Amino acid dipepetide frequency for Labilibacter sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.886AlaAla: 3.886 ± 0.063	0.685AlaCys: 0.685 ± 0.023	3.462AlaAsp: 3.462 ± 0.045	3.893AlaGlu: 3.893 ± 0.057	2.969AlaPhe: 2.969 ± 0.049	4.346AlaGly: 4.346 ± 0.067	1.179AlaHis: 1.179 ± 0.027	4.861AlaIle: 4.861 ± 0.067	4.22AlaLys: 4.22 ± 0.053	5.442AlaLeu: 5.442 ± 0.064	1.487AlaMet: 1.487 ± 0.029	3.253AlaAsn: 3.253 ± 0.05	1.927AlaPro: 1.927 ± 0.034	2.26AlaGln: 2.26 ± 0.036	2.072AlaArg: 2.072 ± 0.035	4.025AlaSer: 4.025 ± 0.061	3.194AlaThr: 3.194 ± 0.057	3.771AlaVal: 3.771 ± 0.047	0.658AlaTrp: 0.658 ± 0.019	2.571AlaTyr: 2.571 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.532CysAla: 0.532 ± 0.02	0.128CysCys: 0.128 ± 0.01	0.534CysAsp: 0.534 ± 0.017	0.536CysGlu: 0.536 ± 0.019	0.481CysPhe: 0.481 ± 0.018	0.712CysGly: 0.712 ± 0.022	0.247CysHis: 0.247 ± 0.014	0.693CysIle: 0.693 ± 0.023	0.631CysLys: 0.631 ± 0.02	0.753CysLeu: 0.753 ± 0.021	0.207CysMet: 0.207 ± 0.011	0.523CysAsn: 0.523 ± 0.02	0.359CysPro: 0.359 ± 0.017	0.295CysGln: 0.295 ± 0.014	0.306CysArg: 0.306 ± 0.014	0.719CysSer: 0.719 ± 0.027	0.509CysThr: 0.509 ± 0.021	0.554CysVal: 0.554 ± 0.02	0.101CysTrp: 0.101 ± 0.008	0.414CysTyr: 0.414 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.443AspAla: 3.443 ± 0.052	0.469AspCys: 0.469 ± 0.019	3.177AspAsp: 3.177 ± 0.055	4.032AspGlu: 4.032 ± 0.06	3.357AspPhe: 3.357 ± 0.044	3.991AspGly: 3.991 ± 0.078	1.08AspHis: 1.08 ± 0.026	4.713AspIle: 4.713 ± 0.057	4.323AspLys: 4.323 ± 0.053	5.12AspLeu: 5.12 ± 0.057	1.365AspMet: 1.365 ± 0.028	3.415AspAsn: 3.415 ± 0.054	2.001AspPro: 2.001 ± 0.043	1.866AspGln: 1.866 ± 0.035	1.881AspArg: 1.881 ± 0.037	3.239AspSer: 3.239 ± 0.045	2.416AspThr: 2.416 ± 0.044	3.76AspVal: 3.76 ± 0.054	0.833AspTrp: 0.833 ± 0.022	2.871AspTyr: 2.871 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.053GluAla: 4.053 ± 0.052	0.465GluCys: 0.465 ± 0.018	3.661GluAsp: 3.661 ± 0.053	5.042GluGlu: 5.042 ± 0.069	2.976GluPhe: 2.976 ± 0.044	4.198GluGly: 4.198 ± 0.056	1.158GluHis: 1.158 ± 0.03	5.182GluIle: 5.182 ± 0.057	5.453GluLys: 5.453 ± 0.071	6.571GluLeu: 6.571 ± 0.072	1.716GluMet: 1.716 ± 0.032	4.186GluAsn: 4.186 ± 0.055	1.682GluPro: 1.682 ± 0.032	2.251GluGln: 2.251 ± 0.035	2.378GluArg: 2.378 ± 0.045	3.728GluSer: 3.728 ± 0.049	3.149GluThr: 3.149 ± 0.049	4.625GluVal: 4.625 ± 0.059	0.795GluTrp: 0.795 ± 0.025	2.774GluTyr: 2.774 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.755PheAla: 2.755 ± 0.042	0.519PheCys: 0.519 ± 0.019	3.084PheAsp: 3.084 ± 0.039	3.163PheGlu: 3.163 ± 0.045	2.423PhePhe: 2.423 ± 0.042	3.245PheGly: 3.245 ± 0.045	0.847PheHis: 0.847 ± 0.021	3.847PheIle: 3.847 ± 0.056	3.655PheLys: 3.655 ± 0.05	4.144PheLeu: 4.144 ± 0.059	1.136PheMet: 1.136 ± 0.027	3.237PheAsn: 3.237 ± 0.048	1.615PhePro: 1.615 ± 0.03	1.275PheGln: 1.275 ± 0.029	1.675PheArg: 1.675 ± 0.034	3.787PheSer: 3.787 ± 0.046	2.909PheThr: 2.909 ± 0.05	3.022PheVal: 3.022 ± 0.046	0.612PheTrp: 0.612 ± 0.02	2.123PheTyr: 2.123 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.095GlyAla: 4.095 ± 0.066	0.731GlyCys: 0.731 ± 0.032	3.668GlyAsp: 3.668 ± 0.062	4.1GlyGlu: 4.1 ± 0.052	3.591GlyPhe: 3.591 ± 0.041	4.66GlyGly: 4.66 ± 0.079	1.233GlyHis: 1.233 ± 0.025	5.617GlyIle: 5.617 ± 0.062	4.954GlyLys: 4.954 ± 0.058	5.829GlyLeu: 5.829 ± 0.067	1.656GlyMet: 1.656 ± 0.037	3.776GlyAsn: 3.776 ± 0.054	1.446GlyPro: 1.446 ± 0.035	1.983GlyGln: 1.983 ± 0.032	2.25GlyArg: 2.25 ± 0.037	4.282GlySer: 4.282 ± 0.071	3.842GlyThr: 3.842 ± 0.073	4.874GlyVal: 4.874 ± 0.078	0.886GlyTrp: 0.886 ± 0.025	3.305GlyTyr: 3.305 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.025HisAla: 1.025 ± 0.026	0.201HisCys: 0.201 ± 0.01	0.931HisAsp: 0.931 ± 0.022	1.104HisGlu: 1.104 ± 0.028	1.173HisPhe: 1.173 ± 0.026	1.221HisGly: 1.221 ± 0.025	0.594HisHis: 0.594 ± 0.021	1.529HisIle: 1.529 ± 0.03	1.348HisLys: 1.348 ± 0.027	1.904HisLeu: 1.904 ± 0.036	0.44HisMet: 0.44 ± 0.017	1.095HisAsn: 1.095 ± 0.023	0.957HisPro: 0.957 ± 0.025	0.816HisGln: 0.816 ± 0.024	0.725HisArg: 0.725 ± 0.022	1.2HisSer: 1.2 ± 0.025	1.007HisThr: 1.007 ± 0.027	1.04HisVal: 1.04 ± 0.024	0.273HisTrp: 0.273 ± 0.014	0.904HisTyr: 0.904 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.87IleAla: 4.87 ± 0.057	0.765IleCys: 0.765 ± 0.021	4.996IleAsp: 4.996 ± 0.058	5.496IleGlu: 5.496 ± 0.062	3.282IlePhe: 3.282 ± 0.049	5.004IleGly: 5.004 ± 0.062	1.577IleHis: 1.577 ± 0.031	5.786IleIle: 5.786 ± 0.065	5.86IleLys: 5.86 ± 0.068	6.451IleLeu: 6.451 ± 0.083	1.434IleMet: 1.434 ± 0.03	4.931IleAsn: 4.931 ± 0.063	3.209IlePro: 3.209 ± 0.042	2.485IleGln: 2.485 ± 0.036	2.738IleArg: 2.738 ± 0.041	5.967IleSer: 5.967 ± 0.06	4.474IleThr: 4.474 ± 0.064	4.607IleVal: 4.607 ± 0.06	0.919IleTrp: 0.919 ± 0.03	2.941IleTyr: 2.941 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.641LysAla: 4.641 ± 0.06	0.516LysCys: 0.516 ± 0.018	4.419LysAsp: 4.419 ± 0.062	6.078LysGlu: 6.078 ± 0.08	2.696LysPhe: 2.696 ± 0.047	4.962LysGly: 4.962 ± 0.054	1.537LysHis: 1.537 ± 0.033	5.536LysIle: 5.536 ± 0.071	6.146LysLys: 6.146 ± 0.081	6.346LysLeu: 6.346 ± 0.068	1.963LysMet: 1.963 ± 0.035	4.707LysAsn: 4.707 ± 0.056	2.504LysPro: 2.504 ± 0.04	2.766LysGln: 2.766 ± 0.045	2.777LysArg: 2.777 ± 0.042	4.653LysSer: 4.653 ± 0.058	4.069LysThr: 4.069 ± 0.047	5.046LysVal: 5.046 ± 0.055	0.924LysTrp: 0.924 ± 0.022	3.307LysTyr: 3.307 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	5.411LeuAla: 5.411 ± 0.061	0.779LeuCys: 0.779 ± 0.021	4.658LeuAsp: 4.658 ± 0.054	5.292LeuGlu: 5.292 ± 0.063	4.552LeuPhe: 4.552 ± 0.057	5.365LeuGly: 5.365 ± 0.062	1.569LeuHis: 1.569 ± 0.03	6.682LeuIle: 6.682 ± 0.082	7.631LeuLys: 7.631 ± 0.086	8.272LeuLeu: 8.272 ± 0.089	2.252LeuMet: 2.252 ± 0.042	5.739LeuAsn: 5.739 ± 0.066	3.524LeuPro: 3.524 ± 0.042	2.805LeuGln: 2.805 ± 0.041	3.091LeuArg: 3.091 ± 0.048	6.958LeuSer: 6.958 ± 0.068	4.838LeuThr: 4.838 ± 0.055	5.421LeuVal: 5.421 ± 0.066	0.997LeuTrp: 0.997 ± 0.024	3.371LeuTyr: 3.371 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.735MetAla: 1.735 ± 0.032	0.19MetCys: 0.19 ± 0.01	1.377MetAsp: 1.377 ± 0.029	1.439MetGlu: 1.439 ± 0.029	0.888MetPhe: 0.888 ± 0.024	1.634MetGly: 1.634 ± 0.032	0.457MetHis: 0.457 ± 0.016	1.67MetIle: 1.67 ± 0.034	2.067MetLys: 2.067 ± 0.034	2.014MetLeu: 2.014 ± 0.038	0.669MetMet: 0.669 ± 0.021	1.374MetAsn: 1.374 ± 0.026	0.974MetPro: 0.974 ± 0.024	0.842MetGln: 0.842 ± 0.026	0.886MetArg: 0.886 ± 0.024	1.452MetSer: 1.452 ± 0.027	1.127MetThr: 1.127 ± 0.027	1.657MetVal: 1.657 ± 0.034	0.225MetTrp: 0.225 ± 0.01	0.783MetTyr: 0.783 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.493AsnAla: 3.493 ± 0.049	0.568AsnCys: 0.568 ± 0.022	3.279AsnAsp: 3.279 ± 0.048	3.733AsnGlu: 3.733 ± 0.049	2.645AsnPhe: 2.645 ± 0.042	4.252AsnGly: 4.252 ± 0.058	1.234AsnHis: 1.234 ± 0.028	5.141AsnIle: 5.141 ± 0.061	4.775AsnLys: 4.775 ± 0.057	5.208AsnLeu: 5.208 ± 0.061	1.359AsnMet: 1.359 ± 0.033	4.11AsnAsn: 4.11 ± 0.073	2.727AsnPro: 2.727 ± 0.037	2.248AsnGln: 2.248 ± 0.037	2.248AsnArg: 2.248 ± 0.035	3.825AsnSer: 3.825 ± 0.052	3.406AsnThr: 3.406 ± 0.048	3.455AsnVal: 3.455 ± 0.049	0.873AsnTrp: 0.873 ± 0.026	2.82AsnTyr: 2.82 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.061ProAla: 2.061 ± 0.04	0.258ProCys: 0.258 ± 0.013	2.374ProAsp: 2.374 ± 0.034	2.94ProGlu: 2.94 ± 0.044	1.901ProPhe: 1.901 ± 0.038	2.324ProGly: 2.324 ± 0.044	0.765ProHis: 0.765 ± 0.021	2.402ProIle: 2.402 ± 0.04	2.166ProLys: 2.166 ± 0.037	2.916ProLeu: 2.916 ± 0.042	0.754ProMet: 0.754 ± 0.021	2.153ProAsn: 2.153 ± 0.034	0.853ProPro: 0.853 ± 0.027	1.22ProGln: 1.22 ± 0.028	1.005ProArg: 1.005 ± 0.027	2.252ProSer: 2.252 ± 0.037	1.855ProThr: 1.855 ± 0.041	2.814ProVal: 2.814 ± 0.056	0.426ProTrp: 0.426 ± 0.018	1.543ProTyr: 1.543 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.947GlnAla: 1.947 ± 0.032	0.236GlnCys: 0.236 ± 0.011	1.607GlnAsp: 1.607 ± 0.031	2.226GlnGlu: 2.226 ± 0.041	1.489GlnPhe: 1.489 ± 0.029	2.02GlnGly: 2.02 ± 0.035	0.613GlnHis: 0.613 ± 0.017	2.536GlnIle: 2.536 ± 0.036	2.835GlnLys: 2.835 ± 0.053	3.33GlnLeu: 3.33 ± 0.048	0.876GlnMet: 0.876 ± 0.02	2.115GlnAsn: 2.115 ± 0.04	1.058GlnPro: 1.058 ± 0.031	1.399GlnGln: 1.399 ± 0.037	1.203GlnArg: 1.203 ± 0.029	2.185GlnSer: 2.185 ± 0.037	1.762GlnThr: 1.762 ± 0.033	2.184GlnVal: 2.184 ± 0.04	0.423GlnTrp: 0.423 ± 0.017	1.441GlnTyr: 1.441 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.904ArgAla: 1.904 ± 0.038	0.298ArgCys: 0.298 ± 0.014	1.848ArgAsp: 1.848 ± 0.033	2.208ArgGlu: 2.208 ± 0.035	1.929ArgPhe: 1.929 ± 0.036	1.991ArgGly: 1.991 ± 0.036	0.663ArgHis: 0.663 ± 0.02	2.928ArgIle: 2.928 ± 0.039	2.873ArgLys: 2.873 ± 0.046	3.27ArgLeu: 3.27 ± 0.044	0.945ArgMet: 0.945 ± 0.022	2.186ArgAsn: 2.186 ± 0.034	1.073ArgPro: 1.073 ± 0.028	1.117ArgGln: 1.117 ± 0.029	1.329ArgArg: 1.329 ± 0.035	2.079ArgSer: 2.079 ± 0.037	1.82ArgThr: 1.82 ± 0.033	2.239ArgVal: 2.239 ± 0.042	0.516ArgTrp: 0.516 ± 0.017	1.753ArgTyr: 1.753 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.936SerAla: 3.936 ± 0.058	0.701SerCys: 0.701 ± 0.02	3.905SerAsp: 3.905 ± 0.05	4.152SerGlu: 4.152 ± 0.055	3.881SerPhe: 3.881 ± 0.051	4.923SerGly: 4.923 ± 0.07	1.301SerHis: 1.301 ± 0.029	5.472SerIle: 5.472 ± 0.062	4.496SerLys: 4.496 ± 0.049	6.178SerLeu: 6.178 ± 0.056	1.489SerMet: 1.489 ± 0.031	3.945SerAsn: 3.945 ± 0.052	2.265SerPro: 2.265 ± 0.035	2.107SerGln: 2.107 ± 0.034	2.273SerArg: 2.273 ± 0.038	4.791SerSer: 4.791 ± 0.08	3.474SerThr: 3.474 ± 0.045	4.512SerVal: 4.512 ± 0.062	0.775SerTrp: 0.775 ± 0.021	2.985SerTyr: 2.985 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.245ThrAla: 3.245 ± 0.054	0.461ThrCys: 0.461 ± 0.023	3.194ThrAsp: 3.194 ± 0.054	3.189ThrGlu: 3.189 ± 0.044	2.64ThrPhe: 2.64 ± 0.05	4.111ThrGly: 4.111 ± 0.062	1.019ThrHis: 1.019 ± 0.024	4.511ThrIle: 4.511 ± 0.072	3.455ThrLys: 3.455 ± 0.048	4.655ThrLeu: 4.655 ± 0.048	0.989ThrMet: 0.989 ± 0.026	3.04ThrAsn: 3.04 ± 0.048	2.494ThrPro: 2.494 ± 0.042	1.747ThrGln: 1.747 ± 0.033	1.676ThrArg: 1.676 ± 0.031	3.592ThrSer: 3.592 ± 0.053	2.951ThrThr: 2.951 ± 0.048	3.399ThrVal: 3.399 ± 0.062	0.627ThrTrp: 0.627 ± 0.021	2.221ThrTyr: 2.221 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	3.93ValAla: 3.93 ± 0.057	0.677ValCys: 0.677 ± 0.02	3.967ValAsp: 3.967 ± 0.058	4.212ValGlu: 4.212 ± 0.057	3.305ValPhe: 3.305 ± 0.051	3.998ValGly: 3.998 ± 0.056	1.106ValHis: 1.106 ± 0.028	4.974ValIle: 4.974 ± 0.062	4.71ValLys: 4.71 ± 0.063	5.782ValLeu: 5.782 ± 0.073	1.449ValMet: 1.449 ± 0.029	3.932ValAsn: 3.932 ± 0.056	2.297ValPro: 2.297 ± 0.036	1.848ValGln: 1.848 ± 0.032	2.235ValArg: 2.235 ± 0.031	4.842ValSer: 4.842 ± 0.059	3.327ValThr: 3.327 ± 0.063	4.552ValVal: 4.552 ± 0.07	0.725ValTrp: 0.725 ± 0.021	2.65ValTyr: 2.65 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.669TrpAla: 0.669 ± 0.02	0.12TrpCys: 0.12 ± 0.008	0.758TrpAsp: 0.758 ± 0.025	0.822TrpGlu: 0.822 ± 0.024	0.548TrpPhe: 0.548 ± 0.02	0.932TrpGly: 0.932 ± 0.026	0.358TrpHis: 0.358 ± 0.013	0.879TrpIle: 0.879 ± 0.026	0.868TrpLys: 0.868 ± 0.025	1.081TrpLeu: 1.081 ± 0.024	0.382TrpMet: 0.382 ± 0.015	0.757TrpAsn: 0.757 ± 0.022	0.341TrpPro: 0.341 ± 0.016	0.473TrpGln: 0.473 ± 0.018	0.472TrpArg: 0.472 ± 0.017	0.826TrpSer: 0.826 ± 0.024	0.623TrpThr: 0.623 ± 0.025	0.791TrpVal: 0.791 ± 0.024	0.18TrpTrp: 0.18 ± 0.011	0.5TrpTyr: 0.5 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.53TyrAla: 2.53 ± 0.04	0.466TyrCys: 0.466 ± 0.018	2.453TyrAsp: 2.453 ± 0.038	2.387TyrGlu: 2.387 ± 0.038	2.348TyrPhe: 2.348 ± 0.039	2.892TyrGly: 2.892 ± 0.045	0.95TyrHis: 0.95 ± 0.022	2.833TyrIle: 2.833 ± 0.047	3.129TyrLys: 3.129 ± 0.047	3.944TyrLeu: 3.944 ± 0.051	0.89TyrMet: 0.89 ± 0.023	2.924TyrAsn: 2.924 ± 0.05	1.673TyrPro: 1.673 ± 0.032	1.681TyrGln: 1.681 ± 0.035	1.746TyrArg: 1.746 ± 0.03	3.161TyrSer: 3.161 ± 0.046	2.465TyrThr: 2.465 ± 0.044	2.197TyrVal: 2.197 ± 0.036	0.611TyrTrp: 0.611 ± 0.019	2.029TyrTyr: 2.029 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4598 proteins (1764307 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---