Amino acid dipepetide frequency for Paenibacillus rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.729AlaAla: 9.729 ± 0.102	0.735AlaCys: 0.735 ± 0.019	4.596AlaAsp: 4.596 ± 0.05	5.772AlaGlu: 5.772 ± 0.059	3.478AlaPhe: 3.478 ± 0.041	7.51AlaGly: 7.51 ± 0.068	1.428AlaHis: 1.428 ± 0.029	4.77AlaIle: 4.77 ± 0.048	4.24AlaLys: 4.24 ± 0.049	8.171AlaLeu: 8.171 ± 0.06	2.348AlaMet: 2.348 ± 0.038	2.469AlaAsn: 2.469 ± 0.041	2.851AlaPro: 2.851 ± 0.039	2.699AlaGln: 2.699 ± 0.035	3.607AlaArg: 3.607 ± 0.043	5.321AlaSer: 5.321 ± 0.055	3.219AlaThr: 3.219 ± 0.04	6.936AlaVal: 6.936 ± 0.067	1.064AlaTrp: 1.064 ± 0.023	2.82AlaTyr: 2.82 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.52CysAla: 0.52 ± 0.016	0.122CysCys: 0.122 ± 0.008	0.366CysAsp: 0.366 ± 0.013	0.407CysGlu: 0.407 ± 0.015	0.31CysPhe: 0.31 ± 0.012	0.785CysGly: 0.785 ± 0.02	0.194CysHis: 0.194 ± 0.009	0.505CysIle: 0.505 ± 0.014	0.279CysLys: 0.279 ± 0.01	0.759CysLeu: 0.759 ± 0.018	0.2CysMet: 0.2 ± 0.009	0.216CysAsn: 0.216 ± 0.009	0.352CysPro: 0.352 ± 0.015	0.224CysGln: 0.224 ± 0.011	0.497CysArg: 0.497 ± 0.016	0.57CysSer: 0.57 ± 0.015	0.433CysThr: 0.433 ± 0.016	0.455CysVal: 0.455 ± 0.013	0.095CysTrp: 0.095 ± 0.007	0.234CysTyr: 0.234 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.219AspAla: 4.219 ± 0.044	0.381AspCys: 0.381 ± 0.014	2.482AspAsp: 2.482 ± 0.038	3.785AspGlu: 3.785 ± 0.046	2.14AspPhe: 2.14 ± 0.033	4.228AspGly: 4.228 ± 0.048	1.28AspHis: 1.28 ± 0.027	3.495AspIle: 3.495 ± 0.042	2.603AspLys: 2.603 ± 0.039	5.065AspLeu: 5.065 ± 0.059	1.496AspMet: 1.496 ± 0.028	1.694AspAsn: 1.694 ± 0.032	2.752AspPro: 2.752 ± 0.039	2.112AspGln: 2.112 ± 0.033	2.914AspArg: 2.914 ± 0.045	2.754AspSer: 2.754 ± 0.038	2.627AspThr: 2.627 ± 0.034	3.53AspVal: 3.53 ± 0.048	0.917AspTrp: 0.917 ± 0.022	2.104AspTyr: 2.104 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.195GluAla: 6.195 ± 0.057	0.374GluCys: 0.374 ± 0.014	3.298GluAsp: 3.298 ± 0.039	5.331GluGlu: 5.331 ± 0.062	2.09GluPhe: 2.09 ± 0.031	4.664GluGly: 4.664 ± 0.053	1.602GluHis: 1.602 ± 0.028	4.004GluIle: 4.004 ± 0.043	3.685GluLys: 3.685 ± 0.054	6.937GluLeu: 6.937 ± 0.063	2.064GluMet: 2.064 ± 0.035	2.273GluAsn: 2.273 ± 0.035	2.411GluPro: 2.411 ± 0.037	3.502GluGln: 3.502 ± 0.049	3.911GluArg: 3.911 ± 0.052	3.411GluSer: 3.411 ± 0.043	3.209GluThr: 3.209 ± 0.044	4.285GluVal: 4.285 ± 0.051	1.003GluTrp: 1.003 ± 0.024	2.035GluTyr: 2.035 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.258PheAla: 3.258 ± 0.041	0.367PheCys: 0.367 ± 0.012	2.24PheAsp: 2.24 ± 0.039	2.351PheGlu: 2.351 ± 0.032	1.835PhePhe: 1.835 ± 0.034	3.261PheGly: 3.261 ± 0.044	0.922PheHis: 0.922 ± 0.023	2.831PheIle: 2.831 ± 0.043	1.959PheLys: 1.959 ± 0.028	3.775PheLeu: 3.775 ± 0.05	1.212PheMet: 1.212 ± 0.029	1.518PheAsn: 1.518 ± 0.029	1.673PhePro: 1.673 ± 0.026	1.444PheGln: 1.444 ± 0.025	2.074PheArg: 2.074 ± 0.033	2.739PheSer: 2.739 ± 0.039	2.458PheThr: 2.458 ± 0.033	2.917PheVal: 2.917 ± 0.038	0.586PheTrp: 0.586 ± 0.016	1.477PheTyr: 1.477 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	5.71GlyAla: 5.71 ± 0.058	0.729GlyCys: 0.729 ± 0.019	3.687GlyAsp: 3.687 ± 0.044	4.595GlyGlu: 4.595 ± 0.054	3.268GlyPhe: 3.268 ± 0.039	6.08GlyGly: 6.08 ± 0.076	1.573GlyHis: 1.573 ± 0.029	5.746GlyIle: 5.746 ± 0.054	4.583GlyLys: 4.583 ± 0.049	7.438GlyLeu: 7.438 ± 0.066	2.518GlyMet: 2.518 ± 0.034	2.591GlyAsn: 2.591 ± 0.04	2.312GlyPro: 2.312 ± 0.034	2.908GlyGln: 2.908 ± 0.036	3.901GlyArg: 3.901 ± 0.043	5.376GlySer: 5.376 ± 0.062	4.652GlyThr: 4.652 ± 0.055	5.301GlyVal: 5.301 ± 0.044	1.199GlyTrp: 1.199 ± 0.027	3.036GlyTyr: 3.036 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.648HisAla: 1.648 ± 0.027	0.194HisCys: 0.194 ± 0.011	1.085HisAsp: 1.085 ± 0.024	1.322HisGlu: 1.322 ± 0.029	1.089HisPhe: 1.089 ± 0.025	1.635HisGly: 1.635 ± 0.031	0.674HisHis: 0.674 ± 0.021	1.432HisIle: 1.432 ± 0.026	0.815HisLys: 0.815 ± 0.018	2.233HisLeu: 2.233 ± 0.058	0.612HisMet: 0.612 ± 0.015	0.672HisAsn: 0.672 ± 0.017	1.375HisPro: 1.375 ± 0.027	0.849HisGln: 0.849 ± 0.022	1.164HisArg: 1.164 ± 0.023	1.181HisSer: 1.181 ± 0.025	1.105HisThr: 1.105 ± 0.024	1.462HisVal: 1.462 ± 0.022	0.353HisTrp: 0.353 ± 0.012	0.874HisTyr: 0.874 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.606IleAla: 5.606 ± 0.067	0.592IleCys: 0.592 ± 0.018	3.499IleAsp: 3.499 ± 0.041	3.915IleGlu: 3.915 ± 0.044	2.355IlePhe: 2.355 ± 0.043	5.248IleGly: 5.248 ± 0.055	1.535IleHis: 1.535 ± 0.027	3.93IleIle: 3.93 ± 0.055	2.7IleLys: 2.7 ± 0.037	5.823IleLeu: 5.823 ± 0.066	1.618IleMet: 1.618 ± 0.027	2.178IleAsn: 2.178 ± 0.037	3.292IlePro: 3.292 ± 0.042	2.61IleGln: 2.61 ± 0.043	3.972IleArg: 3.972 ± 0.053	4.28IleSer: 4.28 ± 0.05	3.647IleThr: 3.647 ± 0.044	4.867IleVal: 4.867 ± 0.058	0.722IleTrp: 0.722 ± 0.02	2.052IleTyr: 2.052 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.226LysAla: 4.226 ± 0.045	0.224LysCys: 0.224 ± 0.011	2.971LysAsp: 2.971 ± 0.039	4.245LysGlu: 4.245 ± 0.057	1.507LysPhe: 1.507 ± 0.03	3.65LysGly: 3.65 ± 0.039	1.111LysHis: 1.111 ± 0.023	2.848LysIle: 2.848 ± 0.04	3.125LysLys: 3.125 ± 0.047	5.07LysLeu: 5.07 ± 0.05	1.587LysMet: 1.587 ± 0.026	1.88LysAsn: 1.88 ± 0.035	2.302LysPro: 2.302 ± 0.031	2.374LysGln: 2.374 ± 0.038	2.804LysArg: 2.804 ± 0.038	2.833LysSer: 2.833 ± 0.035	2.705LysThr: 2.705 ± 0.042	3.505LysVal: 3.505 ± 0.047	0.738LysTrp: 0.738 ± 0.019	1.79LysTyr: 1.79 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	8.384LeuAla: 8.384 ± 0.076	0.818LeuCys: 0.818 ± 0.019	5.215LeuAsp: 5.215 ± 0.054	6.114LeuGlu: 6.114 ± 0.061	4.372LeuPhe: 4.372 ± 0.052	6.932LeuGly: 6.932 ± 0.067	2.196LeuHis: 2.196 ± 0.032	6.529LeuIle: 6.529 ± 0.077	5.303LeuLys: 5.303 ± 0.052	10.919LeuLeu: 10.919 ± 0.099	2.657LeuMet: 2.657 ± 0.037	3.781LeuAsn: 3.781 ± 0.041	4.654LeuPro: 4.654 ± 0.051	4.116LeuGln: 4.116 ± 0.046	4.968LeuArg: 4.968 ± 0.052	6.984LeuSer: 6.984 ± 0.065	5.686LeuThr: 5.686 ± 0.051	6.376LeuVal: 6.376 ± 0.064	1.101LeuTrp: 1.101 ± 0.026	3.229LeuTyr: 3.229 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.285MetAla: 2.285 ± 0.033	0.162MetCys: 0.162 ± 0.008	1.63MetAsp: 1.63 ± 0.03	1.874MetGlu: 1.874 ± 0.034	1.062MetPhe: 1.062 ± 0.021	1.812MetGly: 1.812 ± 0.032	0.495MetHis: 0.495 ± 0.017	2.024MetIle: 2.024 ± 0.032	2.036MetLys: 2.036 ± 0.03	3.099MetLeu: 3.099 ± 0.038	0.949MetMet: 0.949 ± 0.022	1.539MetAsn: 1.539 ± 0.025	1.194MetPro: 1.194 ± 0.024	1.063MetGln: 1.063 ± 0.023	1.326MetArg: 1.326 ± 0.025	1.858MetSer: 1.858 ± 0.029	1.767MetThr: 1.767 ± 0.033	1.85MetVal: 1.85 ± 0.028	0.257MetTrp: 0.257 ± 0.01	0.827MetTyr: 0.827 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.721AsnAla: 2.721 ± 0.033	0.227AsnCys: 0.227 ± 0.01	1.792AsnAsp: 1.792 ± 0.03	2.274AsnGlu: 2.274 ± 0.034	1.263AsnPhe: 1.263 ± 0.024	3.079AsnGly: 3.079 ± 0.046	0.84AsnHis: 0.84 ± 0.021	2.2AsnIle: 2.2 ± 0.032	1.729AsnLys: 1.729 ± 0.032	3.144AsnLeu: 3.144 ± 0.037	1.024AsnMet: 1.024 ± 0.023	1.398AsnAsn: 1.398 ± 0.028	2.053AsnPro: 2.053 ± 0.028	1.443AsnGln: 1.443 ± 0.026	2.113AsnArg: 2.113 ± 0.03	1.926AsnSer: 1.926 ± 0.034	1.948AsnThr: 1.948 ± 0.034	2.528AsnVal: 2.528 ± 0.036	0.52AsnTrp: 0.52 ± 0.016	1.289AsnTyr: 1.289 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	3.744ProAla: 3.744 ± 0.051	0.238ProCys: 0.238 ± 0.011	2.951ProAsp: 2.951 ± 0.042	3.77ProGlu: 3.77 ± 0.042	1.934ProPhe: 1.934 ± 0.029	3.501ProGly: 3.501 ± 0.043	0.964ProHis: 0.964 ± 0.024	2.313ProIle: 2.313 ± 0.034	1.892ProLys: 1.892 ± 0.029	4.174ProLeu: 4.174 ± 0.053	1.063ProMet: 1.063 ± 0.022	1.491ProAsn: 1.491 ± 0.025	1.413ProPro: 1.413 ± 0.028	1.512ProGln: 1.512 ± 0.027	1.497ProArg: 1.497 ± 0.026	2.648ProSer: 2.648 ± 0.036	1.778ProThr: 1.778 ± 0.029	3.64ProVal: 3.64 ± 0.046	0.598ProTrp: 0.598 ± 0.02	1.615ProTyr: 1.615 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.523GlnAla: 3.523 ± 0.046	0.221GlnCys: 0.221 ± 0.01	1.906GlnAsp: 1.906 ± 0.03	2.724GlnGlu: 2.724 ± 0.04	1.453GlnPhe: 1.453 ± 0.026	2.909GlnGly: 2.909 ± 0.045	0.868GlnHis: 0.868 ± 0.019	2.474GlnIle: 2.474 ± 0.038	1.974GlnLys: 1.974 ± 0.034	4.126GlnLeu: 4.126 ± 0.048	1.273GlnMet: 1.273 ± 0.026	1.295GlnAsn: 1.295 ± 0.027	1.675GlnPro: 1.675 ± 0.032	1.94GlnGln: 1.94 ± 0.034	1.977GlnArg: 1.977 ± 0.034	2.283GlnSer: 2.283 ± 0.029	2.052GlnThr: 2.052 ± 0.026	2.648GlnVal: 2.648 ± 0.033	0.564GlnTrp: 0.564 ± 0.014	1.344GlnTyr: 1.344 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.343ArgAla: 3.343 ± 0.044	0.348ArgCys: 0.348 ± 0.016	2.57ArgAsp: 2.57 ± 0.037	3.91ArgGlu: 3.91 ± 0.058	2.301ArgPhe: 2.301 ± 0.033	3.019ArgGly: 3.019 ± 0.038	1.156ArgHis: 1.156 ± 0.024	3.811ArgIle: 3.811 ± 0.046	2.997ArgLys: 2.997 ± 0.041	5.585ArgLeu: 5.585 ± 0.053	1.777ArgMet: 1.777 ± 0.03	1.912ArgAsn: 1.912 ± 0.03	1.831ArgPro: 1.831 ± 0.03	2.193ArgGln: 2.193 ± 0.032	3.014ArgArg: 3.014 ± 0.041	3.324ArgSer: 3.324 ± 0.037	2.721ArgThr: 2.721 ± 0.039	3.281ArgVal: 3.281 ± 0.04	0.752ArgTrp: 0.752 ± 0.019	1.971ArgTyr: 1.971 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.1SerAla: 5.1 ± 0.054	0.427SerCys: 0.427 ± 0.015	3.064SerAsp: 3.064 ± 0.04	3.633SerGlu: 3.633 ± 0.044	2.885SerPhe: 2.885 ± 0.033	5.846SerGly: 5.846 ± 0.062	1.274SerHis: 1.274 ± 0.026	4.105SerIle: 4.105 ± 0.05	3.098SerLys: 3.098 ± 0.038	6.446SerLeu: 6.446 ± 0.056	1.858SerMet: 1.858 ± 0.029	1.941SerAsn: 1.941 ± 0.037	2.655SerPro: 2.655 ± 0.038	2.073SerGln: 2.073 ± 0.029	3.381SerArg: 3.381 ± 0.043	4.271SerSer: 4.271 ± 0.05	3.115SerThr: 3.115 ± 0.035	4.551SerVal: 4.551 ± 0.05	0.878SerTrp: 0.878 ± 0.021	2.245SerTyr: 2.245 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.915ThrAla: 4.915 ± 0.054	0.33ThrCys: 0.33 ± 0.012	2.871ThrAsp: 2.871 ± 0.042	3.09ThrGlu: 3.09 ± 0.039	2.351ThrPhe: 2.351 ± 0.04	4.778ThrGly: 4.778 ± 0.057	0.989ThrHis: 0.989 ± 0.023	3.405ThrIle: 3.405 ± 0.046	2.304ThrLys: 2.304 ± 0.037	5.379ThrLeu: 5.379 ± 0.051	1.372ThrMet: 1.372 ± 0.024	1.77ThrAsn: 1.77 ± 0.034	2.656ThrPro: 2.656 ± 0.039	1.542ThrGln: 1.542 ± 0.027	2.316ThrArg: 2.316 ± 0.031	3.253ThrSer: 3.253 ± 0.041	2.681ThrThr: 2.681 ± 0.043	4.485ThrVal: 4.485 ± 0.054	0.673ThrTrp: 0.673 ± 0.019	1.803ThrTyr: 1.803 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	4.94ValAla: 4.94 ± 0.05	0.613ValCys: 0.613 ± 0.015	3.676ValAsp: 3.676 ± 0.046	4.172ValGlu: 4.172 ± 0.05	2.946ValPhe: 2.946 ± 0.036	4.552ValGly: 4.552 ± 0.048	1.553ValHis: 1.553 ± 0.029	4.919ValIle: 4.919 ± 0.058	3.772ValLys: 3.772 ± 0.048	7.427ValLeu: 7.427 ± 0.067	2.096ValMet: 2.096 ± 0.035	2.799ValAsn: 2.799 ± 0.043	3.22ValPro: 3.22 ± 0.039	2.807ValGln: 2.807 ± 0.038	3.57ValArg: 3.57 ± 0.043	4.907ValSer: 4.907 ± 0.053	4.541ValThr: 4.541 ± 0.063	4.933ValVal: 4.933 ± 0.057	0.924ValTrp: 0.924 ± 0.023	2.459ValTyr: 2.459 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.92TrpAla: 0.92 ± 0.02	0.113TrpCys: 0.113 ± 0.007	0.739TrpAsp: 0.739 ± 0.015	0.8TrpGlu: 0.8 ± 0.02	0.581TrpPhe: 0.581 ± 0.017	0.944TrpGly: 0.944 ± 0.023	0.289TrpHis: 0.289 ± 0.012	0.995TrpIle: 0.995 ± 0.026	0.833TrpLys: 0.833 ± 0.019	1.438TrpLeu: 1.438 ± 0.028	0.472TrpMet: 0.472 ± 0.013	0.77TrpAsn: 0.77 ± 0.021	0.406TrpPro: 0.406 ± 0.016	0.526TrpGln: 0.526 ± 0.013	0.628TrpArg: 0.628 ± 0.02	0.89TrpSer: 0.89 ± 0.024	0.751TrpThr: 0.751 ± 0.021	0.907TrpVal: 0.907 ± 0.021	0.228TrpTrp: 0.228 ± 0.01	0.439TrpTyr: 0.439 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.776TyrAla: 2.776 ± 0.041	0.311TyrCys: 0.311 ± 0.013	1.937TyrAsp: 1.937 ± 0.029	2.204TyrGlu: 2.204 ± 0.036	1.679TyrPhe: 1.679 ± 0.025	2.77TyrGly: 2.77 ± 0.042	0.831TyrHis: 0.831 ± 0.022	2.103TyrIle: 2.103 ± 0.031	1.568TyrLys: 1.568 ± 0.029	3.324TyrLeu: 3.324 ± 0.043	0.909TyrMet: 0.909 ± 0.02	1.322TyrAsn: 1.322 ± 0.029	1.66TyrPro: 1.66 ± 0.033	1.292TyrGln: 1.292 ± 0.024	2.183TyrArg: 2.183 ± 0.031	2.04TyrSer: 2.04 ± 0.032	1.867TyrThr: 1.867 ± 0.029	2.368TyrVal: 2.368 ± 0.034	0.5TyrTrp: 0.5 ± 0.016	1.366TyrTyr: 1.366 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6961 proteins (2180809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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