Amino acid dipepetide frequency for Streptococcus phage 33888

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.721AlaAla: 3.721 ± 0.927
0.465AlaCys: 0.465 ± 0.193
4.093AlaAsp: 4.093 ± 0.655
5.582AlaGlu: 5.582 ± 0.773
2.605AlaPhe: 2.605 ± 0.781
5.117AlaGly: 5.117 ± 0.985
0.558AlaHis: 0.558 ± 0.21
6.419AlaIle: 6.419 ± 1.26
5.489AlaLys: 5.489 ± 0.747
6.047AlaLeu: 6.047 ± 1.098
2.326AlaMet: 2.326 ± 0.57
3.535AlaAsn: 3.535 ± 0.576
1.768AlaPro: 1.768 ± 0.434
3.163AlaGln: 3.163 ± 0.518
2.884AlaArg: 2.884 ± 0.685
4.186AlaSer: 4.186 ± 0.96
3.907AlaThr: 3.907 ± 1.043
4.186AlaVal: 4.186 ± 0.703
0.558AlaTrp: 0.558 ± 0.243
2.605AlaTyr: 2.605 ± 0.49
0.0AlaXaa: 0.0 ± 0.0
Cys
0.372CysAla: 0.372 ± 0.17
0.093CysCys: 0.093 ± 0.09
0.465CysAsp: 0.465 ± 0.186
0.279CysGlu: 0.279 ± 0.159
0.279CysPhe: 0.279 ± 0.182
0.651CysGly: 0.651 ± 0.294
0.093CysHis: 0.093 ± 0.096
0.093CysIle: 0.093 ± 0.092
0.465CysLys: 0.465 ± 0.236
0.186CysLeu: 0.186 ± 0.14
0.279CysMet: 0.279 ± 0.184
0.093CysAsn: 0.093 ± 0.1
0.093CysPro: 0.093 ± 0.105
0.279CysGln: 0.279 ± 0.157
0.279CysArg: 0.279 ± 0.182
0.279CysSer: 0.279 ± 0.146
0.186CysThr: 0.186 ± 0.142
0.093CysVal: 0.093 ± 0.106
0.0CysTrp: 0.0 ± 0.0
0.372CysTyr: 0.372 ± 0.192
0.0CysXaa: 0.0 ± 0.0
Asp
3.442AspAla: 3.442 ± 0.912
0.372AspCys: 0.372 ± 0.231
4.559AspAsp: 4.559 ± 0.836
5.861AspGlu: 5.861 ± 0.694
3.07AspPhe: 3.07 ± 0.694
4.838AspGly: 4.838 ± 0.989
1.023AspHis: 1.023 ± 0.243
4.372AspIle: 4.372 ± 0.651
5.675AspLys: 5.675 ± 0.926
5.21AspLeu: 5.21 ± 0.728
2.419AspMet: 2.419 ± 0.508
3.07AspAsn: 3.07 ± 0.501
2.047AspPro: 2.047 ± 0.769
0.744AspGln: 0.744 ± 0.303
2.419AspArg: 2.419 ± 0.596
4.0AspSer: 4.0 ± 0.531
4.372AspThr: 4.372 ± 0.752
3.814AspVal: 3.814 ± 0.471
0.651AspTrp: 0.651 ± 0.301
4.093AspTyr: 4.093 ± 0.679
0.0AspXaa: 0.0 ± 0.0
Glu
4.372GluAla: 4.372 ± 0.709
0.279GluCys: 0.279 ± 0.172
4.931GluAsp: 4.931 ± 0.962
5.768GluGlu: 5.768 ± 1.001
2.791GluPhe: 2.791 ± 0.571
3.442GluGly: 3.442 ± 0.442
0.93GluHis: 0.93 ± 0.299
6.233GluIle: 6.233 ± 0.857
6.791GluLys: 6.791 ± 1.177
7.35GluLeu: 7.35 ± 1.026
1.861GluMet: 1.861 ± 0.403
4.931GluAsn: 4.931 ± 0.954
1.582GluPro: 1.582 ± 0.421
3.721GluGln: 3.721 ± 0.662
4.931GluArg: 4.931 ± 0.683
3.721GluSer: 3.721 ± 0.628
3.07GluThr: 3.07 ± 0.592
5.024GluVal: 5.024 ± 0.672
0.651GluTrp: 0.651 ± 0.229
2.791GluTyr: 2.791 ± 0.543
0.0GluXaa: 0.0 ± 0.0
Phe
2.791PheAla: 2.791 ± 0.62
0.279PheCys: 0.279 ± 0.155
4.559PheAsp: 4.559 ± 0.759
4.372PheGlu: 4.372 ± 0.766
1.489PhePhe: 1.489 ± 0.397
2.698PheGly: 2.698 ± 0.504
0.093PheHis: 0.093 ± 0.097
3.07PheIle: 3.07 ± 0.673
3.256PheLys: 3.256 ± 0.741
3.349PheLeu: 3.349 ± 0.505
0.93PheMet: 0.93 ± 0.251
2.419PheAsn: 2.419 ± 0.482
0.372PhePro: 0.372 ± 0.204
1.489PheGln: 1.489 ± 0.323
1.116PheArg: 1.116 ± 0.327
2.326PheSer: 2.326 ± 0.466
1.954PheThr: 1.954 ± 0.439
2.605PheVal: 2.605 ± 0.469
0.372PheTrp: 0.372 ± 0.187
1.954PheTyr: 1.954 ± 0.508
0.0PheXaa: 0.0 ± 0.0
Gly
4.279GlyAla: 4.279 ± 0.854
0.186GlyCys: 0.186 ± 0.146
3.721GlyAsp: 3.721 ± 0.702
3.814GlyGlu: 3.814 ± 0.559
2.977GlyPhe: 2.977 ± 0.492
2.884GlyGly: 2.884 ± 0.562
0.93GlyHis: 0.93 ± 0.235
5.954GlyIle: 5.954 ± 0.904
4.279GlyLys: 4.279 ± 0.548
5.954GlyLeu: 5.954 ± 0.978
1.768GlyMet: 1.768 ± 0.444
4.559GlyAsn: 4.559 ± 0.564
0.837GlyPro: 0.837 ± 0.339
3.256GlyGln: 3.256 ± 0.732
2.791GlyArg: 2.791 ± 0.485
3.442GlySer: 3.442 ± 0.773
2.791GlyThr: 2.791 ± 0.437
4.745GlyVal: 4.745 ± 0.788
1.675GlyTrp: 1.675 ± 0.612
2.512GlyTyr: 2.512 ± 0.562
0.0GlyXaa: 0.0 ± 0.0
His
0.558HisAla: 0.558 ± 0.212
0.093HisCys: 0.093 ± 0.1
0.93HisAsp: 0.93 ± 0.266
1.023HisGlu: 1.023 ± 0.334
0.837HisPhe: 0.837 ± 0.272
0.651HisGly: 0.651 ± 0.309
0.465HisHis: 0.465 ± 0.229
0.744HisIle: 0.744 ± 0.298
0.93HisLys: 0.93 ± 0.294
1.023HisLeu: 1.023 ± 0.326
0.093HisMet: 0.093 ± 0.092
0.651HisAsn: 0.651 ± 0.234
0.744HisPro: 0.744 ± 0.222
0.837HisGln: 0.837 ± 0.277
0.744HisArg: 0.744 ± 0.285
0.744HisSer: 0.744 ± 0.33
1.023HisThr: 1.023 ± 0.333
1.023HisVal: 1.023 ± 0.278
0.279HisTrp: 0.279 ± 0.151
0.279HisTyr: 0.279 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
5.954IleAla: 5.954 ± 1.212
0.372IleCys: 0.372 ± 0.214
5.954IleAsp: 5.954 ± 0.562
6.14IleGlu: 6.14 ± 0.892
2.791IlePhe: 2.791 ± 0.627
4.652IleGly: 4.652 ± 0.791
0.93IleHis: 0.93 ± 0.335
4.838IleIle: 4.838 ± 0.755
7.07IleLys: 7.07 ± 0.834
4.0IleLeu: 4.0 ± 0.657
1.768IleMet: 1.768 ± 0.478
4.931IleAsn: 4.931 ± 0.745
2.14IlePro: 2.14 ± 0.38
3.256IleGln: 3.256 ± 0.659
3.349IleArg: 3.349 ± 0.539
5.396IleSer: 5.396 ± 0.717
4.279IleThr: 4.279 ± 0.65
4.838IleVal: 4.838 ± 0.756
0.372IleTrp: 0.372 ± 0.18
1.954IleTyr: 1.954 ± 0.373
0.0IleXaa: 0.0 ± 0.0
Lys
6.233LysAla: 6.233 ± 1.061
0.279LysCys: 0.279 ± 0.191
4.186LysAsp: 4.186 ± 0.572
6.047LysGlu: 6.047 ± 0.869
2.977LysPhe: 2.977 ± 0.459
4.745LysGly: 4.745 ± 0.715
0.93LysHis: 0.93 ± 0.264
5.675LysIle: 5.675 ± 0.95
7.443LysLys: 7.443 ± 1.183
6.698LysLeu: 6.698 ± 0.955
2.419LysMet: 2.419 ± 0.479
4.745LysAsn: 4.745 ± 0.537
2.512LysPro: 2.512 ± 0.525
3.628LysGln: 3.628 ± 0.885
3.349LysArg: 3.349 ± 0.575
5.303LysSer: 5.303 ± 0.702
4.745LysThr: 4.745 ± 0.739
4.838LysVal: 4.838 ± 0.721
1.023LysTrp: 1.023 ± 0.302
2.14LysTyr: 2.14 ± 0.484
0.0LysXaa: 0.0 ± 0.0
Leu
6.14LeuAla: 6.14 ± 0.667
0.279LeuCys: 0.279 ± 0.146
6.326LeuAsp: 6.326 ± 0.772
6.884LeuGlu: 6.884 ± 0.816
2.326LeuPhe: 2.326 ± 0.556
6.326LeuGly: 6.326 ± 0.783
1.116LeuHis: 1.116 ± 0.325
4.838LeuIle: 4.838 ± 0.781
7.815LeuLys: 7.815 ± 0.911
5.489LeuLeu: 5.489 ± 0.677
2.233LeuMet: 2.233 ± 0.513
3.907LeuAsn: 3.907 ± 0.566
3.163LeuPro: 3.163 ± 0.565
3.256LeuGln: 3.256 ± 0.574
4.093LeuArg: 4.093 ± 0.597
6.605LeuSer: 6.605 ± 0.737
4.931LeuThr: 4.931 ± 0.755
4.093LeuVal: 4.093 ± 0.63
0.837LeuTrp: 0.837 ± 0.378
2.326LeuTyr: 2.326 ± 0.497
0.0LeuXaa: 0.0 ± 0.0
Met
2.977MetAla: 2.977 ± 0.777
0.093MetCys: 0.093 ± 0.096
1.209MetAsp: 1.209 ± 0.306
1.675MetGlu: 1.675 ± 0.49
0.651MetPhe: 0.651 ± 0.274
1.302MetGly: 1.302 ± 0.342
0.279MetHis: 0.279 ± 0.153
2.233MetIle: 2.233 ± 0.502
2.233MetLys: 2.233 ± 0.453
2.605MetLeu: 2.605 ± 0.384
0.744MetMet: 0.744 ± 0.347
1.582MetAsn: 1.582 ± 0.384
0.651MetPro: 0.651 ± 0.274
1.675MetGln: 1.675 ± 0.349
0.93MetArg: 0.93 ± 0.34
1.954MetSer: 1.954 ± 0.405
2.233MetThr: 2.233 ± 0.416
1.302MetVal: 1.302 ± 0.373
0.651MetTrp: 0.651 ± 0.252
0.651MetTyr: 0.651 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
4.186AsnAla: 4.186 ± 0.606
0.465AsnCys: 0.465 ± 0.218
3.628AsnAsp: 3.628 ± 0.53
3.721AsnGlu: 3.721 ± 0.659
2.326AsnPhe: 2.326 ± 0.387
3.907AsnGly: 3.907 ± 0.59
0.93AsnHis: 0.93 ± 0.289
3.907AsnIle: 3.907 ± 0.709
3.907AsnLys: 3.907 ± 0.635
3.628AsnLeu: 3.628 ± 0.617
1.023AsnMet: 1.023 ± 0.255
2.605AsnAsn: 2.605 ± 0.5
2.047AsnPro: 2.047 ± 0.56
2.698AsnGln: 2.698 ± 0.513
1.861AsnArg: 1.861 ± 0.475
3.907AsnSer: 3.907 ± 0.593
2.698AsnThr: 2.698 ± 0.543
3.442AsnVal: 3.442 ± 0.561
0.837AsnTrp: 0.837 ± 0.299
1.954AsnTyr: 1.954 ± 0.576
0.0AsnXaa: 0.0 ± 0.0
Pro
1.116ProAla: 1.116 ± 0.334
0.372ProCys: 0.372 ± 0.193
2.512ProAsp: 2.512 ± 0.51
1.861ProGlu: 1.861 ± 0.368
1.675ProPhe: 1.675 ± 0.516
1.209ProGly: 1.209 ± 0.244
0.279ProHis: 0.279 ± 0.156
2.326ProIle: 2.326 ± 0.403
2.512ProLys: 2.512 ± 0.421
2.233ProLeu: 2.233 ± 0.422
0.465ProMet: 0.465 ± 0.232
1.023ProAsn: 1.023 ± 0.333
1.116ProPro: 1.116 ± 0.335
1.489ProGln: 1.489 ± 0.397
0.837ProArg: 0.837 ± 0.315
1.768ProSer: 1.768 ± 0.341
1.302ProThr: 1.302 ± 0.562
1.861ProVal: 1.861 ± 0.46
0.093ProTrp: 0.093 ± 0.078
1.395ProTyr: 1.395 ± 0.332
0.0ProXaa: 0.0 ± 0.0
Gln
4.093GlnAla: 4.093 ± 0.725
0.093GlnCys: 0.093 ± 0.091
1.861GlnAsp: 1.861 ± 0.342
3.349GlnGlu: 3.349 ± 0.714
1.209GlnPhe: 1.209 ± 0.351
2.884GlnGly: 2.884 ± 0.553
0.651GlnHis: 0.651 ± 0.268
3.814GlnIle: 3.814 ± 0.527
2.884GlnLys: 2.884 ± 0.577
4.0GlnLeu: 4.0 ± 0.516
1.023GlnMet: 1.023 ± 0.264
2.698GlnAsn: 2.698 ± 0.465
0.93GlnPro: 0.93 ± 0.315
2.698GlnGln: 2.698 ± 0.663
1.768GlnArg: 1.768 ± 0.424
3.349GlnSer: 3.349 ± 0.504
2.047GlnThr: 2.047 ± 0.397
2.977GlnVal: 2.977 ± 0.545
0.279GlnTrp: 0.279 ± 0.135
1.675GlnTyr: 1.675 ± 0.384
0.0GlnXaa: 0.0 ± 0.0
Arg
2.047ArgAla: 2.047 ± 0.455
0.186ArgCys: 0.186 ± 0.143
1.954ArgAsp: 1.954 ± 0.473
3.07ArgGlu: 3.07 ± 0.549
2.047ArgPhe: 2.047 ± 0.475
2.791ArgGly: 2.791 ± 0.538
0.651ArgHis: 0.651 ± 0.218
2.698ArgIle: 2.698 ± 0.524
3.442ArgLys: 3.442 ± 0.562
4.0ArgLeu: 4.0 ± 0.544
1.209ArgMet: 1.209 ± 0.374
2.884ArgAsn: 2.884 ± 0.51
0.744ArgPro: 0.744 ± 0.312
2.047ArgGln: 2.047 ± 0.406
1.954ArgArg: 1.954 ± 0.38
2.419ArgSer: 2.419 ± 0.524
2.14ArgThr: 2.14 ± 0.541
1.954ArgVal: 1.954 ± 0.397
0.558ArgTrp: 0.558 ± 0.354
2.605ArgTyr: 2.605 ± 0.567
0.0ArgXaa: 0.0 ± 0.0
Ser
5.024SerAla: 5.024 ± 0.964
0.186SerCys: 0.186 ± 0.129
4.652SerAsp: 4.652 ± 0.587
4.838SerGlu: 4.838 ± 0.746
3.163SerPhe: 3.163 ± 0.557
5.024SerGly: 5.024 ± 0.88
0.837SerHis: 0.837 ± 0.329
4.466SerIle: 4.466 ± 0.731
4.279SerLys: 4.279 ± 0.646
5.954SerLeu: 5.954 ± 0.825
1.954SerMet: 1.954 ± 0.536
3.256SerAsn: 3.256 ± 0.623
2.326SerPro: 2.326 ± 0.469
3.721SerGln: 3.721 ± 0.769
2.419SerArg: 2.419 ± 0.534
3.721SerSer: 3.721 ± 1.019
2.977SerThr: 2.977 ± 0.462
4.745SerVal: 4.745 ± 0.758
0.651SerTrp: 0.651 ± 0.224
1.489SerTyr: 1.489 ± 0.285
0.0SerXaa: 0.0 ± 0.0
Thr
4.372ThrAla: 4.372 ± 0.634
0.093ThrCys: 0.093 ± 0.091
3.721ThrAsp: 3.721 ± 0.496
3.256ThrGlu: 3.256 ± 0.482
3.163ThrPhe: 3.163 ± 0.554
3.814ThrGly: 3.814 ± 0.763
1.209ThrHis: 1.209 ± 0.349
5.024ThrIle: 5.024 ± 0.743
2.791ThrLys: 2.791 ± 0.465
5.117ThrLeu: 5.117 ± 0.749
2.14ThrMet: 2.14 ± 0.388
1.582ThrAsn: 1.582 ± 0.427
1.675ThrPro: 1.675 ± 0.404
2.14ThrGln: 2.14 ± 0.496
1.582ThrArg: 1.582 ± 0.406
3.628ThrSer: 3.628 ± 1.224
3.721ThrThr: 3.721 ± 0.627
3.628ThrVal: 3.628 ± 0.541
0.465ThrTrp: 0.465 ± 0.205
2.419ThrTyr: 2.419 ± 0.579
0.0ThrXaa: 0.0 ± 0.0
Val
4.838ValAla: 4.838 ± 0.815
0.372ValCys: 0.372 ± 0.194
3.628ValAsp: 3.628 ± 0.63
4.372ValGlu: 4.372 ± 0.658
1.675ValPhe: 1.675 ± 0.453
3.535ValGly: 3.535 ± 0.607
0.744ValHis: 0.744 ± 0.243
4.279ValIle: 4.279 ± 0.647
5.024ValLys: 5.024 ± 0.752
4.186ValLeu: 4.186 ± 0.683
1.768ValMet: 1.768 ± 0.392
2.791ValAsn: 2.791 ± 0.483
1.675ValPro: 1.675 ± 0.399
1.861ValGln: 1.861 ± 0.499
1.954ValArg: 1.954 ± 0.438
5.954ValSer: 5.954 ± 0.91
4.466ValThr: 4.466 ± 0.628
5.489ValVal: 5.489 ± 0.577
0.93ValTrp: 0.93 ± 0.31
2.884ValTyr: 2.884 ± 0.639
0.0ValXaa: 0.0 ± 0.0
Trp
0.744TrpAla: 0.744 ± 0.238
0.093TrpCys: 0.093 ± 0.092
0.744TrpAsp: 0.744 ± 0.277
0.279TrpGlu: 0.279 ± 0.17
1.023TrpPhe: 1.023 ± 0.362
0.651TrpGly: 0.651 ± 0.242
0.372TrpHis: 0.372 ± 0.216
0.651TrpIle: 0.651 ± 0.255
0.651TrpLys: 0.651 ± 0.259
1.582TrpLeu: 1.582 ± 0.438
0.372TrpMet: 0.372 ± 0.211
0.651TrpAsn: 0.651 ± 0.22
0.0TrpPro: 0.0 ± 0.0
0.651TrpGln: 0.651 ± 0.27
0.651TrpArg: 0.651 ± 0.289
0.558TrpSer: 0.558 ± 0.226
0.837TrpThr: 0.837 ± 0.325
0.372TrpVal: 0.372 ± 0.199
0.279TrpTrp: 0.279 ± 0.204
0.651TrpTyr: 0.651 ± 0.343
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.954TyrAla: 1.954 ± 0.599
0.279TyrCys: 0.279 ± 0.171
2.419TyrAsp: 2.419 ± 0.443
3.07TyrGlu: 3.07 ± 0.669
2.419TyrPhe: 2.419 ± 0.673
2.233TyrGly: 2.233 ± 0.543
0.651TyrHis: 0.651 ± 0.275
3.349TyrIle: 3.349 ± 0.603
2.977TyrLys: 2.977 ± 0.631
4.372TyrLeu: 4.372 ± 0.839
0.744TyrMet: 0.744 ± 0.257
1.768TyrAsn: 1.768 ± 0.442
1.023TyrPro: 1.023 ± 0.347
1.675TyrGln: 1.675 ± 0.585
1.489TyrArg: 1.489 ± 0.526
2.419TyrSer: 2.419 ± 0.387
1.861TyrThr: 1.861 ± 0.441
1.395TyrVal: 1.395 ± 0.348
0.651TyrTrp: 0.651 ± 0.261
1.582TyrTyr: 1.582 ± 0.543
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (10750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski