Amino acid dipepetide frequency for Influenza B virus (strain B/Lee/1940)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.028AlaAla: 4.028 ± 0.615
1.696AlaCys: 1.696 ± 0.746
3.604AlaAsp: 3.604 ± 1.106
3.18AlaGlu: 3.18 ± 1.149
1.06AlaPhe: 1.06 ± 0.44
4.028AlaGly: 4.028 ± 0.812
1.272AlaHis: 1.272 ± 0.584
4.028AlaIle: 4.028 ± 1.023
5.724AlaLys: 5.724 ± 0.95
7.42AlaLeu: 7.42 ± 1.157
2.12AlaMet: 2.12 ± 0.92
2.332AlaAsn: 2.332 ± 0.899
1.696AlaPro: 1.696 ± 0.614
2.12AlaGln: 2.12 ± 0.482
2.12AlaArg: 2.12 ± 0.469
4.24AlaSer: 4.24 ± 1.022
4.24AlaThr: 4.24 ± 0.85
3.392AlaVal: 3.392 ± 0.737
1.06AlaTrp: 1.06 ± 0.445
1.696AlaTyr: 1.696 ± 0.371
0.0AlaXaa: 0.0 ± 0.0
Cys
0.636CysAla: 0.636 ± 0.36
0.212CysCys: 0.212 ± 0.206
0.424CysAsp: 0.424 ± 0.249
0.848CysGlu: 0.848 ± 0.366
1.908CysPhe: 1.908 ± 0.526
0.848CysGly: 0.848 ± 0.497
0.424CysHis: 0.424 ± 0.258
0.848CysIle: 0.848 ± 0.483
0.636CysLys: 0.636 ± 0.264
2.756CysLeu: 2.756 ± 0.622
0.636CysMet: 0.636 ± 0.267
1.06CysAsn: 1.06 ± 0.463
1.484CysPro: 1.484 ± 0.671
0.424CysGln: 0.424 ± 0.258
1.696CysArg: 1.696 ± 0.576
1.696CysSer: 1.696 ± 0.529
1.484CysThr: 1.484 ± 0.911
1.484CysVal: 1.484 ± 0.541
0.212CysTrp: 0.212 ± 0.205
0.848CysTyr: 0.848 ± 0.352
0.0CysXaa: 0.0 ± 0.0
Asp
1.908AspAla: 1.908 ± 0.576
1.06AspCys: 1.06 ± 0.336
3.604AspAsp: 3.604 ± 1.053
4.452AspGlu: 4.452 ± 1.169
1.696AspPhe: 1.696 ± 0.782
3.604AspGly: 3.604 ± 1.094
0.636AspHis: 0.636 ± 0.378
3.18AspIle: 3.18 ± 1.038
2.544AspLys: 2.544 ± 1.013
3.392AspLeu: 3.392 ± 0.718
2.332AspMet: 2.332 ± 0.51
2.968AspAsn: 2.968 ± 0.723
2.12AspPro: 2.12 ± 0.601
2.332AspGln: 2.332 ± 0.624
2.332AspArg: 2.332 ± 0.68
2.332AspSer: 2.332 ± 0.626
3.18AspThr: 3.18 ± 0.931
3.18AspVal: 3.18 ± 0.587
0.424AspTrp: 0.424 ± 0.304
2.756AspTyr: 2.756 ± 0.641
0.0AspXaa: 0.0 ± 0.0
Glu
4.028GluAla: 4.028 ± 0.662
1.908GluCys: 1.908 ± 0.785
3.604GluAsp: 3.604 ± 0.653
6.572GluGlu: 6.572 ± 1.061
1.696GluPhe: 1.696 ± 0.517
7.208GluGly: 7.208 ± 1.677
1.484GluHis: 1.484 ± 0.496
4.876GluIle: 4.876 ± 0.834
4.452GluLys: 4.452 ± 1.307
6.148GluLeu: 6.148 ± 1.674
2.12GluMet: 2.12 ± 0.592
2.332GluAsn: 2.332 ± 0.568
2.756GluPro: 2.756 ± 0.95
1.06GluGln: 1.06 ± 0.46
4.664GluArg: 4.664 ± 0.748
4.24GluSer: 4.24 ± 1.285
3.392GluThr: 3.392 ± 0.736
4.664GluVal: 4.664 ± 1.133
