Amino acid dipepetide frequency for Rothia kristinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.691AlaAla: 20.691 ± 0.258
0.86AlaCys: 0.86 ± 0.041
7.736AlaAsp: 7.736 ± 0.11
9.482AlaGlu: 9.482 ± 0.135
3.402AlaPhe: 3.402 ± 0.077
12.828AlaGly: 12.828 ± 0.171
2.649AlaHis: 2.649 ± 0.076
4.167AlaIle: 4.167 ± 0.083
2.722AlaLys: 2.722 ± 0.088
13.056AlaLeu: 13.056 ± 0.172
2.758AlaMet: 2.758 ± 0.066
1.877AlaAsn: 1.877 ± 0.056
7.004AlaPro: 7.004 ± 0.139
5.306AlaGln: 5.306 ± 0.102
10.154AlaArg: 10.154 ± 0.173
6.402AlaSer: 6.402 ± 0.092
5.521AlaThr: 5.521 ± 0.102
11.634AlaVal: 11.634 ± 0.15
1.836AlaTrp: 1.836 ± 0.056
2.299AlaTyr: 2.299 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.908CysAla: 0.908 ± 0.04
0.073CysCys: 0.073 ± 0.011
0.286CysAsp: 0.286 ± 0.021
0.293CysGlu: 0.293 ± 0.023
0.207CysPhe: 0.207 ± 0.018
0.759CysGly: 0.759 ± 0.04
0.134CysHis: 0.134 ± 0.014
0.215CysIle: 0.215 ± 0.021
0.073CysLys: 0.073 ± 0.01
0.734CysLeu: 0.734 ± 0.037
0.082CysMet: 0.082 ± 0.011
0.082CysAsn: 0.082 ± 0.011
0.411CysPro: 0.411 ± 0.027
0.136CysGln: 0.136 ± 0.013
0.467CysArg: 0.467 ± 0.03
0.4CysSer: 0.4 ± 0.025
0.373CysThr: 0.373 ± 0.022
0.438CysVal: 0.438 ± 0.027
0.109CysTrp: 0.109 ± 0.015
0.144CysTyr: 0.144 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
8.307AspAla: 8.307 ± 0.123
0.278AspCys: 0.278 ± 0.02
2.948AspAsp: 2.948 ± 0.074
3.86AspGlu: 3.86 ± 0.086
1.629AspPhe: 1.629 ± 0.05
5.644AspGly: 5.644 ± 0.112
1.123AspHis: 1.123 ± 0.048
1.804AspIle: 1.804 ± 0.061
0.976AspLys: 0.976 ± 0.045
6.137AspLeu: 6.137 ± 0.093
0.954AspMet: 0.954 ± 0.033
0.694AspAsn: 0.694 ± 0.035
4.891AspPro: 4.891 ± 0.097
1.716AspGln: 1.716 ± 0.055
4.23AspArg: 4.23 ± 0.078
2.624AspSer: 2.624 ± 0.069
2.465AspThr: 2.465 ± 0.064
4.55AspVal: 4.55 ± 0.096
0.893AspTrp: 0.893 ± 0.039
1.275AspTyr: 1.275 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
8.505GluAla: 8.505 ± 0.145
0.269GluCys: 0.269 ± 0.023
4.474GluAsp: 4.474 ± 0.085
4.752GluGlu: 4.752 ± 0.11
1.567GluPhe: 1.567 ± 0.054
4.814GluGly: 4.814 ± 0.093
2.189GluHis: 2.189 ± 0.06
2.828GluIle: 2.828 ± 0.078
1.698GluLys: 1.698 ± 0.063
6.242GluLeu: 6.242 ± 0.111
0.996GluMet: 0.996 ± 0.042
1.216GluAsn: 1.216 ± 0.045
3.161GluPro: 3.161 ± 0.081
3.544GluGln: 3.544 ± 0.082
5.296GluArg: 5.296 ± 0.106
2.714GluSer: 2.714 ± 0.067
3.41GluThr: 3.41 ± 0.074
4.774GluVal: 4.774 ± 0.107
0.653GluTrp: 0.653 ± 0.037
1.207GluTyr: 1.207 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.549PheAla: 3.549 ± 0.08
0.236PheCys: 0.236 ± 0.02
1.931PheAsp: 1.931 ± 0.056
1.469PheGlu: 1.469 ± 0.056
0.982PhePhe: 0.982 ± 0.051
3.095PheGly: 3.095 ± 0.076
0.614PheHis: 0.614 ± 0.036
1.037PheIle: 1.037 ± 0.053
0.506PheLys: 0.506 ± 0.03
3.014PheLeu: 3.014 ± 0.072
0.512PheMet: 0.512 ± 0.03
0.552PheAsn: 0.552 ± 0.032
1.369PhePro: 1.369 ± 0.045
0.75PheGln: 0.75 ± 0.031
1.866PheArg: 1.866 ± 0.057
1.762PheSer: 1.762 ± 0.06
1.887PheThr: 1.887 ± 0.05
2.163PheVal: 2.163 ± 0.061
0.478PheTrp: 0.478 ± 0.027
0.655PheTyr: 0.655 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
11.356GlyAla: 11.356 ± 0.172
0.636GlyCys: 0.636 ± 0.034
4.173GlyAsp: 4.173 ± 0.087
5.185GlyGlu: 5.185 ± 0.11
3.095GlyPhe: 3.095 ± 0.066
7.622GlyGly: 7.622 ± 0.139
2.004GlyHis: 2.004 ± 0.061
4.657GlyIle: 4.657 ± 0.089
2.306GlyLys: 2.306 ± 0.072
9.667GlyLeu: 9.667 ± 0.147
2.13GlyMet: 2.13 ± 0.059
1.629GlyAsn: 1.629 ± 0.057
4.545GlyPro: 4.545 ± 0.106
3.645GlyGln: 3.645 ± 0.084
7.002GlyArg: 7.002 ± 0.118
5.413GlySer: 5.413 ± 0.115
5.753GlyThr: 5.753 ± 0.124
7.309GlyVal: 7.309 ± 0.117
1.709GlyTrp: 1.709 ± 0.053
2.228GlyTyr: 2.228 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.375HisAla: 2.375 ± 0.062
0.136HisCys: 0.136 ± 0.015
1.129HisAsp: 1.129 ± 0.049
1.26HisGlu: 1.26 ± 0.044
0.509HisPhe: 0.509 ± 0.027
2.178HisGly: 2.178 ± 0.057
0.623HisHis: 0.623 ± 0.039
0.623HisIle: 0.623 ± 0.031
0.267HisLys: 0.267 ± 0.023
2.511HisLeu: 2.511 ± 0.07
0.296HisMet: 0.296 ± 0.02
0.337HisAsn: 0.337 ± 0.021
1.902HisPro: 1.902 ± 0.064
0.707HisGln: 0.707 ± 0.036
2.355HisArg: 2.355 ± 0.061
0.892HisSer: 0.892 ± 0.036
1.097HisThr: 1.097 ± 0.041
1.588HisVal: 1.588 ± 0.055
0.316HisTrp: 0.316 ± 0.022
0.411HisTyr: 0.411 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.261IleAla: 5.261 ± 0.104
0.365IleCys: 0.365 ± 0.024
2.461IleAsp: 2.461 ± 0.065
2.386IleGlu: 2.386 ± 0.071
1.245IlePhe: 1.245 ± 0.053
4.276IleGly: 4.276 ± 0.093
0.704IleHis: 0.704 ± 0.033
1.683IleIle: 1.683 ± 0.06
0.83IleLys: 0.83 ± 0.039
4.091IleLeu: 4.091 ± 0.086
0.742IleMet: 0.742 ± 0.033
0.846IleAsn: 0.846 ± 0.042
2.282IlePro: 2.282 ± 0.054
1.075IleGln: 1.075 ± 0.048
2.896IleArg: 2.896 ± 0.073
2.242IleSer: 2.242 ± 0.065
2.764IleThr: 2.764 ± 0.073
3.285IleVal: 3.285 ± 0.084
0.467IleTrp: 0.467 ± 0.029
0.74IleTyr: 0.74 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.579LysAla: 2.579 ± 0.085
0.071LysCys: 0.071 ± 0.01
1.411LysAsp: 1.411 ± 0.056
1.262LysGlu: 1.262 ± 0.05
0.484LysPhe: 0.484 ± 0.028
1.581LysGly: 1.581 ± 0.059
0.476LysHis: 0.476 ± 0.03
1.083LysIle: 1.083 ± 0.049
0.916LysLys: 0.916 ± 0.054
1.853LysLeu: 1.853 ± 0.063
0.427LysMet: 0.427 ± 0.03
0.566LysAsn: 0.566 ± 0.032
1.143LysPro: 1.143 ± 0.055
0.664LysGln: 0.664 ± 0.036
1.333LysArg: 1.333 ± 0.059
1.044LysSer: 1.044 ± 0.056
1.428LysThr: 1.428 ± 0.057
1.73LysVal: 1.73 ± 0.057
0.18LysTrp: 0.18 ± 0.015
0.481LysTyr: 0.481 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
14.054LeuAla: 14.054 ± 0.185
0.713LeuCys: 0.713 ± 0.035
6.158LeuAsp: 6.158 ± 0.099
5.979LeuGlu: 5.979 ± 0.11
2.733LeuPhe: 2.733 ± 0.079
9.836LeuGly: 9.836 ± 0.165
2.029LeuHis: 2.029 ± 0.058
4.306LeuIle: 4.306 ± 0.11
1.994LeuLys: 1.994 ± 0.068
10.915LeuLeu: 10.915 ± 0.221
2.027LeuMet: 2.027 ± 0.058
1.934LeuAsn: 1.934 ± 0.066
5.941LeuPro: 5.941 ± 0.101
2.495LeuGln: 2.495 ± 0.072
8.233LeuArg: 8.233 ± 0.128
5.752LeuSer: 5.752 ± 0.098
6.169LeuThr: 6.169 ± 0.088
8.524LeuVal: 8.524 ± 0.137
1.298LeuTrp: 1.298 ± 0.05
1.724LeuTyr: 1.724 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.465MetAla: 2.465 ± 0.069
0.127MetCys: 0.127 ± 0.016
1.083MetAsp: 1.083 ± 0.046
0.841MetGlu: 0.841 ± 0.041
0.555MetPhe: 0.555 ± 0.031
1.626MetGly: 1.626 ± 0.049
0.364MetHis: 0.364 ± 0.024
1.044MetIle: 1.044 ± 0.043
0.46MetLys: 0.46 ± 0.028
2.056MetLeu: 2.056 ± 0.055
0.419MetMet: 0.419 ± 0.026
0.476MetAsn: 0.476 ± 0.024
1.123MetPro: 1.123 ± 0.038
0.553MetGln: 0.553 ± 0.026
1.452MetArg: 1.452 ± 0.054
1.591MetSer: 1.591 ± 0.045
1.453MetThr: 1.453 ± 0.049
1.52MetVal: 1.52 ± 0.055
0.164MetTrp: 0.164 ± 0.015
0.308MetTyr: 0.308 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.094AsnAla: 2.094 ± 0.068
0.103AsnCys: 0.103 ± 0.014
0.895AsnAsp: 0.895 ± 0.039
0.848AsnGlu: 0.848 ± 0.04
0.544AsnPhe: 0.544 ± 0.031
1.539AsnGly: 1.539 ± 0.056
0.392AsnHis: 0.392 ± 0.026
0.862AsnIle: 0.862 ± 0.038
0.34AsnLys: 0.34 ± 0.025
1.89AsnLeu: 1.89 ± 0.053
0.326AsnMet: 0.326 ± 0.025
0.368AsnAsn: 0.368 ± 0.023
1.466AsnPro: 1.466 ± 0.054
0.525AsnGln: 0.525 ± 0.028
1.314AsnArg: 1.314 ± 0.046
0.862AsnSer: 0.862 ± 0.044
1.063AsnThr: 1.063 ± 0.046
1.314AsnVal: 1.314 ± 0.046
0.251AsnTrp: 0.251 ± 0.021
0.422AsnTyr: 0.422 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
7.901ProAla: 7.901 ± 0.148
0.255ProCys: 0.255 ± 0.019
3.715ProAsp: 3.715 ± 0.102
5.571ProGlu: 5.571 ± 0.113
1.4ProPhe: 1.4 ± 0.049
5.878ProGly: 5.878 ± 0.126
1.221ProHis: 1.221 ± 0.045
1.605ProIle: 1.605 ± 0.051
1.061ProLys: 1.061 ± 0.046
4.861ProLeu: 4.861 ± 0.102
1.003ProMet: 1.003 ± 0.039
0.889ProAsn: 0.889 ± 0.038
1.895ProPro: 1.895 ± 0.062
2.323ProGln: 2.323 ± 0.066
4.034ProArg: 4.034 ± 0.095
2.913ProSer: 2.913 ± 0.071
3.168ProThr: 3.168 ± 0.088
5.092ProVal: 5.092 ± 0.106
0.852ProTrp: 0.852 ± 0.035
0.998ProTyr: 0.998 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.55GlnAla: 4.55 ± 0.092
0.133GlnCys: 0.133 ± 0.016
2.012GlnAsp: 2.012 ± 0.062
2.307GlnGlu: 2.307 ± 0.057
0.742GlnPhe: 0.742 ± 0.036
2.524GlnGly: 2.524 ± 0.067
0.765GlnHis: 0.765 ± 0.035
1.668GlnIle: 1.668 ± 0.057
0.852GlnLys: 0.852 ± 0.048
3.682GlnLeu: 3.682 ± 0.093
0.678GlnMet: 0.678 ± 0.033
0.615GlnAsn: 0.615 ± 0.035
1.847GlnPro: 1.847 ± 0.057
1.555GlnGln: 1.555 ± 0.06
3.262GlnArg: 3.262 ± 0.076
1.355GlnSer: 1.355 ± 0.051
2.016GlnThr: 2.016 ± 0.064
2.715GlnVal: 2.715 ± 0.062
0.498GlnTrp: 0.498 ± 0.026
0.59GlnTyr: 0.59 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
9.609ArgAla: 9.609 ± 0.139
0.476ArgCys: 0.476 ± 0.028
4.199ArgAsp: 4.199 ± 0.089
5.986ArgGlu: 5.986 ± 0.121
2.323ArgPhe: 2.323 ± 0.057
5.998ArgGly: 5.998 ± 0.117
1.649ArgHis: 1.649 ± 0.06
3.895ArgIle: 3.895 ± 0.073
1.469ArgLys: 1.469 ± 0.052
7.996ArgLeu: 7.996 ± 0.133
1.798ArgMet: 1.798 ± 0.063
1.24ArgAsn: 1.24 ± 0.045
4.33ArgPro: 4.33 ± 0.092
2.527ArgGln: 2.527 ± 0.065
8.285ArgArg: 8.285 ± 0.165
3.908ArgSer: 3.908 ± 0.077
5.084ArgThr: 5.084 ± 0.104
5.902ArgVal: 5.902 ± 0.114
1.433ArgTrp: 1.433 ± 0.048
1.581ArgTyr: 1.581 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
7.066SerAla: 7.066 ± 0.119
0.331SerCys: 0.331 ± 0.023
2.363SerAsp: 2.363 ± 0.071
2.818SerGlu: 2.818 ± 0.067
1.697SerPhe: 1.697 ± 0.054
5.642SerGly: 5.642 ± 0.104
0.992SerHis: 0.992 ± 0.041
1.877SerIle: 1.877 ± 0.049
0.935SerLys: 0.935 ± 0.042
5.015SerLeu: 5.015 ± 0.079
1.218SerMet: 1.218 ± 0.042
0.846SerAsn: 0.846 ± 0.037
3.296SerPro: 3.296 ± 0.075
1.588SerGln: 1.588 ± 0.05
3.862SerArg: 3.862 ± 0.087
3.379SerSer: 3.379 ± 0.108
3.286SerThr: 3.286 ± 0.085
4.257SerVal: 4.257 ± 0.104
0.941SerTrp: 0.941 ± 0.044
1.207SerTyr: 1.207 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
7.395ThrAla: 7.395 ± 0.131
0.345ThrCys: 0.345 ± 0.023
3.16ThrAsp: 3.16 ± 0.076
3.37ThrGlu: 3.37 ± 0.072
1.531ThrPhe: 1.531 ± 0.054
6.37ThrGly: 6.37 ± 0.123
1.12ThrHis: 1.12 ± 0.037
2.026ThrIle: 2.026 ± 0.062
1.029ThrLys: 1.029 ± 0.048
5.459ThrLeu: 5.459 ± 0.1
1.039ThrMet: 1.039 ± 0.038
0.949ThrAsn: 0.949 ± 0.04
3.746ThrPro: 3.746 ± 0.085
1.681ThrGln: 1.681 ± 0.063
4.203ThrArg: 4.203 ± 0.084
2.858ThrSer: 2.858 ± 0.073
3.152ThrThr: 3.152 ± 0.088
5.268ThrVal: 5.268 ± 0.103
0.816ThrTrp: 0.816 ± 0.038
1.205ThrTyr: 1.205 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
9.624ValAla: 9.624 ± 0.126
0.652ValCys: 0.652 ± 0.037
4.792ValAsp: 4.792 ± 0.093
4.684ValGlu: 4.684 ± 0.085
2.573ValPhe: 2.573 ± 0.075
6.723ValGly: 6.723 ± 0.109
1.785ValHis: 1.785 ± 0.055
3.958ValIle: 3.958 ± 0.091
1.599ValLys: 1.599 ± 0.063
9.779ValLeu: 9.779 ± 0.143
1.664ValMet: 1.664 ± 0.051
1.562ValAsn: 1.562 ± 0.053
4.613ValPro: 4.613 ± 0.09
2.478ValGln: 2.478 ± 0.063
6.507ValArg: 6.507 ± 0.1
4.613ValSer: 4.613 ± 0.095
4.618ValThr: 4.618 ± 0.088
7.607ValVal: 7.607 ± 0.14
1.063ValTrp: 1.063 ± 0.044
1.488ValTyr: 1.488 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.692TrpAla: 1.692 ± 0.049
0.122TrpCys: 0.122 ± 0.014
0.715TrpAsp: 0.715 ± 0.033
0.84TrpGlu: 0.84 ± 0.04
0.576TrpPhe: 0.576 ± 0.032
1.156TrpGly: 1.156 ± 0.043
0.3TrpHis: 0.3 ± 0.022
0.72TrpIle: 0.72 ± 0.04
0.323TrpLys: 0.323 ± 0.021
1.703TrpLeu: 1.703 ± 0.06
0.312TrpMet: 0.312 ± 0.024
0.346TrpAsn: 0.346 ± 0.027
0.615TrpPro: 0.615 ± 0.034
0.49TrpGln: 0.49 ± 0.027
1.14TrpArg: 1.14 ± 0.043
0.838TrpSer: 0.838 ± 0.041
0.878TrpThr: 0.878 ± 0.039
1.178TrpVal: 1.178 ± 0.043
0.312TrpTrp: 0.312 ± 0.023
0.308TrpTyr: 0.308 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.404TyrAla: 2.404 ± 0.06
0.145TyrCys: 0.145 ± 0.015
1.36TyrAsp: 1.36 ± 0.051
1.113TyrGlu: 1.113 ± 0.05
0.634TyrPhe: 0.634 ± 0.03
1.977TyrGly: 1.977 ± 0.059
0.381TyrHis: 0.381 ± 0.028
0.582TyrIle: 0.582 ± 0.029
0.357TyrLys: 0.357 ± 0.023
2.154TyrLeu: 2.154 ± 0.057
0.299TyrMet: 0.299 ± 0.023
0.392TyrAsn: 0.392 ± 0.028
1.052TyrPro: 1.052 ± 0.04
0.609TyrGln: 0.609 ± 0.03
1.795TyrArg: 1.795 ± 0.06
1.055TyrSer: 1.055 ± 0.041
1.135TyrThr: 1.135 ± 0.044
1.534TyrVal: 1.534 ± 0.054
0.293TyrTrp: 0.293 ± 0.022
0.478TyrTyr: 0.478 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1872 proteins (632351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski