Amino acid dipepetide frequency for Magnetospirillum molischianum DSM 120

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.695AlaAla: 17.695 ± 0.196	1.184AlaCys: 1.184 ± 0.037	6.897AlaAsp: 6.897 ± 0.069	8.309AlaGlu: 8.309 ± 0.1	3.931AlaPhe: 3.931 ± 0.061	9.644AlaGly: 9.644 ± 0.111	2.177AlaHis: 2.177 ± 0.044	5.979AlaIle: 5.979 ± 0.081	3.538AlaLys: 3.538 ± 0.066	13.713AlaLeu: 13.713 ± 0.147	3.159AlaMet: 3.159 ± 0.052	2.684AlaAsn: 2.684 ± 0.056	5.494AlaPro: 5.494 ± 0.088	3.764AlaGln: 3.764 ± 0.065	9.197AlaArg: 9.197 ± 0.106	5.815AlaSer: 5.815 ± 0.069	6.061AlaThr: 6.061 ± 0.081	9.274AlaVal: 9.274 ± 0.09	1.465AlaTrp: 1.465 ± 0.039	2.162AlaTyr: 2.162 ± 0.046	0.005AlaXaa: 0.005 ± 0.002
Cys	0.991CysAla: 0.991 ± 0.03	0.123CysCys: 0.123 ± 0.011	0.626CysAsp: 0.626 ± 0.024	0.4CysGlu: 0.4 ± 0.017	0.335CysPhe: 0.335 ± 0.015	1.063CysGly: 1.063 ± 0.034	0.302CysHis: 0.302 ± 0.017	0.411CysIle: 0.411 ± 0.02	0.227CysLys: 0.227 ± 0.015	0.981CysLeu: 0.981 ± 0.029	0.16CysMet: 0.16 ± 0.011	0.233CysAsn: 0.233 ± 0.016	0.605CysPro: 0.605 ± 0.024	0.265CysGln: 0.265 ± 0.015	0.923CysArg: 0.923 ± 0.032	0.521CysSer: 0.521 ± 0.022	0.444CysThr: 0.444 ± 0.02	0.61CysVal: 0.61 ± 0.022	0.138CysTrp: 0.138 ± 0.011	0.227CysTyr: 0.227 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.849AspAla: 5.849 ± 0.077	0.516AspCys: 0.516 ± 0.022	3.346AspAsp: 3.346 ± 0.068	3.498AspGlu: 3.498 ± 0.062	2.127AspPhe: 2.127 ± 0.045	5.288AspGly: 5.288 ± 0.079	1.317AspHis: 1.317 ± 0.032	3.201AspIle: 3.201 ± 0.055	1.507AspLys: 1.507 ± 0.039	6.996AspLeu: 6.996 ± 0.072	1.112AspMet: 1.112 ± 0.033	1.248AspAsn: 1.248 ± 0.035	3.811AspPro: 3.811 ± 0.065	1.905AspGln: 1.905 ± 0.043	4.834AspArg: 4.834 ± 0.078	3.012AspSer: 3.012 ± 0.054	2.547AspThr: 2.547 ± 0.051	3.828AspVal: 3.828 ± 0.063	0.951AspTrp: 0.951 ± 0.029	1.361AspTyr: 1.361 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.766GluAla: 7.766 ± 0.107	0.433GluCys: 0.433 ± 0.02	2.808GluAsp: 2.808 ± 0.063	3.09GluGlu: 3.09 ± 0.067	1.515GluPhe: 1.515 ± 0.037	4.09GluGly: 4.09 ± 0.06	1.032GluHis: 1.032 ± 0.033	3.731GluIle: 3.731 ± 0.062	1.992GluLys: 1.992 ± 0.053	5.059GluLeu: 5.059 ± 0.077	1.626GluMet: 1.626 ± 0.039	1.294GluAsn: 1.294 ± 0.034	2.555GluPro: 2.555 ± 0.058	2.129GluGln: 2.129 ± 0.045	5.299GluArg: 5.299 ± 0.073	3.019GluSer: 3.019 ± 0.056	3.713GluThr: 3.713 ± 0.05	3.966GluVal: 3.966 ± 0.07	0.68GluTrp: 0.68 ± 0.024	0.905GluTyr: 0.905 ± 0.028	0.002GluXaa: 0.002 ± 0.001
Phe	4.02PheAla: 4.02 ± 0.064	0.407PheCys: 0.407 ± 0.019	2.54PheAsp: 2.54 ± 0.052	1.884PheGlu: 1.884 ± 0.043	1.252PhePhe: 1.252 ± 0.036	3.293PheGly: 3.293 ± 0.048	0.745PheHis: 0.745 ± 0.027	1.508PheIle: 1.508 ± 0.039	0.904PheLys: 0.904 ± 0.029	3.352PheLeu: 3.352 ± 0.065	0.674PheMet: 0.674 ± 0.024	0.966PheAsn: 0.966 ± 0.03	1.554PhePro: 1.554 ± 0.036	0.94PheGln: 0.94 ± 0.029	2.346PheArg: 2.346 ± 0.048	2.153PheSer: 2.153 ± 0.049	1.817PheThr: 1.817 ± 0.043	2.58PheVal: 2.58 ± 0.044	0.46PheTrp: 0.46 ± 0.023	0.731PheTyr: 0.731 ± 0.025	0.001PheXaa: 0.001 ± 0.001
Gly	8.201GlyAla: 8.201 ± 0.089	1.029GlyCys: 1.029 ± 0.03	4.498GlyAsp: 4.498 ± 0.06	4.492GlyGlu: 4.492 ± 0.064	3.253GlyPhe: 3.253 ± 0.058	7.27GlyGly: 7.27 ± 0.101	1.925GlyHis: 1.925 ± 0.047	4.601GlyIle: 4.601 ± 0.067	2.978GlyLys: 2.978 ± 0.063	9.446GlyLeu: 9.446 ± 0.117	2.157GlyMet: 2.157 ± 0.045	2.001GlyAsn: 2.001 ± 0.042	3.491GlyPro: 3.491 ± 0.057	2.799GlyGln: 2.799 ± 0.052	6.82GlyArg: 6.82 ± 0.088	4.453GlySer: 4.453 ± 0.072	4.475GlyThr: 4.475 ± 0.071	5.856GlyVal: 5.856 ± 0.083	1.46GlyTrp: 1.46 ± 0.039	1.942GlyTyr: 1.942 ± 0.038	0.006GlyXaa: 0.006 ± 0.002
His	2.186HisAla: 2.186 ± 0.043	0.241HisCys: 0.241 ± 0.014	1.326HisAsp: 1.326 ± 0.034	0.986HisGlu: 0.986 ± 0.031	0.845HisPhe: 0.845 ± 0.029	1.868HisGly: 1.868 ± 0.04	0.646HisHis: 0.646 ± 0.029	0.923HisIle: 0.923 ± 0.029	0.468HisLys: 0.468 ± 0.02	2.32HisLeu: 2.32 ± 0.044	0.392HisMet: 0.392 ± 0.021	0.472HisAsn: 0.472 ± 0.022	1.592HisPro: 1.592 ± 0.041	0.681HisGln: 0.681 ± 0.025	1.698HisArg: 1.698 ± 0.044	1.072HisSer: 1.072 ± 0.029	0.845HisThr: 0.845 ± 0.027	1.344HisVal: 1.344 ± 0.033	0.324HisTrp: 0.324 ± 0.016	0.525HisTyr: 0.525 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.856IleAla: 6.856 ± 0.075	0.504IleCys: 0.504 ± 0.022	3.983IleAsp: 3.983 ± 0.066	3.885IleGlu: 3.885 ± 0.066	1.352IlePhe: 1.352 ± 0.038	4.903IleGly: 4.903 ± 0.06	1.008IleHis: 1.008 ± 0.03	1.938IleIle: 1.938 ± 0.049	1.521IleLys: 1.521 ± 0.042	4.712IleLeu: 4.712 ± 0.068	0.784IleMet: 0.784 ± 0.028	1.488IleAsn: 1.488 ± 0.037	2.488IlePro: 2.488 ± 0.046	1.309IleGln: 1.309 ± 0.029	3.626IleArg: 3.626 ± 0.058	2.928IleSer: 2.928 ± 0.057	2.57IleThr: 2.57 ± 0.053	3.972IleVal: 3.972 ± 0.062	0.488IleTrp: 0.488 ± 0.02	0.956IleTyr: 0.956 ± 0.029	0.001IleXaa: 0.001 ± 0.001
Lys	3.746LysAla: 3.746 ± 0.062	0.183LysCys: 0.183 ± 0.013	1.575LysAsp: 1.575 ± 0.043	1.442LysGlu: 1.442 ± 0.045	0.77LysPhe: 0.77 ± 0.033	2.489LysGly: 2.489 ± 0.057	0.473LysHis: 0.473 ± 0.02	1.641LysIle: 1.641 ± 0.04	1.162LysLys: 1.162 ± 0.041	2.767LysLeu: 2.767 ± 0.054	0.809LysMet: 0.809 ± 0.029	0.778LysAsn: 0.778 ± 0.026	1.781LysPro: 1.781 ± 0.047	0.855LysGln: 0.855 ± 0.024	2.158LysArg: 2.158 ± 0.049	1.83LysSer: 1.83 ± 0.046	1.908LysThr: 1.908 ± 0.048	2.509LysVal: 2.509 ± 0.058	0.324LysTrp: 0.324 ± 0.019	0.54LysTyr: 0.54 ± 0.024	0.002LysXaa: 0.002 ± 0.001
Leu	14.559LeuAla: 14.559 ± 0.149	1.077LeuCys: 1.077 ± 0.032	6.711LeuAsp: 6.711 ± 0.09	5.217LeuGlu: 5.217 ± 0.078	3.757LeuPhe: 3.757 ± 0.072	8.622LeuGly: 8.622 ± 0.113	2.034LeuHis: 2.034 ± 0.045	5.338LeuIle: 5.338 ± 0.08	3.316LeuLys: 3.316 ± 0.056	10.518LeuLeu: 10.518 ± 0.138	2.225LeuMet: 2.225 ± 0.048	2.555LeuAsn: 2.555 ± 0.053	6.136LeuPro: 6.136 ± 0.083	2.321LeuGln: 2.321 ± 0.049	7.731LeuArg: 7.731 ± 0.086	7.222LeuSer: 7.222 ± 0.085	6.06LeuThr: 6.06 ± 0.072	7.833LeuVal: 7.833 ± 0.107	1.301LeuTrp: 1.301 ± 0.033	2.036LeuTyr: 2.036 ± 0.048	0.003LeuXaa: 0.003 ± 0.001
Met	2.983MetAla: 2.983 ± 0.052	0.167MetCys: 0.167 ± 0.011	1.038MetAsp: 1.038 ± 0.026	1.034MetGlu: 1.034 ± 0.029	0.678MetPhe: 0.678 ± 0.026	1.678MetGly: 1.678 ± 0.036	0.337MetHis: 0.337 ± 0.017	1.309MetIle: 1.309 ± 0.031	0.852MetLys: 0.852 ± 0.028	2.328MetLeu: 2.328 ± 0.049	0.636MetMet: 0.636 ± 0.02	0.673MetAsn: 0.673 ± 0.024	1.323MetPro: 1.323 ± 0.036	0.639MetGln: 0.639 ± 0.025	1.707MetArg: 1.707 ± 0.04	1.631MetSer: 1.631 ± 0.039	1.748MetThr: 1.748 ± 0.043	1.966MetVal: 1.966 ± 0.042	0.19MetTrp: 0.19 ± 0.015	0.277MetTyr: 0.277 ± 0.015	0.001MetXaa: 0.001 ± 0.001
Asn	2.845AsnAla: 2.845 ± 0.057	0.243AsnCys: 0.243 ± 0.017	1.482AsnAsp: 1.482 ± 0.04	1.163AsnGlu: 1.163 ± 0.034	0.769AsnPhe: 0.769 ± 0.031	2.217AsnGly: 2.217 ± 0.05	0.537AsnHis: 0.537 ± 0.02	1.252AsnIle: 1.252 ± 0.037	0.662AsnLys: 0.662 ± 0.025	2.467AsnLeu: 2.467 ± 0.048	0.516AsnMet: 0.516 ± 0.021	0.615AsnAsn: 0.615 ± 0.025	1.724AsnPro: 1.724 ± 0.045	0.805AsnGln: 0.805 ± 0.028	2.03AsnArg: 2.03 ± 0.041	1.193AsnSer: 1.193 ± 0.037	1.186AsnThr: 1.186 ± 0.034	1.699AsnVal: 1.699 ± 0.049	0.318AsnTrp: 0.318 ± 0.017	0.497AsnTyr: 0.497 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.276ProAla: 6.276 ± 0.089	0.434ProCys: 0.434 ± 0.02	3.916ProAsp: 3.916 ± 0.058	3.547ProGlu: 3.547 ± 0.064	1.95ProPhe: 1.95 ± 0.045	4.628ProGly: 4.628 ± 0.067	1.098ProHis: 1.098 ± 0.036	2.317ProIle: 2.317 ± 0.04	1.546ProLys: 1.546 ± 0.043	5.416ProLeu: 5.416 ± 0.08	1.143ProMet: 1.143 ± 0.034	1.243ProAsn: 1.243 ± 0.035	3.809ProPro: 3.809 ± 0.085	1.542ProGln: 1.542 ± 0.041	3.344ProArg: 3.344 ± 0.064	3.198ProSer: 3.198 ± 0.053	2.701ProThr: 2.701 ± 0.05	4.53ProVal: 4.53 ± 0.069	0.726ProTrp: 0.726 ± 0.026	1.014ProTyr: 1.014 ± 0.027	0.001ProXaa: 0.001 ± 0.001
Gln	4.221GlnAla: 4.221 ± 0.067	0.21GlnCys: 0.21 ± 0.014	1.384GlnAsp: 1.384 ± 0.034	1.324GlnGlu: 1.324 ± 0.034	0.947GlnPhe: 0.947 ± 0.027	2.366GlnGly: 2.366 ± 0.045	0.623GlnHis: 0.623 ± 0.025	1.887GlnIle: 1.887 ± 0.037	0.938GlnLys: 0.938 ± 0.029	2.574GlnLeu: 2.574 ± 0.052	0.829GlnMet: 0.829 ± 0.027	0.751GlnAsn: 0.751 ± 0.027	1.789GlnPro: 1.789 ± 0.042	1.059GlnGln: 1.059 ± 0.034	2.304GlnArg: 2.304 ± 0.044	1.88GlnSer: 1.88 ± 0.044	1.911GlnThr: 1.911 ± 0.043	2.521GlnVal: 2.521 ± 0.051	0.328GlnTrp: 0.328 ± 0.017	0.532GlnTyr: 0.532 ± 0.021	0.001GlnXaa: 0.001 ± 0.001
Arg	8.279ArgAla: 8.279 ± 0.09	0.657ArgCys: 0.657 ± 0.026	4.392ArgAsp: 4.392 ± 0.053	4.021ArgGlu: 4.021 ± 0.06	2.937ArgPhe: 2.937 ± 0.052	4.912ArgGly: 4.912 ± 0.073	2.09ArgHis: 2.09 ± 0.053	4.245ArgIle: 4.245 ± 0.062	2.273ArgLys: 2.273 ± 0.048	9.726ArgLeu: 9.726 ± 0.111	1.986ArgMet: 1.986 ± 0.037	1.843ArgAsn: 1.843 ± 0.041	4.208ArgPro: 4.208 ± 0.063	2.927ArgGln: 2.927 ± 0.054	6.986ArgArg: 6.986 ± 0.106	4.047ArgSer: 4.047 ± 0.054	3.674ArgThr: 3.674 ± 0.06	5.28ArgVal: 5.28 ± 0.072	1.128ArgTrp: 1.128 ± 0.037	1.627ArgTyr: 1.627 ± 0.039	0.003ArgXaa: 0.003 ± 0.002
Ser	6.389SerAla: 6.389 ± 0.089	0.543SerCys: 0.543 ± 0.024	3.063SerAsp: 3.063 ± 0.058	2.865SerGlu: 2.865 ± 0.047	2.14SerPhe: 2.14 ± 0.041	5.603SerGly: 5.603 ± 0.077	1.243SerHis: 1.243 ± 0.034	2.721SerIle: 2.721 ± 0.051	1.473SerLys: 1.473 ± 0.035	6.147SerLeu: 6.147 ± 0.079	1.264SerMet: 1.264 ± 0.029	1.397SerAsn: 1.397 ± 0.04	3.211SerPro: 3.211 ± 0.058	1.69SerGln: 1.69 ± 0.041	4.034SerArg: 4.034 ± 0.053	3.441SerSer: 3.441 ± 0.063	2.866SerThr: 2.866 ± 0.059	4.262SerVal: 4.262 ± 0.059	0.821SerTrp: 0.821 ± 0.029	1.17SerTyr: 1.17 ± 0.031	0.001SerXaa: 0.001 ± 0.001
Thr	6.351ThrAla: 6.351 ± 0.077	0.488ThrCys: 0.488 ± 0.022	2.883ThrAsp: 2.883 ± 0.053	3.039ThrGlu: 3.039 ± 0.064	1.792ThrPhe: 1.792 ± 0.047	4.889ThrGly: 4.889 ± 0.07	1.014ThrHis: 1.014 ± 0.033	2.904ThrIle: 2.904 ± 0.055	1.345ThrLys: 1.345 ± 0.04	6.225ThrLeu: 6.225 ± 0.072	1.196ThrMet: 1.196 ± 0.037	1.235ThrAsn: 1.235 ± 0.04	3.246ThrPro: 3.246 ± 0.056	1.471ThrGln: 1.471 ± 0.037	3.471ThrArg: 3.471 ± 0.06	2.689ThrSer: 2.689 ± 0.051	2.786ThrThr: 2.786 ± 0.065	4.763ThrVal: 4.763 ± 0.08	0.614ThrTrp: 0.614 ± 0.024	1.047ThrTyr: 1.047 ± 0.031	0.001ThrXaa: 0.001 ± 0.001
Val	9.578ValAla: 9.578 ± 0.108	0.738ValCys: 0.738 ± 0.028	3.838ValAsp: 3.838 ± 0.067	4.961ValGlu: 4.961 ± 0.072	2.531ValPhe: 2.531 ± 0.045	5.669ValGly: 5.669 ± 0.074	1.346ValHis: 1.346 ± 0.034	3.945ValIle: 3.945 ± 0.065	2.123ValLys: 2.123 ± 0.057	7.997ValLeu: 7.997 ± 0.093	1.881ValMet: 1.881 ± 0.04	1.835ValAsn: 1.835 ± 0.049	3.897ValPro: 3.897 ± 0.067	2.097ValGln: 2.097 ± 0.044	5.493ValArg: 5.493 ± 0.078	4.369ValSer: 4.369 ± 0.068	4.53ValThr: 4.53 ± 0.067	6.579ValVal: 6.579 ± 0.105	0.967ValTrp: 0.967 ± 0.031	1.275ValTyr: 1.275 ± 0.036	0.003ValXaa: 0.003 ± 0.002
Trp	1.246TrpAla: 1.246 ± 0.034	0.163TrpCys: 0.163 ± 0.013	0.632TrpAsp: 0.632 ± 0.028	0.564TrpGlu: 0.564 ± 0.02	0.483TrpPhe: 0.483 ± 0.019	0.962TrpGly: 0.962 ± 0.033	0.314TrpHis: 0.314 ± 0.015	0.63TrpIle: 0.63 ± 0.023	0.403TrpLys: 0.403 ± 0.022	1.724TrpLeu: 1.724 ± 0.048	0.312TrpMet: 0.312 ± 0.015	0.396TrpAsn: 0.396 ± 0.018	0.66TrpPro: 0.66 ± 0.024	0.51TrpGln: 0.51 ± 0.021	1.288TrpArg: 1.288 ± 0.033	0.797TrpSer: 0.797 ± 0.024	0.681TrpThr: 0.681 ± 0.026	0.949TrpVal: 0.949 ± 0.033	0.205TrpTrp: 0.205 ± 0.014	0.28TrpTyr: 0.28 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.111TyrAla: 2.111 ± 0.041	0.246TyrCys: 0.246 ± 0.015	1.313TyrAsp: 1.313 ± 0.039	0.981TyrGlu: 0.981 ± 0.027	0.759TyrPhe: 0.759 ± 0.025	1.698TyrGly: 1.698 ± 0.041	0.494TyrHis: 0.494 ± 0.022	0.79TyrIle: 0.79 ± 0.028	0.511TyrLys: 0.511 ± 0.023	2.1TyrLeu: 2.1 ± 0.051	0.334TyrMet: 0.334 ± 0.016	0.512TyrAsn: 0.512 ± 0.022	1.0TyrPro: 1.0 ± 0.033	0.67TyrGln: 0.67 ± 0.027	1.948TyrArg: 1.948 ± 0.041	1.07TyrSer: 1.07 ± 0.03	0.926TyrThr: 0.926 ± 0.035	1.33TyrVal: 1.33 ± 0.037	0.313TyrTrp: 0.313 ± 0.015	0.496TyrTyr: 0.496 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.003XaaPhe: 0.003 ± 0.002	0.004XaaGly: 0.004 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.003XaaMet: 0.003 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3771 proteins (1146260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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