Amino acid dipepetide frequency for Bacteroides acidifaciens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.641AlaAla: 5.641 ± 0.085	1.0AlaCys: 1.0 ± 0.027	4.168AlaAsp: 4.168 ± 0.064	4.84AlaGlu: 4.84 ± 0.062	3.083AlaPhe: 3.083 ± 0.054	4.967AlaGly: 4.967 ± 0.066	1.201AlaHis: 1.201 ± 0.03	4.699AlaIle: 4.699 ± 0.065	4.301AlaLys: 4.301 ± 0.055	6.464AlaLeu: 6.464 ± 0.077	1.949AlaMet: 1.949 ± 0.043	3.286AlaAsn: 3.286 ± 0.049	2.181AlaPro: 2.181 ± 0.045	2.585AlaGln: 2.585 ± 0.048	3.047AlaArg: 3.047 ± 0.056	4.255AlaSer: 4.255 ± 0.055	3.891AlaThr: 3.891 ± 0.061	4.577AlaVal: 4.577 ± 0.069	0.818AlaTrp: 0.818 ± 0.026	2.958AlaTyr: 2.958 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.779CysAla: 0.779 ± 0.025	0.237CysCys: 0.237 ± 0.015	0.676CysAsp: 0.676 ± 0.025	0.719CysGlu: 0.719 ± 0.022	0.639CysPhe: 0.639 ± 0.022	1.055CysGly: 1.055 ± 0.03	0.275CysHis: 0.275 ± 0.013	0.935CysIle: 0.935 ± 0.024	0.758CysLys: 0.758 ± 0.025	1.121CysLeu: 1.121 ± 0.032	0.336CysMet: 0.336 ± 0.017	0.626CysAsn: 0.626 ± 0.023	0.552CysPro: 0.552 ± 0.023	0.386CysGln: 0.386 ± 0.016	0.66CysArg: 0.66 ± 0.023	0.789CysSer: 0.789 ± 0.028	0.7CysThr: 0.7 ± 0.023	0.767CysVal: 0.767 ± 0.027	0.157CysTrp: 0.157 ± 0.011	0.566CysTyr: 0.566 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.913AspAla: 3.913 ± 0.063	0.683AspCys: 0.683 ± 0.025	2.752AspAsp: 2.752 ± 0.046	4.042AspGlu: 4.042 ± 0.063	3.06AspPhe: 3.06 ± 0.045	4.335AspGly: 4.335 ± 0.065	0.74AspHis: 0.74 ± 0.026	4.17AspIle: 4.17 ± 0.052	4.259AspLys: 4.259 ± 0.055	4.511AspLeu: 4.511 ± 0.067	1.593AspMet: 1.593 ± 0.036	2.928AspAsn: 2.928 ± 0.042	1.793AspPro: 1.793 ± 0.035	1.162AspGln: 1.162 ± 0.028	2.467AspArg: 2.467 ± 0.041	3.165AspSer: 3.165 ± 0.058	2.849AspThr: 2.849 ± 0.05	3.505AspVal: 3.505 ± 0.051	0.906AspTrp: 0.906 ± 0.024	2.966AspTyr: 2.966 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.829GluAla: 4.829 ± 0.074	0.689GluCys: 0.689 ± 0.021	3.407GluAsp: 3.407 ± 0.054	5.422GluGlu: 5.422 ± 0.093	2.579GluPhe: 2.579 ± 0.044	4.22GluGly: 4.22 ± 0.055	1.291GluHis: 1.291 ± 0.031	4.714GluIle: 4.714 ± 0.062	5.44GluLys: 5.44 ± 0.076	6.365GluLeu: 6.365 ± 0.077	2.054GluMet: 2.054 ± 0.042	3.623GluAsn: 3.623 ± 0.058	1.768GluPro: 1.768 ± 0.038	2.844GluGln: 2.844 ± 0.054	3.453GluArg: 3.453 ± 0.054	3.304GluSer: 3.304 ± 0.046	3.487GluThr: 3.487 ± 0.048	4.297GluVal: 4.297 ± 0.058	0.905GluTrp: 0.905 ± 0.024	2.905GluTyr: 2.905 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.947PheAla: 2.947 ± 0.049	0.699PheCys: 0.699 ± 0.025	2.826PheAsp: 2.826 ± 0.047	2.57PheGlu: 2.57 ± 0.045	2.165PhePhe: 2.165 ± 0.046	3.174PheGly: 3.174 ± 0.046	0.851PheHis: 0.851 ± 0.022	3.173PheIle: 3.173 ± 0.05	2.506PheLys: 2.506 ± 0.049	3.892PheLeu: 3.892 ± 0.055	1.211PheMet: 1.211 ± 0.028	2.427PheAsn: 2.427 ± 0.044	1.753PhePro: 1.753 ± 0.04	1.354PheGln: 1.354 ± 0.028	2.184PheArg: 2.184 ± 0.04	3.422PheSer: 3.422 ± 0.049	2.736PheThr: 2.736 ± 0.045	2.793PheVal: 2.793 ± 0.051	0.557PheTrp: 0.557 ± 0.023	1.977PheTyr: 1.977 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.252GlyAla: 4.252 ± 0.069	0.945GlyCys: 0.945 ± 0.029	3.54GlyAsp: 3.54 ± 0.054	4.349GlyGlu: 4.349 ± 0.054	3.147GlyPhe: 3.147 ± 0.049	4.58GlyGly: 4.58 ± 0.073	1.207GlyHis: 1.207 ± 0.029	5.212GlyIle: 5.212 ± 0.068	5.433GlyLys: 5.433 ± 0.068	5.667GlyLeu: 5.667 ± 0.077	2.073GlyMet: 2.073 ± 0.037	3.687GlyAsn: 3.687 ± 0.055	1.19GlyPro: 1.19 ± 0.029	2.111GlyGln: 2.111 ± 0.041	2.906GlyArg: 2.906 ± 0.05	3.855GlySer: 3.855 ± 0.055	4.193GlyThr: 4.193 ± 0.059	4.683GlyVal: 4.683 ± 0.062	1.055GlyTrp: 1.055 ± 0.033	3.477GlyTyr: 3.477 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.154HisAla: 1.154 ± 0.029	0.328HisCys: 0.328 ± 0.015	0.863HisAsp: 0.863 ± 0.027	1.001HisGlu: 1.001 ± 0.03	0.959HisPhe: 0.959 ± 0.026	1.193HisGly: 1.193 ± 0.033	0.431HisHis: 0.431 ± 0.018	1.4HisIle: 1.4 ± 0.037	1.039HisLys: 1.039 ± 0.03	1.706HisLeu: 1.706 ± 0.029	0.324HisMet: 0.324 ± 0.016	0.882HisAsn: 0.882 ± 0.024	1.02HisPro: 1.02 ± 0.027	0.625HisGln: 0.625 ± 0.021	0.898HisArg: 0.898 ± 0.026	1.147HisSer: 1.147 ± 0.033	1.06HisThr: 1.06 ± 0.03	1.003HisVal: 1.003 ± 0.027	0.255HisTrp: 0.255 ± 0.014	0.922HisTyr: 0.922 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.194IleAla: 5.194 ± 0.059	0.973IleCys: 0.973 ± 0.029	4.356IleAsp: 4.356 ± 0.059	4.623IleGlu: 4.623 ± 0.064	2.738IlePhe: 2.738 ± 0.053	4.707IleGly: 4.707 ± 0.072	1.312IleHis: 1.312 ± 0.029	4.57IleIle: 4.57 ± 0.065	4.178IleLys: 4.178 ± 0.053	5.784IleLeu: 5.784 ± 0.093	1.507IleMet: 1.507 ± 0.036	3.481IleAsn: 3.481 ± 0.054	3.116IlePro: 3.116 ± 0.048	2.218IleGln: 2.218 ± 0.038	3.465IleArg: 3.465 ± 0.049	4.629IleSer: 4.629 ± 0.057	4.077IleThr: 4.077 ± 0.061	4.23IleVal: 4.23 ± 0.064	0.687IleTrp: 0.687 ± 0.026	2.852IleTyr: 2.852 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.031LysAla: 5.031 ± 0.071	0.619LysCys: 0.619 ± 0.024	4.209LysAsp: 4.209 ± 0.059	6.059LysGlu: 6.059 ± 0.074	2.339LysPhe: 2.339 ± 0.044	4.635LysGly: 4.635 ± 0.064	1.262LysHis: 1.262 ± 0.028	4.256LysIle: 4.256 ± 0.061	5.327LysLys: 5.327 ± 0.076	5.502LysLeu: 5.502 ± 0.069	2.166LysMet: 2.166 ± 0.034	3.641LysAsn: 3.641 ± 0.056	2.138LysPro: 2.138 ± 0.042	2.653LysGln: 2.653 ± 0.046	3.29LysArg: 3.29 ± 0.047	3.494LysSer: 3.494 ± 0.048	3.647LysThr: 3.647 ± 0.054	4.524LysVal: 4.524 ± 0.056	0.814LysTrp: 0.814 ± 0.023	3.13LysTyr: 3.13 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.119LeuAla: 6.119 ± 0.084	1.337LeuCys: 1.337 ± 0.036	4.53LeuAsp: 4.53 ± 0.063	5.156LeuGlu: 5.156 ± 0.063	4.366LeuPhe: 4.366 ± 0.064	5.377LeuGly: 5.377 ± 0.078	1.73LeuHis: 1.73 ± 0.034	5.3LeuIle: 5.3 ± 0.08	6.463LeuLys: 6.463 ± 0.069	8.692LeuLeu: 8.692 ± 0.103	2.391LeuMet: 2.391 ± 0.048	4.713LeuAsn: 4.713 ± 0.059	4.024LeuPro: 4.024 ± 0.052	3.436LeuGln: 3.436 ± 0.05	4.217LeuArg: 4.217 ± 0.065	6.539LeuSer: 6.539 ± 0.071	5.23LeuThr: 5.23 ± 0.065	5.057LeuVal: 5.057 ± 0.065	1.045LeuTrp: 1.045 ± 0.027	3.732LeuTyr: 3.732 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.039MetAla: 2.039 ± 0.039	0.236MetCys: 0.236 ± 0.014	1.548MetAsp: 1.548 ± 0.029	1.872MetGlu: 1.872 ± 0.041	1.005MetPhe: 1.005 ± 0.026	1.78MetGly: 1.78 ± 0.04	0.437MetHis: 0.437 ± 0.018	1.631MetIle: 1.631 ± 0.039	2.635MetLys: 2.635 ± 0.042	2.431MetLeu: 2.431 ± 0.05	0.811MetMet: 0.811 ± 0.024	1.652MetAsn: 1.652 ± 0.037	1.104MetPro: 1.104 ± 0.026	1.075MetGln: 1.075 ± 0.027	1.339MetArg: 1.339 ± 0.031	1.57MetSer: 1.57 ± 0.032	1.43MetThr: 1.43 ± 0.029	1.597MetVal: 1.597 ± 0.036	0.283MetTrp: 0.283 ± 0.014	0.894MetTyr: 0.894 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.421AsnAla: 3.421 ± 0.051	0.531AsnCys: 0.531 ± 0.022	2.679AsnAsp: 2.679 ± 0.046	3.315AsnGlu: 3.315 ± 0.048	2.272AsnPhe: 2.272 ± 0.046	4.05AsnGly: 4.05 ± 0.07	0.914AsnHis: 0.914 ± 0.026	3.874AsnIle: 3.874 ± 0.055	3.376AsnLys: 3.376 ± 0.047	4.448AsnLeu: 4.448 ± 0.062	1.349AsnMet: 1.349 ± 0.03	2.808AsnAsn: 2.808 ± 0.054	2.496AsnPro: 2.496 ± 0.049	1.692AsnGln: 1.692 ± 0.036	2.572AsnArg: 2.572 ± 0.048	2.906AsnSer: 2.906 ± 0.05	2.812AsnThr: 2.812 ± 0.046	3.332AsnVal: 3.332 ± 0.053	0.692AsnTrp: 0.692 ± 0.024	2.464AsnTyr: 2.464 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.742ProAla: 2.742 ± 0.048	0.376ProCys: 0.376 ± 0.016	2.496ProAsp: 2.496 ± 0.041	3.393ProGlu: 3.393 ± 0.055	1.791ProPhe: 1.791 ± 0.035	2.303ProGly: 2.303 ± 0.048	0.662ProHis: 0.662 ± 0.023	2.341ProIle: 2.341 ± 0.043	2.082ProLys: 2.082 ± 0.038	3.085ProLeu: 3.085 ± 0.048	0.943ProMet: 0.943 ± 0.024	1.754ProAsn: 1.754 ± 0.039	0.813ProPro: 0.813 ± 0.029	1.362ProGln: 1.362 ± 0.029	1.329ProArg: 1.329 ± 0.029	2.18ProSer: 2.18 ± 0.045	1.887ProThr: 1.887 ± 0.033	2.939ProVal: 2.939 ± 0.046	0.433ProTrp: 0.433 ± 0.02	1.707ProTyr: 1.707 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.459GlnAla: 2.459 ± 0.038	0.335GlnCys: 0.335 ± 0.016	1.608GlnAsp: 1.608 ± 0.035	2.478GlnGlu: 2.478 ± 0.048	1.356GlnPhe: 1.356 ± 0.026	2.04GlnGly: 2.04 ± 0.039	0.638GlnHis: 0.638 ± 0.02	2.382GlnIle: 2.382 ± 0.043	2.547GlnLys: 2.547 ± 0.045	3.389GlnLeu: 3.389 ± 0.056	1.04GlnMet: 1.04 ± 0.027	1.806GlnAsn: 1.806 ± 0.036	1.307GlnPro: 1.307 ± 0.03	1.674GlnGln: 1.674 ± 0.048	1.68GlnArg: 1.68 ± 0.041	2.048GlnSer: 2.048 ± 0.036	2.08GlnThr: 2.08 ± 0.035	2.112GlnVal: 2.112 ± 0.042	0.451GlnTrp: 0.451 ± 0.018	1.514GlnTyr: 1.514 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.799ArgAla: 2.799 ± 0.049	0.49ArgCys: 0.49 ± 0.02	2.185ArgAsp: 2.185 ± 0.04	3.051ArgGlu: 3.051 ± 0.054	2.387ArgPhe: 2.387 ± 0.045	2.481ArgGly: 2.481 ± 0.045	0.934ArgHis: 0.934 ± 0.026	3.653ArgIle: 3.653 ± 0.052	3.593ArgLys: 3.593 ± 0.056	4.462ArgLeu: 4.462 ± 0.056	1.583ArgMet: 1.583 ± 0.036	2.525ArgAsn: 2.525 ± 0.048	1.646ArgPro: 1.646 ± 0.043	1.858ArgGln: 1.858 ± 0.041	2.299ArgArg: 2.299 ± 0.045	2.392ArgSer: 2.392 ± 0.043	2.534ArgThr: 2.534 ± 0.039	2.581ArgVal: 2.581 ± 0.05	0.674ArgTrp: 0.674 ± 0.023	2.347ArgTyr: 2.347 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.161SerAla: 4.161 ± 0.06	0.879SerCys: 0.879 ± 0.025	3.443SerAsp: 3.443 ± 0.054	3.643SerGlu: 3.643 ± 0.048	3.168SerPhe: 3.168 ± 0.049	4.452SerGly: 4.452 ± 0.062	1.083SerHis: 1.083 ± 0.032	4.392SerIle: 4.392 ± 0.056	3.549SerLys: 3.549 ± 0.057	5.894SerLeu: 5.894 ± 0.067	1.503SerMet: 1.503 ± 0.036	2.852SerAsn: 2.852 ± 0.053	2.298SerPro: 2.298 ± 0.04	1.968SerGln: 1.968 ± 0.038	2.549SerArg: 2.549 ± 0.052	3.912SerSer: 3.912 ± 0.065	3.297SerThr: 3.297 ± 0.049	4.173SerVal: 4.173 ± 0.058	0.816SerTrp: 0.816 ± 0.027	2.859SerTyr: 2.859 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.052ThrAla: 4.052 ± 0.049	0.604ThrCys: 0.604 ± 0.023	3.469ThrAsp: 3.469 ± 0.059	3.5ThrGlu: 3.5 ± 0.05	2.7ThrPhe: 2.7 ± 0.044	4.261ThrGly: 4.261 ± 0.051	1.02ThrHis: 1.02 ± 0.03	3.863ThrIle: 3.863 ± 0.058	3.038ThrLys: 3.038 ± 0.053	5.346ThrLeu: 5.346 ± 0.064	1.253ThrMet: 1.253 ± 0.033	2.496ThrAsn: 2.496 ± 0.045	2.787ThrPro: 2.787 ± 0.042	1.821ThrGln: 1.821 ± 0.04	2.198ThrArg: 2.198 ± 0.043	3.341ThrSer: 3.341 ± 0.06	3.125ThrThr: 3.125 ± 0.055	4.044ThrVal: 4.044 ± 0.055	0.694ThrTrp: 0.694 ± 0.024	2.486ThrTyr: 2.486 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.509ValAla: 4.509 ± 0.065	0.983ValCys: 0.983 ± 0.032	3.681ValAsp: 3.681 ± 0.052	4.081ValGlu: 4.081 ± 0.06	2.76ValPhe: 2.76 ± 0.042	4.014ValGly: 4.014 ± 0.058	1.057ValHis: 1.057 ± 0.026	4.334ValIle: 4.334 ± 0.056	4.402ValLys: 4.402 ± 0.056	5.504ValLeu: 5.504 ± 0.065	1.67ValMet: 1.67 ± 0.038	3.373ValAsn: 3.373 ± 0.051	2.471ValPro: 2.471 ± 0.045	1.94ValGln: 1.94 ± 0.038	3.057ValArg: 3.057 ± 0.047	4.469ValSer: 4.469 ± 0.061	3.78ValThr: 3.78 ± 0.055	4.295ValVal: 4.295 ± 0.066	0.726ValTrp: 0.726 ± 0.024	2.646ValTyr: 2.646 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.811TrpAla: 0.811 ± 0.023	0.195TrpCys: 0.195 ± 0.014	0.704TrpAsp: 0.704 ± 0.022	0.862TrpGlu: 0.862 ± 0.027	0.572TrpPhe: 0.572 ± 0.023	0.981TrpGly: 0.981 ± 0.027	0.258TrpHis: 0.258 ± 0.012	0.869TrpIle: 0.869 ± 0.031	0.957TrpLys: 0.957 ± 0.026	1.126TrpLeu: 1.126 ± 0.025	0.468TrpMet: 0.468 ± 0.021	0.869TrpAsn: 0.869 ± 0.028	0.254TrpPro: 0.254 ± 0.015	0.51TrpGln: 0.51 ± 0.021	0.565TrpArg: 0.565 ± 0.022	0.714TrpSer: 0.714 ± 0.024	0.659TrpThr: 0.659 ± 0.024	0.702TrpVal: 0.702 ± 0.024	0.194TrpTrp: 0.194 ± 0.011	0.534TrpTyr: 0.534 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.058TyrAla: 3.058 ± 0.049	0.593TyrCys: 0.593 ± 0.02	2.655TyrAsp: 2.655 ± 0.047	2.621TyrGlu: 2.621 ± 0.054	2.132TyrPhe: 2.132 ± 0.044	2.958TyrGly: 2.958 ± 0.052	0.907TyrHis: 0.907 ± 0.028	2.93TyrIle: 2.93 ± 0.053	2.852TyrLys: 2.852 ± 0.049	4.065TyrLeu: 4.065 ± 0.058	1.142TyrMet: 1.142 ± 0.031	2.574TyrAsn: 2.574 ± 0.058	1.905TyrPro: 1.905 ± 0.041	1.67TyrGln: 1.67 ± 0.032	2.3TyrArg: 2.3 ± 0.04	2.76TyrSer: 2.76 ± 0.051	2.627TyrThr: 2.627 ± 0.045	2.543TyrVal: 2.543 ± 0.044	0.641TyrTrp: 0.641 ± 0.022	2.19TyrTyr: 2.19 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3874 proteins (1394016 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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