Amino acid dipepetide frequency for Arthrobacter phage DrYang

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.186AlaAla: 20.186 ± 1.843
0.5AlaCys: 0.5 ± 0.157
6.82AlaAsp: 6.82 ± 0.724
8.047AlaGlu: 8.047 ± 0.823
3.728AlaPhe: 3.728 ± 0.46
8.729AlaGly: 8.729 ± 0.702
2.864AlaHis: 2.864 ± 0.379
4.592AlaIle: 4.592 ± 0.465
6.092AlaLys: 6.092 ± 0.633
10.048AlaLeu: 10.048 ± 0.752
3.319AlaMet: 3.319 ± 0.413
6.001AlaAsn: 6.001 ± 0.662
6.274AlaPro: 6.274 ± 0.564
3.546AlaGln: 3.546 ± 0.469
6.82AlaArg: 6.82 ± 0.533
5.365AlaSer: 5.365 ± 0.565
8.502AlaThr: 8.502 ± 0.858
8.32AlaVal: 8.32 ± 0.808
1.318AlaTrp: 1.318 ± 0.236
2.591AlaTyr: 2.591 ± 0.312
0.0AlaXaa: 0.0 ± 0.0
Cys
0.5CysAla: 0.5 ± 0.178
0.182CysCys: 0.182 ± 0.1
0.318CysAsp: 0.318 ± 0.143
0.5CysGlu: 0.5 ± 0.155
0.136CysPhe: 0.136 ± 0.073
0.773CysGly: 0.773 ± 0.209
0.136CysHis: 0.136 ± 0.098
0.455CysIle: 0.455 ± 0.146
0.227CysLys: 0.227 ± 0.115
0.273CysLeu: 0.273 ± 0.116
0.091CysMet: 0.091 ± 0.063
0.227CysAsn: 0.227 ± 0.095
0.955CysPro: 0.955 ± 0.276
0.546CysGln: 0.546 ± 0.176
0.727CysArg: 0.727 ± 0.187
0.182CysSer: 0.182 ± 0.088
0.591CysThr: 0.591 ± 0.16
0.546CysVal: 0.546 ± 0.145
0.364CysTrp: 0.364 ± 0.139
0.227CysTyr: 0.227 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
7.593AspAla: 7.593 ± 0.549
0.409AspCys: 0.409 ± 0.157
1.819AspAsp: 1.819 ± 0.297
2.364AspGlu: 2.364 ± 0.352
1.228AspPhe: 1.228 ± 0.265
6.82AspGly: 6.82 ± 0.594
1.546AspHis: 1.546 ± 0.251
2.682AspIle: 2.682 ± 0.277
2.728AspLys: 2.728 ± 0.388
5.319AspLeu: 5.319 ± 0.494
1.773AspMet: 1.773 ± 0.234
1.682AspAsn: 1.682 ± 0.268
4.183AspPro: 4.183 ± 0.533
1.819AspGln: 1.819 ± 0.3
2.501AspArg: 2.501 ± 0.285
2.501AspSer: 2.501 ± 0.275
3.728AspThr: 3.728 ± 0.391
3.91AspVal: 3.91 ± 0.406
1.318AspTrp: 1.318 ± 0.33
2.228AspTyr: 2.228 ± 0.268
0.0AspXaa: 0.0 ± 0.0
Glu
7.956GluAla: 7.956 ± 0.843
0.682GluCys: 0.682 ± 0.17
3.592GluAsp: 3.592 ± 0.461
4.41GluGlu: 4.41 ± 0.589
1.273GluPhe: 1.273 ± 0.294
3.91GluGly: 3.91 ± 0.403
1.273GluHis: 1.273 ± 0.258
2.864GluIle: 2.864 ± 0.29
2.591GluLys: 2.591 ± 0.343
5.638GluLeu: 5.638 ± 0.589
1.5GluMet: 1.5 ± 0.234
2.364GluAsn: 2.364 ± 0.324
3.774GluPro: 3.774 ± 0.46
2.501GluGln: 2.501 ± 0.408
4.092GluArg: 4.092 ± 0.419
2.546GluSer: 2.546 ± 0.364
3.637GluThr: 3.637 ± 0.43
4.365GluVal: 4.365 ± 0.409
1.228GluTrp: 1.228 ± 0.268
1.455GluTyr: 1.455 ± 0.226
0.0GluXaa: 0.0 ± 0.0
Phe
2.501PheAla: 2.501 ± 0.405
0.227PheCys: 0.227 ± 0.112
2.091PheAsp: 2.091 ± 0.321
2.41PheGlu: 2.41 ± 0.366
0.909PhePhe: 0.909 ± 0.19
2.364PheGly: 2.364 ± 0.325
0.546PheHis: 0.546 ± 0.15
1.273PheIle: 1.273 ± 0.266
0.955PheLys: 0.955 ± 0.22
2.455PheLeu: 2.455 ± 0.363
0.818PheMet: 0.818 ± 0.175
1.318PheAsn: 1.318 ± 0.291
1.637PhePro: 1.637 ± 0.229
1.409PheGln: 1.409 ± 0.238
1.682PheArg: 1.682 ± 0.297
1.364PheSer: 1.364 ± 0.285
2.364PheThr: 2.364 ± 0.326
1.318PheVal: 1.318 ± 0.223
0.409PheTrp: 0.409 ± 0.153
0.5PheTyr: 0.5 ± 0.139
0.0PheXaa: 0.0 ± 0.0
Gly
8.547GlyAla: 8.547 ± 0.612
0.5GlyCys: 0.5 ± 0.156
5.001GlyAsp: 5.001 ± 0.541
3.774GlyGlu: 3.774 ± 0.424
3.046GlyPhe: 3.046 ± 0.462
8.047GlyGly: 8.047 ± 0.854
2.319GlyHis: 2.319 ± 0.365
3.546GlyIle: 3.546 ± 0.527
4.501GlyLys: 4.501 ± 0.402
5.774GlyLeu: 5.774 ± 0.583
1.728GlyMet: 1.728 ± 0.286
2.91GlyAsn: 2.91 ± 0.409
3.637GlyPro: 3.637 ± 0.404
2.455GlyGln: 2.455 ± 0.272
5.547GlyArg: 5.547 ± 0.483
4.228GlySer: 4.228 ± 0.412
6.683GlyThr: 6.683 ± 0.77
5.956GlyVal: 5.956 ± 0.574
2.046GlyTrp: 2.046 ± 0.294
2.319GlyTyr: 2.319 ± 0.296
0.0GlyXaa: 0.0 ± 0.0
His
2.091HisAla: 2.091 ± 0.318
0.364HisCys: 0.364 ± 0.14
1.728HisAsp: 1.728 ± 0.282
1.864HisGlu: 1.864 ± 0.333
0.364HisPhe: 0.364 ± 0.12
1.318HisGly: 1.318 ± 0.28
0.5HisHis: 0.5 ± 0.177
0.773HisIle: 0.773 ± 0.179
1.0HisLys: 1.0 ± 0.263
1.773HisLeu: 1.773 ± 0.313
0.5HisMet: 0.5 ± 0.136
0.818HisAsn: 0.818 ± 0.212
1.455HisPro: 1.455 ± 0.252
1.091HisGln: 1.091 ± 0.207
1.273HisArg: 1.273 ± 0.316
1.137HisSer: 1.137 ± 0.21
2.046HisThr: 2.046 ± 0.5
1.773HisVal: 1.773 ± 0.26
0.318HisTrp: 0.318 ± 0.109
0.409HisTyr: 0.409 ± 0.124
0.0HisXaa: 0.0 ± 0.0
Ile
4.456IleAla: 4.456 ± 0.468
0.227IleCys: 0.227 ± 0.114
2.364IleAsp: 2.364 ± 0.333
2.546IleGlu: 2.546 ± 0.362
0.727IlePhe: 0.727 ± 0.18
2.637IleGly: 2.637 ± 0.458
0.682IleHis: 0.682 ± 0.137
1.728IleIle: 1.728 ± 0.325
1.728IleLys: 1.728 ± 0.271
2.591IleLeu: 2.591 ± 0.316
0.727IleMet: 0.727 ± 0.21
1.455IleAsn: 1.455 ± 0.235
2.273IlePro: 2.273 ± 0.291
1.91IleGln: 1.91 ± 0.367
2.364IleArg: 2.364 ± 0.339
1.864IleSer: 1.864 ± 0.25
3.092IleThr: 3.092 ± 0.435
3.637IleVal: 3.637 ± 0.382
0.637IleTrp: 0.637 ± 0.169
0.955IleTyr: 0.955 ± 0.192
0.0IleXaa: 0.0 ± 0.0
Lys
6.774LysAla: 6.774 ± 0.695
0.5LysCys: 0.5 ± 0.161
2.182LysAsp: 2.182 ± 0.345
1.728LysGlu: 1.728 ± 0.302
1.0LysPhe: 1.0 ± 0.212
3.046LysGly: 3.046 ± 0.391
1.091LysHis: 1.091 ± 0.221
1.091LysIle: 1.091 ± 0.258
1.819LysLys: 1.819 ± 0.416
4.183LysLeu: 4.183 ± 0.469
1.228LysMet: 1.228 ± 0.208
1.682LysAsn: 1.682 ± 0.274
2.682LysPro: 2.682 ± 0.398
1.455LysGln: 1.455 ± 0.253
2.546LysArg: 2.546 ± 0.458
2.228LysSer: 2.228 ± 0.34
3.501LysThr: 3.501 ± 0.403
3.092LysVal: 3.092 ± 0.394
0.364LysTrp: 0.364 ± 0.139
0.955LysTyr: 0.955 ± 0.231
0.0LysXaa: 0.0 ± 0.0
Leu
8.866LeuAla: 8.866 ± 0.63
0.318LeuCys: 0.318 ± 0.108
4.865LeuAsp: 4.865 ± 0.482
4.456LeuGlu: 4.456 ± 0.627
1.955LeuPhe: 1.955 ± 0.298
5.456LeuGly: 5.456 ± 0.673
1.364LeuHis: 1.364 ± 0.24
2.864LeuIle: 2.864 ± 0.417
3.455LeuLys: 3.455 ± 0.34
5.956LeuLeu: 5.956 ± 0.612
1.546LeuMet: 1.546 ± 0.28
2.91LeuAsn: 2.91 ± 0.509
5.047LeuPro: 5.047 ± 0.579
2.773LeuGln: 2.773 ± 0.325
4.728LeuArg: 4.728 ± 0.499
4.774LeuSer: 4.774 ± 0.458
6.956LeuThr: 6.956 ± 0.448
5.41LeuVal: 5.41 ± 0.675
1.364LeuTrp: 1.364 ± 0.234
1.364LeuTyr: 1.364 ± 0.307
0.0LeuXaa: 0.0 ± 0.0
Met
2.637MetAla: 2.637 ± 0.414
0.091MetCys: 0.091 ± 0.063
1.455MetAsp: 1.455 ± 0.277
1.455MetGlu: 1.455 ± 0.23
0.546MetPhe: 0.546 ± 0.181
2.182MetGly: 2.182 ± 0.384
0.5MetHis: 0.5 ± 0.163
0.727MetIle: 0.727 ± 0.147
0.818MetLys: 0.818 ± 0.17
2.0MetLeu: 2.0 ± 0.287
0.227MetMet: 0.227 ± 0.097
0.909MetAsn: 0.909 ± 0.212
1.728MetPro: 1.728 ± 0.286
0.409MetGln: 0.409 ± 0.137
1.591MetArg: 1.591 ± 0.284
1.591MetSer: 1.591 ± 0.313
2.501MetThr: 2.501 ± 0.338
1.182MetVal: 1.182 ± 0.185
0.455MetTrp: 0.455 ± 0.163
0.182MetTyr: 0.182 ± 0.085
0.0MetXaa: 0.0 ± 0.0
Asn
4.91AsnAla: 4.91 ± 0.337
0.364AsnCys: 0.364 ± 0.12
1.455AsnAsp: 1.455 ± 0.253
1.637AsnGlu: 1.637 ± 0.263
0.682AsnPhe: 0.682 ± 0.194
4.228AsnGly: 4.228 ± 0.343
0.546AsnHis: 0.546 ± 0.155
1.773AsnIle: 1.773 ± 0.312
1.273AsnLys: 1.273 ± 0.316
2.41AsnLeu: 2.41 ± 0.302
0.864AsnMet: 0.864 ± 0.252
1.318AsnAsn: 1.318 ± 0.268
4.001AsnPro: 4.001 ± 0.38
1.182AsnGln: 1.182 ± 0.212
2.137AsnArg: 2.137 ± 0.261
1.591AsnSer: 1.591 ± 0.261
2.682AsnThr: 2.682 ± 0.417
3.273AsnVal: 3.273 ± 0.305
1.0AsnTrp: 1.0 ± 0.225
0.864AsnTyr: 0.864 ± 0.213
0.0AsnXaa: 0.0 ± 0.0
Pro
7.502ProAla: 7.502 ± 0.584
0.546ProCys: 0.546 ± 0.194
4.092ProAsp: 4.092 ± 0.446
4.91ProGlu: 4.91 ± 0.5
1.819ProPhe: 1.819 ± 0.258
5.956ProGly: 5.956 ± 0.6
1.546ProHis: 1.546 ± 0.261
2.319ProIle: 2.319 ± 0.332
2.455ProLys: 2.455 ± 0.36
3.728ProLeu: 3.728 ± 0.372
1.455ProMet: 1.455 ± 0.238
2.0ProAsn: 2.0 ± 0.256
2.546ProPro: 2.546 ± 0.373
1.773ProGln: 1.773 ± 0.286
2.955ProArg: 2.955 ± 0.414
3.046ProSer: 3.046 ± 0.449
4.228ProThr: 4.228 ± 0.54
4.683ProVal: 4.683 ± 0.495
0.909ProTrp: 0.909 ± 0.157
1.0ProTyr: 1.0 ± 0.209
0.0ProXaa: 0.0 ± 0.0
Gln
3.955GlnAla: 3.955 ± 0.409
0.227GlnCys: 0.227 ± 0.142
1.455GlnAsp: 1.455 ± 0.205
2.273GlnGlu: 2.273 ± 0.373
1.091GlnPhe: 1.091 ± 0.249
2.546GlnGly: 2.546 ± 0.258
1.046GlnHis: 1.046 ± 0.231
1.409GlnIle: 1.409 ± 0.266
1.228GlnLys: 1.228 ± 0.225
2.546GlnLeu: 2.546 ± 0.329
0.637GlnMet: 0.637 ± 0.179
1.0GlnAsn: 1.0 ± 0.18
1.637GlnPro: 1.637 ± 0.265
1.318GlnGln: 1.318 ± 0.266
2.682GlnArg: 2.682 ± 0.331
1.091GlnSer: 1.091 ± 0.234
2.682GlnThr: 2.682 ± 0.266
3.183GlnVal: 3.183 ± 0.343
0.727GlnTrp: 0.727 ± 0.253
1.091GlnTyr: 1.091 ± 0.212
0.0GlnXaa: 0.0 ± 0.0
Arg
7.456ArgAla: 7.456 ± 0.631
0.727ArgCys: 0.727 ± 0.223
4.456ArgAsp: 4.456 ± 0.487
4.274ArgGlu: 4.274 ± 0.524
2.364ArgPhe: 2.364 ± 0.371
4.137ArgGly: 4.137 ± 0.41
1.137ArgHis: 1.137 ± 0.22
1.955ArgIle: 1.955 ± 0.281
3.001ArgLys: 3.001 ± 0.474
4.592ArgLeu: 4.592 ± 0.518
1.364ArgMet: 1.364 ± 0.223
2.046ArgAsn: 2.046 ± 0.362
2.591ArgPro: 2.591 ± 0.331
2.0ArgGln: 2.0 ± 0.25
4.592ArgArg: 4.592 ± 0.619
2.728ArgSer: 2.728 ± 0.376
3.501ArgThr: 3.501 ± 0.413
4.501ArgVal: 4.501 ± 0.441
1.318ArgTrp: 1.318 ± 0.252
1.591ArgTyr: 1.591 ± 0.311
0.0ArgXaa: 0.0 ± 0.0
Ser
6.729SerAla: 6.729 ± 0.816
0.409SerCys: 0.409 ± 0.139
2.364SerAsp: 2.364 ± 0.341
2.864SerGlu: 2.864 ± 0.382
1.455SerPhe: 1.455 ± 0.227
5.047SerGly: 5.047 ± 0.717
1.228SerHis: 1.228 ± 0.246
1.637SerIle: 1.637 ± 0.264
1.773SerLys: 1.773 ± 0.339
3.273SerLeu: 3.273 ± 0.399
1.409SerMet: 1.409 ± 0.232
1.546SerAsn: 1.546 ± 0.262
2.819SerPro: 2.819 ± 0.322
1.182SerGln: 1.182 ± 0.299
3.001SerArg: 3.001 ± 0.423
2.228SerSer: 2.228 ± 0.368
4.546SerThr: 4.546 ± 0.491
3.319SerVal: 3.319 ± 0.345
0.864SerTrp: 0.864 ± 0.199
1.91SerTyr: 1.91 ± 0.345
0.0SerXaa: 0.0 ± 0.0
Thr
7.956ThrAla: 7.956 ± 0.786
0.727ThrCys: 0.727 ± 0.199
3.637ThrAsp: 3.637 ± 0.353
4.046ThrGlu: 4.046 ± 0.466
2.0ThrPhe: 2.0 ± 0.302
6.001ThrGly: 6.001 ± 0.743
1.819ThrHis: 1.819 ± 0.413
2.864ThrIle: 2.864 ± 0.4
2.91ThrLys: 2.91 ± 0.323
5.774ThrLeu: 5.774 ± 0.468
1.182ThrMet: 1.182 ± 0.305
2.501ThrAsn: 2.501 ± 0.283
5.729ThrPro: 5.729 ± 0.61
2.501ThrGln: 2.501 ± 0.323
4.046ThrArg: 4.046 ± 0.374
4.637ThrSer: 4.637 ± 0.621
5.319ThrThr: 5.319 ± 0.702
7.183ThrVal: 7.183 ± 0.594
1.864ThrTrp: 1.864 ± 0.384
2.182ThrTyr: 2.182 ± 0.335
0.0ThrXaa: 0.0 ± 0.0
Val
8.684ValAla: 8.684 ± 0.585
0.546ValCys: 0.546 ± 0.18
5.729ValAsp: 5.729 ± 0.555
5.319ValGlu: 5.319 ± 0.523
2.546ValPhe: 2.546 ± 0.36
5.638ValGly: 5.638 ± 0.661
1.409ValHis: 1.409 ± 0.247
2.728ValIle: 2.728 ± 0.377
3.183ValLys: 3.183 ± 0.344
4.91ValLeu: 4.91 ± 0.49
2.091ValMet: 2.091 ± 0.255
2.91ValAsn: 2.91 ± 0.414
4.183ValPro: 4.183 ± 0.41
1.955ValGln: 1.955 ± 0.275
4.365ValArg: 4.365 ± 0.479
4.774ValSer: 4.774 ± 0.5
6.001ValThr: 6.001 ± 0.561
5.41ValVal: 5.41 ± 0.472
0.727ValTrp: 0.727 ± 0.19
1.5ValTyr: 1.5 ± 0.252
0.0ValXaa: 0.0 ± 0.0
Trp
1.773TrpAla: 1.773 ± 0.312
0.182TrpCys: 0.182 ± 0.087
0.909TrpAsp: 0.909 ± 0.237
1.046TrpGlu: 1.046 ± 0.209
1.091TrpPhe: 1.091 ± 0.347
1.455TrpGly: 1.455 ± 0.242
0.637TrpHis: 0.637 ± 0.186
0.773TrpIle: 0.773 ± 0.294
0.773TrpLys: 0.773 ± 0.166
1.728TrpLeu: 1.728 ± 0.355
0.273TrpMet: 0.273 ± 0.096
1.137TrpAsn: 1.137 ± 0.348
0.682TrpPro: 0.682 ± 0.157
0.909TrpGln: 0.909 ± 0.209
1.228TrpArg: 1.228 ± 0.224
0.455TrpSer: 0.455 ± 0.133
0.818TrpThr: 0.818 ± 0.224
1.364TrpVal: 1.364 ± 0.257
0.546TrpTrp: 0.546 ± 0.241
0.318TrpTyr: 0.318 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.591TyrAla: 2.591 ± 0.317
0.227TyrCys: 0.227 ± 0.118
1.819TyrAsp: 1.819 ± 0.291
1.728TyrGlu: 1.728 ± 0.272
0.591TyrPhe: 0.591 ± 0.157
2.273TyrGly: 2.273 ± 0.335
0.409TyrHis: 0.409 ± 0.163
0.546TyrIle: 0.546 ± 0.172
0.637TyrLys: 0.637 ± 0.172
1.455TyrLeu: 1.455 ± 0.243
0.409TyrMet: 0.409 ± 0.116
1.455TyrAsn: 1.455 ± 0.264
1.637TyrPro: 1.637 ± 0.393
1.091TyrGln: 1.091 ± 0.222
1.455TyrArg: 1.455 ± 0.257
1.318TyrSer: 1.318 ± 0.242
1.5TyrThr: 1.5 ± 0.225
2.182TyrVal: 2.182 ± 0.353
0.318TyrTrp: 0.318 ± 0.151
0.864TyrTyr: 0.864 ± 0.225
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 105 proteins (21996 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski