Amino acid dipepetide frequency for Microvirgula aerodenitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.64AlaAla: 16.64 ± 0.192	1.482AlaCys: 1.482 ± 0.042	7.539AlaAsp: 7.539 ± 0.085	6.239AlaGlu: 6.239 ± 0.1	3.945AlaPhe: 3.945 ± 0.064	11.624AlaGly: 11.624 ± 0.13	2.308AlaHis: 2.308 ± 0.044	5.487AlaIle: 5.487 ± 0.077	2.462AlaLys: 2.462 ± 0.063	14.387AlaLeu: 14.387 ± 0.16	3.199AlaMet: 3.199 ± 0.054	2.705AlaAsn: 2.705 ± 0.057	5.29AlaPro: 5.29 ± 0.085	4.315AlaGln: 4.315 ± 0.077	9.624AlaArg: 9.624 ± 0.129	6.79AlaSer: 6.79 ± 0.101	5.85AlaThr: 5.85 ± 0.087	8.511AlaVal: 8.511 ± 0.103	1.619AlaTrp: 1.619 ± 0.043	2.371AlaTyr: 2.371 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.113CysAla: 1.113 ± 0.029	0.157CysCys: 0.157 ± 0.012	0.525CysAsp: 0.525 ± 0.019	0.46CysGlu: 0.46 ± 0.02	0.326CysPhe: 0.326 ± 0.019	0.985CysGly: 0.985 ± 0.031	0.331CysHis: 0.331 ± 0.017	0.373CysIle: 0.373 ± 0.02	0.226CysLys: 0.226 ± 0.014	1.049CysLeu: 1.049 ± 0.03	0.199CysMet: 0.199 ± 0.013	0.251CysAsn: 0.251 ± 0.015	0.584CysPro: 0.584 ± 0.024	0.307CysGln: 0.307 ± 0.017	0.874CysArg: 0.874 ± 0.031	0.55CysSer: 0.55 ± 0.022	0.471CysThr: 0.471 ± 0.02	0.716CysVal: 0.716 ± 0.025	0.183CysTrp: 0.183 ± 0.013	0.289CysTyr: 0.289 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.367AspAla: 7.367 ± 0.102	0.573AspCys: 0.573 ± 0.023	3.521AspAsp: 3.521 ± 0.068	3.283AspGlu: 3.283 ± 0.056	2.132AspPhe: 2.132 ± 0.036	5.779AspGly: 5.779 ± 0.105	1.15AspHis: 1.15 ± 0.036	3.019AspIle: 3.019 ± 0.052	1.77AspLys: 1.77 ± 0.049	5.305AspLeu: 5.305 ± 0.069	1.401AspMet: 1.401 ± 0.036	1.512AspAsn: 1.512 ± 0.042	3.159AspPro: 3.159 ± 0.07	1.721AspGln: 1.721 ± 0.039	3.953AspArg: 3.953 ± 0.058	3.082AspSer: 3.082 ± 0.054	3.0AspThr: 3.0 ± 0.053	3.966AspVal: 3.966 ± 0.055	1.131AspTrp: 1.131 ± 0.033	1.746AspTyr: 1.746 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.234GluAla: 6.234 ± 0.086	0.434GluCys: 0.434 ± 0.02	2.008GluAsp: 2.008 ± 0.041	2.057GluGlu: 2.057 ± 0.049	1.523GluPhe: 1.523 ± 0.037	2.913GluGly: 2.913 ± 0.055	1.279GluHis: 1.279 ± 0.033	2.789GluIle: 2.789 ± 0.054	1.742GluLys: 1.742 ± 0.047	5.731GluLeu: 5.731 ± 0.088	1.139GluMet: 1.139 ± 0.032	1.334GluAsn: 1.334 ± 0.031	2.333GluPro: 2.333 ± 0.054	2.675GluGln: 2.675 ± 0.06	4.587GluArg: 4.587 ± 0.083	2.414GluSer: 2.414 ± 0.05	2.661GluThr: 2.661 ± 0.056	3.523GluVal: 3.523 ± 0.061	0.708GluTrp: 0.708 ± 0.026	1.126GluTyr: 1.126 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.15PheAla: 4.15 ± 0.066	0.404PheCys: 0.404 ± 0.02	2.546PheAsp: 2.546 ± 0.053	1.701PheGlu: 1.701 ± 0.037	1.263PhePhe: 1.263 ± 0.041	3.22PheGly: 3.22 ± 0.048	0.787PheHis: 0.787 ± 0.026	1.64PheIle: 1.64 ± 0.037	0.902PheLys: 0.902 ± 0.03	3.159PheLeu: 3.159 ± 0.059	0.809PheMet: 0.809 ± 0.028	1.187PheAsn: 1.187 ± 0.038	1.513PhePro: 1.513 ± 0.039	0.935PheGln: 0.935 ± 0.03	2.183PheArg: 2.183 ± 0.042	2.411PheSer: 2.411 ± 0.055	1.761PheThr: 1.761 ± 0.038	2.629PheVal: 2.629 ± 0.054	0.529PheTrp: 0.529 ± 0.027	0.931PheTyr: 0.931 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.922GlyAla: 7.922 ± 0.099	0.968GlyCys: 0.968 ± 0.033	4.528GlyAsp: 4.528 ± 0.077	4.571GlyGlu: 4.571 ± 0.075	3.375GlyPhe: 3.375 ± 0.07	6.65GlyGly: 6.65 ± 0.124	2.112GlyHis: 2.112 ± 0.051	4.275GlyIle: 4.275 ± 0.072	3.436GlyLys: 3.436 ± 0.062	9.141GlyLeu: 9.141 ± 0.099	2.436GlyMet: 2.436 ± 0.047	2.508GlyAsn: 2.508 ± 0.061	2.686GlyPro: 2.686 ± 0.058	3.517GlyGln: 3.517 ± 0.069	6.127GlyArg: 6.127 ± 0.108	4.662GlySer: 4.662 ± 0.073	4.095GlyThr: 4.095 ± 0.077	6.167GlyVal: 6.167 ± 0.078	1.454GlyTrp: 1.454 ± 0.033	2.413GlyTyr: 2.413 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.823HisAla: 2.823 ± 0.055	0.297HisCys: 0.297 ± 0.016	1.487HisAsp: 1.487 ± 0.052	1.039HisGlu: 1.039 ± 0.031	0.956HisPhe: 0.956 ± 0.031	2.294HisGly: 2.294 ± 0.046	0.643HisHis: 0.643 ± 0.029	1.043HisIle: 1.043 ± 0.03	0.526HisLys: 0.526 ± 0.023	2.094HisLeu: 2.094 ± 0.042	0.45HisMet: 0.45 ± 0.02	0.526HisAsn: 0.526 ± 0.019	1.514HisPro: 1.514 ± 0.04	0.76HisGln: 0.76 ± 0.026	1.495HisArg: 1.495 ± 0.035	1.136HisSer: 1.136 ± 0.033	1.02HisThr: 1.02 ± 0.03	1.557HisVal: 1.557 ± 0.038	0.383HisTrp: 0.383 ± 0.017	0.723HisTyr: 0.723 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.191IleAla: 6.191 ± 0.079	0.422IleCys: 0.422 ± 0.019	3.755IleAsp: 3.755 ± 0.067	3.134IleGlu: 3.134 ± 0.052	1.168IlePhe: 1.168 ± 0.04	4.626IleGly: 4.626 ± 0.073	1.008IleHis: 1.008 ± 0.028	1.763IleIle: 1.763 ± 0.048	1.413IleLys: 1.413 ± 0.04	3.811IleLeu: 3.811 ± 0.073	0.803IleMet: 0.803 ± 0.026	1.529IleAsn: 1.529 ± 0.041	2.058IlePro: 2.058 ± 0.044	1.272IleGln: 1.272 ± 0.032	3.277IleArg: 3.277 ± 0.055	2.664IleSer: 2.664 ± 0.051	2.383IleThr: 2.383 ± 0.052	3.536IleVal: 3.536 ± 0.057	0.466IleTrp: 0.466 ± 0.022	0.968IleTyr: 0.968 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.141LysAla: 3.141 ± 0.06	0.144LysCys: 0.144 ± 0.012	1.352LysAsp: 1.352 ± 0.035	1.247LysGlu: 1.247 ± 0.04	0.792LysPhe: 0.792 ± 0.031	2.029LysGly: 2.029 ± 0.05	0.605LysHis: 0.605 ± 0.023	1.415LysIle: 1.415 ± 0.044	1.338LysLys: 1.338 ± 0.052	3.34LysLeu: 3.34 ± 0.061	0.718LysMet: 0.718 ± 0.026	0.925LysAsn: 0.925 ± 0.032	1.828LysPro: 1.828 ± 0.047	1.299LysGln: 1.299 ± 0.036	2.002LysArg: 2.002 ± 0.045	1.623LysSer: 1.623 ± 0.043	1.856LysThr: 1.856 ± 0.047	2.075LysVal: 2.075 ± 0.048	0.371LysTrp: 0.371 ± 0.02	0.64LysTyr: 0.64 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.76LeuAla: 15.76 ± 0.163	1.13LeuCys: 1.13 ± 0.031	6.946LeuAsp: 6.946 ± 0.091	4.997LeuGlu: 4.997 ± 0.09	3.938LeuPhe: 3.938 ± 0.065	8.692LeuGly: 8.692 ± 0.096	2.336LeuHis: 2.336 ± 0.045	4.977LeuIle: 4.977 ± 0.071	3.489LeuLys: 3.489 ± 0.062	12.695LeuLeu: 12.695 ± 0.17	2.432LeuMet: 2.432 ± 0.06	3.041LeuAsn: 3.041 ± 0.059	6.673LeuPro: 6.673 ± 0.09	3.714LeuGln: 3.714 ± 0.07	7.011LeuArg: 7.011 ± 0.088	7.208LeuSer: 7.208 ± 0.097	6.373LeuThr: 6.373 ± 0.086	7.808LeuVal: 7.808 ± 0.097	1.336LeuTrp: 1.336 ± 0.032	2.489LeuTyr: 2.489 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.857MetAla: 2.857 ± 0.061	0.173MetCys: 0.173 ± 0.011	1.046MetAsp: 1.046 ± 0.031	0.972MetGlu: 0.972 ± 0.032	0.648MetPhe: 0.648 ± 0.025	1.509MetGly: 1.509 ± 0.043	0.487MetHis: 0.487 ± 0.021	1.016MetIle: 1.016 ± 0.032	0.92MetLys: 0.92 ± 0.028	2.788MetLeu: 2.788 ± 0.055	0.581MetMet: 0.581 ± 0.023	0.809MetAsn: 0.809 ± 0.026	1.481MetPro: 1.481 ± 0.037	1.049MetGln: 1.049 ± 0.031	1.622MetArg: 1.622 ± 0.034	1.634MetSer: 1.634 ± 0.041	1.588MetThr: 1.588 ± 0.039	1.652MetVal: 1.652 ± 0.038	0.196MetTrp: 0.196 ± 0.014	0.396MetTyr: 0.396 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.029AsnAla: 3.029 ± 0.063	0.23AsnCys: 0.23 ± 0.015	1.524AsnAsp: 1.524 ± 0.049	1.212AsnGlu: 1.212 ± 0.034	0.802AsnPhe: 0.802 ± 0.028	2.597AsnGly: 2.597 ± 0.058	0.579AsnHis: 0.579 ± 0.021	1.315AsnIle: 1.315 ± 0.039	0.807AsnLys: 0.807 ± 0.027	2.828AsnLeu: 2.828 ± 0.055	0.549AsnMet: 0.549 ± 0.022	0.793AsnAsn: 0.793 ± 0.034	1.721AsnPro: 1.721 ± 0.044	0.993AsnGln: 0.993 ± 0.035	2.01AsnArg: 2.01 ± 0.045	1.267AsnSer: 1.267 ± 0.038	1.432AsnThr: 1.432 ± 0.039	1.922AsnVal: 1.922 ± 0.044	0.418AsnTrp: 0.418 ± 0.02	0.701AsnTyr: 0.701 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.467ProAla: 7.467 ± 0.105	0.438ProCys: 0.438 ± 0.018	3.704ProAsp: 3.704 ± 0.062	2.77ProGlu: 2.77 ± 0.055	1.838ProPhe: 1.838 ± 0.041	4.374ProGly: 4.374 ± 0.072	1.053ProHis: 1.053 ± 0.03	1.773ProIle: 1.773 ± 0.043	1.262ProLys: 1.262 ± 0.037	5.755ProLeu: 5.755 ± 0.078	1.086ProMet: 1.086 ± 0.028	1.113ProAsn: 1.113 ± 0.033	2.5ProPro: 2.5 ± 0.065	1.877ProGln: 1.877 ± 0.037	2.906ProArg: 2.906 ± 0.052	2.485ProSer: 2.485 ± 0.052	2.301ProThr: 2.301 ± 0.052	4.452ProVal: 4.452 ± 0.065	0.724ProTrp: 0.724 ± 0.027	1.184ProTyr: 1.184 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.069GlnAla: 5.069 ± 0.08	0.301GlnCys: 0.301 ± 0.015	1.63GlnAsp: 1.63 ± 0.04	1.412GlnGlu: 1.412 ± 0.039	1.217GlnPhe: 1.217 ± 0.032	2.676GlnGly: 2.676 ± 0.051	0.886GlnHis: 0.886 ± 0.028	1.866GlnIle: 1.866 ± 0.043	1.098GlnLys: 1.098 ± 0.031	4.473GlnLeu: 4.473 ± 0.071	0.992GlnMet: 0.992 ± 0.032	0.898GlnAsn: 0.898 ± 0.029	2.161GlnPro: 2.161 ± 0.053	2.157GlnGln: 2.157 ± 0.059	3.099GlnArg: 3.099 ± 0.067	2.039GlnSer: 2.039 ± 0.05	1.993GlnThr: 1.993 ± 0.045	2.876GlnVal: 2.876 ± 0.051	0.56GlnTrp: 0.56 ± 0.023	0.866GlnTyr: 0.866 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.51ArgAla: 7.51 ± 0.098	0.648ArgCys: 0.648 ± 0.025	4.457ArgAsp: 4.457 ± 0.071	4.163ArgGlu: 4.163 ± 0.066	2.958ArgPhe: 2.958 ± 0.054	4.587ArgGly: 4.587 ± 0.071	2.289ArgHis: 2.289 ± 0.058	3.761ArgIle: 3.761 ± 0.061	1.979ArgLys: 1.979 ± 0.046	9.292ArgLeu: 9.292 ± 0.119	1.774ArgMet: 1.774 ± 0.039	1.863ArgAsn: 1.863 ± 0.038	3.59ArgPro: 3.59 ± 0.064	3.663ArgGln: 3.663 ± 0.074	5.622ArgArg: 5.622 ± 0.102	3.286ArgSer: 3.286 ± 0.051	3.323ArgThr: 3.323 ± 0.056	5.199ArgVal: 5.199 ± 0.076	1.035ArgTrp: 1.035 ± 0.032	2.173ArgTyr: 2.173 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	6.435SerAla: 6.435 ± 0.098	0.545SerCys: 0.545 ± 0.021	2.842SerAsp: 2.842 ± 0.058	2.47SerGlu: 2.47 ± 0.053	1.916SerPhe: 1.916 ± 0.048	5.502SerGly: 5.502 ± 0.084	1.352SerHis: 1.352 ± 0.038	2.55SerIle: 2.55 ± 0.057	1.457SerLys: 1.457 ± 0.042	6.407SerLeu: 6.407 ± 0.076	1.357SerMet: 1.357 ± 0.035	1.433SerAsn: 1.433 ± 0.037	2.871SerPro: 2.871 ± 0.056	2.042SerGln: 2.042 ± 0.047	4.153SerArg: 4.153 ± 0.058	3.218SerSer: 3.218 ± 0.083	3.012SerThr: 3.012 ± 0.074	4.069SerVal: 4.069 ± 0.069	0.742SerTrp: 0.742 ± 0.026	1.444SerTyr: 1.444 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.965ThrAla: 5.965 ± 0.091	0.438ThrCys: 0.438 ± 0.021	2.676ThrAsp: 2.676 ± 0.054	2.198ThrGlu: 2.198 ± 0.056	1.78ThrPhe: 1.78 ± 0.04	4.859ThrGly: 4.859 ± 0.068	1.087ThrHis: 1.087 ± 0.033	2.089ThrIle: 2.089 ± 0.046	0.787ThrLys: 0.787 ± 0.031	7.575ThrLeu: 7.575 ± 0.092	0.905ThrMet: 0.905 ± 0.026	1.04ThrAsn: 1.04 ± 0.031	3.449ThrPro: 3.449 ± 0.063	1.703ThrGln: 1.703 ± 0.041	4.018ThrArg: 4.018 ± 0.064	2.545ThrSer: 2.545 ± 0.06	2.7ThrThr: 2.7 ± 0.059	4.314ThrVal: 4.314 ± 0.065	0.519ThrTrp: 0.519 ± 0.022	1.07ThrTyr: 1.07 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.861ValAla: 8.861 ± 0.106	0.768ValCys: 0.768 ± 0.028	4.36ValAsp: 4.36 ± 0.065	3.883ValGlu: 3.883 ± 0.063	2.643ValPhe: 2.643 ± 0.05	5.26ValGly: 5.26 ± 0.077	1.495ValHis: 1.495 ± 0.035	3.627ValIle: 3.627 ± 0.056	2.101ValLys: 2.101 ± 0.054	8.13ValLeu: 8.13 ± 0.113	1.848ValMet: 1.848 ± 0.041	2.192ValAsn: 2.192 ± 0.047	3.592ValPro: 3.592 ± 0.06	2.284ValGln: 2.284 ± 0.043	5.11ValArg: 5.11 ± 0.069	4.73ValSer: 4.73 ± 0.064	4.09ValThr: 4.09 ± 0.064	5.822ValVal: 5.822 ± 0.075	0.913ValTrp: 0.913 ± 0.029	1.552ValTyr: 1.552 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.141TrpAla: 1.141 ± 0.032	0.152TrpCys: 0.152 ± 0.012	0.579TrpAsp: 0.579 ± 0.024	0.47TrpGlu: 0.47 ± 0.018	0.522TrpPhe: 0.522 ± 0.021	0.794TrpGly: 0.794 ± 0.027	0.434TrpHis: 0.434 ± 0.019	0.648TrpIle: 0.648 ± 0.023	0.387TrpLys: 0.387 ± 0.022	2.308TrpLeu: 2.308 ± 0.057	0.356TrpMet: 0.356 ± 0.018	0.397TrpAsn: 0.397 ± 0.016	0.72TrpPro: 0.72 ± 0.029	0.903TrpGln: 0.903 ± 0.03	1.344TrpArg: 1.344 ± 0.039	0.726TrpSer: 0.726 ± 0.028	0.587TrpThr: 0.587 ± 0.024	0.904TrpVal: 0.904 ± 0.027	0.221TrpTrp: 0.221 ± 0.013	0.292TrpTyr: 0.292 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.713TyrAla: 2.713 ± 0.055	0.264TyrCys: 0.264 ± 0.015	1.546TyrAsp: 1.546 ± 0.084	0.935TyrGlu: 0.935 ± 0.035	0.917TyrPhe: 0.917 ± 0.03	2.075TyrGly: 2.075 ± 0.049	0.543TyrHis: 0.543 ± 0.024	0.82TyrIle: 0.82 ± 0.03	0.639TyrLys: 0.639 ± 0.027	2.779TyrLeu: 2.779 ± 0.052	0.39TyrMet: 0.39 ± 0.017	0.672TyrAsn: 0.672 ± 0.037	1.338TyrPro: 1.338 ± 0.038	1.079TyrGln: 1.079 ± 0.034	2.155TyrArg: 2.155 ± 0.042	1.349TyrSer: 1.349 ± 0.054	1.223TyrThr: 1.223 ± 0.038	1.561TyrVal: 1.561 ± 0.037	0.378TyrTrp: 0.378 ± 0.018	0.647TyrTyr: 0.647 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3570 proteins (1163100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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