Amino acid dipepetide frequency for Ostreococcus tauri virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.01AlaAla: 5.01 ± 0.453
0.873AlaCys: 0.873 ± 0.138
3.055AlaAsp: 3.055 ± 0.378
3.456AlaGlu: 3.456 ± 0.367
2.217AlaPhe: 2.217 ± 0.201
3.98AlaGly: 3.98 ± 0.631
1.117AlaHis: 1.117 ± 0.173
4.067AlaIle: 4.067 ± 0.279
4.748AlaLys: 4.748 ± 0.776
5.481AlaLeu: 5.481 ± 0.375
1.92AlaMet: 1.92 ± 0.195
3.16AlaAsn: 3.16 ± 0.564
1.955AlaPro: 1.955 ± 0.203
2.95AlaGln: 2.95 ± 0.363
3.352AlaArg: 3.352 ± 0.289
3.526AlaSer: 3.526 ± 0.319
3.98AlaThr: 3.98 ± 0.419
4.399AlaVal: 4.399 ± 0.728
0.506AlaTrp: 0.506 ± 0.108
1.938AlaTyr: 1.938 ± 0.208
0.0AlaXaa: 0.0 ± 0.0
Cys
0.908CysAla: 0.908 ± 0.142
0.506CysCys: 0.506 ± 0.125
1.117CysAsp: 1.117 ± 0.166
1.466CysGlu: 1.466 ± 0.253
0.716CysPhe: 0.716 ± 0.139
1.205CysGly: 1.205 ± 0.2
0.367CysHis: 0.367 ± 0.076
0.751CysIle: 0.751 ± 0.149
1.205CysLys: 1.205 ± 0.243
1.047CysLeu: 1.047 ± 0.161
0.576CysMet: 0.576 ± 0.111
0.576CysAsn: 0.576 ± 0.109
1.03CysPro: 1.03 ± 0.161
0.436CysGln: 0.436 ± 0.094
0.96CysArg: 0.96 ± 0.159
0.943CysSer: 0.943 ± 0.143
0.855CysThr: 0.855 ± 0.157
0.89CysVal: 0.89 ± 0.144
0.105CysTrp: 0.105 ± 0.045
0.716CysTyr: 0.716 ± 0.127
0.0CysXaa: 0.0 ± 0.0
Asp
3.683AspAla: 3.683 ± 0.256
1.117AspCys: 1.117 ± 0.168
4.015AspAsp: 4.015 ± 0.343
4.748AspGlu: 4.748 ± 0.31
2.671AspPhe: 2.671 ± 0.225
3.858AspGly: 3.858 ± 0.32
1.17AspHis: 1.17 ± 0.171
4.242AspIle: 4.242 ± 0.298
3.771AspLys: 3.771 ± 0.306
4.975AspLeu: 4.975 ± 0.286
1.85AspMet: 1.85 ± 0.236
2.339AspAsn: 2.339 ± 0.208
2.392AspPro: 2.392 ± 0.236
1.274AspGln: 1.274 ± 0.17
2.915AspArg: 2.915 ± 0.247
2.444AspSer: 2.444 ± 0.271
3.561AspThr: 3.561 ± 0.287
4.312AspVal: 4.312 ± 0.388
0.698AspTrp: 0.698 ± 0.118
2.95AspTyr: 2.95 ± 0.258
0.0AspXaa: 0.0 ± 0.0
Glu
4.312GluAla: 4.312 ± 0.475
1.187GluCys: 1.187 ± 0.183
3.806GluAsp: 3.806 ± 0.337
6.075GluGlu: 6.075 ± 0.552
3.02GluPhe: 3.02 ± 0.26
3.439GluGly: 3.439 ± 0.271
1.763GluHis: 1.763 ± 0.25
4.312GluIle: 4.312 ± 0.34
5.289GluLys: 5.289 ± 0.454
5.83GluLeu: 5.83 ± 0.446
2.042GluMet: 2.042 ± 0.242
3.334GluAsn: 3.334 ± 0.226
2.461GluPro: 2.461 ± 0.252
2.06GluGln: 2.06 ± 0.189
3.84GluArg: 3.84 ± 0.295
3.09GluSer: 3.09 ± 0.318
3.858GluThr: 3.858 ± 0.315
4.137GluVal: 4.137 ± 0.302
0.89GluTrp: 0.89 ± 0.138
2.863GluTyr: 2.863 ± 0.268
0.0GluXaa: 0.0 ± 0.0
Phe
2.863PheAla: 2.863 ± 0.273
0.751PheCys: 0.751 ± 0.139
2.688PheAsp: 2.688 ± 0.243
2.566PheGlu: 2.566 ± 0.297
2.008PhePhe: 2.008 ± 0.251
2.531PheGly: 2.531 ± 0.249
0.925PheHis: 0.925 ± 0.142
2.828PheIle: 2.828 ± 0.259
2.688PheLys: 2.688 ± 0.242
3.421PheLeu: 3.421 ± 0.29
1.536PheMet: 1.536 ± 0.195
2.269PheAsn: 2.269 ± 0.254
1.327PhePro: 1.327 ± 0.153
1.135PheGln: 1.135 ± 0.166
1.658PheArg: 1.658 ± 0.144
3.02PheSer: 3.02 ± 0.241
2.095PheThr: 2.095 ± 0.218
3.125PheVal: 3.125 ± 0.332
0.367PheTrp: 0.367 ± 0.079
1.92PheTyr: 1.92 ± 0.223
0.0PheXaa: 0.0 ± 0.0
Gly
3.806GlyAla: 3.806 ± 0.386
1.082GlyCys: 1.082 ± 0.183
3.718GlyAsp: 3.718 ± 0.371
4.067GlyGlu: 4.067 ± 0.251
2.828GlyPhe: 2.828 ± 0.227
4.259GlyGly: 4.259 ± 0.394
1.466GlyHis: 1.466 ± 0.165
3.491GlyIle: 3.491 ± 0.295
4.399GlyLys: 4.399 ± 0.32
5.307GlyLeu: 5.307 ± 0.442
1.484GlyMet: 1.484 ± 0.182
3.701GlyAsn: 3.701 ± 0.6
1.99GlyPro: 1.99 ± 0.229
2.269GlyGln: 2.269 ± 0.297
3.439GlyArg: 3.439 ± 0.325
3.788GlySer: 3.788 ± 0.361
3.806GlyThr: 3.806 ± 0.43
3.928GlyVal: 3.928 ± 0.32
0.873GlyTrp: 0.873 ± 0.131
2.863GlyTyr: 2.863 ± 0.27
0.0GlyXaa: 0.0 ± 0.0
His
1.257HisAla: 1.257 ± 0.152
0.471HisCys: 0.471 ± 0.091
0.908HisAsp: 0.908 ± 0.119
1.414HisGlu: 1.414 ± 0.192
0.925HisPhe: 0.925 ± 0.158
1.501HisGly: 1.501 ± 0.181
0.768HisHis: 0.768 ± 0.125
1.85HisIle: 1.85 ± 0.207
1.257HisLys: 1.257 ± 0.161
1.571HisLeu: 1.571 ± 0.15
0.733HisMet: 0.733 ± 0.131
1.239HisAsn: 1.239 ± 0.195
1.082HisPro: 1.082 ± 0.143
0.594HisGln: 0.594 ± 0.106
0.978HisArg: 0.978 ± 0.145
1.082HisSer: 1.082 ± 0.158
1.641HisThr: 1.641 ± 0.198
1.17HisVal: 1.17 ± 0.191
0.402HisTrp: 0.402 ± 0.092
0.873HisTyr: 0.873 ± 0.136
0.0HisXaa: 0.0 ± 0.0
Ile
3.387IleAla: 3.387 ± 0.243
0.908IleCys: 0.908 ± 0.207
4.102IleAsp: 4.102 ± 0.317
4.277IleGlu: 4.277 ± 0.3
2.252IlePhe: 2.252 ± 0.248
3.526IleGly: 3.526 ± 0.337
1.658IleHis: 1.658 ± 0.186
3.195IleIle: 3.195 ± 0.331
5.237IleLys: 5.237 ± 0.326
4.888IleLeu: 4.888 ± 0.374
1.501IleMet: 1.501 ± 0.145
3.299IleAsn: 3.299 ± 0.333
2.741IlePro: 2.741 ± 0.232
2.409IleGln: 2.409 ± 0.181
2.95IleArg: 2.95 ± 0.223
3.107IleSer: 3.107 ± 0.276
3.701IleThr: 3.701 ± 0.315
4.207IleVal: 4.207 ± 0.365
0.506IleTrp: 0.506 ± 0.098
2.112IleTyr: 2.112 ± 0.234
0.017IleXaa: 0.017 ± 0.017
Lys
4.556LysAla: 4.556 ± 0.687
1.501LysCys: 1.501 ± 0.219
4.155LysAsp: 4.155 ± 0.324
5.15LysGlu: 5.15 ± 0.45
3.195LysPhe: 3.195 ± 0.31
3.387LysGly: 3.387 ± 0.287
1.449LysHis: 1.449 ± 0.168
4.643LysIle: 4.643 ± 0.304
7.559LysLys: 7.559 ± 0.789
6.197LysLeu: 6.197 ± 0.455
2.514LysMet: 2.514 ± 0.202
5.586LysAsn: 5.586 ± 0.858
2.758LysPro: 2.758 ± 0.226
2.653LysGln: 2.653 ± 0.279
4.783LysArg: 4.783 ± 0.655
4.242LysSer: 4.242 ± 0.285
5.621LysThr: 5.621 ± 0.394
4.539LysVal: 4.539 ± 0.333
0.594LysTrp: 0.594 ± 0.099
3.247LysTyr: 3.247 ± 0.299
0.0LysXaa: 0.0 ± 0.0
Leu
4.539LeuAla: 4.539 ± 0.257
1.17LeuCys: 1.17 ± 0.182
5.115LeuAsp: 5.115 ± 0.295
5.586LeuGlu: 5.586 ± 0.391
2.758LeuPhe: 2.758 ± 0.283
4.731LeuGly: 4.731 ± 0.345
1.466LeuHis: 1.466 ± 0.163
4.888LeuIle: 4.888 ± 0.247
7.035LeuLys: 7.035 ± 0.644
6.162LeuLeu: 6.162 ± 0.347
1.885LeuMet: 1.885 ± 0.204
5.377LeuAsn: 5.377 ± 1.032
3.282LeuPro: 3.282 ± 0.337
2.688LeuGln: 2.688 ± 0.307
4.556LeuArg: 4.556 ± 0.365
4.835LeuSer: 4.835 ± 0.312
4.905LeuThr: 4.905 ± 0.378
5.359LeuVal: 5.359 ± 0.463
0.698LeuTrp: 0.698 ± 0.126
2.741LeuTyr: 2.741 ± 0.242
0.0LeuXaa: 0.0 ± 0.0
Met
1.589MetAla: 1.589 ± 0.187
0.541MetCys: 0.541 ± 0.107
1.815MetAsp: 1.815 ± 0.2
1.885MetGlu: 1.885 ± 0.215
1.239MetPhe: 1.239 ± 0.147
1.868MetGly: 1.868 ± 0.201
0.559MetHis: 0.559 ± 0.113
1.379MetIle: 1.379 ± 0.155
2.584MetLys: 2.584 ± 0.298
1.693MetLeu: 1.693 ± 0.234
1.187MetMet: 1.187 ± 0.2
1.798MetAsn: 1.798 ± 0.282
0.978MetPro: 0.978 ± 0.12
0.628MetGln: 0.628 ± 0.104
1.711MetArg: 1.711 ± 0.184
2.374MetSer: 2.374 ± 0.208
1.571MetThr: 1.571 ± 0.161
1.606MetVal: 1.606 ± 0.17
0.471MetTrp: 0.471 ± 0.092
1.519MetTyr: 1.519 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
4.277AsnAla: 4.277 ± 1.15
0.576AsnCys: 0.576 ± 0.112
2.793AsnAsp: 2.793 ± 0.226
2.828AsnGlu: 2.828 ± 0.228
2.706AsnPhe: 2.706 ± 0.26
3.491AsnGly: 3.491 ± 0.385
1.205AsnHis: 1.205 ± 0.145
3.631AsnIle: 3.631 ± 0.259
4.678AsnLys: 4.678 ± 0.791
4.87AsnLeu: 4.87 ± 0.432
1.711AsnMet: 1.711 ± 0.19
3.387AsnAsn: 3.387 ± 0.431
2.287AsnPro: 2.287 ± 0.256
2.2AsnGln: 2.2 ± 0.416
3.037AsnArg: 3.037 ± 0.688
3.003AsnSer: 3.003 ± 0.334
4.347AsnThr: 4.347 ± 0.752
4.609AsnVal: 4.609 ± 0.859
0.628AsnTrp: 0.628 ± 0.126
2.234AsnTyr: 2.234 ± 0.255
0.0AsnXaa: 0.0 ± 0.0
Pro
1.885ProAla: 1.885 ± 0.209
0.628ProCys: 0.628 ± 0.13
2.549ProAsp: 2.549 ± 0.274
3.195ProGlu: 3.195 ± 0.33
1.554ProPhe: 1.554 ± 0.174
2.566ProGly: 2.566 ± 0.236
0.716ProHis: 0.716 ± 0.127
2.112ProIle: 2.112 ± 0.231
3.491ProLys: 3.491 ± 0.284
2.357ProLeu: 2.357 ± 0.229
1.205ProMet: 1.205 ± 0.161
2.357ProAsn: 2.357 ± 0.203
2.182ProPro: 2.182 ± 0.251
1.868ProGln: 1.868 ± 0.182
1.728ProArg: 1.728 ± 0.238
2.2ProSer: 2.2 ± 0.216
2.898ProThr: 2.898 ± 0.243
2.653ProVal: 2.653 ± 0.268
0.402ProTrp: 0.402 ± 0.088
1.466ProTyr: 1.466 ± 0.182
0.0ProXaa: 0.0 ± 0.0
Gln
1.868GlnAla: 1.868 ± 0.22
0.576GlnCys: 0.576 ± 0.11
1.763GlnAsp: 1.763 ± 0.157
2.304GlnGlu: 2.304 ± 0.264
1.362GlnPhe: 1.362 ± 0.187
2.339GlnGly: 2.339 ± 0.575
0.611GlnHis: 0.611 ± 0.112
2.077GlnIle: 2.077 ± 0.183
2.653GlnLys: 2.653 ± 0.311
3.055GlnLeu: 3.055 ± 0.222
1.17GlnMet: 1.17 ± 0.138
2.147GlnAsn: 2.147 ± 0.32
1.466GlnPro: 1.466 ± 0.165
1.449GlnGln: 1.449 ± 0.182
2.147GlnArg: 2.147 ± 0.239
1.833GlnSer: 1.833 ± 0.209
2.234GlnThr: 2.234 ± 0.258
2.095GlnVal: 2.095 ± 0.225
0.402GlnTrp: 0.402 ± 0.081
1.449GlnTyr: 1.449 ± 0.179
0.0GlnXaa: 0.0 ± 0.0
Arg
3.02ArgAla: 3.02 ± 0.361
0.786ArgCys: 0.786 ± 0.174
3.509ArgAsp: 3.509 ± 0.25
4.172ArgGlu: 4.172 ± 0.344
2.077ArgPhe: 2.077 ± 0.172
3.072ArgGly: 3.072 ± 0.236
1.362ArgHis: 1.362 ± 0.185
3.16ArgIle: 3.16 ± 0.276
4.032ArgLys: 4.032 ± 0.386
4.19ArgLeu: 4.19 ± 0.254
1.449ArgMet: 1.449 ± 0.171
3.055ArgAsn: 3.055 ± 0.438
2.322ArgPro: 2.322 ± 0.238
2.008ArgGln: 2.008 ± 0.185
3.037ArgArg: 3.037 ± 0.298
2.723ArgSer: 2.723 ± 0.221
2.269ArgThr: 2.269 ± 0.209
3.928ArgVal: 3.928 ± 0.254
0.594ArgTrp: 0.594 ± 0.093
1.92ArgTyr: 1.92 ± 0.215
0.0ArgXaa: 0.0 ± 0.0
Ser
3.596SerAla: 3.596 ± 0.346
0.646SerCys: 0.646 ± 0.105
3.055SerAsp: 3.055 ± 0.315
3.91SerGlu: 3.91 ± 0.322
2.845SerPhe: 2.845 ± 0.218
4.277SerGly: 4.277 ± 0.376
1.047SerHis: 1.047 ± 0.131
3.369SerIle: 3.369 ± 0.26
4.102SerLys: 4.102 ± 0.289
4.347SerLeu: 4.347 ± 0.3
1.431SerMet: 1.431 ± 0.171
4.067SerAsn: 4.067 ± 0.736
1.868SerPro: 1.868 ± 0.191
2.374SerGln: 2.374 ± 0.323
2.409SerArg: 2.409 ± 0.263
3.474SerSer: 3.474 ± 0.368
3.753SerThr: 3.753 ± 0.359
3.683SerVal: 3.683 ± 0.302
0.576SerTrp: 0.576 ± 0.104
1.99SerTyr: 1.99 ± 0.225
0.0SerXaa: 0.0 ± 0.0
Thr
3.875ThrAla: 3.875 ± 0.51
0.978ThrCys: 0.978 ± 0.143
3.579ThrAsp: 3.579 ± 0.347
2.95ThrGlu: 2.95 ± 0.249
2.618ThrPhe: 2.618 ± 0.237
4.486ThrGly: 4.486 ± 0.457
1.606ThrHis: 1.606 ± 0.191
3.334ThrIle: 3.334 ± 0.305
4.818ThrLys: 4.818 ± 0.334
5.167ThrLeu: 5.167 ± 0.359
1.571ThrMet: 1.571 ± 0.155
4.067ThrAsn: 4.067 ± 0.719
3.125ThrPro: 3.125 ± 0.233
2.269ThrGln: 2.269 ± 0.203
3.229ThrArg: 3.229 ± 0.284
4.102ThrSer: 4.102 ± 0.462
4.12ThrThr: 4.12 ± 0.425
3.701ThrVal: 3.701 ± 0.277
0.681ThrTrp: 0.681 ± 0.127
2.252ThrTyr: 2.252 ± 0.215
0.017ThrXaa: 0.017 ± 0.017
Val
4.486ValAla: 4.486 ± 0.458
1.379ValCys: 1.379 ± 0.156
4.137ValAsp: 4.137 ± 0.318
4.242ValGlu: 4.242 ± 0.254
2.653ValPhe: 2.653 ± 0.248
4.574ValGly: 4.574 ± 0.629
1.414ValHis: 1.414 ± 0.182
3.299ValIle: 3.299 ± 0.333
4.87ValLys: 4.87 ± 0.293
4.609ValLeu: 4.609 ± 0.336
1.554ValMet: 1.554 ± 0.171
3.526ValAsn: 3.526 ± 0.435
3.195ValPro: 3.195 ± 0.313
2.374ValGln: 2.374 ± 0.24
3.631ValArg: 3.631 ± 0.303
3.963ValSer: 3.963 ± 0.389
4.172ValThr: 4.172 ± 0.465
4.678ValVal: 4.678 ± 0.417
0.873ValTrp: 0.873 ± 0.149
2.758ValTyr: 2.758 ± 0.356
0.0ValXaa: 0.0 ± 0.0
Trp
0.402TrpAla: 0.402 ± 0.095
0.227TrpCys: 0.227 ± 0.079
0.628TrpAsp: 0.628 ± 0.103
0.628TrpGlu: 0.628 ± 0.12
0.471TrpPhe: 0.471 ± 0.088
0.803TrpGly: 0.803 ± 0.134
0.279TrpHis: 0.279 ± 0.085
0.82TrpIle: 0.82 ± 0.144
0.908TrpLys: 0.908 ± 0.145
0.873TrpLeu: 0.873 ± 0.122
0.262TrpMet: 0.262 ± 0.073
0.768TrpAsn: 0.768 ± 0.118
0.332TrpPro: 0.332 ± 0.084
0.244TrpGln: 0.244 ± 0.071
0.454TrpArg: 0.454 ± 0.108
0.786TrpSer: 0.786 ± 0.126
0.541TrpThr: 0.541 ± 0.112
0.751TrpVal: 0.751 ± 0.125
0.192TrpTrp: 0.192 ± 0.068
0.349TrpTyr: 0.349 ± 0.083
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.374TyrAla: 2.374 ± 0.221
0.471TyrCys: 0.471 ± 0.1
2.479TyrAsp: 2.479 ± 0.236
2.688TyrGlu: 2.688 ± 0.302
1.606TyrPhe: 1.606 ± 0.19
2.671TyrGly: 2.671 ± 0.302
0.768TyrHis: 0.768 ± 0.121
2.514TyrIle: 2.514 ± 0.225
3.003TyrLys: 3.003 ± 0.263
3.736TyrLeu: 3.736 ± 0.257
1.414TyrMet: 1.414 ± 0.154
2.444TyrAsn: 2.444 ± 0.218
1.239TyrPro: 1.239 ± 0.178
1.117TyrGln: 1.117 ± 0.153
1.868TyrArg: 1.868 ± 0.185
2.287TyrSer: 2.287 ± 0.212
2.618TyrThr: 2.618 ± 0.251
2.618TyrVal: 2.618 ± 0.239
0.244TyrTrp: 0.244 ± 0.06
1.397TyrTyr: 1.397 ± 0.175
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.017XaaIle: 0.017 ± 0.017
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.017XaaTrp: 0.017 ± 0.017
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 230 proteins (57286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski