Amino acid dipepetide frequency for Streptomyces hygroscopicus subsp. jinggangensis (strain 5008)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.46AlaAla: 21.46 ± 0.137	1.133AlaCys: 1.133 ± 0.022	8.521AlaAsp: 8.521 ± 0.065	8.911AlaGlu: 8.911 ± 0.091	3.576AlaPhe: 3.576 ± 0.039	13.479AlaGly: 13.479 ± 0.081	3.188AlaHis: 3.188 ± 0.037	3.187AlaIle: 3.187 ± 0.044	2.656AlaLys: 2.656 ± 0.038	14.883AlaLeu: 14.883 ± 0.104	2.343AlaMet: 2.343 ± 0.025	1.831AlaAsn: 1.831 ± 0.029	7.252AlaPro: 7.252 ± 0.073	3.76AlaGln: 3.76 ± 0.042	11.121AlaArg: 11.121 ± 0.075	5.724AlaSer: 5.724 ± 0.053	7.009AlaThr: 7.009 ± 0.056	12.448AlaVal: 12.448 ± 0.087	1.955AlaTrp: 1.955 ± 0.031	2.873AlaTyr: 2.873 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.162CysAla: 1.162 ± 0.02	0.111CysCys: 0.111 ± 0.007	0.443CysAsp: 0.443 ± 0.013	0.398CysGlu: 0.398 ± 0.014	0.234CysPhe: 0.234 ± 0.008	0.971CysGly: 0.971 ± 0.02	0.213CysHis: 0.213 ± 0.009	0.142CysIle: 0.142 ± 0.007	0.102CysLys: 0.102 ± 0.006	0.82CysLeu: 0.82 ± 0.019	0.126CysMet: 0.126 ± 0.007	0.134CysAsn: 0.134 ± 0.007	0.536CysPro: 0.536 ± 0.016	0.175CysGln: 0.175 ± 0.008	0.675CysArg: 0.675 ± 0.019	0.4CysSer: 0.4 ± 0.012	0.515CysThr: 0.515 ± 0.014	0.688CysVal: 0.688 ± 0.019	0.136CysTrp: 0.136 ± 0.006	0.163CysTyr: 0.163 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.716AspAla: 7.716 ± 0.059	0.426AspCys: 0.426 ± 0.012	3.552AspAsp: 3.552 ± 0.04	3.64AspGlu: 3.64 ± 0.038	1.655AspPhe: 1.655 ± 0.026	6.418AspGly: 6.418 ± 0.059	1.532AspHis: 1.532 ± 0.023	1.842AspIle: 1.842 ± 0.028	1.144AspLys: 1.144 ± 0.026	6.333AspLeu: 6.333 ± 0.057	0.77AspMet: 0.77 ± 0.017	0.937AspAsn: 0.937 ± 0.021	4.561AspPro: 4.561 ± 0.049	1.567AspGln: 1.567 ± 0.025	5.114AspArg: 5.114 ± 0.048	2.462AspSer: 2.462 ± 0.033	3.4AspThr: 3.4 ± 0.043	4.737AspVal: 4.737 ± 0.045	1.062AspTrp: 1.062 ± 0.021	1.107AspTyr: 1.107 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.446GluAla: 7.446 ± 0.062	0.369GluCys: 0.369 ± 0.012	2.844GluAsp: 2.844 ± 0.035	3.732GluGlu: 3.732 ± 0.048	1.37GluPhe: 1.37 ± 0.022	4.15GluGly: 4.15 ± 0.04	1.593GluHis: 1.593 ± 0.022	2.137GluIle: 2.137 ± 0.031	1.36GluLys: 1.36 ± 0.029	6.618GluLeu: 6.618 ± 0.058	0.833GluMet: 0.833 ± 0.019	0.97GluAsn: 0.97 ± 0.018	3.383GluPro: 3.383 ± 0.042	2.214GluGln: 2.214 ± 0.03	5.637GluArg: 5.637 ± 0.048	2.34GluSer: 2.34 ± 0.029	2.884GluThr: 2.884 ± 0.038	4.257GluVal: 4.257 ± 0.048	0.763GluTrp: 0.763 ± 0.017	1.072GluTyr: 1.072 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.639PheAla: 3.639 ± 0.037	0.252PheCys: 0.252 ± 0.01	1.924PheAsp: 1.924 ± 0.029	1.399PheGlu: 1.399 ± 0.025	0.885PhePhe: 0.885 ± 0.02	2.963PheGly: 2.963 ± 0.034	0.651PheHis: 0.651 ± 0.015	0.644PheIle: 0.644 ± 0.017	0.471PheLys: 0.471 ± 0.014	2.627PheLeu: 2.627 ± 0.032	0.384PheMet: 0.384 ± 0.013	0.521PheAsn: 0.521 ± 0.014	1.404PhePro: 1.404 ± 0.024	0.696PheGln: 0.696 ± 0.014	1.916PheArg: 1.916 ± 0.03	1.416PheSer: 1.416 ± 0.027	1.999PheThr: 1.999 ± 0.028	2.187PheVal: 2.187 ± 0.026	0.404PheTrp: 0.404 ± 0.013	0.569PheTyr: 0.569 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.065GlyAla: 11.065 ± 0.081	0.857GlyCys: 0.857 ± 0.019	5.177GlyAsp: 5.177 ± 0.048	4.939GlyGlu: 4.939 ± 0.041	2.836GlyPhe: 2.836 ± 0.037	8.685GlyGly: 8.685 ± 0.096	2.514GlyHis: 2.514 ± 0.032	3.3GlyIle: 3.3 ± 0.042	2.325GlyLys: 2.325 ± 0.035	9.442GlyLeu: 9.442 ± 0.067	1.922GlyMet: 1.922 ± 0.025	1.722GlyAsn: 1.722 ± 0.032	5.393GlyPro: 5.393 ± 0.048	2.631GlyGln: 2.631 ± 0.033	8.213GlyArg: 8.213 ± 0.061	5.13GlySer: 5.13 ± 0.047	6.751GlyThr: 6.751 ± 0.064	7.44GlyVal: 7.44 ± 0.052	1.728GlyTrp: 1.728 ± 0.029	2.326GlyTyr: 2.326 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.945HisAla: 2.945 ± 0.039	0.234HisCys: 0.234 ± 0.009	1.418HisAsp: 1.418 ± 0.024	1.254HisGlu: 1.254 ± 0.021	0.672HisPhe: 0.672 ± 0.014	2.627HisGly: 2.627 ± 0.032	0.785HisHis: 0.785 ± 0.022	0.67HisIle: 0.67 ± 0.017	0.368HisLys: 0.368 ± 0.013	2.585HisLeu: 2.585 ± 0.033	0.37HisMet: 0.37 ± 0.011	0.345HisAsn: 0.345 ± 0.01	2.026HisPro: 2.026 ± 0.027	0.701HisGln: 0.701 ± 0.016	2.376HisArg: 2.376 ± 0.027	1.036HisSer: 1.036 ± 0.018	1.452HisThr: 1.452 ± 0.023	1.757HisVal: 1.757 ± 0.028	0.4HisTrp: 0.4 ± 0.012	0.512HisTyr: 0.512 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.531IleAla: 4.531 ± 0.051	0.265IleCys: 0.265 ± 0.009	2.117IleAsp: 2.117 ± 0.031	1.873IleGlu: 1.873 ± 0.029	0.622IlePhe: 0.622 ± 0.016	3.321IleGly: 3.321 ± 0.04	0.591IleHis: 0.591 ± 0.014	0.776IleIle: 0.776 ± 0.018	0.683IleLys: 0.683 ± 0.019	2.223IleLeu: 2.223 ± 0.031	0.391IleMet: 0.391 ± 0.015	0.621IleAsn: 0.621 ± 0.016	1.658IlePro: 1.658 ± 0.026	0.709IleGln: 0.709 ± 0.017	2.206IleArg: 2.206 ± 0.031	1.541IleSer: 1.541 ± 0.024	2.154IleThr: 2.154 ± 0.033	2.551IleVal: 2.551 ± 0.037	0.341IleTrp: 0.341 ± 0.012	0.481IleTyr: 0.481 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.862LysAla: 2.862 ± 0.042	0.11LysCys: 0.11 ± 0.008	1.298LysAsp: 1.298 ± 0.03	1.138LysGlu: 1.138 ± 0.025	0.43LysPhe: 0.43 ± 0.011	1.78LysGly: 1.78 ± 0.032	0.414LysHis: 0.414 ± 0.012	0.778LysIle: 0.778 ± 0.02	0.812LysLys: 0.812 ± 0.025	1.905LysLeu: 1.905 ± 0.036	0.346LysMet: 0.346 ± 0.012	0.483LysAsn: 0.483 ± 0.015	1.279LysPro: 1.279 ± 0.028	0.663LysGln: 0.663 ± 0.018	1.397LysArg: 1.397 ± 0.028	1.013LysSer: 1.013 ± 0.025	1.26LysThr: 1.26 ± 0.023	1.816LysVal: 1.816 ± 0.032	0.262LysTrp: 0.262 ± 0.01	0.43LysTyr: 0.43 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.394LeuAla: 15.394 ± 0.103	0.863LeuCys: 0.863 ± 0.02	6.758LeuAsp: 6.758 ± 0.06	4.67LeuGlu: 4.67 ± 0.047	2.598LeuPhe: 2.598 ± 0.032	9.259LeuGly: 9.259 ± 0.066	2.462LeuHis: 2.462 ± 0.032	3.074LeuIle: 3.074 ± 0.039	2.04LeuLys: 2.04 ± 0.037	11.62LeuLeu: 11.62 ± 0.087	1.539LeuMet: 1.539 ± 0.028	1.623LeuAsn: 1.623 ± 0.026	6.803LeuPro: 6.803 ± 0.063	2.112LeuGln: 2.112 ± 0.029	9.096LeuArg: 9.096 ± 0.068	5.185LeuSer: 5.185 ± 0.053	7.1LeuThr: 7.1 ± 0.054	8.765LeuVal: 8.765 ± 0.066	1.378LeuTrp: 1.378 ± 0.027	1.945LeuTyr: 1.945 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.146MetAla: 2.146 ± 0.027	0.141MetCys: 0.141 ± 0.007	0.839MetAsp: 0.839 ± 0.021	0.713MetGlu: 0.713 ± 0.019	0.443MetPhe: 0.443 ± 0.013	1.219MetGly: 1.219 ± 0.022	0.348MetHis: 0.348 ± 0.009	0.623MetIle: 0.623 ± 0.016	0.386MetLys: 0.386 ± 0.013	1.604MetLeu: 1.604 ± 0.023	0.286MetMet: 0.286 ± 0.01	0.414MetAsn: 0.414 ± 0.013	1.054MetPro: 1.054 ± 0.02	0.417MetGln: 0.417 ± 0.013	1.4MetArg: 1.4 ± 0.028	1.199MetSer: 1.199 ± 0.025	1.49MetThr: 1.49 ± 0.023	1.232MetVal: 1.232 ± 0.021	0.216MetTrp: 0.216 ± 0.009	0.323MetTyr: 0.323 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.137AsnAla: 2.137 ± 0.027	0.159AsnCys: 0.159 ± 0.008	0.916AsnAsp: 0.916 ± 0.02	0.738AsnGlu: 0.738 ± 0.019	0.473AsnPhe: 0.473 ± 0.013	1.849AsnGly: 1.849 ± 0.035	0.391AsnHis: 0.391 ± 0.012	0.575AsnIle: 0.575 ± 0.015	0.375AsnLys: 0.375 ± 0.012	1.606AsnLeu: 1.606 ± 0.025	0.264AsnMet: 0.264 ± 0.011	0.391AsnAsn: 0.391 ± 0.014	1.31AsnPro: 1.31 ± 0.022	0.514AsnGln: 0.514 ± 0.015	1.215AsnArg: 1.215 ± 0.019	0.871AsnSer: 0.871 ± 0.021	1.076AsnThr: 1.076 ± 0.025	1.306AsnVal: 1.306 ± 0.022	0.283AsnTrp: 0.283 ± 0.01	0.394AsnTyr: 0.394 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.387ProAla: 9.387 ± 0.082	0.377ProCys: 0.377 ± 0.012	4.644ProAsp: 4.644 ± 0.052	4.301ProGlu: 4.301 ± 0.048	1.511ProPhe: 1.511 ± 0.025	6.942ProGly: 6.942 ± 0.056	1.531ProHis: 1.531 ± 0.022	1.14ProIle: 1.14 ± 0.019	1.122ProLys: 1.122 ± 0.024	5.636ProLeu: 5.636 ± 0.057	0.964ProMet: 0.964 ± 0.02	0.837ProAsn: 0.837 ± 0.017	3.645ProPro: 3.645 ± 0.058	1.684ProGln: 1.684 ± 0.028	4.283ProArg: 4.283 ± 0.045	3.112ProSer: 3.112 ± 0.043	3.092ProThr: 3.092 ± 0.038	5.665ProVal: 5.665 ± 0.048	0.924ProTrp: 0.924 ± 0.018	1.456ProTyr: 1.456 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.789GlnAla: 3.789 ± 0.047	0.168GlnCys: 0.168 ± 0.008	1.443GlnAsp: 1.443 ± 0.023	1.486GlnGlu: 1.486 ± 0.025	0.679GlnPhe: 0.679 ± 0.016	2.308GlnGly: 2.308 ± 0.032	0.695GlnHis: 0.695 ± 0.017	1.025GlnIle: 1.025 ± 0.021	0.591GlnLys: 0.591 ± 0.018	2.943GlnLeu: 2.943 ± 0.033	0.467GlnMet: 0.467 ± 0.013	0.466GlnAsn: 0.466 ± 0.014	1.656GlnPro: 1.656 ± 0.03	1.227GlnGln: 1.227 ± 0.029	2.434GlnArg: 2.434 ± 0.03	1.184GlnSer: 1.184 ± 0.022	1.338GlnThr: 1.338 ± 0.025	2.34GlnVal: 2.34 ± 0.03	0.475GlnTrp: 0.475 ± 0.016	0.605GlnTyr: 0.605 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	10.639ArgAla: 10.639 ± 0.079	0.689ArgCys: 0.689 ± 0.015	4.403ArgAsp: 4.403 ± 0.042	4.855ArgGlu: 4.855 ± 0.046	2.394ArgPhe: 2.394 ± 0.03	6.025ArgGly: 6.025 ± 0.055	2.43ArgHis: 2.43 ± 0.034	3.147ArgIle: 3.147 ± 0.034	1.593ArgLys: 1.593 ± 0.026	9.595ArgLeu: 9.595 ± 0.072	1.752ArgMet: 1.752 ± 0.026	1.334ArgAsn: 1.334 ± 0.024	5.475ArgPro: 5.475 ± 0.057	2.448ArgGln: 2.448 ± 0.034	8.434ArgArg: 8.434 ± 0.079	3.984ArgSer: 3.984 ± 0.043	5.708ArgThr: 5.708 ± 0.048	6.084ArgVal: 6.084 ± 0.052	1.449ArgTrp: 1.449 ± 0.025	1.902ArgTyr: 1.902 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.624SerAla: 6.624 ± 0.065	0.41SerCys: 0.41 ± 0.013	2.495SerAsp: 2.495 ± 0.036	2.163SerGlu: 2.163 ± 0.028	1.479SerPhe: 1.479 ± 0.024	5.744SerGly: 5.744 ± 0.055	1.039SerHis: 1.039 ± 0.02	1.267SerIle: 1.267 ± 0.024	0.931SerLys: 0.931 ± 0.022	4.66SerLeu: 4.66 ± 0.038	1.007SerMet: 1.007 ± 0.02	0.81SerAsn: 0.81 ± 0.018	3.161SerPro: 3.161 ± 0.042	1.153SerGln: 1.153 ± 0.023	3.725SerArg: 3.725 ± 0.036	2.625SerSer: 2.625 ± 0.04	2.886SerThr: 2.886 ± 0.038	4.127SerVal: 4.127 ± 0.038	0.893SerTrp: 0.893 ± 0.018	1.2SerTyr: 1.2 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.425ThrAla: 9.425 ± 0.065	0.447ThrCys: 0.447 ± 0.013	3.772ThrAsp: 3.772 ± 0.049	3.264ThrGlu: 3.264 ± 0.038	1.562ThrPhe: 1.562 ± 0.026	7.017ThrGly: 7.017 ± 0.061	1.252ThrHis: 1.252 ± 0.017	1.598ThrIle: 1.598 ± 0.03	1.092ThrLys: 1.092 ± 0.026	5.738ThrLeu: 5.738 ± 0.045	0.871ThrMet: 0.871 ± 0.018	0.961ThrAsn: 0.961 ± 0.02	4.247ThrPro: 4.247 ± 0.047	1.313ThrGln: 1.313 ± 0.025	4.168ThrArg: 4.168 ± 0.04	3.081ThrSer: 3.081 ± 0.04	3.812ThrThr: 3.812 ± 0.052	6.129ThrVal: 6.129 ± 0.055	0.918ThrTrp: 0.918 ± 0.022	1.368ThrTyr: 1.368 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.416ValAla: 10.416 ± 0.07	0.787ValCys: 0.787 ± 0.018	4.914ValAsp: 4.914 ± 0.041	4.49ValGlu: 4.49 ± 0.041	2.388ValPhe: 2.388 ± 0.03	6.264ValGly: 6.264 ± 0.059	2.081ValHis: 2.081 ± 0.027	2.705ValIle: 2.705 ± 0.036	1.686ValLys: 1.686 ± 0.031	9.511ValLeu: 9.511 ± 0.064	1.332ValMet: 1.332 ± 0.026	1.611ValAsn: 1.611 ± 0.027	5.505ValPro: 5.505 ± 0.05	2.054ValGln: 2.054 ± 0.024	7.613ValArg: 7.613 ± 0.066	4.189ValSer: 4.189 ± 0.044	5.789ValThr: 5.789 ± 0.056	7.799ValVal: 7.799 ± 0.066	1.195ValTrp: 1.195 ± 0.023	1.632ValTyr: 1.632 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.737TrpAla: 1.737 ± 0.026	0.161TrpCys: 0.161 ± 0.007	0.859TrpAsp: 0.859 ± 0.019	0.762TrpGlu: 0.762 ± 0.016	0.502TrpPhe: 0.502 ± 0.013	1.048TrpGly: 1.048 ± 0.022	0.41TrpHis: 0.41 ± 0.013	0.557TrpIle: 0.557 ± 0.015	0.36TrpLys: 0.36 ± 0.011	1.819TrpLeu: 1.819 ± 0.026	0.269TrpMet: 0.269 ± 0.011	0.423TrpAsn: 0.423 ± 0.013	0.806TrpPro: 0.806 ± 0.019	0.646TrpGln: 0.646 ± 0.014	1.432TrpArg: 1.432 ± 0.025	0.964TrpSer: 0.964 ± 0.022	1.073TrpThr: 1.073 ± 0.02	0.963TrpVal: 0.963 ± 0.019	0.336TrpTrp: 0.336 ± 0.013	0.363TrpTyr: 0.363 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.793TyrAla: 2.793 ± 0.033	0.182TyrCys: 0.182 ± 0.009	1.639TyrAsp: 1.639 ± 0.03	1.245TyrGlu: 1.245 ± 0.021	0.641TyrPhe: 0.641 ± 0.018	2.329TyrGly: 2.329 ± 0.032	0.41TyrHis: 0.41 ± 0.012	0.469TyrIle: 0.469 ± 0.015	0.38TyrLys: 0.38 ± 0.014	2.119TyrLeu: 2.119 ± 0.031	0.255TyrMet: 0.255 ± 0.01	0.411TyrAsn: 0.411 ± 0.014	1.098TyrPro: 1.098 ± 0.021	0.632TyrGln: 0.632 ± 0.015	1.885TyrArg: 1.885 ± 0.025	0.946TyrSer: 0.946 ± 0.021	1.246TyrThr: 1.246 ± 0.023	1.67TyrVal: 1.67 ± 0.025	0.372TyrTrp: 0.372 ± 0.013	0.454TyrTyr: 0.454 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9046 proteins (2850891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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