1.06GluTrp: 1.06 ± 0.615
1.484GluTyr: 1.484 ± 0.808
0.0GluXaa: 0.0 ± 0.0
Phe
1.696PheAla: 1.696 ± 0.463
0.848PheCys: 0.848 ± 0.488
1.696PheAsp: 1.696 ± 0.519
3.18PheGlu: 3.18 ± 0.729
1.696PhePhe: 1.696 ± 0.641
3.18PheGly: 3.18 ± 0.542
1.484PheHis: 1.484 ± 0.426
2.968PheIle: 2.968 ± 0.696
1.272PheLys: 1.272 ± 0.601
3.816PheLeu: 3.816 ± 1.075
0.848PheMet: 0.848 ± 0.387
2.544PheAsn: 2.544 ± 0.706
1.272PhePro: 1.272 ± 0.449
1.484PheGln: 1.484 ± 0.379
0.636PheArg: 0.636 ± 0.458
3.392PheSer: 3.392 ± 0.935
0.848PheThr: 0.848 ± 0.391
1.908PheVal: 1.908 ± 0.852
0.424PheTrp: 0.424 ± 0.257
0.848PheTyr: 0.848 ± 0.517
0.0PheXaa: 0.0 ± 0.0
Gly
2.756GlyAla: 2.756 ± 0.666
0.848GlyCys: 0.848 ± 0.436
4.028GlyAsp: 4.028 ± 0.575
4.876GlyGlu: 4.876 ± 1.33
4.664GlyPhe: 4.664 ± 0.662
5.3GlyGly: 5.3 ± 1.199
1.272GlyHis: 1.272 ± 0.574
5.512GlyIle: 5.512 ± 0.861
5.724GlyLys: 5.724 ± 1.074
4.664GlyLeu: 4.664 ± 0.995
2.968GlyMet: 2.968 ± 0.964
3.604GlyAsn: 3.604 ± 0.612
3.18GlyPro: 3.18 ± 0.703
2.332GlyGln: 2.332 ± 0.595
4.452GlyArg: 4.452 ± 0.695
4.028GlySer: 4.028 ± 1.123
5.512GlyThr: 5.512 ± 0.982
4.452GlyVal: 4.452 ± 0.89
0.848GlyTrp: 0.848 ± 0.413
1.696GlyTyr: 1.696 ± 0.31
0.0GlyXaa: 0.0 ± 0.0
His
0.212HisAla: 0.212 ± 0.178
0.424HisCys: 0.424 ± 0.261
0.848HisAsp: 0.848 ± 0.578
1.272HisGlu: 1.272 ± 0.479
0.636HisPhe: 0.636 ± 0.372
1.484HisGly: 1.484 ± 0.523
0.0HisHis: 0.0 ± 0.0
1.06HisIle: 1.06 ± 0.41
0.636HisLys: 0.636 ± 0.467
1.484HisLeu: 1.484 ± 0.458
0.212HisMet: 0.212 ± 0.214
0.848HisAsn: 0.848 ± 0.442
1.06HisPro: 1.06 ± 0.571
0.424HisGln: 0.424 ± 0.403
1.908HisArg: 1.908 ± 0.969
2.332HisSer: 2.332 ± 0.893
0.636HisThr: 0.636 ± 0.298
0.848HisVal: 0.848 ± 0.278
0.0HisTrp: 0.0 ± 0.0
0.636HisTyr: 0.636 ± 0.298
0.0HisXaa: 0.0 ± 0.0
Ile
4.24IleAla: 4.24 ± 0.871
1.908IleCys: 1.908 ± 0.496
2.968IleAsp: 2.968 ± 0.869
5.3IleGlu: 5.3 ± 1.15
1.484IlePhe: 1.484 ± 0.438
6.36IleGly: 6.36 ± 0.736
0.212IleHis: 0.212 ± 0.203
4.028IleIle: 4.028 ± 0.994
6.784IleLys: 6.784 ± 1.586
6.148IleLeu: 6.148 ± 1.239
1.696IleMet: 1.696 ± 0.501
3.604IleAsn: 3.604 ± 0.905
3.392IlePro: 3.392 ± 0.623
3.392IleGln: 3.392 ± 0.883
3.816IleArg: 3.816 ± 1.027
3.816IleSer: 3.816 ± 0.718
4.452IleThr: 4.452 ± 0.832
2.544IleVal: 2.544 ± 0.984
0.636IleTrp: 0.636 ± 0.267
1.06IleTyr: 1.06 ± 0.395
0.0IleXaa: 0.0 ± 0.0
Lys
4.24LysAla: 4.24 ± 0.638
2.544LysCys: 2.544 ± 0.562
3.604LysAsp: 3.604 ± 1.109
5.936LysGlu: 5.936 ± 0.935
0.848LysPhe: 0.848 ± 0.351
6.996LysGly: 6.996 ± 1.439
0.424LysHis: 0.424 ± 0.303
5.3LysIle: 5.3 ± 0.802
5.3LysLys: 5.3 ± 1.292
6.784LysLeu: 6.784 ± 0.703
2.968LysMet: 2.968 ± 0.803
4.452LysAsn: 4.452 ± 0.848
2.968LysPro: 2.968 ± 0.464
1.908LysGln: 1.908 ± 0.7
6.148LysArg: 6.148 ± 1.295
2.756LysSer: 2.756 ± 0.585
6.572LysThr: 6.572 ± 1.437
3.18LysVal: 3.18 ± 0.739
1.484LysTrp: 1.484 ± 0.644
2.544LysTyr: 2.544 ± 0.704
0.0LysXaa: 0.0 ± 0.0
Leu
5.512LeuAla: 5.512 ± 1.222
0.848LeuCys: 0.848 ± 0.422
4.028LeuAsp: 4.028 ± 0.581
6.148LeuGlu: 6.148 ± 1.065
4.028LeuPhe: 4.028 ± 1.246
4.452LeuGly: 4.452 ± 0.649
2.332LeuHis: 2.332 ± 0.632
4.028LeuIle: 4.028 ± 0.944
8.692LeuLys: 8.692 ± 1.865
8.904LeuLeu: 8.904 ± 1.3
4.028LeuMet: 4.028 ± 0.951
4.876LeuAsn: 4.876 ± 0.862
3.604LeuPro: 3.604 ± 0.612
2.544LeuGln: 2.544 ± 0.728
5.512LeuArg: 5.512 ± 0.78
8.056LeuSer: 8.056 ± 1.22
3.816LeuThr: 3.816 ± 0.716
3.816LeuVal: 3.816 ± 0.654
1.272LeuTrp: 1.272 ± 0.562
2.756LeuTyr: 2.756 ± 0.843
0.0LeuXaa: 0.0 ± 0.0
Met
3.816MetAla: 3.816 ± 0.914
0.636MetCys: 0.636 ± 0.4
1.696MetAsp: 1.696 ± 0.782
2.756MetGlu: 2.756 ± 0.478
1.272MetPhe: 1.272 ± 0.652
3.604MetGly: 3.604 ± 0.821
0.424MetHis: 0.424 ± 0.23
2.756MetIle: 2.756 ± 0.668
3.18MetLys: 3.18 ± 0.907
2.332MetLeu: 2.332 ± 0.571
1.696MetMet: 1.696 ± 0.556
2.544MetAsn: 2.544 ± 0.665
0.424MetPro: 0.424 ± 0.249
0.636MetGln: 0.636 ± 0.456
1.06MetArg: 1.06 ± 0.607
2.544MetSer: 2.544 ± 0.536
2.544MetThr: 2.544 ± 0.64
3.392MetVal: 3.392 ± 1.002
0.212MetTrp: 0.212 ± 0.203
1.06MetTyr: 1.06 ± 0.44
0.0MetXaa: 0.0 ± 0.0
Asn
4.24AsnAla: 4.24 ± 0.438
1.484AsnCys: 1.484 ± 0.748
2.332AsnAsp: 2.332 ± 0.765
4.028AsnGlu: 4.028 ± 1.446
2.12AsnPhe: 2.12 ± 0.744
3.816AsnGly: 3.816 ± 0.999
0.848AsnHis: 0.848 ± 0.317
3.604AsnIle: 3.604 ± 0.984
4.876AsnLys: 4.876 ± 0.869
4.664AsnLeu: 4.664 ± 0.941
2.544AsnMet: 2.544 ± 0.926
2.12AsnAsn: 2.12 ± 0.842
3.816AsnPro: 3.816 ± 0.634
1.272AsnGln: 1.272 ± 0.378
1.908AsnArg: 1.908 ± 0.778
2.332AsnSer: 2.332 ± 0.758
3.604AsnThr: 3.604 ± 0.73
2.332AsnVal: 2.332 ± 0.875
0.212AsnTrp: 0.212 ± 0.203
1.272AsnTyr: 1.272 ± 0.512
0.0AsnXaa: 0.0 ± 0.0
Pro
2.12ProAla: 2.12 ± 0.744
0.636ProCys: 0.636 ± 0.427
1.484ProAsp: 1.484 ± 0.475
3.18ProGlu: 3.18 ± 0.968
1.484ProPhe: 1.484 ± 0.647
3.392ProGly: 3.392 ± 0.758
0.636ProHis: 0.636 ± 0.298
4.028ProIle: 4.028 ± 1.054
2.968ProLys: 2.968 ± 1.131
3.18ProLeu: 3.18 ± 1.033
0.636ProMet: 0.636 ± 0.28
2.544ProAsn: 2.544 ± 0.904
1.908ProPro: 1.908 ± 0.416
1.696ProGln: 1.696 ± 0.454
2.12ProArg: 2.12 ± 0.506
2.756ProSer: 2.756 ± 0.841
1.696ProThr: 1.696 ± 0.737
2.332ProVal: 2.332 ± 0.634
0.636ProTrp: 0.636 ± 0.382
1.908ProTyr: 1.908 ± 0.636
0.0ProXaa: 0.0 ± 0.0
Gln
2.12GlnAla: 2.12 ± 0.608
0.424GlnCys: 0.424 ± 0.349
0.848GlnAsp: 0.848 ± 0.308
1.908GlnGlu: 1.908 ± 0.728
1.272GlnPhe: 1.272 ± 0.58
1.908GlnGly: 1.908 ± 0.695
0.212GlnHis: 0.212 ± 0.206
2.756GlnIle: 2.756 ± 0.853
4.028GlnLys: 4.028 ± 0.964
2.756GlnLeu: 2.756 ± 0.775
2.12GlnMet: 2.12 ± 0.658
1.484GlnAsn: 1.484 ± 0.372
0.636GlnPro: 0.636 ± 0.257
0.424GlnGln: 0.424 ± 0.257
2.332GlnArg: 2.332 ± 0.573
1.908GlnSer: 1.908 ± 0.51
2.968GlnThr: 2.968 ± 0.427
0.848GlnVal: 0.848 ± 0.5
0.636GlnTrp: 0.636 ± 0.609
0.848GlnTyr: 0.848 ± 0.419
0.0GlnXaa: 0.0 ± 0.0
Arg
2.968ArgAla: 2.968 ± 0.611
0.848ArgCys: 0.848 ± 0.455
3.816ArgAsp: 3.816 ± 0.856
2.332ArgGlu: 2.332 ± 0.922
1.908ArgPhe: 1.908 ± 0.592
2.968ArgGly: 2.968 ± 0.751
0.636ArgHis: 0.636 ± 0.516
3.604ArgIle: 3.604 ± 0.888
3.816ArgLys: 3.816 ± 0.917
5.088ArgLeu: 5.088 ± 1.321
3.392ArgMet: 3.392 ± 0.824
3.18ArgAsn: 3.18 ± 0.82
1.908ArgPro: 1.908 ± 0.75
1.908ArgGln: 1.908 ± 0.9
2.544ArgArg: 2.544 ± 0.86
3.392ArgSer: 3.392 ± 1.18
2.12ArgThr: 2.12 ± 0.545
3.18ArgVal: 3.18 ± 1.088
0.424ArgTrp: 0.424 ± 0.403
1.272ArgTyr: 1.272 ± 0.549
0.0ArgXaa: 0.0 ± 0.0
Ser
5.724SerAla: 5.724 ± 1.4
1.272SerCys: 1.272 ± 0.514
2.544SerAsp: 2.544 ± 0.443
2.332SerGlu: 2.332 ± 0.691
1.908SerPhe: 1.908 ± 0.477
5.512SerGly: 5.512 ± 1.317
1.272SerHis: 1.272 ± 0.479
5.3SerIle: 5.3 ± 0.832
4.028SerLys: 4.028 ± 0.923
6.572SerLeu: 6.572 ± 1.256
3.18SerMet: 3.18 ± 0.97
5.3SerAsn: 5.3 ± 0.89
2.756SerPro: 2.756 ± 0.592
2.756SerGln: 2.756 ± 0.817
2.12SerArg: 2.12 ± 0.457
3.816SerSer: 3.816 ± 1.333
4.664SerThr: 4.664 ± 0.87
1.484SerVal: 1.484 ± 0.632
0.424SerTrp: 0.424 ± 0.304
1.908SerTyr: 1.908 ± 0.653
0.0SerXaa: 0.0 ± 0.0
Thr
4.24ThrAla: 4.24 ± 1.21
