Human papillomavirus 21

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 1

Average proteome isoelectric point is 5.82

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P50787|VL1_HPV21 Major capsid protein L1 OS=Human papillomavirus 21 OX=31548 GN=L1 PE=3 SV=1
MM1 pKa = 7.37IGKK4 pKa = 8.93EE5 pKa = 3.9VTLQDD10 pKa = 3.25IVLEE14 pKa = 4.25LNEE17 pKa = 4.72LQPEE21 pKa = 4.3VQPVDD26 pKa = 3.84LFCEE30 pKa = 4.21EE31 pKa = 4.7EE32 pKa = 4.49LPSEE36 pKa = 4.09QQEE39 pKa = 4.58TEE41 pKa = 3.94EE42 pKa = 4.17EE43 pKa = 4.28LPEE46 pKa = 3.82RR47 pKa = 11.84TAYY50 pKa = 9.76KK51 pKa = 10.33VVTPCGCCKK60 pKa = 9.89VKK62 pKa = 10.76LRR64 pKa = 11.84IFVNATQFAIRR75 pKa = 11.84TFQNLLFEE83 pKa = 4.86EE84 pKa = 4.56LQLLCPEE91 pKa = 4.3CRR93 pKa = 11.84GNCKK97 pKa = 10.3HH98 pKa = 6.48GGSS101 pKa = 3.89

Molecular weight: 11.53 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P50779|VE7_HPV21 Protein E7 OS=Human papillomavirus 21 OX=31548 GN=E7 PE=3 SV=1
MM1 pKa = 7.73EE2 pKa = 5.02NLSDD6 pKa = 4.25RR7 pKa = 11.84FNVLQDD13 pKa = 3.28QLMNIYY19 pKa = 9.96EE20 pKa = 4.37SAANTIEE27 pKa = 3.99SQIEE31 pKa = 3.68HH32 pKa = 6.21WQTLRR37 pKa = 11.84KK38 pKa = 9.15EE39 pKa = 4.05AVLLYY44 pKa = 8.98FARR47 pKa = 11.84QKK49 pKa = 11.08GVTRR53 pKa = 11.84LGYY56 pKa = 10.42QYY58 pKa = 11.01VPPLAVSEE66 pKa = 4.48SRR68 pKa = 11.84AKK70 pKa = 10.0QAIGMMLQLQSLQKK84 pKa = 10.18SEE86 pKa = 4.19YY87 pKa = 10.66AKK89 pKa = 10.59EE90 pKa = 3.82PWSLVDD96 pKa = 3.61TSAEE100 pKa = 4.25TFRR103 pKa = 11.84SPPEE107 pKa = 3.58NHH109 pKa = 6.22FKK111 pKa = 10.7KK112 pKa = 10.69GPVSVEE118 pKa = 3.72VIYY121 pKa = 11.24DD122 pKa = 3.62NDD124 pKa = 3.68KK125 pKa = 11.71DD126 pKa = 3.79NANAYY131 pKa = 6.88TMWRR135 pKa = 11.84YY136 pKa = 10.06VYY138 pKa = 10.84YY139 pKa = 10.87VDD141 pKa = 6.59DD142 pKa = 5.43DD143 pKa = 4.53DD144 pKa = 4.44QWHH147 pKa = 6.9KK148 pKa = 11.3SPSGVNHH155 pKa = 5.96TGIYY159 pKa = 10.08FMQGTFRR166 pKa = 11.84HH167 pKa = 6.06YY168 pKa = 10.72YY169 pKa = 10.34VLFADD174 pKa = 4.09DD175 pKa = 3.6ASRR178 pKa = 11.84YY179 pKa = 9.65SRR181 pKa = 11.84TGHH184 pKa = 6.19WEE186 pKa = 3.84VNVNKK191 pKa = 8.65EE192 pKa = 4.3TVFAPVTSSTPPDD205 pKa = 3.8SPGGQADD212 pKa = 4.3SNTSSTTPATTTDD225 pKa = 3.11STSRR229 pKa = 11.84LSSTRR234 pKa = 11.84KK235 pKa = 9.57QSQQTNTKK243 pKa = 7.71GRR245 pKa = 11.84RR246 pKa = 11.84YY247 pKa = 9.84GRR249 pKa = 11.84RR250 pKa = 11.84PSSRR254 pKa = 11.84TRR256 pKa = 11.84RR257 pKa = 11.84TTQTHH262 pKa = 3.33QRR264 pKa = 11.84RR265 pKa = 11.84RR266 pKa = 11.84SRR268 pKa = 11.84SKK270 pKa = 9.28SRR272 pKa = 11.84SRR274 pKa = 11.84SRR276 pKa = 11.84SRR278 pKa = 11.84SRR280 pKa = 11.84LRR282 pKa = 11.84SRR284 pKa = 11.84SRR286 pKa = 11.84SRR288 pKa = 11.84SRR290 pKa = 11.84SYY292 pKa = 10.97SRR294 pKa = 11.84SRR296 pKa = 11.84SQSSDD301 pKa = 2.85QPQYY305 pKa = 10.72RR306 pKa = 11.84FRR308 pKa = 11.84SGGQVSLITTATTTTTTATNYY329 pKa = 6.89STRR332 pKa = 11.84GSGRR336 pKa = 11.84GSSSTSSSTSKK347 pKa = 10.38RR348 pKa = 11.84PRR350 pKa = 11.84RR351 pKa = 11.84PRR353 pKa = 11.84GGAIGGSSGRR363 pKa = 11.84GRR365 pKa = 11.84RR366 pKa = 11.84SSSTSPSPSKK376 pKa = 10.44RR377 pKa = 11.84SRR379 pKa = 11.84GKK381 pKa = 10.25SEE383 pKa = 3.94SVRR386 pKa = 11.84QRR388 pKa = 11.84GISPDD393 pKa = 3.65DD394 pKa = 3.59VGKK397 pKa = 10.53SLQSVSTRR405 pKa = 11.84NTGRR409 pKa = 11.84LGRR412 pKa = 11.84LLDD415 pKa = 3.94EE416 pKa = 5.3ALDD419 pKa = 3.88PPVILVRR426 pKa = 11.84GEE428 pKa = 4.16PNTLKK433 pKa = 10.67CFRR436 pKa = 11.84NRR438 pKa = 11.84AKK440 pKa = 10.61LKK442 pKa = 10.33YY443 pKa = 9.64AGLYY447 pKa = 9.9KK448 pKa = 10.58AFSTAWSWVAGDD460 pKa = 3.33GTEE463 pKa = 3.75RR464 pKa = 11.84LGRR467 pKa = 11.84SRR469 pKa = 11.84MLISFFSFEE478 pKa = 3.86QRR480 pKa = 11.84KK481 pKa = 10.04DD482 pKa = 2.92FDD484 pKa = 3.77KK485 pKa = 10.79TVKK488 pKa = 10.16YY489 pKa = 9.85PKK491 pKa = 10.59GVDD494 pKa = 2.96RR495 pKa = 11.84SYY497 pKa = 12.02GSFDD501 pKa = 3.4SLL503 pKa = 4.36

Molecular weight: 56.75 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2739

101

603

391.3

43.9

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.111 ± 0.656

1.899 ± 0.624

5.988 ± 0.345

6.17 ± 0.891

3.943 ± 0.481

6.645 ± 0.769

2.081 ± 0.261

4.527 ± 0.529

4.892 ± 0.549

7.959 ± 0.761

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.789 ± 0.398

4.381 ± 0.666

7.375 ± 1.798

4.856 ± 0.421

6.608 ± 1.165

8.58 ± 1.421

6.937 ± 1.12

5.769 ± 0.517

1.168 ± 0.288

3.322 ± 0.48
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski