Amino acid dipepetide frequency for Arthrobacter phage StarLord

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.609AlaAla: 7.609 ± 0.923
0.527AlaCys: 0.527 ± 0.186
5.443AlaAsp: 5.443 ± 0.548
5.326AlaGlu: 5.326 ± 0.667
3.16AlaPhe: 3.16 ± 0.416
6.438AlaGly: 6.438 ± 1.264
1.58AlaHis: 1.58 ± 0.368
5.619AlaIle: 5.619 ± 0.549
5.385AlaLys: 5.385 ± 0.662
7.667AlaLeu: 7.667 ± 1.147
3.395AlaMet: 3.395 ± 0.803
3.102AlaAsn: 3.102 ± 0.459
3.629AlaPro: 3.629 ± 0.562
3.395AlaGln: 3.395 ± 0.442
4.565AlaArg: 4.565 ± 0.568
5.677AlaSer: 5.677 ± 0.668
5.033AlaThr: 5.033 ± 0.524
7.023AlaVal: 7.023 ± 0.784
1.405AlaTrp: 1.405 ± 0.369
2.692AlaTyr: 2.692 ± 0.409
0.0AlaXaa: 0.0 ± 0.0
Cys
0.41CysAla: 0.41 ± 0.158
0.0CysCys: 0.0 ± 0.0
0.41CysAsp: 0.41 ± 0.137
0.41CysGlu: 0.41 ± 0.139
0.234CysPhe: 0.234 ± 0.115
0.468CysGly: 0.468 ± 0.192
0.293CysHis: 0.293 ± 0.145
0.468CysIle: 0.468 ± 0.18
0.176CysLys: 0.176 ± 0.13
0.585CysLeu: 0.585 ± 0.179
0.059CysMet: 0.059 ± 0.059
0.234CysAsn: 0.234 ± 0.11
0.468CysPro: 0.468 ± 0.171
0.059CysGln: 0.059 ± 0.049
0.351CysArg: 0.351 ± 0.141
0.293CysSer: 0.293 ± 0.114
0.527CysThr: 0.527 ± 0.193
0.293CysVal: 0.293 ± 0.142
0.117CysTrp: 0.117 ± 0.081
0.176CysTyr: 0.176 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
5.853AspAla: 5.853 ± 0.621
0.468AspCys: 0.468 ± 0.2
3.921AspAsp: 3.921 ± 0.723
4.038AspGlu: 4.038 ± 0.627
3.043AspPhe: 3.043 ± 0.504
4.448AspGly: 4.448 ± 0.541
0.761AspHis: 0.761 ± 0.209
3.804AspIle: 3.804 ± 0.503
3.98AspLys: 3.98 ± 0.597
4.565AspLeu: 4.565 ± 0.495
1.463AspMet: 1.463 ± 0.229
2.809AspAsn: 2.809 ± 0.383
2.868AspPro: 2.868 ± 0.62
2.634AspGln: 2.634 ± 0.42
2.692AspArg: 2.692 ± 0.423
2.926AspSer: 2.926 ± 0.471
3.043AspThr: 3.043 ± 0.41
4.331AspVal: 4.331 ± 0.606
1.112AspTrp: 1.112 ± 0.253
1.873AspTyr: 1.873 ± 0.367
0.0AspXaa: 0.0 ± 0.0
Glu
5.736GluAla: 5.736 ± 0.561
0.527GluCys: 0.527 ± 0.191
3.687GluAsp: 3.687 ± 0.541
5.619GluGlu: 5.619 ± 0.855
2.458GluPhe: 2.458 ± 0.364
4.858GluGly: 4.858 ± 0.504
1.171GluHis: 1.171 ± 0.277
4.097GluIle: 4.097 ± 0.507
4.038GluLys: 4.038 ± 0.778
5.385GluLeu: 5.385 ± 0.579
2.048GluMet: 2.048 ± 0.341
2.283GluAsn: 2.283 ± 0.339
2.634GluPro: 2.634 ± 0.464
2.517GluGln: 2.517 ± 0.417
3.687GluArg: 3.687 ± 0.43
2.985GluSer: 2.985 ± 0.396
4.097GluThr: 4.097 ± 0.556
4.624GluVal: 4.624 ± 0.633
1.346GluTrp: 1.346 ± 0.26
2.4GluTyr: 2.4 ± 0.374
0.0GluXaa: 0.0 ± 0.0
Phe
2.341PheAla: 2.341 ± 0.405
0.176PheCys: 0.176 ± 0.1
2.809PheAsp: 2.809 ± 0.368
2.751PheGlu: 2.751 ± 0.413
1.288PhePhe: 1.288 ± 0.266
2.985PheGly: 2.985 ± 0.429
0.761PheHis: 0.761 ± 0.182
2.341PheIle: 2.341 ± 0.394
1.99PheLys: 1.99 ± 0.325
2.575PheLeu: 2.575 ± 0.332
1.405PheMet: 1.405 ± 0.3
2.283PheAsn: 2.283 ± 0.319
1.112PhePro: 1.112 ± 0.285
0.936PheGln: 0.936 ± 0.201
1.814PheArg: 1.814 ± 0.402
1.99PheSer: 1.99 ± 0.349
2.926PheThr: 2.926 ± 0.468
2.517PheVal: 2.517 ± 0.344
0.761PheTrp: 0.761 ± 0.225
1.053PheTyr: 1.053 ± 0.285
0.0PheXaa: 0.0 ± 0.0
Gly
7.901GlyAla: 7.901 ± 0.796
0.351GlyCys: 0.351 ± 0.134
5.092GlyAsp: 5.092 ± 0.57
3.863GlyGlu: 3.863 ± 0.387
2.751GlyPhe: 2.751 ± 0.338
5.56GlyGly: 5.56 ± 0.88
1.053GlyHis: 1.053 ± 0.25
4.682GlyIle: 4.682 ± 0.775
3.629GlyLys: 3.629 ± 0.473
6.731GlyLeu: 6.731 ± 1.134
2.458GlyMet: 2.458 ± 0.57
3.16GlyAsn: 3.16 ± 0.613
1.697GlyPro: 1.697 ± 0.306
1.931GlyGln: 1.931 ± 0.266
3.278GlyArg: 3.278 ± 0.355
5.326GlySer: 5.326 ± 0.726
4.507GlyThr: 4.507 ± 0.499
6.614GlyVal: 6.614 ± 0.627
1.756GlyTrp: 1.756 ± 0.256
2.575GlyTyr: 2.575 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
1.405HisAla: 1.405 ± 0.317
0.059HisCys: 0.059 ± 0.055
0.644HisAsp: 0.644 ± 0.177
1.463HisGlu: 1.463 ± 0.361
0.41HisPhe: 0.41 ± 0.151
1.697HisGly: 1.697 ± 0.405
0.585HisHis: 0.585 ± 0.197
0.819HisIle: 0.819 ± 0.211
0.819HisLys: 0.819 ± 0.208
0.936HisLeu: 0.936 ± 0.215
0.761HisMet: 0.761 ± 0.214
0.995HisAsn: 0.995 ± 0.232
0.819HisPro: 0.819 ± 0.241
0.819HisGln: 0.819 ± 0.214
0.936HisArg: 0.936 ± 0.221
0.936HisSer: 0.936 ± 0.236
0.936HisThr: 0.936 ± 0.226
1.229HisVal: 1.229 ± 0.234
0.234HisTrp: 0.234 ± 0.124
1.346HisTyr: 1.346 ± 0.304
0.0HisXaa: 0.0 ± 0.0
Ile
5.092IleAla: 5.092 ± 0.844
0.468IleCys: 0.468 ± 0.188
5.092IleAsp: 5.092 ± 0.538
3.687IleGlu: 3.687 ± 0.46
1.756IlePhe: 1.756 ± 0.298
3.921IleGly: 3.921 ± 0.747
1.346IleHis: 1.346 ± 0.315
2.868IleIle: 2.868 ± 0.461
3.219IleLys: 3.219 ± 0.366
5.033IleLeu: 5.033 ± 0.741
1.697IleMet: 1.697 ± 0.296
3.336IleAsn: 3.336 ± 0.52
2.107IlePro: 2.107 ± 0.382
1.814IleGln: 1.814 ± 0.294
3.219IleArg: 3.219 ± 0.439
3.57IleSer: 3.57 ± 0.454
3.863IleThr: 3.863 ± 0.435
4.448IleVal: 4.448 ± 0.53
0.995IleTrp: 0.995 ± 0.23
1.814IleTyr: 1.814 ± 0.337
0.0IleXaa: 0.0 ± 0.0
Lys
6.204LysAla: 6.204 ± 0.555
0.176LysCys: 0.176 ± 0.084
3.219LysAsp: 3.219 ± 0.558
4.975LysGlu: 4.975 ± 0.675
2.107LysPhe: 2.107 ± 0.397
4.682LysGly: 4.682 ± 0.704
1.463LysHis: 1.463 ± 0.38
3.804LysIle: 3.804 ± 0.387
5.209LysLys: 5.209 ± 0.643
5.385LysLeu: 5.385 ± 0.614
2.224LysMet: 2.224 ± 0.35
1.99LysAsn: 1.99 ± 0.301
2.926LysPro: 2.926 ± 0.408
2.341LysGln: 2.341 ± 0.401
3.102LysArg: 3.102 ± 0.57
3.921LysSer: 3.921 ± 0.443
3.278LysThr: 3.278 ± 0.538
3.629LysVal: 3.629 ± 0.42
1.288LysTrp: 1.288 ± 0.298
1.814LysTyr: 1.814 ± 0.357
0.0LysXaa: 0.0 ± 0.0
Leu
8.662LeuAla: 8.662 ± 1.018
0.585LeuCys: 0.585 ± 0.2
4.507LeuAsp: 4.507 ± 0.42
5.033LeuGlu: 5.033 ± 0.507
2.692LeuPhe: 2.692 ± 0.398
6.204LeuGly: 6.204 ± 1.182
1.346LeuHis: 1.346 ± 0.227
5.15LeuIle: 5.15 ± 0.683
5.267LeuLys: 5.267 ± 0.607
5.209LeuLeu: 5.209 ± 0.735
2.166LeuMet: 2.166 ± 0.339
3.921LeuAsn: 3.921 ± 0.552
3.395LeuPro: 3.395 ± 0.38
2.634LeuGln: 2.634 ± 0.373
4.507LeuArg: 4.507 ± 0.548
4.975LeuSer: 4.975 ± 0.669
5.385LeuThr: 5.385 ± 0.561
5.033LeuVal: 5.033 ± 0.54
1.112LeuTrp: 1.112 ± 0.219
2.751LeuTyr: 2.751 ± 0.453
0.0LeuXaa: 0.0 ± 0.0
Met
3.102MetAla: 3.102 ± 0.554
0.0MetCys: 0.0 ± 0.0
1.814MetAsp: 1.814 ± 0.268
2.107MetGlu: 2.107 ± 0.452
1.405MetPhe: 1.405 ± 0.271
1.697MetGly: 1.697 ± 0.398
0.644MetHis: 0.644 ± 0.229
1.288MetIle: 1.288 ± 0.317
1.639MetLys: 1.639 ± 0.321
2.224MetLeu: 2.224 ± 0.337
0.761MetMet: 0.761 ± 0.238
0.936MetAsn: 0.936 ± 0.231
0.761MetPro: 0.761 ± 0.19
1.171MetGln: 1.171 ± 0.302
1.463MetArg: 1.463 ± 0.266
2.634MetSer: 2.634 ± 0.404
2.166MetThr: 2.166 ± 0.471
1.229MetVal: 1.229 ± 0.296
0.41MetTrp: 0.41 ± 0.145
0.702MetTyr: 0.702 ± 0.282
0.0MetXaa: 0.0 ± 0.0
Asn
3.336AsnAla: 3.336 ± 0.444
0.351AsnCys: 0.351 ± 0.133
2.107AsnAsp: 2.107 ± 0.378
2.751AsnGlu: 2.751 ± 0.406
1.99AsnPhe: 1.99 ± 0.379
4.565AsnGly: 4.565 ± 0.663
0.761AsnHis: 0.761 ± 0.214
2.751AsnIle: 2.751 ± 0.35
2.926AsnLys: 2.926 ± 0.453
3.512AsnLeu: 3.512 ± 0.363
1.288AsnMet: 1.288 ± 0.296
1.756AsnAsn: 1.756 ± 0.377
3.102AsnPro: 3.102 ± 0.541
1.522AsnGln: 1.522 ± 0.299
2.341AsnArg: 2.341 ± 0.45
2.751AsnSer: 2.751 ± 0.357
2.575AsnThr: 2.575 ± 0.3
2.4AsnVal: 2.4 ± 0.404
0.702AsnTrp: 0.702 ± 0.188
1.639AsnTyr: 1.639 ± 0.327
0.0AsnXaa: 0.0 ± 0.0
Pro
3.687ProAla: 3.687 ± 0.495
0.351ProCys: 0.351 ± 0.157
2.985ProAsp: 2.985 ± 0.444
3.57ProGlu: 3.57 ± 0.542
1.171ProPhe: 1.171 ± 0.203
3.043ProGly: 3.043 ± 0.353
0.936ProHis: 0.936 ± 0.241
1.814ProIle: 1.814 ± 0.295
2.341ProLys: 2.341 ± 0.38
2.4ProLeu: 2.4 ± 0.44
0.702ProMet: 0.702 ± 0.226
2.166ProAsn: 2.166 ± 0.417
1.873ProPro: 1.873 ± 0.344
1.171ProGln: 1.171 ± 0.262
2.048ProArg: 2.048 ± 0.403
3.043ProSer: 3.043 ± 0.398
2.926ProThr: 2.926 ± 0.427
3.102ProVal: 3.102 ± 0.418
0.585ProTrp: 0.585 ± 0.183
1.756ProTyr: 1.756 ± 0.355
0.0ProXaa: 0.0 ± 0.0
Gln
3.102GlnAla: 3.102 ± 0.469
0.117GlnCys: 0.117 ± 0.082
1.346GlnAsp: 1.346 ± 0.308
1.639GlnGlu: 1.639 ± 0.384
1.229GlnPhe: 1.229 ± 0.262
2.283GlnGly: 2.283 ± 0.384
0.936GlnHis: 0.936 ± 0.271
2.4GlnIle: 2.4 ± 0.302
2.283GlnLys: 2.283 ± 0.321
3.336GlnLeu: 3.336 ± 0.494
0.468GlnMet: 0.468 ± 0.174
1.756GlnAsn: 1.756 ± 0.412
1.288GlnPro: 1.288 ± 0.283
1.229GlnGln: 1.229 ± 0.296
2.048GlnArg: 2.048 ± 0.334
1.522GlnSer: 1.522 ± 0.248
2.107GlnThr: 2.107 ± 0.397
2.166GlnVal: 2.166 ± 0.366
0.468GlnTrp: 0.468 ± 0.171
1.463GlnTyr: 1.463 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
3.687ArgAla: 3.687 ± 0.418
0.176ArgCys: 0.176 ± 0.096
2.868ArgAsp: 2.868 ± 0.444
2.985ArgGlu: 2.985 ± 0.386
1.814ArgPhe: 1.814 ± 0.256
2.809ArgGly: 2.809 ± 0.434
0.936ArgHis: 0.936 ± 0.218
3.453ArgIle: 3.453 ± 0.382
4.214ArgLys: 4.214 ± 0.653
4.858ArgLeu: 4.858 ± 0.481
1.639ArgMet: 1.639 ± 0.321
2.751ArgAsn: 2.751 ± 0.332
2.283ArgPro: 2.283 ± 0.336
1.99ArgGln: 1.99 ± 0.405
3.863ArgArg: 3.863 ± 0.604
2.517ArgSer: 2.517 ± 0.441
3.395ArgThr: 3.395 ± 0.523
3.102ArgVal: 3.102 ± 0.508
0.819ArgTrp: 0.819 ± 0.249
2.048ArgTyr: 2.048 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
5.267SerAla: 5.267 ± 0.682
0.527SerCys: 0.527 ± 0.215
2.751SerAsp: 2.751 ± 0.497
4.155SerGlu: 4.155 ± 0.48
2.166SerPhe: 2.166 ± 0.4
4.448SerGly: 4.448 ± 0.537
0.936SerHis: 0.936 ± 0.248
3.746SerIle: 3.746 ± 0.406
3.921SerLys: 3.921 ± 0.586
4.858SerLeu: 4.858 ± 0.505
1.756SerMet: 1.756 ± 0.325
2.4SerAsn: 2.4 ± 0.313
2.692SerPro: 2.692 ± 0.434
1.346SerGln: 1.346 ± 0.277
3.512SerArg: 3.512 ± 0.489
4.155SerSer: 4.155 ± 0.568
4.624SerThr: 4.624 ± 0.706
3.16SerVal: 3.16 ± 0.439
1.288SerTrp: 1.288 ± 0.247
1.99SerTyr: 1.99 ± 0.39
0.0SerXaa: 0.0 ± 0.0
Thr
5.033ThrAla: 5.033 ± 0.742
0.41ThrCys: 0.41 ± 0.159
3.453ThrAsp: 3.453 ± 0.551
4.214ThrGlu: 4.214 ± 0.582
2.107ThrPhe: 2.107 ± 0.304
5.794ThrGly: 5.794 ± 0.681
1.112ThrHis: 1.112 ± 0.313
3.921ThrIle: 3.921 ± 0.492
3.804ThrLys: 3.804 ± 0.418
5.853ThrLeu: 5.853 ± 0.609
1.58ThrMet: 1.58 ± 0.33
2.751ThrAsn: 2.751 ± 0.422
3.746ThrPro: 3.746 ± 0.424
1.814ThrGln: 1.814 ± 0.307
2.166ThrArg: 2.166 ± 0.307
3.336ThrSer: 3.336 ± 0.452
4.331ThrThr: 4.331 ± 0.567
5.385ThrVal: 5.385 ± 0.671
0.761ThrTrp: 0.761 ± 0.257
2.4ThrTyr: 2.4 ± 0.429
0.0ThrXaa: 0.0 ± 0.0
Val
6.087ValAla: 6.087 ± 0.672
0.234ValCys: 0.234 ± 0.107
4.975ValAsp: 4.975 ± 0.55
4.273ValGlu: 4.273 ± 0.567
2.517ValPhe: 2.517 ± 0.413
4.682ValGly: 4.682 ± 0.709
0.585ValHis: 0.585 ± 0.186
4.155ValIle: 4.155 ± 0.412
5.267ValLys: 5.267 ± 0.549
5.911ValLeu: 5.911 ± 0.753
1.463ValMet: 1.463 ± 0.283
3.746ValAsn: 3.746 ± 0.558
2.809ValPro: 2.809 ± 0.398
2.107ValGln: 2.107 ± 0.409
3.57ValArg: 3.57 ± 0.556
3.863ValSer: 3.863 ± 0.485
4.975ValThr: 4.975 ± 0.628
5.502ValVal: 5.502 ± 0.749
0.995ValTrp: 0.995 ± 0.286
1.99ValTyr: 1.99 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
0.936TrpAla: 0.936 ± 0.22
0.117TrpCys: 0.117 ± 0.082
1.288TrpAsp: 1.288 ± 0.306
1.229TrpGlu: 1.229 ± 0.304
0.761TrpPhe: 0.761 ± 0.161
1.171TrpGly: 1.171 ± 0.268
0.176TrpHis: 0.176 ± 0.092
0.761TrpIle: 0.761 ± 0.206
1.463TrpLys: 1.463 ± 0.322
1.346TrpLeu: 1.346 ± 0.294
0.351TrpMet: 0.351 ± 0.161
1.053TrpAsn: 1.053 ± 0.266
0.293TrpPro: 0.293 ± 0.122
0.644TrpGln: 0.644 ± 0.219
0.995TrpArg: 0.995 ± 0.377
1.053TrpSer: 1.053 ± 0.295
0.995TrpThr: 0.995 ± 0.228
1.463TrpVal: 1.463 ± 0.289
0.468TrpTrp: 0.468 ± 0.177
0.702TrpTyr: 0.702 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.278TyrAla: 3.278 ± 0.434
0.41TyrCys: 0.41 ± 0.173
2.224TyrAsp: 2.224 ± 0.43
2.107TyrGlu: 2.107 ± 0.349
1.756TyrPhe: 1.756 ± 0.284
3.16TyrGly: 3.16 ± 0.522
0.468TyrHis: 0.468 ± 0.18
1.405TyrIle: 1.405 ± 0.329
2.166TyrLys: 2.166 ± 0.525
2.166TyrLeu: 2.166 ± 0.411
0.41TyrMet: 0.41 ± 0.134
1.697TyrAsn: 1.697 ± 0.234
1.171TyrPro: 1.171 ± 0.296
1.112TyrGln: 1.112 ± 0.269
2.048TyrArg: 2.048 ± 0.398
2.224TyrSer: 2.224 ± 0.373
2.283TyrThr: 2.283 ± 0.533
2.458TyrVal: 2.458 ± 0.469
0.644TyrTrp: 0.644 ± 0.194
1.112TyrTyr: 1.112 ± 0.372
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 87 proteins (17087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski