Amino acid dipepetide frequency for Cognatiyoonia koreensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.938AlaAla: 14.938 ± 0.131	1.123AlaCys: 1.123 ± 0.032	7.459AlaAsp: 7.459 ± 0.094	7.211AlaGlu: 7.211 ± 0.105	4.491AlaPhe: 4.491 ± 0.072	9.783AlaGly: 9.783 ± 0.112	2.264AlaHis: 2.264 ± 0.055	6.255AlaIle: 6.255 ± 0.078	4.288AlaLys: 4.288 ± 0.075	12.212AlaLeu: 12.212 ± 0.143	3.746AlaMet: 3.746 ± 0.068	3.267AlaAsn: 3.267 ± 0.06	5.085AlaPro: 5.085 ± 0.084	4.214AlaGln: 4.214 ± 0.069	6.926AlaArg: 6.926 ± 0.099	5.423AlaSer: 5.423 ± 0.084	6.45AlaThr: 6.45 ± 0.094	7.988AlaVal: 7.988 ± 0.088	1.324AlaTrp: 1.324 ± 0.038	2.602AlaTyr: 2.602 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.087CysAla: 1.087 ± 0.031	0.112CysCys: 0.112 ± 0.01	0.659CysAsp: 0.659 ± 0.026	0.472CysGlu: 0.472 ± 0.02	0.354CysPhe: 0.354 ± 0.018	0.996CysGly: 0.996 ± 0.034	0.256CysHis: 0.256 ± 0.014	0.475CysIle: 0.475 ± 0.023	0.264CysLys: 0.264 ± 0.017	0.834CysLeu: 0.834 ± 0.026	0.189CysMet: 0.189 ± 0.013	0.27CysAsn: 0.27 ± 0.015	0.494CysPro: 0.494 ± 0.024	0.254CysGln: 0.254 ± 0.016	0.466CysArg: 0.466 ± 0.021	0.459CysSer: 0.459 ± 0.024	0.492CysThr: 0.492 ± 0.024	0.632CysVal: 0.632 ± 0.026	0.109CysTrp: 0.109 ± 0.009	0.232CysTyr: 0.232 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.696AspAla: 7.696 ± 0.096	0.557AspCys: 0.557 ± 0.024	4.28AspAsp: 4.28 ± 0.127	3.553AspGlu: 3.553 ± 0.058	2.529AspPhe: 2.529 ± 0.057	6.296AspGly: 6.296 ± 0.109	1.435AspHis: 1.435 ± 0.037	3.606AspIle: 3.606 ± 0.056	1.947AspLys: 1.947 ± 0.044	6.429AspLeu: 6.429 ± 0.087	1.84AspMet: 1.84 ± 0.042	1.604AspAsn: 1.604 ± 0.037	3.737AspPro: 3.737 ± 0.065	2.187AspGln: 2.187 ± 0.046	4.019AspArg: 4.019 ± 0.074	2.424AspSer: 2.424 ± 0.051	3.599AspThr: 3.599 ± 0.091	5.165AspVal: 5.165 ± 0.076	1.161AspTrp: 1.161 ± 0.041	1.651AspTyr: 1.651 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.641GluAla: 6.641 ± 0.114	0.358GluCys: 0.358 ± 0.017	3.436GluAsp: 3.436 ± 0.068	3.144GluGlu: 3.144 ± 0.06	1.768GluPhe: 1.768 ± 0.048	4.322GluGly: 4.322 ± 0.063	1.041GluHis: 1.041 ± 0.031	3.618GluIle: 3.618 ± 0.058	2.242GluLys: 2.242 ± 0.056	4.741GluLeu: 4.741 ± 0.078	1.819GluMet: 1.819 ± 0.042	2.029GluAsn: 2.029 ± 0.042	2.231GluPro: 2.231 ± 0.051	1.831GluGln: 1.831 ± 0.039	3.599GluArg: 3.599 ± 0.074	2.492GluSer: 2.492 ± 0.053	3.92GluThr: 3.92 ± 0.066	4.126GluVal: 4.126 ± 0.055	0.646GluTrp: 0.646 ± 0.025	1.048GluTyr: 1.048 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.701PheAla: 4.701 ± 0.064	0.468PheCys: 0.468 ± 0.022	3.015PheAsp: 3.015 ± 0.047	2.284PheGlu: 2.284 ± 0.047	1.584PhePhe: 1.584 ± 0.043	4.023PheGly: 4.023 ± 0.06	0.76PheHis: 0.76 ± 0.026	1.946PheIle: 1.946 ± 0.047	1.142PheLys: 1.142 ± 0.035	3.491PheLeu: 3.491 ± 0.06	0.963PheMet: 0.963 ± 0.029	1.234PheAsn: 1.234 ± 0.035	1.605PhePro: 1.605 ± 0.042	1.2PheGln: 1.2 ± 0.033	2.026PheArg: 2.026 ± 0.042	2.243PheSer: 2.243 ± 0.048	2.232PheThr: 2.232 ± 0.046	2.977PheVal: 2.977 ± 0.057	0.607PheTrp: 0.607 ± 0.024	1.003PheTyr: 1.003 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.85GlyAla: 8.85 ± 0.099	0.842GlyCys: 0.842 ± 0.031	5.304GlyAsp: 5.304 ± 0.117	4.541GlyGlu: 4.541 ± 0.072	3.84GlyPhe: 3.84 ± 0.066	7.481GlyGly: 7.481 ± 0.143	1.789GlyHis: 1.789 ± 0.05	4.775GlyIle: 4.775 ± 0.073	3.396GlyLys: 3.396 ± 0.069	8.48GlyLeu: 8.48 ± 0.11	2.518GlyMet: 2.518 ± 0.05	2.581GlyAsn: 2.581 ± 0.077	3.601GlyPro: 3.601 ± 0.066	3.182GlyGln: 3.182 ± 0.056	5.011GlyArg: 5.011 ± 0.071	4.349GlySer: 4.349 ± 0.089	5.101GlyThr: 5.101 ± 0.089	6.401GlyVal: 6.401 ± 0.078	1.459GlyTrp: 1.459 ± 0.041	2.291GlyTyr: 2.291 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.228HisAla: 2.228 ± 0.052	0.235HisCys: 0.235 ± 0.014	1.38HisAsp: 1.38 ± 0.038	0.984HisGlu: 0.984 ± 0.034	0.841HisPhe: 0.841 ± 0.029	1.813HisGly: 1.813 ± 0.045	0.527HisHis: 0.527 ± 0.025	1.089HisIle: 1.089 ± 0.034	0.609HisLys: 0.609 ± 0.025	1.991HisLeu: 1.991 ± 0.051	0.583HisMet: 0.583 ± 0.024	0.518HisAsn: 0.518 ± 0.022	1.299HisPro: 1.299 ± 0.033	0.598HisGln: 0.598 ± 0.026	1.158HisArg: 1.158 ± 0.035	0.844HisSer: 0.844 ± 0.03	0.944HisThr: 0.944 ± 0.028	1.533HisVal: 1.533 ± 0.044	0.332HisTrp: 0.332 ± 0.02	0.566HisTyr: 0.566 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.697IleAla: 7.697 ± 0.088	0.643IleCys: 0.643 ± 0.025	3.928IleAsp: 3.928 ± 0.054	3.346IleGlu: 3.346 ± 0.058	1.943IlePhe: 1.943 ± 0.05	5.298IleGly: 5.298 ± 0.083	0.949IleHis: 0.949 ± 0.028	2.851IleIle: 2.851 ± 0.062	1.841IleLys: 1.841 ± 0.041	4.896IleLeu: 4.896 ± 0.077	1.312IleMet: 1.312 ± 0.036	1.672IleAsn: 1.672 ± 0.044	2.523IlePro: 2.523 ± 0.045	1.307IleGln: 1.307 ± 0.033	3.043IleArg: 3.043 ± 0.056	3.223IleSer: 3.223 ± 0.053	3.464IleThr: 3.464 ± 0.066	4.255IleVal: 4.255 ± 0.079	0.776IleTrp: 0.776 ± 0.03	1.342IleTyr: 1.342 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.294LysAla: 4.294 ± 0.072	0.2LysCys: 0.2 ± 0.013	2.236LysAsp: 2.236 ± 0.053	1.712LysGlu: 1.712 ± 0.045	1.0LysPhe: 1.0 ± 0.031	2.881LysGly: 2.881 ± 0.06	0.73LysHis: 0.73 ± 0.03	1.879LysIle: 1.879 ± 0.048	1.428LysLys: 1.428 ± 0.043	3.125LysLeu: 3.125 ± 0.058	0.956LysMet: 0.956 ± 0.026	0.981LysAsn: 0.981 ± 0.031	1.894LysPro: 1.894 ± 0.048	1.013LysGln: 1.013 ± 0.031	2.307LysArg: 2.307 ± 0.052	2.126LysSer: 2.126 ± 0.049	2.219LysThr: 2.219 ± 0.04	2.447LysVal: 2.447 ± 0.052	0.44LysTrp: 0.44 ± 0.021	0.675LysTyr: 0.675 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.513LeuAla: 11.513 ± 0.132	0.92LeuCys: 0.92 ± 0.028	5.836LeuAsp: 5.836 ± 0.073	4.892LeuGlu: 4.892 ± 0.083	3.699LeuPhe: 3.699 ± 0.073	7.783LeuGly: 7.783 ± 0.092	1.756LeuHis: 1.756 ± 0.047	5.522LeuIle: 5.522 ± 0.075	3.227LeuLys: 3.227 ± 0.06	8.417LeuLeu: 8.417 ± 0.116	2.598LeuMet: 2.598 ± 0.047	2.928LeuAsn: 2.928 ± 0.052	5.042LeuPro: 5.042 ± 0.071	2.979LeuGln: 2.979 ± 0.055	6.165LeuArg: 6.165 ± 0.098	6.312LeuSer: 6.312 ± 0.078	6.316LeuThr: 6.316 ± 0.076	6.466LeuVal: 6.466 ± 0.084	1.224LeuTrp: 1.224 ± 0.034	1.911LeuTyr: 1.911 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.27MetAla: 3.27 ± 0.055	0.224MetCys: 0.224 ± 0.015	1.514MetAsp: 1.514 ± 0.036	1.303MetGlu: 1.303 ± 0.036	0.9MetPhe: 0.9 ± 0.03	2.202MetGly: 2.202 ± 0.054	0.518MetHis: 0.518 ± 0.02	1.712MetIle: 1.712 ± 0.046	1.169MetLys: 1.169 ± 0.029	2.683MetLeu: 2.683 ± 0.054	0.835MetMet: 0.835 ± 0.03	1.001MetAsn: 1.001 ± 0.028	1.564MetPro: 1.564 ± 0.039	1.031MetGln: 1.031 ± 0.03	1.903MetArg: 1.903 ± 0.042	1.839MetSer: 1.839 ± 0.04	2.204MetThr: 2.204 ± 0.049	1.851MetVal: 1.851 ± 0.039	0.282MetTrp: 0.282 ± 0.016	0.378MetTyr: 0.378 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.695AsnAla: 3.695 ± 0.064	0.275AsnCys: 0.275 ± 0.014	1.979AsnAsp: 1.979 ± 0.068	1.396AsnGlu: 1.396 ± 0.034	1.15AsnPhe: 1.15 ± 0.037	2.893AsnGly: 2.893 ± 0.067	0.597AsnHis: 0.597 ± 0.021	1.701AsnIle: 1.701 ± 0.042	0.818AsnLys: 0.818 ± 0.027	2.728AsnLeu: 2.728 ± 0.051	0.819AsnMet: 0.819 ± 0.025	0.902AsnAsn: 0.902 ± 0.035	1.993AsnPro: 1.993 ± 0.047	0.875AsnGln: 0.875 ± 0.031	1.801AsnArg: 1.801 ± 0.044	1.289AsnSer: 1.289 ± 0.032	1.628AsnThr: 1.628 ± 0.044	2.2AsnVal: 2.2 ± 0.051	0.487AsnTrp: 0.487 ± 0.022	0.781AsnTyr: 0.781 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.303ProAla: 5.303 ± 0.078	0.37ProCys: 0.37 ± 0.017	4.192ProAsp: 4.192 ± 0.066	3.524ProGlu: 3.524 ± 0.06	2.02ProPhe: 2.02 ± 0.046	3.734ProGly: 3.734 ± 0.067	1.044ProHis: 1.044 ± 0.035	2.53ProIle: 2.53 ± 0.052	1.757ProLys: 1.757 ± 0.045	4.327ProLeu: 4.327 ± 0.059	1.298ProMet: 1.298 ± 0.035	1.533ProAsn: 1.533 ± 0.037	2.105ProPro: 2.105 ± 0.054	1.629ProGln: 1.629 ± 0.041	2.418ProArg: 2.418 ± 0.047	2.345ProSer: 2.345 ± 0.054	2.79ProThr: 2.79 ± 0.062	4.04ProVal: 4.04 ± 0.068	0.612ProTrp: 0.612 ± 0.025	1.169ProTyr: 1.169 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.807GlnAla: 3.807 ± 0.064	0.237GlnCys: 0.237 ± 0.015	1.926GlnAsp: 1.926 ± 0.046	1.662GlnGlu: 1.662 ± 0.043	1.243GlnPhe: 1.243 ± 0.037	2.496GlnGly: 2.496 ± 0.052	0.6GlnHis: 0.6 ± 0.023	2.161GlnIle: 2.161 ± 0.043	1.184GlnLys: 1.184 ± 0.036	2.879GlnLeu: 2.879 ± 0.049	1.104GlnMet: 1.104 ± 0.037	1.069GlnAsn: 1.069 ± 0.027	1.543GlnPro: 1.543 ± 0.043	1.21GlnGln: 1.21 ± 0.036	2.097GlnArg: 2.097 ± 0.048	2.015GlnSer: 2.015 ± 0.04	2.186GlnThr: 2.186 ± 0.047	2.371GlnVal: 2.371 ± 0.05	0.442GlnTrp: 0.442 ± 0.021	0.646GlnTyr: 0.646 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.586ArgAla: 6.586 ± 0.09	0.448ArgCys: 0.448 ± 0.021	4.029ArgAsp: 4.029 ± 0.062	3.296ArgGlu: 3.296 ± 0.058	2.539ArgPhe: 2.539 ± 0.048	3.964ArgGly: 3.964 ± 0.058	1.302ArgHis: 1.302 ± 0.035	3.727ArgIle: 3.727 ± 0.061	2.324ArgLys: 2.324 ± 0.048	6.066ArgLeu: 6.066 ± 0.093	1.887ArgMet: 1.887 ± 0.041	1.898ArgAsn: 1.898 ± 0.048	2.779ArgPro: 2.779 ± 0.05	2.176ArgGln: 2.176 ± 0.047	3.921ArgArg: 3.921 ± 0.073	2.89ArgSer: 2.89 ± 0.05	3.124ArgThr: 3.124 ± 0.055	4.22ArgVal: 4.22 ± 0.071	0.826ArgTrp: 0.826 ± 0.03	1.518ArgTyr: 1.518 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.645SerAla: 5.645 ± 0.069	0.459SerCys: 0.459 ± 0.023	3.726SerAsp: 3.726 ± 0.067	2.873SerGlu: 2.873 ± 0.053	2.362SerPhe: 2.362 ± 0.049	5.358SerGly: 5.358 ± 0.095	1.057SerHis: 1.057 ± 0.029	2.717SerIle: 2.717 ± 0.057	1.687SerLys: 1.687 ± 0.04	4.879SerLeu: 4.879 ± 0.073	1.361SerMet: 1.361 ± 0.038	1.554SerAsn: 1.554 ± 0.046	2.457SerPro: 2.457 ± 0.046	1.668SerGln: 1.668 ± 0.039	3.006SerArg: 3.006 ± 0.055	2.495SerSer: 2.495 ± 0.051	2.596SerThr: 2.596 ± 0.056	3.942SerVal: 3.942 ± 0.065	0.714SerTrp: 0.714 ± 0.022	1.363SerTyr: 1.363 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.558ThrAla: 6.558 ± 0.087	0.563ThrCys: 0.563 ± 0.03	3.818ThrAsp: 3.818 ± 0.078	2.987ThrGlu: 2.987 ± 0.054	2.467ThrPhe: 2.467 ± 0.044	5.495ThrGly: 5.495 ± 0.091	1.259ThrHis: 1.259 ± 0.031	3.348ThrIle: 3.348 ± 0.081	1.806ThrLys: 1.806 ± 0.039	6.336ThrLeu: 6.336 ± 0.076	1.448ThrMet: 1.448 ± 0.034	1.628ThrAsn: 1.628 ± 0.046	3.54ThrPro: 3.54 ± 0.067	1.891ThrGln: 1.891 ± 0.052	3.276ThrArg: 3.276 ± 0.051	2.914ThrSer: 2.914 ± 0.051	3.217ThrThr: 3.217 ± 0.069	4.688ThrVal: 4.688 ± 0.075	0.736ThrTrp: 0.736 ± 0.028	1.523ThrTyr: 1.523 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.609ValAla: 8.609 ± 0.092	0.703ValCys: 0.703 ± 0.028	4.369ValAsp: 4.369 ± 0.065	3.928ValGlu: 3.928 ± 0.067	3.128ValPhe: 3.128 ± 0.063	5.705ValGly: 5.705 ± 0.083	1.345ValHis: 1.345 ± 0.039	4.556ValIle: 4.556 ± 0.071	2.295ValLys: 2.295 ± 0.048	7.178ValLeu: 7.178 ± 0.083	2.188ValMet: 2.188 ± 0.05	2.216ValAsn: 2.216 ± 0.047	3.55ValPro: 3.55 ± 0.064	2.298ValGln: 2.298 ± 0.044	3.998ValArg: 3.998 ± 0.059	4.32ValSer: 4.32 ± 0.065	4.983ValThr: 4.983 ± 0.1	5.587ValVal: 5.587 ± 0.082	0.965ValTrp: 0.965 ± 0.031	1.552ValTyr: 1.552 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.347TrpAla: 1.347 ± 0.036	0.124TrpCys: 0.124 ± 0.01	0.88TrpAsp: 0.88 ± 0.029	0.662TrpGlu: 0.662 ± 0.024	0.62TrpPhe: 0.62 ± 0.022	1.008TrpGly: 1.008 ± 0.033	0.314TrpHis: 0.314 ± 0.016	0.776TrpIle: 0.776 ± 0.024	0.452TrpLys: 0.452 ± 0.024	1.464TrpLeu: 1.464 ± 0.039	0.427TrpMet: 0.427 ± 0.019	0.459TrpAsn: 0.459 ± 0.02	0.64TrpPro: 0.64 ± 0.023	0.577TrpGln: 0.577 ± 0.025	0.918TrpArg: 0.918 ± 0.03	0.795TrpSer: 0.795 ± 0.027	0.825TrpThr: 0.825 ± 0.025	0.931TrpVal: 0.931 ± 0.028	0.243TrpTrp: 0.243 ± 0.016	0.294TrpTyr: 0.294 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.584TyrAla: 2.584 ± 0.053	0.245TyrCys: 0.245 ± 0.014	1.751TyrAsp: 1.751 ± 0.048	1.286TyrGlu: 1.286 ± 0.038	1.023TyrPhe: 1.023 ± 0.03	2.261TyrGly: 2.261 ± 0.061	0.53TyrHis: 0.53 ± 0.023	1.065TyrIle: 1.065 ± 0.028	0.667TyrLys: 0.667 ± 0.024	2.351TyrLeu: 2.351 ± 0.05	0.49TyrMet: 0.49 ± 0.02	0.665TyrAsn: 0.665 ± 0.024	1.056TyrPro: 1.056 ± 0.028	0.757TyrGln: 0.757 ± 0.025	1.463TyrArg: 1.463 ± 0.036	1.119TyrSer: 1.119 ± 0.037	1.21TyrThr: 1.21 ± 0.036	1.653TyrVal: 1.653 ± 0.04	0.37TyrTrp: 0.37 ± 0.019	0.636TyrTyr: 0.636 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3582 proteins (1123027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---