Amino acid dipepetide frequency for Kalanchoe top-spotting virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.47AlaAla: 4.47 ± 1.116
0.894AlaCys: 0.894 ± 0.386
2.682AlaAsp: 2.682 ± 1.158
3.129AlaGlu: 3.129 ± 1.188
3.576AlaPhe: 3.576 ± 1.544
4.023AlaGly: 4.023 ± 1.108
0.447AlaHis: 0.447 ± 0.193
5.364AlaIle: 5.364 ± 1.35
2.682AlaLys: 2.682 ± 1.874
5.364AlaLeu: 5.364 ± 1.972
1.788AlaMet: 1.788 ± 0.772
1.341AlaAsn: 1.341 ± 0.579
4.023AlaPro: 4.023 ± 1.736
4.023AlaGln: 4.023 ± 1.736
4.023AlaArg: 4.023 ± 2.871
2.682AlaSer: 2.682 ± 1.271
2.682AlaThr: 2.682 ± 1.874
3.129AlaVal: 3.129 ± 1.351
0.894AlaTrp: 0.894 ± 0.386
3.576AlaTyr: 3.576 ± 0.855
0.0AlaXaa: 0.0 ± 0.0
Cys
1.341CysAla: 1.341 ± 0.579
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.447CysGlu: 0.447 ± 0.193
0.894CysPhe: 0.894 ± 0.386
0.894CysGly: 0.894 ± 0.386
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
3.129CysLys: 3.129 ± 1.351
0.0CysLeu: 0.0 ± 0.0
0.447CysMet: 0.447 ± 0.193
0.894CysAsn: 0.894 ± 0.386
0.447CysPro: 0.447 ± 0.193
0.894CysGln: 0.894 ± 0.386
0.894CysArg: 0.894 ± 0.386
0.447CysSer: 0.447 ± 0.193
0.894CysThr: 0.894 ± 0.386
1.341CysVal: 1.341 ± 0.579
0.0CysTrp: 0.0 ± 0.0
0.894CysTyr: 0.894 ± 0.386
0.0CysXaa: 0.0 ± 0.0
Asp
2.682AspAla: 2.682 ± 1.158
1.341AspCys: 1.341 ± 0.579
5.364AspAsp: 5.364 ± 2.315
6.705AspGlu: 6.705 ± 1.568
2.682AspPhe: 2.682 ± 1.158
3.129AspGly: 3.129 ± 1.351
2.235AspHis: 2.235 ± 0.965
5.364AspIle: 5.364 ± 3.749
3.129AspLys: 3.129 ± 0.803
4.917AspLeu: 4.917 ± 2.836
0.894AspMet: 0.894 ± 0.386
2.235AspAsn: 2.235 ± 0.965
1.788AspPro: 1.788 ± 1.499
2.682AspGln: 2.682 ± 0.795
2.235AspArg: 2.235 ± 1.376
2.235AspSer: 2.235 ± 0.965
5.364AspThr: 5.364 ± 0.758
1.341AspVal: 1.341 ± 0.579
1.341AspTrp: 1.341 ± 1.021
2.682AspTyr: 2.682 ± 1.271
0.0AspXaa: 0.0 ± 0.0
Glu
7.599GluAla: 7.599 ± 4.836
0.894GluCys: 0.894 ± 0.386
8.941GluAsp: 8.941 ± 2.352
12.517GluGlu: 12.517 ± 2.417
1.341GluPhe: 1.341 ± 1.021
3.576GluGly: 3.576 ± 1.495
1.341GluHis: 1.341 ± 0.579
4.917GluIle: 4.917 ± 1.618
4.47GluLys: 4.47 ± 1.929
9.835GluLeu: 9.835 ± 2.994
1.341GluMet: 1.341 ± 0.579
3.576GluAsn: 3.576 ± 1.132
4.47GluPro: 4.47 ± 1.929
3.129GluGln: 3.129 ± 0.803
5.811GluArg: 5.811 ± 1.586
4.47GluSer: 4.47 ± 1.929
2.682GluThr: 2.682 ± 1.271
7.599GluVal: 7.599 ± 2.516
0.447GluTrp: 0.447 ± 0.193
3.576GluTyr: 3.576 ± 0.855
0.0GluXaa: 0.0 ± 0.0
Phe
2.235PheAla: 2.235 ± 0.965
0.447PheCys: 0.447 ± 0.193
3.129PheAsp: 3.129 ± 1.351
1.341PheGlu: 1.341 ± 1.021
1.341PhePhe: 1.341 ± 0.579
1.341PheGly: 1.341 ± 0.579
0.894PheHis: 0.894 ± 0.386
2.235PheIle: 2.235 ± 0.965
1.341PheLys: 1.341 ± 0.579
3.129PheLeu: 3.129 ± 1.351
0.447PheMet: 0.447 ± 0.193
1.788PheAsn: 1.788 ± 0.772
0.447PhePro: 0.447 ± 0.193
1.788PheGln: 1.788 ± 0.772
1.341PheArg: 1.341 ± 0.579
0.447PheSer: 0.447 ± 0.193
2.682PheThr: 2.682 ± 1.158
0.894PheVal: 0.894 ± 0.386
0.894PheTrp: 0.894 ± 0.386
1.341PheTyr: 1.341 ± 0.579
0.0PheXaa: 0.0 ± 0.0
Gly
3.576GlyAla: 3.576 ± 1.132
0.894GlyCys: 0.894 ± 0.386
2.235GlyAsp: 2.235 ± 0.965
4.917GlyGlu: 4.917 ± 2.122
2.682GlyPhe: 2.682 ± 1.158
0.894GlyGly: 0.894 ± 0.386
0.894GlyHis: 0.894 ± 0.386
3.576GlyIle: 3.576 ± 1.132
3.576GlyLys: 3.576 ± 1.132
4.47GlyLeu: 4.47 ± 1.116
1.788GlyMet: 1.788 ± 0.718
1.341GlyAsn: 1.341 ± 0.579
2.235GlyPro: 2.235 ± 1.376
2.682GlyGln: 2.682 ± 1.158
2.682GlyArg: 2.682 ± 0.795
1.788GlySer: 1.788 ± 0.912
4.917GlyThr: 4.917 ± 1.158
3.576GlyVal: 3.576 ± 1.132
1.341GlyTrp: 1.341 ± 0.579
1.341GlyTyr: 1.341 ± 0.579
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.894HisAsp: 0.894 ± 0.386
1.788HisGlu: 1.788 ± 1.499
0.447HisPhe: 0.447 ± 0.193
0.894HisGly: 0.894 ± 0.386
0.447HisHis: 0.447 ± 0.193
3.129HisIle: 3.129 ± 0.803
2.682HisLys: 2.682 ± 1.158
2.235HisLeu: 2.235 ± 0.965
0.0HisMet: 0.0 ± 0.0
0.894HisAsn: 0.894 ± 1.153
0.447HisPro: 0.447 ± 0.193
1.788HisGln: 1.788 ± 0.772
1.341HisArg: 1.341 ± 0.579
0.447HisSer: 0.447 ± 1.299
0.447HisThr: 0.447 ± 0.193
1.341HisVal: 1.341 ± 0.579
0.447HisTrp: 0.447 ± 0.193
1.788HisTyr: 1.788 ± 0.912
0.0HisXaa: 0.0 ± 0.0
Ile
2.235IleAla: 2.235 ± 0.965
1.788IleCys: 1.788 ± 0.772
4.47IleAsp: 4.47 ± 1.667
5.811IleGlu: 5.811 ± 1.586
2.682IlePhe: 2.682 ± 1.158
3.129IleGly: 3.129 ± 1.188
0.447IleHis: 0.447 ± 0.193
6.258IleIle: 6.258 ± 0.437
5.364IleLys: 5.364 ± 2.542
7.152IleLeu: 7.152 ± 2.684
0.894IleMet: 0.894 ± 0.386
3.129IleAsn: 3.129 ± 1.351
3.576IlePro: 3.576 ± 0.855
3.129IleGln: 3.129 ± 1.927
6.705IleArg: 6.705 ± 1.568
3.129IleSer: 3.129 ± 1.685
2.682IleThr: 2.682 ± 1.271
2.682IleVal: 2.682 ± 1.158
0.447IleTrp: 0.447 ± 0.193
2.235IleTyr: 2.235 ± 1.376
0.0IleXaa: 0.0 ± 0.0
Lys
2.235LysAla: 2.235 ± 2.065
0.894LysCys: 0.894 ± 0.386
2.682LysAsp: 2.682 ± 4.894
9.388LysGlu: 9.388 ± 0.51
2.682LysPhe: 2.682 ± 1.158
2.682LysGly: 2.682 ± 1.158
4.023LysHis: 4.023 ± 0.944
4.917LysIle: 4.917 ± 1.199
3.576LysLys: 3.576 ± 4.512
5.811LysLeu: 5.811 ± 1.785
2.235LysMet: 2.235 ± 0.925
4.47LysAsn: 4.47 ± 4.13
2.235LysPro: 2.235 ± 1.376
0.447LysGln: 0.447 ± 0.193
5.811LysArg: 5.811 ± 1.51
4.023LysSer: 4.023 ± 1.736
1.788LysThr: 1.788 ± 1.499
4.917LysVal: 4.917 ± 2.16
1.341LysTrp: 1.341 ± 1.021
0.894LysTyr: 0.894 ± 0.386
0.0LysXaa: 0.0 ± 0.0
Leu
4.47LeuAla: 4.47 ± 2.752
0.894LeuCys: 0.894 ± 0.386
4.917LeuAsp: 4.917 ± 0.937
11.623LeuGlu: 11.623 ± 3.275
0.0LeuPhe: 0.0 ± 0.0
7.152LeuGly: 7.152 ± 0.324
0.894LeuHis: 0.894 ± 1.153
4.917LeuIle: 4.917 ± 3.021
6.705LeuLys: 6.705 ± 4.306
4.917LeuLeu: 4.917 ± 1.618
1.341LeuMet: 1.341 ± 1.021
5.811LeuAsn: 5.811 ± 0.588
3.576LeuPro: 3.576 ± 1.544
5.811LeuGln: 5.811 ± 3.206
5.364LeuArg: 5.364 ± 3.384
6.258LeuSer: 6.258 ± 4.622
5.364LeuThr: 5.364 ± 5.489
6.258LeuVal: 6.258 ± 1.606
0.447LeuTrp: 0.447 ± 0.193
3.576LeuTyr: 3.576 ± 1.544
0.0LeuXaa: 0.0 ± 0.0
Met
2.682MetAla: 2.682 ± 1.158
0.0MetCys: 0.0 ± 0.0
0.894MetAsp: 0.894 ± 0.386
2.235MetGlu: 2.235 ± 0.965
0.447MetPhe: 0.447 ± 0.193
1.788MetGly: 1.788 ± 0.912
0.894MetHis: 0.894 ± 0.386
0.894MetIle: 0.894 ± 0.386
1.341MetLys: 1.341 ± 0.579
1.788MetLeu: 1.788 ± 0.772
0.0MetMet: 0.0 ± 0.0
2.235MetAsn: 2.235 ± 1.376
1.341MetPro: 1.341 ± 0.579
0.0MetGln: 0.0 ± 0.0
0.894MetArg: 0.894 ± 0.386
0.447MetSer: 0.447 ± 0.193
2.682MetThr: 2.682 ± 0.795
1.341MetVal: 1.341 ± 0.579
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.341AsnAla: 1.341 ± 0.579
0.447AsnCys: 0.447 ± 0.193
2.682AsnAsp: 2.682 ± 0.795
1.788AsnGlu: 1.788 ± 0.772
3.129AsnPhe: 3.129 ± 1.351
2.235AsnGly: 2.235 ± 0.965
0.447AsnHis: 0.447 ± 0.193
3.576AsnIle: 3.576 ± 1.132
0.894AsnLys: 0.894 ± 0.386
5.811AsnLeu: 5.811 ± 6.099
0.894AsnMet: 0.894 ± 0.386
1.341AsnAsn: 1.341 ± 0.579
3.576AsnPro: 3.576 ± 1.544
0.894AsnGln: 0.894 ± 0.386
1.788AsnArg: 1.788 ± 0.772
4.023AsnSer: 4.023 ± 1.736
5.811AsnThr: 5.811 ± 3.559
0.0AsnVal: 0.0 ± 0.0
1.341AsnTrp: 1.341 ± 1.635
2.682AsnTyr: 2.682 ± 1.158
0.0AsnXaa: 0.0 ± 0.0
Pro
3.576ProAla: 3.576 ± 1.544
0.0ProCys: 0.0 ± 0.0
3.129ProAsp: 3.129 ± 1.351
4.023ProGlu: 4.023 ± 1.307
0.447ProPhe: 0.447 ± 0.193
0.894ProGly: 0.894 ± 0.386
1.341ProHis: 1.341 ± 0.579
1.788ProIle: 1.788 ± 0.772
4.023ProLys: 4.023 ± 1.307
2.235ProLeu: 2.235 ± 0.834
0.447ProMet: 0.447 ± 0.193
1.788ProAsn: 1.788 ± 0.772
2.235ProPro: 2.235 ± 0.965
1.788ProGln: 1.788 ± 0.772
4.023ProArg: 4.023 ± 1.736
5.364ProSer: 5.364 ± 1.228
1.788ProThr: 1.788 ± 0.772
1.341ProVal: 1.341 ± 0.579
0.447ProTrp: 0.447 ± 0.193
0.894ProTyr: 0.894 ± 1.782
0.0ProXaa: 0.0 ± 0.0
Gln
4.023GlnAla: 4.023 ± 1.736
0.447GlnCys: 0.447 ± 0.193
1.788GlnAsp: 1.788 ± 1.499
3.129GlnGlu: 3.129 ± 1.927
0.447GlnPhe: 0.447 ± 0.193
1.788GlnGly: 1.788 ± 0.772
1.788GlnHis: 1.788 ± 0.772
2.235GlnIle: 2.235 ± 1.376
2.235GlnLys: 2.235 ± 0.834
4.023GlnLeu: 4.023 ± 2.537
0.447GlnMet: 0.447 ± 0.193
4.023GlnAsn: 4.023 ± 3.064
3.129GlnPro: 3.129 ± 0.803
3.576GlnGln: 3.576 ± 3.189
3.576GlnArg: 3.576 ± 0.855
1.341GlnSer: 1.341 ± 0.579
2.235GlnThr: 2.235 ± 0.834
1.788GlnVal: 1.788 ± 0.772
0.0GlnTrp: 0.0 ± 0.0
2.235GlnTyr: 2.235 ± 0.965
0.0GlnXaa: 0.0 ± 0.0
Arg
3.576ArgAla: 3.576 ± 1.132
0.894ArgCys: 0.894 ± 0.386
1.788ArgAsp: 1.788 ± 1.499
4.023ArgGlu: 4.023 ± 0.944
1.788ArgPhe: 1.788 ± 0.772
3.576ArgGly: 3.576 ± 1.544
1.341ArgHis: 1.341 ± 1.021
4.917ArgIle: 4.917 ± 0.937
4.023ArgLys: 4.023 ± 0.944
7.599ArgLeu: 7.599 ± 1.791
2.682ArgMet: 2.682 ± 1.158
2.235ArgAsn: 2.235 ± 0.965
2.682ArgPro: 2.682 ± 0.795
2.682ArgGln: 2.682 ± 1.874
2.682ArgArg: 2.682 ± 1.158
4.47ArgSer: 4.47 ± 2.348
6.705ArgThr: 6.705 ± 0.333
4.917ArgVal: 4.917 ± 1.199
2.235ArgTrp: 2.235 ± 0.965
1.341ArgTyr: 1.341 ± 0.579
0.0ArgXaa: 0.0 ± 0.0
Ser
3.576SerAla: 3.576 ± 0.855
0.447SerCys: 0.447 ± 0.193
2.682SerAsp: 2.682 ± 1.158
4.917SerGlu: 4.917 ± 3.021
0.0SerPhe: 0.0 ± 0.0
4.917SerGly: 4.917 ± 2.642
0.894SerHis: 0.894 ± 1.782
3.129SerIle: 3.129 ± 1.351
6.258SerLys: 6.258 ± 3.369
4.917SerLeu: 4.917 ± 1.158
0.894SerMet: 0.894 ± 0.386
1.788SerAsn: 1.788 ± 0.772
2.235SerPro: 2.235 ± 0.965
2.682SerGln: 2.682 ± 2.042
3.576SerArg: 3.576 ± 1.132
2.682SerSer: 2.682 ± 3.271
5.364SerThr: 5.364 ± 2.315
3.129SerVal: 3.129 ± 0.803
0.447SerTrp: 0.447 ± 0.193
1.341SerTyr: 1.341 ± 0.579
0.0SerXaa: 0.0 ± 0.0
Thr
4.023ThrAla: 4.023 ± 1.736
0.894ThrCys: 0.894 ± 0.386
4.47ThrAsp: 4.47 ± 2.946
7.599ThrGlu: 7.599 ± 1.791
1.788ThrPhe: 1.788 ± 0.772
3.576ThrGly: 3.576 ± 1.544
0.894ThrHis: 0.894 ± 0.386
4.023ThrIle: 4.023 ± 0.944
5.811ThrLys: 5.811 ± 3.559
6.705ThrLeu: 6.705 ± 7.262
2.235ThrMet: 2.235 ± 0.909
1.788ThrAsn: 1.788 ± 0.772
1.788ThrPro: 1.788 ± 1.499
1.341ThrGln: 1.341 ± 0.579
6.705ThrArg: 6.705 ± 1.647
4.023ThrSer: 4.023 ± 1.108
4.47ThrThr: 4.47 ± 1.116
1.788ThrVal: 1.788 ± 1.499
0.894ThrTrp: 0.894 ± 0.386
1.788ThrTyr: 1.788 ± 1.499
0.0ThrXaa: 0.0 ± 0.0
Val
3.129ValAla: 3.129 ± 1.927
2.235ValCys: 2.235 ± 0.965
3.129ValAsp: 3.129 ± 1.351
2.682ValGlu: 2.682 ± 0.795
2.235ValPhe: 2.235 ± 0.965
4.47ValGly: 4.47 ± 1.116
1.788ValHis: 1.788 ± 0.912
3.576ValIle: 3.576 ± 1.544
1.788ValLys: 1.788 ± 0.912
4.47ValLeu: 4.47 ± 3.192
1.788ValMet: 1.788 ± 0.772
2.682ValAsn: 2.682 ± 0.795
0.894ValPro: 0.894 ± 0.386
1.788ValGln: 1.788 ± 0.772
2.235ValArg: 2.235 ± 0.965
3.576ValSer: 3.576 ± 0.855
4.47ValThr: 4.47 ± 1.929
2.682ValVal: 2.682 ± 2.042
0.447ValTrp: 0.447 ± 1.299
2.235ValTyr: 2.235 ± 1.376
0.0ValXaa: 0.0 ± 0.0
Trp
1.341TrpAla: 1.341 ± 0.579
0.0TrpCys: 0.0 ± 0.0
2.235TrpAsp: 2.235 ± 1.376
1.788TrpGlu: 1.788 ± 0.912
0.0TrpPhe: 0.0 ± 0.0
0.447TrpGly: 0.447 ± 0.193
0.447TrpHis: 0.447 ± 0.193
0.447TrpIle: 0.447 ± 0.193
0.894TrpLys: 0.894 ± 1.153
1.341TrpLeu: 1.341 ± 0.579
0.447TrpMet: 0.447 ± 0.193
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.894TrpGln: 0.894 ± 1.153
1.788TrpArg: 1.788 ± 0.912
0.447TrpSer: 0.447 ± 0.193
1.341TrpThr: 1.341 ± 0.579
0.447TrpVal: 0.447 ± 0.193
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 1.158
0.447TyrCys: 0.447 ± 0.193
2.235TyrAsp: 2.235 ± 0.965
2.682TyrGlu: 2.682 ± 1.158
0.894TyrPhe: 0.894 ± 0.386
0.447TyrGly: 0.447 ± 0.193
0.0TyrHis: 0.0 ± 0.0
2.682TyrIle: 2.682 ± 0.795
3.129TyrLys: 3.129 ± 1.188
3.576TyrLeu: 3.576 ± 1.132
0.447TyrMet: 0.447 ± 0.193
1.341TyrAsn: 1.341 ± 0.579
0.447TyrPro: 0.447 ± 0.193
2.235TyrGln: 2.235 ± 1.376
2.682TyrArg: 2.682 ± 0.795
3.576TyrSer: 3.576 ± 1.132
2.235TyrThr: 2.235 ± 1.376
1.788TyrVal: 1.788 ± 0.772
0.894TyrTrp: 0.894 ± 1.153
2.682TyrTyr: 2.682 ± 1.158
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2238 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski