Amino acid dipepetide frequency for Muromegalovirus G4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.952AlaAla: 11.952 ± 0.842
1.454AlaCys: 1.454 ± 0.16
4.346AlaAsp: 4.346 ± 0.3
3.765AlaGlu: 3.765 ± 0.253
2.693AlaPhe: 2.693 ± 0.195
4.821AlaGly: 4.821 ± 0.391
1.515AlaHis: 1.515 ± 0.195
3.627AlaIle: 3.627 ± 0.241
2.494AlaLys: 2.494 ± 0.203
6.642AlaLeu: 6.642 ± 0.377
1.745AlaMet: 1.745 ± 0.139
2.173AlaAsn: 2.173 ± 0.198
4.224AlaPro: 4.224 ± 0.329
1.867AlaGln: 1.867 ± 0.168
5.494AlaArg: 5.494 ± 0.351
6.611AlaSer: 6.611 ± 0.395
6.045AlaThr: 6.045 ± 0.397
6.55AlaVal: 6.55 ± 0.431
0.75AlaTrp: 0.75 ± 0.129
1.576AlaTyr: 1.576 ± 0.131
0.0AlaXaa: 0.0 ± 0.0
Cys
1.515CysAla: 1.515 ± 0.152
0.597CysCys: 0.597 ± 0.113
1.439CysAsp: 1.439 ± 0.145
1.148CysGlu: 1.148 ± 0.133
0.75CysPhe: 0.75 ± 0.1
1.53CysGly: 1.53 ± 0.193
0.428CysHis: 0.428 ± 0.075
0.949CysIle: 0.949 ± 0.141
0.704CysLys: 0.704 ± 0.118
2.387CysLeu: 2.387 ± 0.224
0.474CysMet: 0.474 ± 0.067
0.689CysAsn: 0.689 ± 0.109
0.949CysPro: 0.949 ± 0.127
0.719CysGln: 0.719 ± 0.115
2.204CysArg: 2.204 ± 0.201
1.331CysSer: 1.331 ± 0.187
1.24CysThr: 1.24 ± 0.142
2.142CysVal: 2.142 ± 0.205
0.168CysTrp: 0.168 ± 0.055
0.704CysTyr: 0.704 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
5.004AspAla: 5.004 ± 0.331
0.75AspCys: 0.75 ± 0.1
5.754AspAsp: 5.754 ± 0.64
4.729AspGlu: 4.729 ± 0.446
2.051AspPhe: 2.051 ± 0.182
4.56AspGly: 4.56 ± 0.365
1.117AspHis: 1.117 ± 0.133
2.387AspIle: 2.387 ± 0.214
1.454AspLys: 1.454 ± 0.145
5.05AspLeu: 5.05 ± 0.336
1.347AspMet: 1.347 ± 0.159
1.974AspAsn: 1.974 ± 0.171
3.627AspPro: 3.627 ± 0.286
1.5AspGln: 1.5 ± 0.171
4.331AspArg: 4.331 ± 0.245
4.3AspSer: 4.3 ± 0.302
3.275AspThr: 3.275 ± 0.274
4.009AspVal: 4.009 ± 0.296
0.398AspTrp: 0.398 ± 0.061
1.316AspTyr: 1.316 ± 0.152
0.0AspXaa: 0.0 ± 0.0
Glu
3.382GluAla: 3.382 ± 0.28
1.224GluCys: 1.224 ± 0.148
4.254GluAsp: 4.254 ± 0.399
4.453GluGlu: 4.453 ± 0.521
1.852GluPhe: 1.852 ± 0.195
2.923GluGly: 2.923 ± 0.21
1.087GluHis: 1.087 ± 0.128
2.586GluIle: 2.586 ± 0.235
2.234GluLys: 2.234 ± 0.204
4.453GluLeu: 4.453 ± 0.31
1.331GluMet: 1.331 ± 0.158
2.035GluAsn: 2.035 ± 0.195
2.969GluPro: 2.969 ± 0.375
1.316GluGln: 1.316 ± 0.159
4.591GluArg: 4.591 ± 0.326
4.193GluSer: 4.193 ± 0.261
3.872GluThr: 3.872 ± 0.261
2.678GluVal: 2.678 ± 0.224
0.505GluTrp: 0.505 ± 0.092
1.622GluTyr: 1.622 ± 0.169
0.0GluXaa: 0.0 ± 0.0
Phe
2.892PheAla: 2.892 ± 0.234
1.025PheCys: 1.025 ± 0.131
2.142PheAsp: 2.142 ± 0.158
1.882PheGlu: 1.882 ± 0.178
1.989PhePhe: 1.989 ± 0.155
2.51PheGly: 2.51 ± 0.195
0.872PheHis: 0.872 ± 0.153
1.5PheIle: 1.5 ± 0.192
1.27PheLys: 1.27 ± 0.145
3.749PheLeu: 3.749 ± 0.266
0.78PheMet: 0.78 ± 0.117
1.194PheAsn: 1.194 ± 0.132
1.683PhePro: 1.683 ± 0.176
0.872PheGln: 0.872 ± 0.143
2.678PheArg: 2.678 ± 0.253
3.275PheSer: 3.275 ± 0.284
2.158PheThr: 2.158 ± 0.187
3.443PheVal: 3.443 ± 0.256
0.49PheTrp: 0.49 ± 0.082
1.5PheTyr: 1.5 ± 0.179
0.0PheXaa: 0.0 ± 0.0
Gly
5.31GlyAla: 5.31 ± 0.303
1.331GlyCys: 1.331 ± 0.189
4.04GlyAsp: 4.04 ± 0.399
3.474GlyGlu: 3.474 ± 0.261
2.54GlyPhe: 2.54 ± 0.234
7.789GlyGly: 7.789 ± 0.665
1.5GlyHis: 1.5 ± 0.154
2.418GlyIle: 2.418 ± 0.195
2.02GlyLys: 2.02 ± 0.18
4.805GlyLeu: 4.805 ± 0.322
1.209GlyMet: 1.209 ± 0.153
1.882GlyAsn: 1.882 ± 0.188
2.999GlyPro: 2.999 ± 0.265
1.699GlyGln: 1.699 ± 0.175
5.203GlyArg: 5.203 ± 0.384
5.723GlySer: 5.723 ± 0.559
4.591GlyThr: 4.591 ± 0.351
4.821GlyVal: 4.821 ± 0.316
0.918GlyTrp: 0.918 ± 0.134
2.081GlyTyr: 2.081 ± 0.198
0.0GlyXaa: 0.0 ± 0.0
His
1.653HisAla: 1.653 ± 0.164
0.26HisCys: 0.26 ± 0.074
1.27HisAsp: 1.27 ± 0.164
1.071HisGlu: 1.071 ± 0.145
0.75HisPhe: 0.75 ± 0.101
1.423HisGly: 1.423 ± 0.174
1.301HisHis: 1.301 ± 0.352
0.903HisIle: 0.903 ± 0.108
0.78HisLys: 0.78 ± 0.141
1.974HisLeu: 1.974 ± 0.195
0.459HisMet: 0.459 ± 0.085
0.704HisAsn: 0.704 ± 0.094
1.576HisPro: 1.576 ± 0.178
0.796HisGln: 0.796 ± 0.109
1.989HisArg: 1.989 ± 0.187
1.331HisSer: 1.331 ± 0.188
1.484HisThr: 1.484 ± 0.171
1.592HisVal: 1.592 ± 0.136
0.153HisTrp: 0.153 ± 0.046
0.612HisTyr: 0.612 ± 0.093
0.0HisXaa: 0.0 ± 0.0
Ile
2.969IleAla: 2.969 ± 0.215
1.01IleCys: 1.01 ± 0.12
2.188IleAsp: 2.188 ± 0.174
2.234IleGlu: 2.234 ± 0.22
1.944IlePhe: 1.944 ± 0.216
2.678IleGly: 2.678 ± 0.257
0.934IleHis: 0.934 ± 0.123
1.653IleIle: 1.653 ± 0.191
1.515IleLys: 1.515 ± 0.185
3.902IleLeu: 3.902 ± 0.238
1.025IleMet: 1.025 ± 0.114
1.898IleAsn: 1.898 ± 0.183
2.709IlePro: 2.709 ± 0.231
1.178IleGln: 1.178 ± 0.127
3.382IleArg: 3.382 ± 0.268
3.688IleSer: 3.688 ± 0.275
2.908IleThr: 2.908 ± 0.251
3.566IleVal: 3.566 ± 0.255
0.367IleTrp: 0.367 ± 0.088
1.836IleTyr: 1.836 ± 0.206
0.0IleXaa: 0.0 ± 0.0
Lys
2.035LysAla: 2.035 ± 0.194
0.796LysCys: 0.796 ± 0.136
1.745LysAsp: 1.745 ± 0.138
1.668LysGlu: 1.668 ± 0.156
0.979LysPhe: 0.979 ± 0.115
1.515LysGly: 1.515 ± 0.173
0.979LysHis: 0.979 ± 0.15
2.28LysIle: 2.28 ± 0.199
2.449LysLys: 2.449 ± 0.261
2.908LysLeu: 2.908 ± 0.22
1.025LysMet: 1.025 ± 0.136
1.637LysAsn: 1.637 ± 0.207
1.592LysPro: 1.592 ± 0.194
1.087LysGln: 1.087 ± 0.124
3.168LysArg: 3.168 ± 0.254
2.739LysSer: 2.739 ± 0.211
2.755LysThr: 2.755 ± 0.213
2.188LysVal: 2.188 ± 0.216
0.367LysTrp: 0.367 ± 0.084
1.148LysTyr: 1.148 ± 0.123
0.0LysXaa: 0.0 ± 0.0
Leu
6.382LeuAla: 6.382 ± 0.318
2.954LeuCys: 2.954 ± 0.245
4.499LeuAsp: 4.499 ± 0.319
4.132LeuGlu: 4.132 ± 0.278
3.474LeuPhe: 3.474 ± 0.26
4.851LeuGly: 4.851 ± 0.323
2.035LeuHis: 2.035 ± 0.151
3.734LeuIle: 3.734 ± 0.221
3.122LeuLys: 3.122 ± 0.29
8.218LeuLeu: 8.218 ± 0.471
1.898LeuMet: 1.898 ± 0.208
2.525LeuAsn: 2.525 ± 0.244
5.264LeuPro: 5.264 ± 0.337
2.525LeuGln: 2.525 ± 0.199
6.932LeuArg: 6.932 ± 0.42
7.545LeuSer: 7.545 ± 0.352
5.632LeuThr: 5.632 ± 0.394
6.06LeuVal: 6.06 ± 0.404
0.842LeuTrp: 0.842 ± 0.111
2.617LeuTyr: 2.617 ± 0.216
0.0LeuXaa: 0.0 ± 0.0
Met
1.76MetAla: 1.76 ± 0.171
0.505MetCys: 0.505 ± 0.078
1.194MetAsp: 1.194 ± 0.152
1.148MetGlu: 1.148 ± 0.111
0.995MetPhe: 0.995 ± 0.117
0.979MetGly: 0.979 ± 0.122
0.367MetHis: 0.367 ± 0.079
1.178MetIle: 1.178 ± 0.151
0.872MetLys: 0.872 ± 0.126
2.097MetLeu: 2.097 ± 0.193
0.704MetMet: 0.704 ± 0.117
0.842MetAsn: 0.842 ± 0.117
1.102MetPro: 1.102 ± 0.148
0.582MetGln: 0.582 ± 0.088
1.714MetArg: 1.714 ± 0.181
1.974MetSer: 1.974 ± 0.184
1.515MetThr: 1.515 ± 0.154
1.27MetVal: 1.27 ± 0.161
0.275MetTrp: 0.275 ± 0.07
0.903MetTyr: 0.903 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
2.862AsnAla: 2.862 ± 0.258
0.582AsnCys: 0.582 ± 0.106
1.729AsnAsp: 1.729 ± 0.177
1.714AsnGlu: 1.714 ± 0.172
1.01AsnPhe: 1.01 ± 0.134
2.54AsnGly: 2.54 ± 0.216
0.704AsnHis: 0.704 ± 0.103
1.79AsnIle: 1.79 ± 0.163
1.209AsnLys: 1.209 ± 0.146
2.801AsnLeu: 2.801 ± 0.193
0.826AsnMet: 0.826 ± 0.108
1.821AsnAsn: 1.821 ± 0.168
1.653AsnPro: 1.653 ± 0.152
0.735AsnGln: 0.735 ± 0.108
2.25AsnArg: 2.25 ± 0.175
2.51AsnSer: 2.51 ± 0.23
2.54AsnThr: 2.54 ± 0.234
2.403AsnVal: 2.403 ± 0.205
0.337AsnTrp: 0.337 ± 0.077
0.964AsnTyr: 0.964 ± 0.123
0.0AsnXaa: 0.0 ± 0.0
Pro
4.836ProAla: 4.836 ± 0.385
0.964ProCys: 0.964 ± 0.135
3.183ProAsp: 3.183 ± 0.271
3.443ProGlu: 3.443 ± 0.341
2.02ProPhe: 2.02 ± 0.173
3.673ProGly: 3.673 ± 0.258
1.285ProHis: 1.285 ± 0.165
2.387ProIle: 2.387 ± 0.23
1.989ProLys: 1.989 ± 0.167
5.065ProLeu: 5.065 ± 0.307
1.041ProMet: 1.041 ± 0.13
1.53ProAsn: 1.53 ± 0.187
7.177ProPro: 7.177 ± 0.702
1.913ProGln: 1.913 ± 0.192
4.606ProArg: 4.606 ± 0.33
5.127ProSer: 5.127 ± 0.44
3.719ProThr: 3.719 ± 0.375
4.346ProVal: 4.346 ± 0.289
0.52ProTrp: 0.52 ± 0.095
1.515ProTyr: 1.515 ± 0.148
0.0ProXaa: 0.0 ± 0.0
Gln
1.637GlnAla: 1.637 ± 0.186
0.597GlnCys: 0.597 ± 0.103
1.377GlnAsp: 1.377 ± 0.147
1.607GlnGlu: 1.607 ± 0.218
0.979GlnPhe: 0.979 ± 0.117
1.285GlnGly: 1.285 ± 0.139
0.796GlnHis: 0.796 ± 0.105
1.377GlnIle: 1.377 ± 0.139
1.331GlnLys: 1.331 ± 0.163
2.602GlnLeu: 2.602 ± 0.24
0.704GlnMet: 0.704 ± 0.113
1.117GlnAsn: 1.117 ± 0.129
1.668GlnPro: 1.668 ± 0.19
2.678GlnGln: 2.678 ± 0.518
2.647GlnArg: 2.647 ± 0.193
2.035GlnSer: 2.035 ± 0.185
2.188GlnThr: 2.188 ± 0.209
1.546GlnVal: 1.546 ± 0.149
0.23GlnTrp: 0.23 ± 0.073
0.704GlnTyr: 0.704 ± 0.108
0.0GlnXaa: 0.0 ± 0.0
Arg
5.479ArgAla: 5.479 ± 0.287
1.989ArgCys: 1.989 ± 0.163
4.897ArgAsp: 4.897 ± 0.29
4.04ArgGlu: 4.04 ± 0.273
2.999ArgPhe: 2.999 ± 0.256
5.371ArgGly: 5.371 ± 0.351
2.127ArgHis: 2.127 ± 0.196
2.954ArgIle: 2.954 ± 0.214
2.755ArgLys: 2.755 ± 0.225
6.994ArgLeu: 6.994 ± 0.401
1.959ArgMet: 1.959 ± 0.186
2.525ArgAsn: 2.525 ± 0.237
5.295ArgPro: 5.295 ± 0.387
2.54ArgGln: 2.54 ± 0.213
9.549ArgArg: 9.549 ± 0.583
6.489ArgSer: 6.489 ± 0.394
4.208ArgThr: 4.208 ± 0.234
5.433ArgVal: 5.433 ± 0.345
0.995ArgTrp: 0.995 ± 0.153
2.586ArgTyr: 2.586 ± 0.173
0.0ArgXaa: 0.0 ± 0.0
Ser
6.014SerAla: 6.014 ± 0.342
1.852SerCys: 1.852 ± 0.182
5.218SerAsp: 5.218 ± 0.387
4.652SerGlu: 4.652 ± 0.327
2.923SerPhe: 2.923 ± 0.224
6.198SerGly: 6.198 ± 0.49
1.607SerHis: 1.607 ± 0.156
3.29SerIle: 3.29 ± 0.25
2.418SerLys: 2.418 ± 0.197
6.382SerLeu: 6.382 ± 0.319
1.668SerMet: 1.668 ± 0.196
2.341SerAsn: 2.341 ± 0.219
5.28SerPro: 5.28 ± 0.429
2.234SerGln: 2.234 ± 0.236
6.978SerArg: 6.978 ± 0.407
11.462SerSer: 11.462 ± 1.128
5.831SerThr: 5.831 ± 0.459
6.351SerVal: 6.351 ± 0.459
0.842SerTrp: 0.842 ± 0.116
2.112SerTyr: 2.112 ± 0.165
0.0SerXaa: 0.0 ± 0.0
Thr
6.152ThrAla: 6.152 ± 0.352
1.209ThrCys: 1.209 ± 0.144
3.474ThrAsp: 3.474 ± 0.295
3.367ThrGlu: 3.367 ± 0.293
2.693ThrPhe: 2.693 ± 0.212
4.254ThrGly: 4.254 ± 0.294
1.224ThrHis: 1.224 ± 0.153
3.382ThrIle: 3.382 ± 0.272
2.525ThrLys: 2.525 ± 0.226
4.958ThrLeu: 4.958 ± 0.316
1.546ThrMet: 1.546 ± 0.164
2.051ThrAsn: 2.051 ± 0.177
4.392ThrPro: 4.392 ± 0.292
1.882ThrGln: 1.882 ± 0.192
4.132ThrArg: 4.132 ± 0.266
5.632ThrSer: 5.632 ± 0.475
6.994ThrThr: 6.994 ± 0.886
6.519ThrVal: 6.519 ± 0.437
0.826ThrTrp: 0.826 ± 0.133
1.729ThrTyr: 1.729 ± 0.149
0.0ThrXaa: 0.0 ± 0.0
Val
5.877ValAla: 5.877 ± 0.347
1.974ValCys: 1.974 ± 0.164
4.055ValAsp: 4.055 ± 0.265
3.076ValGlu: 3.076 ± 0.213
3.627ValPhe: 3.627 ± 0.288
5.081ValGly: 5.081 ± 0.32
1.301ValHis: 1.301 ± 0.138
3.275ValIle: 3.275 ± 0.257
2.479ValLys: 2.479 ± 0.242
6.489ValLeu: 6.489 ± 0.411
1.423ValMet: 1.423 ± 0.142
2.525ValAsn: 2.525 ± 0.23
4.361ValPro: 4.361 ± 0.334
1.928ValGln: 1.928 ± 0.167
5.326ValArg: 5.326 ± 0.336
6.733ValSer: 6.733 ± 0.392
5.02ValThr: 5.02 ± 0.362
6.106ValVal: 6.106 ± 0.418
0.949ValTrp: 0.949 ± 0.14
2.678ValTyr: 2.678 ± 0.203
0.0ValXaa: 0.0 ± 0.0
Trp
0.643TrpAla: 0.643 ± 0.108
0.306TrpCys: 0.306 ± 0.071
0.337TrpAsp: 0.337 ± 0.077
0.444TrpGlu: 0.444 ± 0.101
0.444TrpPhe: 0.444 ± 0.086
0.474TrpGly: 0.474 ± 0.086
0.26TrpHis: 0.26 ± 0.064
0.643TrpIle: 0.643 ± 0.109
0.444TrpLys: 0.444 ± 0.094
0.934TrpLeu: 0.934 ± 0.138
0.26TrpMet: 0.26 ± 0.069
0.321TrpAsn: 0.321 ± 0.086
0.597TrpPro: 0.597 ± 0.099
0.383TrpGln: 0.383 ± 0.079
1.087TrpArg: 1.087 ± 0.141
0.765TrpSer: 0.765 ± 0.112
0.949TrpThr: 0.949 ± 0.119
0.566TrpVal: 0.566 ± 0.103
0.321TrpTrp: 0.321 ± 0.078
0.474TrpTyr: 0.474 ± 0.093
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.005TyrAla: 2.005 ± 0.183
0.689TyrCys: 0.689 ± 0.099
1.79TyrAsp: 1.79 ± 0.147
1.515TyrGlu: 1.515 ± 0.161
1.194TyrPhe: 1.194 ± 0.132
1.898TyrGly: 1.898 ± 0.162
0.643TyrHis: 0.643 ± 0.118
1.27TyrIle: 1.27 ± 0.153
0.995TyrLys: 0.995 ± 0.137
2.831TyrLeu: 2.831 ± 0.208
0.536TyrMet: 0.536 ± 0.072
1.194TyrAsn: 1.194 ± 0.146
1.224TyrPro: 1.224 ± 0.149
0.673TyrGln: 0.673 ± 0.094
2.923TyrArg: 2.923 ± 0.226
2.188TyrSer: 2.188 ± 0.224
2.02TyrThr: 2.02 ± 0.171
2.693TyrVal: 2.693 ± 0.198
0.398TyrTrp: 0.398 ± 0.081
1.071TyrTyr: 1.071 ± 0.135
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 163 proteins (65346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski