Amino acid dipepetide frequency for Brachybacterium vulturis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.636AlaAla: 19.636 ± 0.201	0.756AlaCys: 0.756 ± 0.027	7.748AlaAsp: 7.748 ± 0.095	9.067AlaGlu: 9.067 ± 0.103	3.218AlaPhe: 3.218 ± 0.062	11.971AlaGly: 11.971 ± 0.134	2.78AlaHis: 2.78 ± 0.051	4.811AlaIle: 4.811 ± 0.067	2.077AlaLys: 2.077 ± 0.054	14.64AlaLeu: 14.64 ± 0.161	2.88AlaMet: 2.88 ± 0.055	1.628AlaAsn: 1.628 ± 0.038	7.396AlaPro: 7.396 ± 0.106	4.269AlaGln: 4.269 ± 0.067	9.58AlaArg: 9.58 ± 0.129	6.527AlaSer: 6.527 ± 0.088	6.989AlaThr: 6.989 ± 0.079	10.989AlaVal: 10.989 ± 0.12	1.679AlaTrp: 1.679 ± 0.043	1.981AlaTyr: 1.981 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.744CysAla: 0.744 ± 0.028	0.045CysCys: 0.045 ± 0.006	0.307CysAsp: 0.307 ± 0.017	0.356CysGlu: 0.356 ± 0.018	0.178CysPhe: 0.178 ± 0.014	0.715CysGly: 0.715 ± 0.025	0.155CysHis: 0.155 ± 0.013	0.159CysIle: 0.159 ± 0.012	0.06CysLys: 0.06 ± 0.008	0.531CysLeu: 0.531 ± 0.024	0.08CysMet: 0.08 ± 0.008	0.109CysAsn: 0.109 ± 0.011	0.369CysPro: 0.369 ± 0.023	0.123CysGln: 0.123 ± 0.01	0.411CysArg: 0.411 ± 0.022	0.316CysSer: 0.316 ± 0.018	0.4CysThr: 0.4 ± 0.017	0.397CysVal: 0.397 ± 0.018	0.096CysTrp: 0.096 ± 0.009	0.108CysTyr: 0.108 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.918AspAla: 7.918 ± 0.09	0.288AspCys: 0.288 ± 0.015	3.462AspAsp: 3.462 ± 0.072	4.28AspGlu: 4.28 ± 0.07	1.573AspPhe: 1.573 ± 0.039	6.367AspGly: 6.367 ± 0.097	1.523AspHis: 1.523 ± 0.041	2.103AspIle: 2.103 ± 0.046	0.747AspLys: 0.747 ± 0.031	6.96AspLeu: 6.96 ± 0.089	0.882AspMet: 0.882 ± 0.03	0.742AspAsn: 0.742 ± 0.03	4.84AspPro: 4.84 ± 0.073	1.771AspGln: 1.771 ± 0.042	4.466AspArg: 4.466 ± 0.078	2.843AspSer: 2.843 ± 0.048	2.787AspThr: 2.787 ± 0.062	4.99AspVal: 4.99 ± 0.066	0.884AspTrp: 0.884 ± 0.029	1.028AspTyr: 1.028 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.632GluAla: 7.632 ± 0.092	0.251GluCys: 0.251 ± 0.015	4.309GluAsp: 4.309 ± 0.074	4.379GluGlu: 4.379 ± 0.081	1.626GluPhe: 1.626 ± 0.045	4.838GluGly: 4.838 ± 0.077	2.103GluHis: 2.103 ± 0.048	3.146GluIle: 3.146 ± 0.05	1.417GluLys: 1.417 ± 0.043	6.971GluLeu: 6.971 ± 0.083	1.123GluMet: 1.123 ± 0.034	1.289GluAsn: 1.289 ± 0.035	3.087GluPro: 3.087 ± 0.061	3.033GluGln: 3.033 ± 0.06	5.261GluArg: 5.261 ± 0.079	2.963GluSer: 2.963 ± 0.051	3.245GluThr: 3.245 ± 0.052	5.268GluVal: 5.268 ± 0.075	0.69GluTrp: 0.69 ± 0.026	1.084GluTyr: 1.084 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.532PheAla: 3.532 ± 0.059	0.196PheCys: 0.196 ± 0.013	2.009PheAsp: 2.009 ± 0.043	1.657PheGlu: 1.657 ± 0.043	0.959PhePhe: 0.959 ± 0.032	2.871PheGly: 2.871 ± 0.055	0.614PheHis: 0.614 ± 0.023	0.945PheIle: 0.945 ± 0.03	0.349PheLys: 0.349 ± 0.019	2.857PheLeu: 2.857 ± 0.064	0.487PheMet: 0.487 ± 0.022	0.487PheAsn: 0.487 ± 0.021	1.404PhePro: 1.404 ± 0.038	0.717PheGln: 0.717 ± 0.027	1.672PheArg: 1.672 ± 0.043	1.765PheSer: 1.765 ± 0.044	2.167PheThr: 2.167 ± 0.051	2.325PheVal: 2.325 ± 0.053	0.436PheTrp: 0.436 ± 0.021	0.552PheTyr: 0.552 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.558GlyAla: 11.558 ± 0.133	0.595GlyCys: 0.595 ± 0.026	4.946GlyAsp: 4.946 ± 0.072	5.745GlyGlu: 5.745 ± 0.076	2.843GlyPhe: 2.843 ± 0.051	8.194GlyGly: 8.194 ± 0.106	2.061GlyHis: 2.061 ± 0.042	4.516GlyIle: 4.516 ± 0.064	1.871GlyLys: 1.871 ± 0.044	8.922GlyLeu: 8.922 ± 0.105	2.31GlyMet: 2.31 ± 0.048	1.434GlyAsn: 1.434 ± 0.036	4.668GlyPro: 4.668 ± 0.074	2.665GlyGln: 2.665 ± 0.06	6.946GlyArg: 6.946 ± 0.092	5.467GlySer: 5.467 ± 0.072	6.375GlyThr: 6.375 ± 0.083	6.966GlyVal: 6.966 ± 0.084	1.492GlyTrp: 1.492 ± 0.041	1.912GlyTyr: 1.912 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.52HisAla: 2.52 ± 0.055	0.149HisCys: 0.149 ± 0.012	1.561HisAsp: 1.561 ± 0.039	1.44HisGlu: 1.44 ± 0.035	0.515HisPhe: 0.515 ± 0.022	2.458HisGly: 2.458 ± 0.052	0.741HisHis: 0.741 ± 0.026	0.619HisIle: 0.619 ± 0.024	0.261HisLys: 0.261 ± 0.016	2.811HisLeu: 2.811 ± 0.059	0.315HisMet: 0.315 ± 0.018	0.333HisAsn: 0.333 ± 0.018	1.749HisPro: 1.749 ± 0.041	0.668HisGln: 0.668 ± 0.024	2.252HisArg: 2.252 ± 0.048	1.093HisSer: 1.093 ± 0.028	1.139HisThr: 1.139 ± 0.035	1.717HisVal: 1.717 ± 0.048	0.348HisTrp: 0.348 ± 0.018	0.434HisTyr: 0.434 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.316IleAla: 6.316 ± 0.088	0.239IleCys: 0.239 ± 0.016	3.245IleAsp: 3.245 ± 0.058	2.685IleGlu: 2.685 ± 0.048	1.024IlePhe: 1.024 ± 0.033	4.409IleGly: 4.409 ± 0.071	0.77IleHis: 0.77 ± 0.026	1.657IleIle: 1.657 ± 0.049	0.509IleLys: 0.509 ± 0.022	3.517IleLeu: 3.517 ± 0.075	0.671IleMet: 0.671 ± 0.029	0.737IleAsn: 0.737 ± 0.028	2.366IlePro: 2.366 ± 0.053	0.87IleGln: 0.87 ± 0.031	2.39IleArg: 2.39 ± 0.053	2.407IleSer: 2.407 ± 0.049	2.804IleThr: 2.804 ± 0.057	3.727IleVal: 3.727 ± 0.053	0.467IleTrp: 0.467 ± 0.022	0.631IleTyr: 0.631 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.809LysAla: 1.809 ± 0.052	0.057LysCys: 0.057 ± 0.008	1.022LysAsp: 1.022 ± 0.035	0.947LysGlu: 0.947 ± 0.033	0.383LysPhe: 0.383 ± 0.021	1.388LysGly: 1.388 ± 0.042	0.385LysHis: 0.385 ± 0.019	0.797LysIle: 0.797 ± 0.027	0.626LysLys: 0.626 ± 0.035	1.528LysLeu: 1.528 ± 0.044	0.317LysMet: 0.317 ± 0.019	0.44LysAsn: 0.44 ± 0.02	0.846LysPro: 0.846 ± 0.033	0.589LysGln: 0.589 ± 0.024	1.221LysArg: 1.221 ± 0.038	0.95LysSer: 0.95 ± 0.027	0.895LysThr: 0.895 ± 0.028	1.305LysVal: 1.305 ± 0.037	0.168LysTrp: 0.168 ± 0.014	0.378LysTyr: 0.378 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.906LeuAla: 14.906 ± 0.156	0.646LeuCys: 0.646 ± 0.024	6.715LeuAsp: 6.715 ± 0.087	6.633LeuGlu: 6.633 ± 0.077	2.709LeuPhe: 2.709 ± 0.055	9.723LeuGly: 9.723 ± 0.108	2.351LeuHis: 2.351 ± 0.048	4.166LeuIle: 4.166 ± 0.074	1.311LeuLys: 1.311 ± 0.04	12.145LeuLeu: 12.145 ± 0.153	1.948LeuMet: 1.948 ± 0.05	1.593LeuAsn: 1.593 ± 0.044	6.216LeuPro: 6.216 ± 0.073	2.839LeuGln: 2.839 ± 0.05	8.513LeuArg: 8.513 ± 0.105	5.961LeuSer: 5.961 ± 0.079	6.733LeuThr: 6.733 ± 0.088	9.122LeuVal: 9.122 ± 0.093	1.224LeuTrp: 1.224 ± 0.038	1.574LeuTyr: 1.574 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.314MetAla: 2.314 ± 0.054	0.12MetCys: 0.12 ± 0.011	1.005MetAsp: 1.005 ± 0.034	0.841MetGlu: 0.841 ± 0.032	0.605MetPhe: 0.605 ± 0.024	1.454MetGly: 1.454 ± 0.041	0.421MetHis: 0.421 ± 0.021	1.058MetIle: 1.058 ± 0.034	0.376MetLys: 0.376 ± 0.023	2.246MetLeu: 2.246 ± 0.047	0.427MetMet: 0.427 ± 0.021	0.526MetAsn: 0.526 ± 0.023	1.197MetPro: 1.197 ± 0.037	0.584MetGln: 0.584 ± 0.022	1.454MetArg: 1.454 ± 0.037	1.566MetSer: 1.566 ± 0.038	1.765MetThr: 1.765 ± 0.035	1.549MetVal: 1.549 ± 0.043	0.233MetTrp: 0.233 ± 0.015	0.315MetTyr: 0.315 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	1.906AsnAla: 1.906 ± 0.045	0.103AsnCys: 0.103 ± 0.01	0.893AsnAsp: 0.893 ± 0.03	0.77AsnGlu: 0.77 ± 0.032	0.537AsnPhe: 0.537 ± 0.022	1.442AsnGly: 1.442 ± 0.041	0.36AsnHis: 0.36 ± 0.019	0.753AsnIle: 0.753 ± 0.029	0.265AsnLys: 0.265 ± 0.017	1.756AsnLeu: 1.756 ± 0.041	0.307AsnMet: 0.307 ± 0.017	0.357AsnAsn: 0.357 ± 0.019	1.266AsnPro: 1.266 ± 0.038	0.49AsnGln: 0.49 ± 0.024	1.136AsnArg: 1.136 ± 0.036	0.912AsnSer: 0.912 ± 0.032	0.922AsnThr: 0.922 ± 0.031	1.233AsnVal: 1.233 ± 0.033	0.233AsnTrp: 0.233 ± 0.016	0.377AsnTyr: 0.377 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.125ProAla: 8.125 ± 0.095	0.224ProCys: 0.224 ± 0.015	3.72ProAsp: 3.72 ± 0.068	4.534ProGlu: 4.534 ± 0.067	1.687ProPhe: 1.687 ± 0.041	5.741ProGly: 5.741 ± 0.078	1.327ProHis: 1.327 ± 0.036	1.781ProIle: 1.781 ± 0.045	0.772ProLys: 0.772 ± 0.03	5.472ProLeu: 5.472 ± 0.079	1.054ProMet: 1.054 ± 0.031	0.784ProAsn: 0.784 ± 0.03	2.782ProPro: 2.782 ± 0.056	1.869ProGln: 1.869 ± 0.045	3.947ProArg: 3.947 ± 0.06	3.47ProSer: 3.47 ± 0.062	3.552ProThr: 3.552 ± 0.059	4.914ProVal: 4.914 ± 0.073	0.861ProTrp: 0.861 ± 0.032	0.996ProTyr: 0.996 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.493GlnAla: 3.493 ± 0.06	0.139GlnCys: 0.139 ± 0.012	1.781GlnAsp: 1.781 ± 0.04	2.024GlnGlu: 2.024 ± 0.043	0.803GlnPhe: 0.803 ± 0.027	2.431GlnGly: 2.431 ± 0.047	0.751GlnHis: 0.751 ± 0.025	1.464GlnIle: 1.464 ± 0.034	0.632GlnLys: 0.632 ± 0.027	3.525GlnLeu: 3.525 ± 0.067	0.602GlnMet: 0.602 ± 0.023	0.553GlnAsn: 0.553 ± 0.026	1.409GlnPro: 1.409 ± 0.041	1.415GlnGln: 1.415 ± 0.038	2.638GlnArg: 2.638 ± 0.055	1.423GlnSer: 1.423 ± 0.034	1.349GlnThr: 1.349 ± 0.037	2.741GlnVal: 2.741 ± 0.063	0.514GlnTrp: 0.514 ± 0.023	0.573GlnTyr: 0.573 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.269ArgAla: 9.269 ± 0.119	0.462ArgCys: 0.462 ± 0.022	4.195ArgAsp: 4.195 ± 0.066	5.262ArgGlu: 5.262 ± 0.083	2.28ArgPhe: 2.28 ± 0.043	5.946ArgGly: 5.946 ± 0.086	1.83ArgHis: 1.83 ± 0.04	3.631ArgIle: 3.631 ± 0.061	1.148ArgLys: 1.148 ± 0.036	7.493ArgLeu: 7.493 ± 0.102	1.806ArgMet: 1.806 ± 0.036	1.158ArgAsn: 1.158 ± 0.034	4.316ArgPro: 4.316 ± 0.06	1.981ArgGln: 1.981 ± 0.043	7.757ArgArg: 7.757 ± 0.121	4.836ArgSer: 4.836 ± 0.078	5.235ArgThr: 5.235 ± 0.062	5.158ArgVal: 5.158 ± 0.065	1.25ArgTrp: 1.25 ± 0.037	1.44ArgTyr: 1.44 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.376SerAla: 7.376 ± 0.087	0.331SerCys: 0.331 ± 0.018	2.876SerAsp: 2.876 ± 0.057	2.83SerGlu: 2.83 ± 0.06	1.848SerPhe: 1.848 ± 0.043	5.772SerGly: 5.772 ± 0.073	1.132SerHis: 1.132 ± 0.029	2.214SerIle: 2.214 ± 0.046	0.939SerLys: 0.939 ± 0.034	5.642SerLeu: 5.642 ± 0.074	1.335SerMet: 1.335 ± 0.035	0.862SerAsn: 0.862 ± 0.03	3.432SerPro: 3.432 ± 0.053	1.503SerGln: 1.503 ± 0.041	4.177SerArg: 4.177 ± 0.067	3.666SerSer: 3.666 ± 0.068	3.968SerThr: 3.968 ± 0.061	4.318SerVal: 4.318 ± 0.071	0.978SerTrp: 0.978 ± 0.031	1.047SerTyr: 1.047 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.466ThrAla: 8.466 ± 0.092	0.322ThrCys: 0.322 ± 0.019	3.607ThrAsp: 3.607 ± 0.057	3.436ThrGlu: 3.436 ± 0.066	1.765ThrPhe: 1.765 ± 0.041	6.259ThrGly: 6.259 ± 0.081	1.181ThrHis: 1.181 ± 0.035	2.517ThrIle: 2.517 ± 0.043	0.903ThrLys: 0.903 ± 0.032	6.127ThrLeu: 6.127 ± 0.087	1.143ThrMet: 1.143 ± 0.035	0.922ThrAsn: 0.922 ± 0.033	3.853ThrPro: 3.853 ± 0.061	1.48ThrGln: 1.48 ± 0.04	3.93ThrArg: 3.93 ± 0.058	3.673ThrSer: 3.673 ± 0.06	4.004ThrThr: 4.004 ± 0.064	5.821ThrVal: 5.821 ± 0.07	0.948ThrTrp: 0.948 ± 0.035	1.156ThrTyr: 1.156 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.66ValAla: 9.66 ± 0.104	0.513ValCys: 0.513 ± 0.022	5.14ValAsp: 5.14 ± 0.071	4.954ValGlu: 4.954 ± 0.066	2.303ValPhe: 2.303 ± 0.05	6.708ValGly: 6.708 ± 0.098	1.964ValHis: 1.964 ± 0.042	3.892ValIle: 3.892 ± 0.068	1.26ValLys: 1.26 ± 0.036	10.447ValLeu: 10.447 ± 0.114	1.742ValMet: 1.742 ± 0.044	1.384ValAsn: 1.384 ± 0.041	4.792ValPro: 4.792 ± 0.063	2.275ValGln: 2.275 ± 0.046	6.124ValArg: 6.124 ± 0.076	4.479ValSer: 4.479 ± 0.067	5.313ValThr: 5.313 ± 0.078	7.697ValVal: 7.697 ± 0.088	0.913ValTrp: 0.913 ± 0.028	1.178ValTyr: 1.178 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.463TrpAla: 1.463 ± 0.04	0.098TrpCys: 0.098 ± 0.009	0.78TrpAsp: 0.78 ± 0.03	0.817TrpGlu: 0.817 ± 0.028	0.52TrpPhe: 0.52 ± 0.022	1.052TrpGly: 1.052 ± 0.031	0.347TrpHis: 0.347 ± 0.02	0.658TrpIle: 0.658 ± 0.022	0.286TrpLys: 0.286 ± 0.017	1.452TrpLeu: 1.452 ± 0.039	0.358TrpMet: 0.358 ± 0.018	0.375TrpAsn: 0.375 ± 0.019	0.67TrpPro: 0.67 ± 0.026	0.538TrpGln: 0.538 ± 0.024	1.093TrpArg: 1.093 ± 0.035	0.876TrpSer: 0.876 ± 0.03	0.964TrpThr: 0.964 ± 0.032	1.064TrpVal: 1.064 ± 0.034	0.349TrpTrp: 0.349 ± 0.018	0.288TrpTyr: 0.288 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.977TyrAla: 1.977 ± 0.041	0.124TyrCys: 0.124 ± 0.011	1.132TyrAsp: 1.132 ± 0.034	1.057TyrGlu: 1.057 ± 0.034	0.627TyrPhe: 0.627 ± 0.025	1.749TyrGly: 1.749 ± 0.039	0.327TyrHis: 0.327 ± 0.018	0.553TyrIle: 0.553 ± 0.023	0.242TyrLys: 0.242 ± 0.017	1.985TyrLeu: 1.985 ± 0.045	0.27TyrMet: 0.27 ± 0.016	0.307TyrAsn: 0.307 ± 0.018	0.954TyrPro: 0.954 ± 0.03	0.58TyrGln: 0.58 ± 0.023	1.486TyrArg: 1.486 ± 0.037	1.054TyrSer: 1.054 ± 0.032	0.905TyrThr: 0.905 ± 0.029	1.438TyrVal: 1.438 ± 0.037	0.285TyrTrp: 0.285 ± 0.016	0.417TyrTyr: 0.417 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3244 proteins (1105779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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