Amino acid dipepetide frequency for Arcticibacter svalbardensis MN12-7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.249AlaAla: 5.249 ± 0.083	0.6AlaCys: 0.6 ± 0.023	3.945AlaAsp: 3.945 ± 0.057	4.32AlaGlu: 4.32 ± 0.06	3.41AlaPhe: 3.41 ± 0.056	5.25AlaGly: 5.25 ± 0.083	1.183AlaHis: 1.183 ± 0.03	5.381AlaIle: 5.381 ± 0.069	4.372AlaLys: 4.372 ± 0.058	6.763AlaLeu: 6.763 ± 0.083	1.639AlaMet: 1.639 ± 0.038	3.491AlaAsn: 3.491 ± 0.056	2.067AlaPro: 2.067 ± 0.045	2.537AlaGln: 2.537 ± 0.045	2.273AlaArg: 2.273 ± 0.042	4.693AlaSer: 4.693 ± 0.067	3.729AlaThr: 3.729 ± 0.068	4.706AlaVal: 4.706 ± 0.074	0.697AlaTrp: 0.697 ± 0.022	2.805AlaTyr: 2.805 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.522CysAla: 0.522 ± 0.024	0.126CysCys: 0.126 ± 0.009	0.371CysAsp: 0.371 ± 0.016	0.363CysGlu: 0.363 ± 0.018	0.403CysPhe: 0.403 ± 0.019	0.592CysGly: 0.592 ± 0.023	0.191CysHis: 0.191 ± 0.012	0.68CysIle: 0.68 ± 0.02	0.484CysLys: 0.484 ± 0.018	0.769CysLeu: 0.769 ± 0.024	0.189CysMet: 0.189 ± 0.012	0.398CysAsn: 0.398 ± 0.019	0.311CysPro: 0.311 ± 0.019	0.219CysGln: 0.219 ± 0.013	0.316CysArg: 0.316 ± 0.017	0.591CysSer: 0.591 ± 0.025	0.454CysThr: 0.454 ± 0.019	0.446CysVal: 0.446 ± 0.02	0.102CysTrp: 0.102 ± 0.023	0.306CysTyr: 0.306 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.79AspAla: 3.79 ± 0.059	0.386AspCys: 0.386 ± 0.017	2.582AspAsp: 2.582 ± 0.054	3.285AspGlu: 3.285 ± 0.055	3.096AspPhe: 3.096 ± 0.047	3.576AspGly: 3.576 ± 0.056	1.046AspHis: 1.046 ± 0.028	4.104AspIle: 4.104 ± 0.056	3.783AspLys: 3.783 ± 0.056	5.505AspLeu: 5.505 ± 0.06	1.182AspMet: 1.182 ± 0.031	2.656AspAsn: 2.656 ± 0.05	2.203AspPro: 2.203 ± 0.039	2.081AspGln: 2.081 ± 0.037	2.058AspArg: 2.058 ± 0.04	3.041AspSer: 3.041 ± 0.05	2.523AspThr: 2.523 ± 0.042	3.378AspVal: 3.378 ± 0.051	0.725AspTrp: 0.725 ± 0.029	2.612AspTyr: 2.612 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.067GluAla: 4.067 ± 0.067	0.345GluCys: 0.345 ± 0.019	2.914GluAsp: 2.914 ± 0.05	3.995GluGlu: 3.995 ± 0.068	2.577GluPhe: 2.577 ± 0.052	3.473GluGly: 3.473 ± 0.049	1.085GluHis: 1.085 ± 0.029	4.735GluIle: 4.735 ± 0.069	4.652GluLys: 4.652 ± 0.075	5.884GluLeu: 5.884 ± 0.083	1.528GluMet: 1.528 ± 0.037	3.425GluAsn: 3.425 ± 0.049	1.624GluPro: 1.624 ± 0.035	2.351GluGln: 2.351 ± 0.046	2.555GluArg: 2.555 ± 0.054	3.321GluSer: 3.321 ± 0.054	2.919GluThr: 2.919 ± 0.053	3.862GluVal: 3.862 ± 0.057	0.662GluTrp: 0.662 ± 0.024	2.1GluTyr: 2.1 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.121PheAla: 3.121 ± 0.054	0.48PheCys: 0.48 ± 0.019	2.866PheAsp: 2.866 ± 0.048	2.727PheGlu: 2.727 ± 0.045	2.488PhePhe: 2.488 ± 0.052	3.228PheGly: 3.228 ± 0.052	0.833PheHis: 0.833 ± 0.025	3.886PheIle: 3.886 ± 0.063	3.534PheLys: 3.534 ± 0.052	4.528PheLeu: 4.528 ± 0.058	1.171PheMet: 1.171 ± 0.033	3.141PheAsn: 3.141 ± 0.057	1.785PhePro: 1.785 ± 0.034	1.496PheGln: 1.496 ± 0.035	1.778PheArg: 1.778 ± 0.036	3.972PheSer: 3.972 ± 0.062	3.019PheThr: 3.019 ± 0.052	2.739PheVal: 2.739 ± 0.041	0.551PheTrp: 0.551 ± 0.02	2.132PheTyr: 2.132 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.376GlyAla: 4.376 ± 0.075	0.629GlyCys: 0.629 ± 0.026	3.266GlyAsp: 3.266 ± 0.055	3.212GlyGlu: 3.212 ± 0.05	3.556GlyPhe: 3.556 ± 0.057	4.569GlyGly: 4.569 ± 0.094	1.157GlyHis: 1.157 ± 0.032	5.73GlyIle: 5.73 ± 0.073	5.214GlyLys: 5.214 ± 0.064	6.383GlyLeu: 6.383 ± 0.087	1.712GlyMet: 1.712 ± 0.036	3.653GlyAsn: 3.653 ± 0.054	1.564GlyPro: 1.564 ± 0.032	2.054GlyGln: 2.054 ± 0.041	2.451GlyArg: 2.451 ± 0.044	4.51GlySer: 4.51 ± 0.076	4.179GlyThr: 4.179 ± 0.084	4.414GlyVal: 4.414 ± 0.064	0.851GlyTrp: 0.851 ± 0.031	3.044GlyTyr: 3.044 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.188HisAla: 1.188 ± 0.029	0.195HisCys: 0.195 ± 0.012	0.959HisAsp: 0.959 ± 0.027	0.98HisGlu: 0.98 ± 0.028	1.071HisPhe: 1.071 ± 0.025	1.095HisGly: 1.095 ± 0.032	0.507HisHis: 0.507 ± 0.022	1.459HisIle: 1.459 ± 0.037	0.996HisLys: 0.996 ± 0.028	1.862HisLeu: 1.862 ± 0.039	0.343HisMet: 0.343 ± 0.015	0.874HisAsn: 0.874 ± 0.025	0.974HisPro: 0.974 ± 0.028	0.732HisGln: 0.732 ± 0.025	0.734HisArg: 0.734 ± 0.026	1.151HisSer: 1.151 ± 0.026	1.011HisThr: 1.011 ± 0.028	1.063HisVal: 1.063 ± 0.029	0.211HisTrp: 0.211 ± 0.013	0.862HisTyr: 0.862 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.726IleAla: 5.726 ± 0.084	0.776IleCys: 0.776 ± 0.024	4.322IleAsp: 4.322 ± 0.073	4.418IleGlu: 4.418 ± 0.052	3.209IlePhe: 3.209 ± 0.055	5.154IleGly: 5.154 ± 0.074	1.467IleHis: 1.467 ± 0.038	5.717IleIle: 5.717 ± 0.069	5.716IleLys: 5.716 ± 0.08	7.008IleLeu: 7.008 ± 0.079	1.608IleMet: 1.608 ± 0.041	4.569IleAsn: 4.569 ± 0.068	3.442IlePro: 3.442 ± 0.05	2.644IleGln: 2.644 ± 0.045	3.172IleArg: 3.172 ± 0.046	5.772IleSer: 5.772 ± 0.061	4.722IleThr: 4.722 ± 0.067	4.417IleVal: 4.417 ± 0.06	0.756IleTrp: 0.756 ± 0.024	2.85IleTyr: 2.85 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.946LysAla: 4.946 ± 0.07	0.349LysCys: 0.349 ± 0.017	4.139LysAsp: 4.139 ± 0.061	5.133LysGlu: 5.133 ± 0.066	2.669LysPhe: 2.669 ± 0.053	4.786LysGly: 4.786 ± 0.065	1.168LysHis: 1.168 ± 0.033	5.213LysIle: 5.213 ± 0.068	5.571LysLys: 5.571 ± 0.08	6.345LysLeu: 6.345 ± 0.078	1.808LysMet: 1.808 ± 0.035	4.367LysAsn: 4.367 ± 0.065	2.633LysPro: 2.633 ± 0.05	2.685LysGln: 2.685 ± 0.045	2.917LysArg: 2.917 ± 0.055	4.489LysSer: 4.489 ± 0.065	4.077LysThr: 4.077 ± 0.06	4.522LysVal: 4.522 ± 0.058	0.773LysTrp: 0.773 ± 0.028	2.784LysTyr: 2.784 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	6.453LeuAla: 6.453 ± 0.076	0.748LeuCys: 0.748 ± 0.022	4.919LeuAsp: 4.919 ± 0.067	5.171LeuGlu: 5.171 ± 0.073	4.942LeuPhe: 4.942 ± 0.073	5.801LeuGly: 5.801 ± 0.084	1.802LeuHis: 1.802 ± 0.039	7.517LeuIle: 7.517 ± 0.093	7.765LeuLys: 7.765 ± 0.087	9.529LeuLeu: 9.529 ± 0.11	2.309LeuMet: 2.309 ± 0.05	6.028LeuAsn: 6.028 ± 0.082	3.959LeuPro: 3.959 ± 0.054	3.534LeuGln: 3.534 ± 0.051	3.688LeuArg: 3.688 ± 0.055	7.408LeuSer: 7.408 ± 0.096	5.463LeuThr: 5.463 ± 0.064	5.549LeuVal: 5.549 ± 0.07	0.882LeuTrp: 0.882 ± 0.025	3.453LeuTyr: 3.453 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.807MetAla: 1.807 ± 0.037	0.147MetCys: 0.147 ± 0.01	1.289MetAsp: 1.289 ± 0.031	1.436MetGlu: 1.436 ± 0.036	0.859MetPhe: 0.859 ± 0.023	1.579MetGly: 1.579 ± 0.039	0.441MetHis: 0.441 ± 0.019	1.719MetIle: 1.719 ± 0.039	1.957MetLys: 1.957 ± 0.034	2.262MetLeu: 2.262 ± 0.047	0.606MetMet: 0.606 ± 0.025	1.418MetAsn: 1.418 ± 0.033	1.035MetPro: 1.035 ± 0.032	0.881MetGln: 0.881 ± 0.026	0.894MetArg: 0.894 ± 0.026	1.439MetSer: 1.439 ± 0.031	1.134MetThr: 1.134 ± 0.032	1.492MetVal: 1.492 ± 0.035	0.185MetTrp: 0.185 ± 0.011	0.673MetTyr: 0.673 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.779AsnAla: 3.779 ± 0.053	0.41AsnCys: 0.41 ± 0.017	2.832AsnAsp: 2.832 ± 0.052	3.203AsnGlu: 3.203 ± 0.057	2.666AsnPhe: 2.666 ± 0.046	3.789AsnGly: 3.789 ± 0.059	1.016AsnHis: 1.016 ± 0.029	4.206AsnIle: 4.206 ± 0.068	4.061AsnLys: 4.061 ± 0.061	5.316AsnLeu: 5.316 ± 0.064	1.28AsnMet: 1.28 ± 0.031	3.161AsnAsn: 3.161 ± 0.06	2.656AsnPro: 2.656 ± 0.047	2.22AsnGln: 2.22 ± 0.045	2.297AsnArg: 2.297 ± 0.04	3.685AsnSer: 3.685 ± 0.063	3.391AsnThr: 3.391 ± 0.062	3.232AsnVal: 3.232 ± 0.053	0.79AsnTrp: 0.79 ± 0.023	2.62AsnTyr: 2.62 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.824ProAla: 2.824 ± 0.048	0.215ProCys: 0.215 ± 0.013	2.599ProAsp: 2.599 ± 0.049	2.907ProGlu: 2.907 ± 0.05	1.973ProPhe: 1.973 ± 0.037	2.619ProGly: 2.619 ± 0.056	0.635ProHis: 0.635 ± 0.023	2.582ProIle: 2.582 ± 0.044	2.129ProLys: 2.129 ± 0.047	3.545ProLeu: 3.545 ± 0.053	0.721ProMet: 0.721 ± 0.025	1.866ProAsn: 1.866 ± 0.042	0.898ProPro: 0.898 ± 0.035	1.277ProGln: 1.277 ± 0.035	1.062ProArg: 1.062 ± 0.028	2.476ProSer: 2.476 ± 0.043	1.868ProThr: 1.868 ± 0.045	3.039ProVal: 3.039 ± 0.046	0.394ProTrp: 0.394 ± 0.018	1.541ProTyr: 1.541 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.456GlnAla: 2.456 ± 0.046	0.174GlnCys: 0.174 ± 0.013	1.792GlnAsp: 1.792 ± 0.041	2.089GlnGlu: 2.089 ± 0.04	1.66GlnPhe: 1.66 ± 0.034	2.084GlnGly: 2.084 ± 0.042	0.724GlnHis: 0.724 ± 0.026	2.731GlnIle: 2.731 ± 0.048	2.547GlnLys: 2.547 ± 0.05	3.701GlnLeu: 3.701 ± 0.059	0.884GlnMet: 0.884 ± 0.025	2.023GlnAsn: 2.023 ± 0.043	1.26GlnPro: 1.26 ± 0.034	1.713GlnGln: 1.713 ± 0.04	1.455GlnArg: 1.455 ± 0.036	2.387GlnSer: 2.387 ± 0.048	2.027GlnThr: 2.027 ± 0.04	2.367GlnVal: 2.367 ± 0.046	0.383GlnTrp: 0.383 ± 0.019	1.527GlnTyr: 1.527 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.313ArgAla: 2.313 ± 0.052	0.235ArgCys: 0.235 ± 0.014	2.02ArgAsp: 2.02 ± 0.038	2.269ArgGlu: 2.269 ± 0.044	2.154ArgPhe: 2.154 ± 0.04	2.179ArgGly: 2.179 ± 0.048	0.664ArgHis: 0.664 ± 0.023	3.22ArgIle: 3.22 ± 0.049	2.806ArgLys: 2.806 ± 0.05	3.836ArgLeu: 3.836 ± 0.051	1.06ArgMet: 1.06 ± 0.029	2.272ArgAsn: 2.272 ± 0.046	1.29ArgPro: 1.29 ± 0.029	1.326ArgGln: 1.326 ± 0.033	1.495ArgArg: 1.495 ± 0.036	2.424ArgSer: 2.424 ± 0.046	2.063ArgThr: 2.063 ± 0.037	2.386ArgVal: 2.386 ± 0.046	0.488ArgTrp: 0.488 ± 0.02	1.71ArgTyr: 1.71 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.751SerAla: 4.751 ± 0.062	0.618SerCys: 0.618 ± 0.024	3.422SerAsp: 3.422 ± 0.049	3.337SerGlu: 3.337 ± 0.059	3.925SerPhe: 3.925 ± 0.063	5.099SerGly: 5.099 ± 0.079	1.167SerHis: 1.167 ± 0.03	5.414SerIle: 5.414 ± 0.066	4.484SerLys: 4.484 ± 0.06	6.882SerLeu: 6.882 ± 0.079	1.541SerMet: 1.541 ± 0.034	3.532SerAsn: 3.532 ± 0.066	2.545SerPro: 2.545 ± 0.045	2.13SerGln: 2.13 ± 0.04	2.632SerArg: 2.632 ± 0.052	5.105SerSer: 5.105 ± 0.081	4.014SerThr: 4.014 ± 0.068	4.274SerVal: 4.274 ± 0.058	0.765SerTrp: 0.765 ± 0.026	2.975SerTyr: 2.975 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.168ThrAla: 4.168 ± 0.085	0.364ThrCys: 0.364 ± 0.019	3.284ThrAsp: 3.284 ± 0.047	3.178ThrGlu: 3.178 ± 0.048	2.802ThrPhe: 2.802 ± 0.045	4.56ThrGly: 4.56 ± 0.09	0.953ThrHis: 0.953 ± 0.025	4.511ThrIle: 4.511 ± 0.053	3.221ThrLys: 3.221 ± 0.048	5.398ThrLeu: 5.398 ± 0.066	1.024ThrMet: 1.024 ± 0.027	2.994ThrAsn: 2.994 ± 0.061	2.434ThrPro: 2.434 ± 0.051	1.908ThrGln: 1.908 ± 0.038	1.89ThrArg: 1.89 ± 0.039	3.886ThrSer: 3.886 ± 0.084	3.433ThrThr: 3.433 ± 0.087	3.702ThrVal: 3.702 ± 0.066	0.625ThrTrp: 0.625 ± 0.024	2.329ThrTyr: 2.329 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.207ValAla: 4.207 ± 0.068	0.563ValCys: 0.563 ± 0.021	3.301ValAsp: 3.301 ± 0.049	3.384ValGlu: 3.384 ± 0.046	3.174ValPhe: 3.174 ± 0.045	3.544ValGly: 3.544 ± 0.058	1.13ValHis: 1.13 ± 0.03	5.122ValIle: 5.122 ± 0.064	4.528ValLys: 4.528 ± 0.07	6.27ValLeu: 6.27 ± 0.069	1.472ValMet: 1.472 ± 0.031	3.586ValAsn: 3.586 ± 0.053	2.413ValPro: 2.413 ± 0.051	2.039ValGln: 2.039 ± 0.041	2.342ValArg: 2.342 ± 0.043	4.655ValSer: 4.655 ± 0.069	3.574ValThr: 3.574 ± 0.078	4.078ValVal: 4.078 ± 0.062	0.624ValTrp: 0.624 ± 0.023	2.522ValTyr: 2.522 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.71TrpAla: 0.71 ± 0.022	0.103TrpCys: 0.103 ± 0.009	0.651TrpAsp: 0.651 ± 0.026	0.655TrpGlu: 0.655 ± 0.024	0.583TrpPhe: 0.583 ± 0.022	0.72TrpGly: 0.72 ± 0.026	0.232TrpHis: 0.232 ± 0.014	0.814TrpIle: 0.814 ± 0.023	0.839TrpLys: 0.839 ± 0.028	1.084TrpLeu: 1.084 ± 0.03	0.345TrpMet: 0.345 ± 0.017	0.695TrpAsn: 0.695 ± 0.028	0.341TrpPro: 0.341 ± 0.02	0.439TrpGln: 0.439 ± 0.022	0.427TrpArg: 0.427 ± 0.019	0.674TrpSer: 0.674 ± 0.024	0.569TrpThr: 0.569 ± 0.028	0.639TrpVal: 0.639 ± 0.022	0.157TrpTrp: 0.157 ± 0.012	0.46TrpTyr: 0.46 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.656TyrAla: 2.656 ± 0.046	0.368TyrCys: 0.368 ± 0.017	2.14TyrAsp: 2.14 ± 0.046	2.011TyrGlu: 2.011 ± 0.038	2.258TyrPhe: 2.258 ± 0.04	2.827TyrGly: 2.827 ± 0.053	0.868TyrHis: 0.868 ± 0.026	2.728TyrIle: 2.728 ± 0.041	2.714TyrLys: 2.714 ± 0.044	4.05TyrLeu: 4.05 ± 0.059	0.831TyrMet: 0.831 ± 0.022	2.46TyrAsn: 2.46 ± 0.048	1.739TyrPro: 1.739 ± 0.04	1.718TyrGln: 1.718 ± 0.043	1.773TyrArg: 1.773 ± 0.04	2.933TyrSer: 2.933 ± 0.054	2.493TyrThr: 2.493 ± 0.049	2.222TyrVal: 2.222 ± 0.04	0.517TyrTrp: 0.517 ± 0.028	1.88TyrTyr: 1.88 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4309 proteins (1348798 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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