0.848ThrCys: 0.848 ± 0.418
3.604ThrAsp: 3.604 ± 0.972
3.816ThrGlu: 3.816 ± 1.008
3.18ThrPhe: 3.18 ± 0.515
4.028ThrGly: 4.028 ± 1.011
1.484ThrHis: 1.484 ± 0.65
4.664ThrIle: 4.664 ± 0.426
5.3ThrLys: 5.3 ± 1.088
3.604ThrLeu: 3.604 ± 0.876
2.332ThrMet: 2.332 ± 0.485
2.12ThrAsn: 2.12 ± 0.717
3.392ThrPro: 3.392 ± 0.859
2.12ThrGln: 2.12 ± 0.909
1.908ThrArg: 1.908 ± 0.644
4.028ThrSer: 4.028 ± 1.009
4.028ThrThr: 4.028 ± 0.845
4.664ThrVal: 4.664 ± 1.028
0.848ThrTrp: 0.848 ± 0.584
2.12ThrTyr: 2.12 ± 0.786
0.0ThrXaa: 0.0 ± 0.0
Val
4.452ValAla: 4.452 ± 0.692
0.636ValCys: 0.636 ± 0.264
2.756ValAsp: 2.756 ± 0.409
4.452ValGlu: 4.452 ± 0.682
1.272ValPhe: 1.272 ± 0.573
2.12ValGly: 2.12 ± 0.691
0.848ValHis: 0.848 ± 0.483
3.816ValIle: 3.816 ± 1.029
4.876ValLys: 4.876 ± 1.061
6.572ValLeu: 6.572 ± 1.001
1.272ValMet: 1.272 ± 0.44
2.756ValAsn: 2.756 ± 0.89
1.908ValPro: 1.908 ± 0.513
1.272ValGln: 1.272 ± 0.418
1.908ValArg: 1.908 ± 0.973
4.452ValSer: 4.452 ± 0.71
3.18ValThr: 3.18 ± 0.832
3.604ValVal: 3.604 ± 0.743
0.424ValTrp: 0.424 ± 0.356
1.272ValTyr: 1.272 ± 0.427
0.0ValXaa: 0.0 ± 0.0
Trp
0.848TrpAla: 0.848 ± 0.413
0.212TrpCys: 0.212 ± 0.178
0.848TrpAsp: 0.848 ± 0.397
1.06TrpGlu: 1.06 ± 0.306
0.636TrpPhe: 0.636 ± 0.293
0.848TrpGly: 0.848 ± 0.405
0.424TrpHis: 0.424 ± 0.289
0.424TrpIle: 0.424 ± 0.261
0.212TrpLys: 0.212 ± 0.181
0.424TrpLeu: 0.424 ± 0.251
0.212TrpMet: 0.212 ± 0.181
0.424TrpAsn: 0.424 ± 0.269
0.212TrpPro: 0.212 ± 0.181
0.424TrpGln: 0.424 ± 0.305
1.06TrpArg: 1.06 ± 0.392
0.212TrpSer: 0.212 ± 0.214
1.272TrpThr: 1.272 ± 0.746
1.272TrpVal: 1.272 ± 0.572
0.212TrpTrp: 0.212 ± 0.203
0.424TrpTyr: 0.424 ± 0.429
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.272TyrAla: 1.272 ± 0.438
1.272TyrCys: 1.272 ± 0.478
1.696TyrAsp: 1.696 ± 0.421
2.12TyrGlu: 2.12 ± 0.547
1.272TyrPhe: 1.272 ± 0.499
1.06TyrGly: 1.06 ± 0.39
0.636TyrHis: 0.636 ± 0.389
1.06TyrIle: 1.06 ± 0.38
1.908TyrLys: 1.908 ± 0.567
2.544TyrLeu: 2.544 ± 1.011
1.06TyrMet: 1.06 ± 0.358
2.332TyrAsn: 2.332 ± 0.55
0.848TyrPro: 0.848 ± 0.663
1.908TyrGln: 1.908 ± 0.772
1.06TyrArg: 1.06 ± 0.801
2.756TyrSer: 2.756 ± 0.521
2.12TyrThr: 2.12 ± 0.544
1.272TyrVal: 1.272 ± 0.627
0.212TyrTrp: 0.212 ± 0.181
0.636TyrTyr: 0.636 ± 0.429
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski