Amino acid dipepetide frequency for Faecalibacterium sp. An121

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.707AlaAla: 15.707 ± 0.237
1.919AlaCys: 1.919 ± 0.053
5.835AlaAsp: 5.835 ± 0.087
6.204AlaGlu: 6.204 ± 0.12
3.723AlaPhe: 3.723 ± 0.084
9.783AlaGly: 9.783 ± 0.161
1.677AlaHis: 1.677 ± 0.051
4.798AlaIle: 4.798 ± 0.086
3.835AlaLys: 3.835 ± 0.073
11.252AlaLeu: 11.252 ± 0.185
2.818AlaMet: 2.818 ± 0.064
2.67AlaAsn: 2.67 ± 0.061
4.117AlaPro: 4.117 ± 0.089
4.616AlaGln: 4.616 ± 0.089
6.545AlaArg: 6.545 ± 0.123
5.254AlaSer: 5.254 ± 0.084
3.508AlaThr: 3.508 ± 0.075
8.486AlaVal: 8.486 ± 0.13
1.094AlaTrp: 1.094 ± 0.036
2.893AlaTyr: 2.893 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.852CysAla: 1.852 ± 0.048
0.394CysCys: 0.394 ± 0.024
0.926CysAsp: 0.926 ± 0.031
0.864CysGlu: 0.864 ± 0.03
0.659CysPhe: 0.659 ± 0.03
1.932CysGly: 1.932 ± 0.054
0.333CysHis: 0.333 ± 0.022
0.989CysIle: 0.989 ± 0.032
0.655CysLys: 0.655 ± 0.029
1.572CysLeu: 1.572 ± 0.044
0.416CysMet: 0.416 ± 0.021
0.513CysAsn: 0.513 ± 0.028
0.956CysPro: 0.956 ± 0.04
0.597CysGln: 0.597 ± 0.028
1.226CysArg: 1.226 ± 0.046
0.93CysSer: 0.93 ± 0.038
0.991CysThr: 0.991 ± 0.033
1.112CysVal: 1.112 ± 0.037
0.201CysTrp: 0.201 ± 0.017
0.581CysTyr: 0.581 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
5.666AspAla: 5.666 ± 0.079
0.948AspCys: 0.948 ± 0.036
2.587AspAsp: 2.587 ± 0.071
3.633AspGlu: 3.633 ± 0.075
2.374AspPhe: 2.374 ± 0.054
4.996AspGly: 4.996 ± 0.104
0.995AspHis: 0.995 ± 0.034
3.042AspIle: 3.042 ± 0.062
2.401AspLys: 2.401 ± 0.066
5.445AspLeu: 5.445 ± 0.091
1.329AspMet: 1.329 ± 0.041
1.613AspAsn: 1.613 ± 0.047
3.243AspPro: 3.243 ± 0.072
1.901AspGln: 1.901 ± 0.058
3.11AspArg: 3.11 ± 0.075
2.798AspSer: 2.798 ± 0.069
3.198AspThr: 3.198 ± 0.054
3.576AspVal: 3.576 ± 0.063
0.786AspTrp: 0.786 ± 0.036
2.316AspTyr: 2.316 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
6.465GluAla: 6.465 ± 0.102
0.727GluCys: 0.727 ± 0.029
3.562GluAsp: 3.562 ± 0.071
4.739GluGlu: 4.739 ± 0.103
1.6GluPhe: 1.6 ± 0.047
4.684GluGly: 4.684 ± 0.093
1.084GluHis: 1.084 ± 0.039
3.464GluIle: 3.464 ± 0.074
3.827GluLys: 3.827 ± 0.086
5.941GluLeu: 5.941 ± 0.087
1.96GluMet: 1.96 ± 0.05
2.632GluAsn: 2.632 ± 0.068
2.176GluPro: 2.176 ± 0.064
3.118GluGln: 3.118 ± 0.068
3.426GluArg: 3.426 ± 0.081
2.648GluSer: 2.648 ± 0.064
2.953GluThr: 2.953 ± 0.063
3.638GluVal: 3.638 ± 0.065
0.56GluTrp: 0.56 ± 0.024
2.149GluTyr: 2.149 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.67PheAla: 3.67 ± 0.063
0.841PheCys: 0.841 ± 0.028
2.446PheAsp: 2.446 ± 0.059
2.149PheGlu: 2.149 ± 0.062
1.547PhePhe: 1.547 ± 0.049
3.21PheGly: 3.21 ± 0.077
0.715PheHis: 0.715 ± 0.028
1.878PheIle: 1.878 ± 0.054
1.191PheLys: 1.191 ± 0.042
3.43PheLeu: 3.43 ± 0.077
0.829PheMet: 0.829 ± 0.035
1.112PheAsn: 1.112 ± 0.041
1.378PhePro: 1.378 ± 0.045
1.119PheGln: 1.119 ± 0.037
1.884PheArg: 1.884 ± 0.049
2.319PheSer: 2.319 ± 0.058
2.295PheThr: 2.295 ± 0.054
2.615PheVal: 2.615 ± 0.063
0.505PheTrp: 0.505 ± 0.03
1.498PheTyr: 1.498 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
7.538GlyAla: 7.538 ± 0.126
1.795GlyCys: 1.795 ± 0.057
3.871GlyAsp: 3.871 ± 0.072
4.368GlyGlu: 4.368 ± 0.075
3.008GlyPhe: 3.008 ± 0.062
6.353GlyGly: 6.353 ± 0.112
1.437GlyHis: 1.437 ± 0.043
4.571GlyIle: 4.571 ± 0.094
3.875GlyLys: 3.875 ± 0.071
7.881GlyLeu: 7.881 ± 0.125
2.49GlyMet: 2.49 ± 0.058
2.206GlyAsn: 2.206 ± 0.064
2.658GlyPro: 2.658 ± 0.069
3.357GlyGln: 3.357 ± 0.072
5.178GlyArg: 5.178 ± 0.096
4.65GlySer: 4.65 ± 0.083
4.331GlyThr: 4.331 ± 0.065
6.168GlyVal: 6.168 ± 0.097
1.148GlyTrp: 1.148 ± 0.039
3.101GlyTyr: 3.101 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.433HisAla: 1.433 ± 0.044
0.38HisCys: 0.38 ± 0.025
0.944HisAsp: 0.944 ± 0.034
0.82HisGlu: 0.82 ± 0.034
0.803HisPhe: 0.803 ± 0.033
1.426HisGly: 1.426 ± 0.045
0.409HisHis: 0.409 ± 0.035
1.096HisIle: 1.096 ± 0.035
0.786HisLys: 0.786 ± 0.031
1.731HisLeu: 1.731 ± 0.052
0.475HisMet: 0.475 ± 0.022
0.633HisAsn: 0.633 ± 0.027
1.128HisPro: 1.128 ± 0.045
0.66HisGln: 0.66 ± 0.028
1.04HisArg: 1.04 ± 0.035
1.017HisSer: 1.017 ± 0.044
1.189HisThr: 1.189 ± 0.04
1.061HisVal: 1.061 ± 0.041
0.237HisTrp: 0.237 ± 0.016
0.729HisTyr: 0.729 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.059IleAla: 5.059 ± 0.078
1.012IleCys: 1.012 ± 0.035
3.2IleAsp: 3.2 ± 0.067
3.004IleGlu: 3.004 ± 0.064
1.838IlePhe: 1.838 ± 0.058
3.82IleGly: 3.82 ± 0.089
1.067IleHis: 1.067 ± 0.039
2.495IleIle: 2.495 ± 0.071
1.837IleLys: 1.837 ± 0.051
5.505IleLeu: 5.505 ± 0.101
1.148IleMet: 1.148 ± 0.039
1.695IleAsn: 1.695 ± 0.052
2.653IlePro: 2.653 ± 0.06
2.17IleGln: 2.17 ± 0.056
3.431IleArg: 3.431 ± 0.069
3.055IleSer: 3.055 ± 0.07
3.093IleThr: 3.093 ± 0.066
3.412IleVal: 3.412 ± 0.07
0.582IleTrp: 0.582 ± 0.03
1.753IleTyr: 1.753 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.437LysAla: 4.437 ± 0.088
0.463LysCys: 0.463 ± 0.027
2.34LysAsp: 2.34 ± 0.06
3.145LysGlu: 3.145 ± 0.075
1.049LysPhe: 1.049 ± 0.04
3.049LysGly: 3.049 ± 0.073
0.684LysHis: 0.684 ± 0.027
2.231LysIle: 2.231 ± 0.058
2.967LysLys: 2.967 ± 0.081
4.016LysLeu: 4.016 ± 0.089
1.263LysMet: 1.263 ± 0.041
1.767LysAsn: 1.767 ± 0.051
1.901LysPro: 1.901 ± 0.053
1.68LysGln: 1.68 ± 0.053
2.198LysArg: 2.198 ± 0.064
2.015LysSer: 2.015 ± 0.054
2.531LysThr: 2.531 ± 0.061
2.839LysVal: 2.839 ± 0.076
0.413LysTrp: 0.413 ± 0.025
1.575LysTyr: 1.575 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
11.605LeuAla: 11.605 ± 0.181
2.154LeuCys: 2.154 ± 0.063
6.095LeuAsp: 6.095 ± 0.086
6.205LeuGlu: 6.205 ± 0.096
3.829LeuPhe: 3.829 ± 0.085
7.287LeuGly: 7.287 ± 0.126
1.881LeuHis: 1.881 ± 0.052
4.474LeuIle: 4.474 ± 0.082
3.802LeuLys: 3.802 ± 0.079
10.459LeuLeu: 10.459 ± 0.185
2.623LeuMet: 2.623 ± 0.06
3.006LeuAsn: 3.006 ± 0.066
5.144LeuPro: 5.144 ± 0.096
3.362LeuGln: 3.362 ± 0.071
5.987LeuArg: 5.987 ± 0.106
5.853LeuSer: 5.853 ± 0.104
5.93LeuThr: 5.93 ± 0.1
6.624LeuVal: 6.624 ± 0.111
1.134LeuTrp: 1.134 ± 0.042
3.61LeuTyr: 3.61 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.959MetAla: 2.959 ± 0.07
0.308MetCys: 0.308 ± 0.02
1.694MetAsp: 1.694 ± 0.047
2.056MetGlu: 2.056 ± 0.056
0.76MetPhe: 0.76 ± 0.031
2.19MetGly: 2.19 ± 0.061
0.438MetHis: 0.438 ± 0.023
1.315MetIle: 1.315 ± 0.045
1.455MetLys: 1.455 ± 0.047
2.763MetLeu: 2.763 ± 0.064
0.76MetMet: 0.76 ± 0.037
1.041MetAsn: 1.041 ± 0.035
1.355MetPro: 1.355 ± 0.038
1.093MetGln: 1.093 ± 0.035
1.348MetArg: 1.348 ± 0.044
1.479MetSer: 1.479 ± 0.045
1.618MetThr: 1.618 ± 0.04
1.841MetVal: 1.841 ± 0.052
0.186MetTrp: 0.186 ± 0.02
0.635MetTyr: 0.635 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.969AsnAla: 2.969 ± 0.063
0.514AsnCys: 0.514 ± 0.026
1.575AsnAsp: 1.575 ± 0.042
1.643AsnGlu: 1.643 ± 0.05
1.18AsnPhe: 1.18 ± 0.04
2.813AsnGly: 2.813 ± 0.075
0.59AsnHis: 0.59 ± 0.028
2.002AsnIle: 2.002 ± 0.056
1.249AsnLys: 1.249 ± 0.044
2.998AsnLeu: 2.998 ± 0.068
0.861AsnMet: 0.861 ± 0.036
1.108AsnAsn: 1.108 ± 0.041
1.714AsnPro: 1.714 ± 0.047
1.194AsnGln: 1.194 ± 0.042
1.734AsnArg: 1.734 ± 0.049
1.561AsnSer: 1.561 ± 0.049
1.806AsnThr: 1.806 ± 0.054
2.135AsnVal: 2.135 ± 0.058
0.4AsnTrp: 0.4 ± 0.024
1.278AsnTyr: 1.278 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
5.803ProAla: 5.803 ± 0.126
0.686ProCys: 0.686 ± 0.03
3.298ProAsp: 3.298 ± 0.068
3.759ProGlu: 3.759 ± 0.083
1.687ProPhe: 1.687 ± 0.047
3.848ProGly: 3.848 ± 0.081
0.796ProHis: 0.796 ± 0.032
1.919ProIle: 1.919 ± 0.052
1.617ProLys: 1.617 ± 0.057
3.988ProLeu: 3.988 ± 0.079
1.073ProMet: 1.073 ± 0.041
1.186ProAsn: 1.186 ± 0.041
1.607ProPro: 1.607 ± 0.053
1.87ProGln: 1.87 ± 0.058
2.148ProArg: 2.148 ± 0.057
2.19ProSer: 2.19 ± 0.061
1.922ProThr: 1.922 ± 0.043
3.623ProVal: 3.623 ± 0.067
0.533ProTrp: 0.533 ± 0.025
1.507ProTyr: 1.507 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
4.57GlnAla: 4.57 ± 0.088
0.502GlnCys: 0.502 ± 0.024
2.047GlnAsp: 2.047 ± 0.056
2.612GlnGlu: 2.612 ± 0.076
1.22GlnPhe: 1.22 ± 0.04
2.772GlnGly: 2.772 ± 0.059
0.652GlnHis: 0.652 ± 0.028
2.268GlnIle: 2.268 ± 0.054
2.208GlnLys: 2.208 ± 0.061
4.2GlnLeu: 4.2 ± 0.077
1.369GlnMet: 1.369 ± 0.043
1.42GlnAsn: 1.42 ± 0.044
1.955GlnPro: 1.955 ± 0.053
2.076GlnGln: 2.076 ± 0.061
2.279GlnArg: 2.279 ± 0.064
1.856GlnSer: 1.856 ± 0.047
2.071GlnThr: 2.071 ± 0.054
2.871GlnVal: 2.871 ± 0.06
0.453GlnTrp: 0.453 ± 0.023
1.42GlnTyr: 1.42 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.497ArgAla: 5.497 ± 0.111
1.059ArgCys: 1.059 ± 0.04
2.943ArgAsp: 2.943 ± 0.062
3.665ArgGlu: 3.665 ± 0.074
2.264ArgPhe: 2.264 ± 0.054
3.54ArgGly: 3.54 ± 0.071
1.061ArgHis: 1.061 ± 0.043
3.233ArgIle: 3.233 ± 0.065
2.528ArgLys: 2.528 ± 0.066
6.284ArgLeu: 6.284 ± 0.113
1.873ArgMet: 1.873 ± 0.043
1.62ArgAsn: 1.62 ± 0.049
2.845ArgPro: 2.845 ± 0.062
3.255ArgGln: 3.255 ± 0.077
4.673ArgArg: 4.673 ± 0.101
3.067ArgSer: 3.067 ± 0.063
3.07ArgThr: 3.07 ± 0.064
3.638ArgVal: 3.638 ± 0.08
0.791ArgTrp: 0.791 ± 0.032
2.386ArgTyr: 2.386 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
5.291SerAla: 5.291 ± 0.082
0.919SerCys: 0.919 ± 0.033
2.682SerAsp: 2.682 ± 0.057
2.792SerGlu: 2.792 ± 0.059
2.386SerPhe: 2.386 ± 0.058
4.849SerGly: 4.849 ± 0.083
1.008SerHis: 1.008 ± 0.036
2.911SerIle: 2.911 ± 0.07
1.913SerLys: 1.913 ± 0.053
5.257SerLeu: 5.257 ± 0.098
1.516SerMet: 1.516 ± 0.054
1.577SerAsn: 1.577 ± 0.046
2.194SerPro: 2.194 ± 0.057
2.01SerGln: 2.01 ± 0.055
3.215SerArg: 3.215 ± 0.076
3.475SerSer: 3.475 ± 0.109
2.864SerThr: 2.864 ± 0.067
3.946SerVal: 3.946 ± 0.076
0.709SerTrp: 0.709 ± 0.031
2.034SerTyr: 2.034 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.897ThrAla: 5.897 ± 0.093
0.784ThrCys: 0.784 ± 0.031
2.941ThrAsp: 2.941 ± 0.059
2.802ThrGlu: 2.802 ± 0.059
2.085ThrPhe: 2.085 ± 0.053
4.943ThrGly: 4.943 ± 0.082
0.962ThrHis: 0.962 ± 0.035
2.973ThrIle: 2.973 ± 0.071
1.673ThrLys: 1.673 ± 0.046
5.61ThrLeu: 5.61 ± 0.09
1.338ThrMet: 1.338 ± 0.04
1.542ThrAsn: 1.542 ± 0.046
2.881ThrPro: 2.881 ± 0.074
1.682ThrGln: 1.682 ± 0.047
2.728ThrArg: 2.728 ± 0.059
2.646ThrSer: 2.646 ± 0.057
2.721ThrThr: 2.721 ± 0.063
4.785ThrVal: 4.785 ± 0.084
0.521ThrTrp: 0.521 ± 0.029
1.723ThrTyr: 1.723 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
6.078ValAla: 6.078 ± 0.123
1.496ValCys: 1.496 ± 0.05
3.96ValAsp: 3.96 ± 0.064
4.238ValGlu: 4.238 ± 0.064
2.753ValPhe: 2.753 ± 0.067
4.714ValGly: 4.714 ± 0.08
1.213ValHis: 1.213 ± 0.043
3.772ValIle: 3.772 ± 0.078
2.771ValLys: 2.771 ± 0.067
7.753ValLeu: 7.753 ± 0.12
1.948ValMet: 1.948 ± 0.056
2.217ValAsn: 2.217 ± 0.063
3.173ValPro: 3.173 ± 0.059
2.696ValGln: 2.696 ± 0.058
4.276ValArg: 4.276 ± 0.07
4.386ValSer: 4.386 ± 0.085
4.277ValThr: 4.277 ± 0.075
5.236ValVal: 5.236 ± 0.097
0.876ValTrp: 0.876 ± 0.035
2.502ValTyr: 2.502 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.057TrpAla: 1.057 ± 0.043
0.2TrpCys: 0.2 ± 0.017
0.715TrpAsp: 0.715 ± 0.038
0.672TrpGlu: 0.672 ± 0.032
0.446TrpPhe: 0.446 ± 0.026
0.851TrpGly: 0.851 ± 0.036
0.224TrpHis: 0.224 ± 0.016
0.495TrpIle: 0.495 ± 0.025
0.55TrpLys: 0.55 ± 0.026
1.364TrpLeu: 1.364 ± 0.045
0.391TrpMet: 0.391 ± 0.022
0.476TrpAsn: 0.476 ± 0.029
0.457TrpPro: 0.457 ± 0.022
0.76TrpGln: 0.76 ± 0.032
0.656TrpArg: 0.656 ± 0.031
0.527TrpSer: 0.527 ± 0.027
0.557TrpThr: 0.557 ± 0.028
0.691TrpVal: 0.691 ± 0.031
0.132TrpTrp: 0.132 ± 0.015
0.43TrpTyr: 0.43 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.18TyrAla: 3.18 ± 0.072
0.599TyrCys: 0.599 ± 0.028
2.299TyrAsp: 2.299 ± 0.089
1.984TyrGlu: 1.984 ± 0.051
1.419TyrPhe: 1.419 ± 0.049
2.921TyrGly: 2.921 ± 0.061
0.773TyrHis: 0.773 ± 0.036
1.904TyrIle: 1.904 ± 0.053
1.421TyrLys: 1.421 ± 0.05
3.617TyrLeu: 3.617 ± 0.075
0.812TyrMet: 0.812 ± 0.032
1.29TyrAsn: 1.29 ± 0.044
1.525TyrPro: 1.525 ± 0.044
1.607TyrGln: 1.607 ± 0.048
2.211TyrArg: 2.211 ± 0.055
1.819TyrSer: 1.819 ± 0.049
2.312TyrThr: 2.312 ± 0.067
2.038TyrVal: 2.038 ± 0.054
0.39TyrTrp: 0.39 ± 0.022
1.507TyrTyr: 1.507 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2414 proteins (781649 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski