ± 0.036	0.422TrpMet: 0.422 ± 0.016	0.482TrpAsn: 0.482 ± 0.017	0.556TrpPro: 0.556 ± 0.022	0.663TrpGln: 0.663 ± 0.023	1.047TrpArg: 1.047 ± 0.024	0.702TrpSer: 0.702 ± 0.019	0.703TrpThr: 0.703 ± 0.02	0.82TrpVal: 0.82 ± 0.022	0.23TrpTrp: 0.23 ± 0.012	0.32TrpTyr: 0.32 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.041	0.28TyrCys: 0.28 ± 0.014	1.333TyrAsp: 1.333 ± 0.045	1.152TyrGlu: 1.152 ± 0.027	1.035TyrPhe: 1.035 ± 0.024	2.009TyrGly: 2.009 ± 0.036	0.524TyrHis: 0.524 ± 0.017	0.939TyrIle: 0.939 ± 0.023	0.815TyrLys: 0.815 ± 0.019	2.584TyrLeu: 2.584 ± 0.041	0.481TyrMet: 0.481 ± 0.016	0.644TyrAsn: 0.644 ± 0.018	1.175TyrPro: 1.175 ± 0.03	0.994TyrGln: 0.994 ± 0.024	1.85TyrArg: 1.85 ± 0.033	1.341TyrSer: 1.341 ± 0.035	1.155TyrThr: 1.155 ± 0.031	1.679TyrVal: 1.679 ± 0.028	0.359TyrTrp: 0.359 ± 0.013	0.668TyrTyr: 0.668 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5472 proteins (1783336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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