Amino acid dipepetide frequency for Lactobacillus prophage Lj771

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.845AlaAla: 5.845 ± 1.877
0.494AlaCys: 0.494 ± 0.177
5.268AlaAsp: 5.268 ± 0.616
4.198AlaGlu: 4.198 ± 0.538
2.14AlaPhe: 2.14 ± 0.477
4.198AlaGly: 4.198 ± 0.825
0.741AlaHis: 0.741 ± 0.237
5.268AlaIle: 5.268 ± 0.917
6.338AlaLys: 6.338 ± 0.66
7.326AlaLeu: 7.326 ± 1.361
2.716AlaMet: 2.716 ± 0.784
4.939AlaAsn: 4.939 ± 1.139
1.399AlaPro: 1.399 ± 0.437
2.963AlaGln: 2.963 ± 0.545
3.128AlaArg: 3.128 ± 0.479
4.445AlaSer: 4.445 ± 0.713
5.021AlaThr: 5.021 ± 0.724
5.845AlaVal: 5.845 ± 1.676
0.988AlaTrp: 0.988 ± 0.305
1.976AlaTyr: 1.976 ± 0.328
0.0AlaXaa: 0.0 ± 0.0
Cys
0.329CysAla: 0.329 ± 0.134
0.082CysCys: 0.082 ± 0.082
0.412CysAsp: 0.412 ± 0.172
0.494CysGlu: 0.494 ± 0.195
0.082CysPhe: 0.082 ± 0.078
0.329CysGly: 0.329 ± 0.154
0.082CysHis: 0.082 ± 0.077
0.494CysIle: 0.494 ± 0.215
0.0CysLys: 0.0 ± 0.0
0.412CysLeu: 0.412 ± 0.195
0.0CysMet: 0.0 ± 0.0
0.247CysAsn: 0.247 ± 0.116
0.247CysPro: 0.247 ± 0.185
0.082CysGln: 0.082 ± 0.081
0.494CysArg: 0.494 ± 0.218
0.576CysSer: 0.576 ± 0.19
0.659CysThr: 0.659 ± 0.213
0.329CysVal: 0.329 ± 0.192
0.082CysTrp: 0.082 ± 0.071
0.165CysTyr: 0.165 ± 0.091
0.0CysXaa: 0.0 ± 0.0
Asp
5.598AspAla: 5.598 ± 0.822
0.329AspCys: 0.329 ± 0.137
5.845AspAsp: 5.845 ± 0.961
4.61AspGlu: 4.61 ± 0.801
3.128AspPhe: 3.128 ± 0.492
4.281AspGly: 4.281 ± 0.587
0.412AspHis: 0.412 ± 0.202
4.61AspIle: 4.61 ± 0.642
7.409AspLys: 7.409 ± 0.76
6.256AspLeu: 6.256 ± 0.865
1.893AspMet: 1.893 ± 0.37
4.198AspAsn: 4.198 ± 0.77
3.046AspPro: 3.046 ± 0.485
2.305AspGln: 2.305 ± 0.383
2.47AspArg: 2.47 ± 0.473
3.21AspSer: 3.21 ± 0.438
2.881AspThr: 2.881 ± 0.536
4.61AspVal: 4.61 ± 0.709
1.482AspTrp: 1.482 ± 0.328
3.54AspTyr: 3.54 ± 0.567
0.0AspXaa: 0.0 ± 0.0
Glu
4.445GluAla: 4.445 ± 0.692
0.247GluCys: 0.247 ± 0.138
4.692GluAsp: 4.692 ± 0.648
5.021GluGlu: 5.021 ± 0.829
2.552GluPhe: 2.552 ± 0.448
3.54GluGly: 3.54 ± 0.635
0.988GluHis: 0.988 ± 0.229
3.951GluIle: 3.951 ± 0.555
5.021GluLys: 5.021 ± 0.917
4.774GluLeu: 4.774 ± 0.647
1.729GluMet: 1.729 ± 0.463
3.457GluAsn: 3.457 ± 0.594
1.811GluPro: 1.811 ± 0.351
3.128GluGln: 3.128 ± 0.578
3.046GluArg: 3.046 ± 0.711
2.387GluSer: 2.387 ± 0.409
2.881GluThr: 2.881 ± 0.508
4.034GluVal: 4.034 ± 0.577
0.494GluTrp: 0.494 ± 0.202
2.552GluTyr: 2.552 ± 0.454
0.0GluXaa: 0.0 ± 0.0
Phe
2.552PheAla: 2.552 ± 0.477
0.082PheCys: 0.082 ± 0.082
4.116PheAsp: 4.116 ± 0.6
2.963PheGlu: 2.963 ± 0.464
1.482PhePhe: 1.482 ± 0.373
2.881PheGly: 2.881 ± 0.439
0.082PheHis: 0.082 ± 0.072
1.646PheIle: 1.646 ± 0.426
3.128PheLys: 3.128 ± 0.503
2.387PheLeu: 2.387 ± 0.347
0.823PheMet: 0.823 ± 0.308
1.811PheAsn: 1.811 ± 0.305
0.741PhePro: 0.741 ± 0.299
1.646PheGln: 1.646 ± 0.431
0.988PheArg: 0.988 ± 0.286
2.305PheSer: 2.305 ± 0.373
2.634PheThr: 2.634 ± 0.514
2.058PheVal: 2.058 ± 0.358
0.082PheTrp: 0.082 ± 0.081
1.729PheTyr: 1.729 ± 0.453
0.0PheXaa: 0.0 ± 0.0
Gly
5.186GlyAla: 5.186 ± 1.309
0.165GlyCys: 0.165 ± 0.12
3.704GlyAsp: 3.704 ± 0.466
2.552GlyGlu: 2.552 ± 0.42
2.881GlyPhe: 2.881 ± 0.534
4.692GlyGly: 4.692 ± 0.896
1.07GlyHis: 1.07 ± 0.283
5.021GlyIle: 5.021 ± 0.792
5.021GlyLys: 5.021 ± 0.519
6.503GlyLeu: 6.503 ± 1.443
1.317GlyMet: 1.317 ± 0.46
4.445GlyAsn: 4.445 ± 0.649
0.905GlyPro: 0.905 ± 0.283
2.963GlyGln: 2.963 ± 0.405
3.128GlyArg: 3.128 ± 0.448
3.704GlySer: 3.704 ± 0.529
4.034GlyThr: 4.034 ± 0.624
4.61GlyVal: 4.61 ± 0.632
1.152GlyTrp: 1.152 ± 0.28
2.963GlyTyr: 2.963 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
0.659HisAla: 0.659 ± 0.23
0.165HisCys: 0.165 ± 0.104
0.905HisAsp: 0.905 ± 0.228
1.317HisGlu: 1.317 ± 0.313
0.576HisPhe: 0.576 ± 0.273
1.07HisGly: 1.07 ± 0.294
0.247HisHis: 0.247 ± 0.141
0.905HisIle: 0.905 ± 0.214
1.152HisLys: 1.152 ± 0.266
1.317HisLeu: 1.317 ± 0.269
0.082HisMet: 0.082 ± 0.081
0.823HisAsn: 0.823 ± 0.208
0.659HisPro: 0.659 ± 0.204
0.576HisGln: 0.576 ± 0.195
0.412HisArg: 0.412 ± 0.158
0.988HisSer: 0.988 ± 0.279
0.494HisThr: 0.494 ± 0.197
0.412HisVal: 0.412 ± 0.225
0.412HisTrp: 0.412 ± 0.167
0.412HisTyr: 0.412 ± 0.158
0.0HisXaa: 0.0 ± 0.0
Ile
5.515IleAla: 5.515 ± 0.807
0.082IleCys: 0.082 ± 0.069
5.021IleAsp: 5.021 ± 0.661
3.951IleGlu: 3.951 ± 0.617
2.305IlePhe: 2.305 ± 0.319
3.951IleGly: 3.951 ± 0.732
0.659IleHis: 0.659 ± 0.22
3.046IleIle: 3.046 ± 0.415
5.927IleLys: 5.927 ± 0.719
4.857IleLeu: 4.857 ± 0.535
0.988IleMet: 0.988 ± 0.335
4.939IleAsn: 4.939 ± 0.612
2.223IlePro: 2.223 ± 0.443
2.387IleGln: 2.387 ± 0.363
2.223IleArg: 2.223 ± 0.45
3.787IleSer: 3.787 ± 0.57
4.116IleThr: 4.116 ± 0.494
4.281IleVal: 4.281 ± 0.623
0.576IleTrp: 0.576 ± 0.231
2.387IleTyr: 2.387 ± 0.408
0.0IleXaa: 0.0 ± 0.0
Lys
7.079LysAla: 7.079 ± 0.582
0.576LysCys: 0.576 ± 0.231
6.174LysAsp: 6.174 ± 0.754
5.762LysGlu: 5.762 ± 0.736
2.716LysPhe: 2.716 ± 0.451
4.61LysGly: 4.61 ± 0.516
1.317LysHis: 1.317 ± 0.292
4.857LysIle: 4.857 ± 0.573
7.985LysLys: 7.985 ± 0.684
8.149LysLeu: 8.149 ± 0.705
2.799LysMet: 2.799 ± 0.549
4.527LysAsn: 4.527 ± 0.582
2.799LysPro: 2.799 ± 0.408
3.54LysGln: 3.54 ± 0.544
3.375LysArg: 3.375 ± 0.694
4.281LysSer: 4.281 ± 0.576
5.268LysThr: 5.268 ± 0.634
5.598LysVal: 5.598 ± 0.728
1.317LysTrp: 1.317 ± 0.368
3.046LysTyr: 3.046 ± 0.527
0.0LysXaa: 0.0 ± 0.0
Leu
5.351LeuAla: 5.351 ± 0.889
0.165LeuCys: 0.165 ± 0.109
6.009LeuAsp: 6.009 ± 0.751
3.622LeuGlu: 3.622 ± 0.636
2.47LeuPhe: 2.47 ± 0.383
6.421LeuGly: 6.421 ± 0.708
1.811LeuHis: 1.811 ± 0.295
5.433LeuIle: 5.433 ± 0.85
8.479LeuLys: 8.479 ± 0.785
7.656LeuLeu: 7.656 ± 1.557
2.058LeuMet: 2.058 ± 0.617
5.598LeuAsn: 5.598 ± 0.746
3.54LeuPro: 3.54 ± 0.647
2.799LeuGln: 2.799 ± 0.431
3.787LeuArg: 3.787 ± 0.6
5.433LeuSer: 5.433 ± 0.758
5.515LeuThr: 5.515 ± 0.576
6.668LeuVal: 6.668 ± 1.08
0.412LeuTrp: 0.412 ± 0.164
2.47LeuTyr: 2.47 ± 0.496
0.0LeuXaa: 0.0 ± 0.0
Met
2.552MetAla: 2.552 ± 0.611
0.165MetCys: 0.165 ± 0.107
1.152MetAsp: 1.152 ± 0.33
1.399MetGlu: 1.399 ± 0.359
0.329MetPhe: 0.329 ± 0.14
1.235MetGly: 1.235 ± 0.358
0.247MetHis: 0.247 ± 0.141
1.399MetIle: 1.399 ± 0.381
2.058MetLys: 2.058 ± 0.378
2.634MetLeu: 2.634 ± 0.634
0.741MetMet: 0.741 ± 0.258
1.482MetAsn: 1.482 ± 0.346
0.659MetPro: 0.659 ± 0.225
0.659MetGln: 0.659 ± 0.229
0.823MetArg: 0.823 ± 0.243
1.564MetSer: 1.564 ± 0.375
1.482MetThr: 1.482 ± 0.305
2.963MetVal: 2.963 ± 0.65
0.082MetTrp: 0.082 ± 0.083
1.152MetTyr: 1.152 ± 0.272
0.0MetXaa: 0.0 ± 0.0
Asn
4.116AsnAla: 4.116 ± 0.633
0.823AsnCys: 0.823 ± 0.251
4.034AsnAsp: 4.034 ± 0.602
3.21AsnGlu: 3.21 ± 0.494
3.21AsnPhe: 3.21 ± 0.623
5.433AsnGly: 5.433 ± 0.774
0.741AsnHis: 0.741 ± 0.247
3.457AsnIle: 3.457 ± 0.444
4.939AsnLys: 4.939 ± 0.705
3.54AsnLeu: 3.54 ± 0.666
1.564AsnMet: 1.564 ± 0.34
4.774AsnAsn: 4.774 ± 0.686
1.893AsnPro: 1.893 ± 0.292
1.893AsnGln: 1.893 ± 0.336
1.811AsnArg: 1.811 ± 0.499
3.951AsnSer: 3.951 ± 0.575
3.622AsnThr: 3.622 ± 0.995
3.293AsnVal: 3.293 ± 0.532
1.317AsnTrp: 1.317 ± 0.33
2.881AsnTyr: 2.881 ± 0.62
0.0AsnXaa: 0.0 ± 0.0
Pro
3.622ProAla: 3.622 ± 0.491
0.165ProCys: 0.165 ± 0.114
2.552ProAsp: 2.552 ± 0.384
1.646ProGlu: 1.646 ± 0.37
0.659ProPhe: 0.659 ± 0.22
1.646ProGly: 1.646 ± 0.405
0.247ProHis: 0.247 ± 0.127
2.14ProIle: 2.14 ± 0.355
2.47ProLys: 2.47 ± 0.487
1.811ProLeu: 1.811 ± 0.41
0.494ProMet: 0.494 ± 0.209
1.893ProAsn: 1.893 ± 0.437
0.659ProPro: 0.659 ± 0.186
1.317ProGln: 1.317 ± 0.263
1.07ProArg: 1.07 ± 0.308
1.811ProSer: 1.811 ± 0.379
2.058ProThr: 2.058 ± 0.405
2.47ProVal: 2.47 ± 0.465
0.494ProTrp: 0.494 ± 0.177
1.07ProTyr: 1.07 ± 0.305
0.0ProXaa: 0.0 ± 0.0
Gln
3.046GlnAla: 3.046 ± 0.419
0.329GlnCys: 0.329 ± 0.169
2.387GlnAsp: 2.387 ± 0.458
2.716GlnGlu: 2.716 ± 0.535
1.893GlnPhe: 1.893 ± 0.481
1.976GlnGly: 1.976 ± 0.374
0.576GlnHis: 0.576 ± 0.205
3.704GlnIle: 3.704 ± 0.424
2.634GlnLys: 2.634 ± 0.547
4.61GlnLeu: 4.61 ± 0.53
1.152GlnMet: 1.152 ± 0.254
1.564GlnAsn: 1.564 ± 0.383
1.152GlnPro: 1.152 ± 0.29
2.552GlnGln: 2.552 ± 0.453
1.564GlnArg: 1.564 ± 0.382
2.387GlnSer: 2.387 ± 0.421
2.634GlnThr: 2.634 ± 0.482
1.893GlnVal: 1.893 ± 0.36
0.823GlnTrp: 0.823 ± 0.21
1.482GlnTyr: 1.482 ± 0.387
0.0GlnXaa: 0.0 ± 0.0
Arg
2.387ArgAla: 2.387 ± 0.331
0.165ArgCys: 0.165 ± 0.112
2.716ArgAsp: 2.716 ± 0.384
3.375ArgGlu: 3.375 ± 0.621
1.564ArgPhe: 1.564 ± 0.305
1.811ArgGly: 1.811 ± 0.318
0.988ArgHis: 0.988 ± 0.313
2.47ArgIle: 2.47 ± 0.534
2.552ArgLys: 2.552 ± 0.485
3.54ArgLeu: 3.54 ± 0.551
0.905ArgMet: 0.905 ± 0.392
2.223ArgAsn: 2.223 ± 0.416
1.07ArgPro: 1.07 ± 0.335
1.564ArgGln: 1.564 ± 0.459
2.223ArgArg: 2.223 ± 0.439
2.881ArgSer: 2.881 ± 0.417
1.811ArgThr: 1.811 ± 0.338
2.305ArgVal: 2.305 ± 0.511
0.905ArgTrp: 0.905 ± 0.21
1.976ArgTyr: 1.976 ± 0.362
0.0ArgXaa: 0.0 ± 0.0
Ser
4.034SerAla: 4.034 ± 0.806
0.165SerCys: 0.165 ± 0.113
3.704SerAsp: 3.704 ± 0.486
3.704SerGlu: 3.704 ± 0.527
1.893SerPhe: 1.893 ± 0.369
4.034SerGly: 4.034 ± 0.708
0.988SerHis: 0.988 ± 0.312
3.54SerIle: 3.54 ± 0.518
6.256SerLys: 6.256 ± 0.793
5.104SerLeu: 5.104 ± 0.582
1.317SerMet: 1.317 ± 0.491
4.281SerAsn: 4.281 ± 0.541
2.963SerPro: 2.963 ± 0.397
2.552SerGln: 2.552 ± 0.485
1.235SerArg: 1.235 ± 0.273
4.363SerSer: 4.363 ± 0.643
3.128SerThr: 3.128 ± 0.516
3.457SerVal: 3.457 ± 0.423
0.988SerTrp: 0.988 ± 0.307
2.634SerTyr: 2.634 ± 0.459
0.0SerXaa: 0.0 ± 0.0
Thr
4.527ThrAla: 4.527 ± 0.816
0.247ThrCys: 0.247 ± 0.137
4.61ThrAsp: 4.61 ± 0.6
3.293ThrGlu: 3.293 ± 0.672
2.14ThrPhe: 2.14 ± 0.424
3.869ThrGly: 3.869 ± 0.5
0.823ThrHis: 0.823 ± 0.243
3.951ThrIle: 3.951 ± 0.568
5.351ThrLys: 5.351 ± 0.556
5.104ThrLeu: 5.104 ± 0.774
1.482ThrMet: 1.482 ± 0.339
3.046ThrAsn: 3.046 ± 0.637
1.235ThrPro: 1.235 ± 0.265
2.305ThrGln: 2.305 ± 0.436
2.14ThrArg: 2.14 ± 0.504
4.034ThrSer: 4.034 ± 0.604
4.034ThrThr: 4.034 ± 0.68
4.363ThrVal: 4.363 ± 0.64
0.823ThrTrp: 0.823 ± 0.343
2.47ThrTyr: 2.47 ± 0.413
0.0ThrXaa: 0.0 ± 0.0
Val
5.351ValAla: 5.351 ± 1.208
0.494ValCys: 0.494 ± 0.225
5.68ValAsp: 5.68 ± 0.763
4.198ValGlu: 4.198 ± 0.767
1.811ValPhe: 1.811 ± 0.38
5.351ValGly: 5.351 ± 1.484
0.329ValHis: 0.329 ± 0.142
3.787ValIle: 3.787 ± 0.49
5.351ValLys: 5.351 ± 0.658
4.857ValLeu: 4.857 ± 0.634
1.235ValMet: 1.235 ± 0.287
4.198ValAsn: 4.198 ± 0.701
2.14ValPro: 2.14 ± 0.431
3.046ValGln: 3.046 ± 0.527
2.799ValArg: 2.799 ± 0.53
4.61ValSer: 4.61 ± 0.75
3.787ValThr: 3.787 ± 0.739
4.527ValVal: 4.527 ± 0.726
0.823ValTrp: 0.823 ± 0.289
2.14ValTyr: 2.14 ± 0.47
0.0ValXaa: 0.0 ± 0.0
Trp
0.576TrpAla: 0.576 ± 0.233
0.082TrpCys: 0.082 ± 0.083
0.741TrpAsp: 0.741 ± 0.219
0.741TrpGlu: 0.741 ± 0.289
0.659TrpPhe: 0.659 ± 0.209
1.317TrpGly: 1.317 ± 0.308
0.494TrpHis: 0.494 ± 0.26
0.905TrpIle: 0.905 ± 0.265
1.317TrpLys: 1.317 ± 0.361
1.235TrpLeu: 1.235 ± 0.314
0.247TrpMet: 0.247 ± 0.134
0.823TrpAsn: 0.823 ± 0.241
0.494TrpPro: 0.494 ± 0.213
0.988TrpGln: 0.988 ± 0.289
0.494TrpArg: 0.494 ± 0.203
0.494TrpSer: 0.494 ± 0.222
1.235TrpThr: 1.235 ± 0.374
0.905TrpVal: 0.905 ± 0.264
0.082TrpTrp: 0.082 ± 0.077
0.412TrpTyr: 0.412 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.47TyrAla: 2.47 ± 0.403
0.576TyrCys: 0.576 ± 0.168
2.387TyrAsp: 2.387 ± 0.514
1.976TyrGlu: 1.976 ± 0.382
1.646TyrPhe: 1.646 ± 0.333
3.375TyrGly: 3.375 ± 0.386
0.741TyrHis: 0.741 ± 0.249
2.634TyrIle: 2.634 ± 0.407
2.387TyrLys: 2.387 ± 0.462
3.622TyrLeu: 3.622 ± 0.58
1.152TyrMet: 1.152 ± 0.279
1.235TyrAsn: 1.235 ± 0.365
0.659TyrPro: 0.659 ± 0.244
1.893TyrGln: 1.893 ± 0.552
2.223TyrArg: 2.223 ± 0.428
3.128TyrSer: 3.128 ± 0.618
2.552TyrThr: 2.552 ± 0.457
1.893TyrVal: 1.893 ± 0.416
0.905TyrTrp: 0.905 ± 0.265
1.399TyrTyr: 1.399 ± 0.349
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (12149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski