Amino acid dipepetide frequency for Paraphotobacterium marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.393AlaAla: 3.393 ± 0.109
0.747AlaCys: 0.747 ± 0.063
2.801AlaAsp: 2.801 ± 0.302
2.702AlaGlu: 2.702 ± 0.144
2.834AlaPhe: 2.834 ± 0.221
3.314AlaGly: 3.314 ± 0.095
1.055AlaHis: 1.055 ± 0.045
5.023AlaIle: 5.023 ± 0.108
3.95AlaLys: 3.95 ± 0.102
6.001AlaLeu: 6.001 ± 0.123
1.324AlaMet: 1.324 ± 0.047
3.099AlaAsn: 3.099 ± 0.114
1.604AlaPro: 1.604 ± 0.052
1.955AlaGln: 1.955 ± 0.066
1.793AlaArg: 1.793 ± 0.063
3.901AlaSer: 3.901 ± 0.081
2.876AlaThr: 2.876 ± 0.115
2.976AlaVal: 2.976 ± 0.083
0.472AlaTrp: 0.472 ± 0.027
1.8AlaTyr: 1.8 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.625CysAla: 0.625 ± 0.031
0.155CysCys: 0.155 ± 0.015
0.892CysAsp: 0.892 ± 0.22
0.574CysGlu: 0.574 ± 0.032
0.689CysPhe: 0.689 ± 0.036
0.783CysGly: 0.783 ± 0.039
0.249CysHis: 0.249 ± 0.02
0.964CysIle: 0.964 ± 0.044
0.669CysLys: 0.669 ± 0.032
1.224CysLeu: 1.224 ± 0.048
0.224CysMet: 0.224 ± 0.02
0.594CysAsn: 0.594 ± 0.029
0.457CysPro: 0.457 ± 0.032
0.344CysGln: 0.344 ± 0.023
0.253CysArg: 0.253 ± 0.021
0.952CysSer: 0.952 ± 0.036
0.436CysThr: 0.436 ± 0.028
0.652CysVal: 0.652 ± 0.029
0.122CysTrp: 0.122 ± 0.014
0.401CysTyr: 0.401 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.332AspAla: 3.332 ± 0.348
0.616AspCys: 0.616 ± 0.056
5.207AspAsp: 5.207 ± 1.192
3.325AspGlu: 3.325 ± 0.08
2.937AspPhe: 2.937 ± 0.11
4.312AspGly: 4.312 ± 0.775
0.942AspHis: 0.942 ± 0.039
4.831AspIle: 4.831 ± 0.103
3.849AspLys: 3.849 ± 0.103
5.173AspLeu: 5.173 ± 0.1
1.06AspMet: 1.06 ± 0.039
4.267AspAsn: 4.267 ± 0.584
1.774AspPro: 1.774 ± 0.14
1.537AspGln: 1.537 ± 0.043
1.594AspArg: 1.594 ± 0.05
3.594AspSer: 3.594 ± 0.133
3.264AspThr: 3.264 ± 0.634
3.034AspVal: 3.034 ± 0.076
0.557AspTrp: 0.557 ± 0.031
2.187AspTyr: 2.187 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
2.966GluAla: 2.966 ± 0.101
0.457GluCys: 0.457 ± 0.028
2.883GluAsp: 2.883 ± 0.231
3.135GluGlu: 3.135 ± 0.092
2.29GluPhe: 2.29 ± 0.062
2.408GluGly: 2.408 ± 0.079
1.247GluHis: 1.247 ± 0.042
5.219GluIle: 5.219 ± 0.119
5.192GluLys: 5.192 ± 0.109
5.879GluLeu: 5.879 ± 0.109
1.253GluMet: 1.253 ± 0.046
4.151GluAsn: 4.151 ± 0.097
1.486GluPro: 1.486 ± 0.055
2.393GluGln: 2.393 ± 0.071
2.006GluArg: 2.006 ± 0.09
3.805GluSer: 3.805 ± 0.092
2.66GluThr: 2.66 ± 0.066
3.395GluVal: 3.395 ± 0.081
0.545GluTrp: 0.545 ± 0.03
1.967GluTyr: 1.967 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.609PheAla: 2.609 ± 0.08
0.743PheCys: 0.743 ± 0.04
2.892PheAsp: 2.892 ± 0.114
2.66PheGlu: 2.66 ± 0.068
3.132PhePhe: 3.132 ± 0.09
3.021PheGly: 3.021 ± 0.074
0.98PheHis: 0.98 ± 0.041
5.128PheIle: 5.128 ± 0.121
3.912PheLys: 3.912 ± 0.087
5.543PheLeu: 5.543 ± 0.126
1.229PheMet: 1.229 ± 0.048
3.56PheAsn: 3.56 ± 0.087
1.861PhePro: 1.861 ± 0.229
1.607PheGln: 1.607 ± 0.06
1.345PheArg: 1.345 ± 0.052
4.401PheSer: 4.401 ± 0.097
2.489PheThr: 2.489 ± 0.063
2.842PheVal: 2.842 ± 0.078
0.554PheTrp: 0.554 ± 0.028
2.136PheTyr: 2.136 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
3.544GlyAla: 3.544 ± 0.128
1.043GlyCys: 1.043 ± 0.13
3.395GlyAsp: 3.395 ± 0.432
2.602GlyGlu: 2.602 ± 0.07
3.172GlyPhe: 3.172 ± 0.077
3.652GlyGly: 3.652 ± 0.098
1.139GlyHis: 1.139 ± 0.049
5.038GlyIle: 5.038 ± 0.108
3.976GlyLys: 3.976 ± 0.093
5.825GlyLeu: 5.825 ± 0.115
1.399GlyMet: 1.399 ± 0.048
2.865GlyAsn: 2.865 ± 0.098
1.398GlyPro: 1.398 ± 0.048
1.895GlyGln: 1.895 ± 0.055
1.901GlyArg: 1.901 ± 0.067
3.683GlySer: 3.683 ± 0.089
3.473GlyThr: 3.473 ± 0.333
4.077GlyVal: 4.077 ± 0.131
0.631GlyTrp: 0.631 ± 0.034
2.358GlyTyr: 2.358 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
0.932HisAla: 0.932 ± 0.038
0.244HisCys: 0.244 ± 0.019
0.915HisAsp: 0.915 ± 0.039
1.143HisGlu: 1.143 ± 0.049
1.082HisPhe: 1.082 ± 0.042
1.098HisGly: 1.098 ± 0.041
0.518HisHis: 0.518 ± 0.035
1.604HisIle: 1.604 ± 0.055
1.507HisLys: 1.507 ± 0.054
1.966HisLeu: 1.966 ± 0.05
0.423HisMet: 0.423 ± 0.024
1.259HisAsn: 1.259 ± 0.048
0.889HisPro: 0.889 ± 0.047
0.861HisGln: 0.861 ± 0.032
0.672HisArg: 0.672 ± 0.03
1.341HisSer: 1.341 ± 0.045
0.876HisThr: 0.876 ± 0.041
0.939HisVal: 0.939 ± 0.038
0.227HisTrp: 0.227 ± 0.019
0.854HisTyr: 0.854 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.192IleAla: 5.192 ± 0.108
1.121IleCys: 1.121 ± 0.045
5.064IleAsp: 5.064 ± 0.108
5.467IleGlu: 5.467 ± 0.117
4.928IlePhe: 4.928 ± 0.107
5.385IleGly: 5.385 ± 0.104
1.71IleHis: 1.71 ± 0.055
8.251IleIle: 8.251 ± 0.157
7.554IleLys: 7.554 ± 0.153
9.27IleLeu: 9.27 ± 0.176
1.805IleMet: 1.805 ± 0.063
6.24IleAsn: 6.24 ± 0.126
3.46IlePro: 3.46 ± 0.076
3.051IleGln: 3.051 ± 0.077
2.578IleArg: 2.578 ± 0.074
7.332IleSer: 7.332 ± 0.137
4.5IleThr: 4.5 ± 0.083
4.733IleVal: 4.733 ± 0.106
0.675IleTrp: 0.675 ± 0.038
3.044IleTyr: 3.044 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
3.842LysAla: 3.842 ± 0.11
0.575LysCys: 0.575 ± 0.03
4.251LysAsp: 4.251 ± 0.097
5.179LysGlu: 5.179 ± 0.124
3.436LysPhe: 3.436 ± 0.072
3.568LysGly: 3.568 ± 0.103
1.533LysHis: 1.533 ± 0.053
7.591LysIle: 7.591 ± 0.156
8.111LysLys: 8.111 ± 0.181
7.93LysLeu: 7.93 ± 0.147
1.868LysMet: 1.868 ± 0.054
6.935LysAsn: 6.935 ± 0.128
2.416LysPro: 2.416 ± 0.075
3.033LysGln: 3.033 ± 0.088
2.643LysArg: 2.643 ± 0.08
5.618LysSer: 5.618 ± 0.104
3.97LysThr: 3.97 ± 0.079
4.731LysVal: 4.731 ± 0.108
0.78LysTrp: 0.78 ± 0.039
3.121LysTyr: 3.121 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
5.54LeuAla: 5.54 ± 0.115
1.148LeuCys: 1.148 ± 0.04
5.501LeuAsp: 5.501 ± 0.245
5.419LeuGlu: 5.419 ± 0.105
5.422LeuPhe: 5.422 ± 0.124
6.099LeuGly: 6.099 ± 0.132
1.656LeuHis: 1.656 ± 0.051
9.777LeuIle: 9.777 ± 0.19
8.777LeuLys: 8.777 ± 0.159
9.814LeuLeu: 9.814 ± 0.183
2.548LeuMet: 2.548 ± 0.07
7.487LeuAsn: 7.487 ± 0.123
3.635LeuPro: 3.635 ± 0.09
2.893LeuGln: 2.893 ± 0.077
3.081LeuArg: 3.081 ± 0.076
9.064LeuSer: 9.064 ± 0.144
5.361LeuThr: 5.361 ± 0.105
5.41LeuVal: 5.41 ± 0.11
0.793LeuTrp: 0.793 ± 0.04
3.155LeuTyr: 3.155 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
1.283MetAla: 1.283 ± 0.051
0.207MetCys: 0.207 ± 0.016
1.038MetAsp: 1.038 ± 0.043
1.084MetGlu: 1.084 ± 0.044
1.071MetPhe: 1.071 ± 0.045
1.359MetGly: 1.359 ± 0.048
0.388MetHis: 0.388 ± 0.026
2.054MetIle: 2.054 ± 0.068
2.085MetLys: 2.085 ± 0.064
2.099MetLeu: 2.099 ± 0.058
0.626MetMet: 0.626 ± 0.033
1.557MetAsn: 1.557 ± 0.05
0.864MetPro: 0.864 ± 0.04
0.75MetGln: 0.75 ± 0.033
0.741MetArg: 0.741 ± 0.032
1.807MetSer: 1.807 ± 0.061
1.241MetThr: 1.241 ± 0.047
1.19MetVal: 1.19 ± 0.048
0.155MetTrp: 0.155 ± 0.016
0.661MetTyr: 0.661 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.312AsnAla: 3.312 ± 0.199
0.666AsnCys: 0.666 ± 0.033
4.372AsnAsp: 4.372 ± 0.478
4.007AsnGlu: 4.007 ± 0.091
3.562AsnPhe: 3.562 ± 0.087
3.203AsnGly: 3.203 ± 0.078
1.43AsnHis: 1.43 ± 0.046
6.73AsnIle: 6.73 ± 0.134
5.953AsnLys: 5.953 ± 0.12
6.824AsnLeu: 6.824 ± 0.128
1.416AsnMet: 1.416 ± 0.049
5.092AsnAsn: 5.092 ± 0.114
2.314AsnPro: 2.314 ± 0.071
3.035AsnGln: 3.035 ± 0.078
1.973AsnArg: 1.973 ± 0.062
4.561AsnSer: 4.561 ± 0.086
3.49AsnThr: 3.49 ± 0.125
3.266AsnVal: 3.266 ± 0.08
0.747AsnTrp: 0.747 ± 0.031
2.805AsnTyr: 2.805 ± 0.081
0.0AsnXaa: 0.0 ± 0.0
Pro
1.476ProAla: 1.476 ± 0.069
0.321ProCys: 0.321 ± 0.02
1.777ProAsp: 1.777 ± 0.106
2.233ProGlu: 2.233 ± 0.06
1.771ProPhe: 1.771 ± 0.052
1.713ProGly: 1.713 ± 0.057
0.707ProHis: 0.707 ± 0.029
2.943ProIle: 2.943 ± 0.072
2.482ProLys: 2.482 ± 0.074
3.595ProLeu: 3.595 ± 0.209
0.726ProMet: 0.726 ± 0.034
2.317ProAsn: 2.317 ± 0.07
0.844ProPro: 0.844 ± 0.039
1.192ProGln: 1.192 ± 0.044
0.854ProArg: 0.854 ± 0.04
2.527ProSer: 2.527 ± 0.058
1.848ProThr: 1.848 ± 0.105
2.013ProVal: 2.013 ± 0.059
0.358ProTrp: 0.358 ± 0.025
1.311ProTyr: 1.311 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
1.959GlnAla: 1.959 ± 0.094
0.321GlnCys: 0.321 ± 0.023
1.597GlnAsp: 1.597 ± 0.051
1.93GlnGlu: 1.93 ± 0.059
1.757GlnPhe: 1.757 ± 0.065
1.685GlnGly: 1.685 ± 0.05
0.665GlnHis: 0.665 ± 0.031
3.176GlnIle: 3.176 ± 0.077
3.334GlnLys: 3.334 ± 0.087
3.656GlnLeu: 3.656 ± 0.081
0.805GlnMet: 0.805 ± 0.035
2.932GlnAsn: 2.932 ± 0.111
1.04GlnPro: 1.04 ± 0.04
1.372GlnGln: 1.372 ± 0.056
1.089GlnArg: 1.089 ± 0.04
2.507GlnSer: 2.507 ± 0.068
1.899GlnThr: 1.899 ± 0.063
2.107GlnVal: 2.107 ± 0.096
0.325GlnTrp: 0.325 ± 0.022
1.297GlnTyr: 1.297 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
1.781ArgAla: 1.781 ± 0.06
0.29ArgCys: 0.29 ± 0.022
1.619ArgAsp: 1.619 ± 0.057
1.937ArgGlu: 1.937 ± 0.065
1.548ArgPhe: 1.548 ± 0.046
1.562ArgGly: 1.562 ± 0.055
0.591ArgHis: 0.591 ± 0.03
2.587ArgIle: 2.587 ± 0.068
2.642ArgLys: 2.642 ± 0.087
3.202ArgLeu: 3.202 ± 0.079
0.712ArgMet: 0.712 ± 0.035
1.936ArgAsn: 1.936 ± 0.067
0.953ArgPro: 0.953 ± 0.033
1.126ArgGln: 1.126 ± 0.077
1.169ArgArg: 1.169 ± 0.048
1.918ArgSer: 1.918 ± 0.054
1.499ArgThr: 1.499 ± 0.053
2.023ArgVal: 2.023 ± 0.061
0.344ArgTrp: 0.344 ± 0.029
1.259ArgTyr: 1.259 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.554SerAla: 3.554 ± 0.081
0.801SerCys: 0.801 ± 0.034
3.966SerAsp: 3.966 ± 0.107
4.084SerGlu: 4.084 ± 0.104
4.499SerPhe: 4.499 ± 0.089
4.429SerGly: 4.429 ± 0.094
1.476SerHis: 1.476 ± 0.049
6.879SerIle: 6.879 ± 0.124
5.882SerLys: 5.882 ± 0.111
8.204SerLeu: 8.204 ± 0.144
1.626SerMet: 1.626 ± 0.051
4.937SerAsn: 4.937 ± 0.102
2.236SerPro: 2.236 ± 0.058
2.737SerGln: 2.737 ± 0.076
2.176SerArg: 2.176 ± 0.067
6.048SerSer: 6.048 ± 0.115
3.447SerThr: 3.447 ± 0.086
3.868SerVal: 3.868 ± 0.087
0.862SerTrp: 0.862 ± 0.041
2.886SerTyr: 2.886 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
2.649ThrAla: 2.649 ± 0.095
0.459ThrCys: 0.459 ± 0.03
3.487ThrAsp: 3.487 ± 0.725
2.712ThrGlu: 2.712 ± 0.153
2.714ThrPhe: 2.714 ± 0.072
3.369ThrGly: 3.369 ± 0.169
1.115ThrHis: 1.115 ± 0.038
4.406ThrIle: 4.406 ± 0.092
3.741ThrLys: 3.741 ± 0.077
5.361ThrLeu: 5.361 ± 0.105
0.913ThrMet: 0.913 ± 0.038
3.101ThrAsn: 3.101 ± 0.073
2.122ThrPro: 2.122 ± 0.071
1.984ThrGln: 1.984 ± 0.102
1.493ThrArg: 1.493 ± 0.051
3.713ThrSer: 3.713 ± 0.097
2.675ThrThr: 2.675 ± 0.072
2.903ThrVal: 2.903 ± 0.089
0.442ThrTrp: 0.442 ± 0.024
1.75ThrTyr: 1.75 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
3.301ValAla: 3.301 ± 0.081
0.716ValCys: 0.716 ± 0.031
3.138ValAsp: 3.138 ± 0.095
2.898ValGlu: 2.898 ± 0.083
3.018ValPhe: 3.018 ± 0.076
3.469ValGly: 3.469 ± 0.081
0.996ValHis: 0.996 ± 0.038
5.291ValIle: 5.291 ± 0.116
4.087ValLys: 4.087 ± 0.104
5.619ValLeu: 5.619 ± 0.091
1.342ValMet: 1.342 ± 0.043
3.51ValAsn: 3.51 ± 0.105
1.997ValPro: 1.997 ± 0.089
1.663ValGln: 1.663 ± 0.074
1.751ValArg: 1.751 ± 0.066
4.428ValSer: 4.428 ± 0.088
3.021ValThr: 3.021 ± 0.099
3.452ValVal: 3.452 ± 0.08
0.489ValTrp: 0.489 ± 0.026
1.928ValTyr: 1.928 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.473TrpAla: 0.473 ± 0.028
0.131TrpCys: 0.131 ± 0.014
0.527TrpAsp: 0.527 ± 0.028
0.44TrpGlu: 0.44 ± 0.031
0.528TrpPhe: 0.528 ± 0.031
0.625TrpGly: 0.625 ± 0.033
0.175TrpHis: 0.175 ± 0.016
0.824TrpIle: 0.824 ± 0.041
0.723TrpLys: 0.723 ± 0.036
1.197TrpLeu: 1.197 ± 0.047
0.254TrpMet: 0.254 ± 0.02
0.571TrpAsn: 0.571 ± 0.029
0.288TrpPro: 0.288 ± 0.021
0.399TrpGln: 0.399 ± 0.023
0.322TrpArg: 0.322 ± 0.027
0.73TrpSer: 0.73 ± 0.03
0.372TrpThr: 0.372 ± 0.026
0.589TrpVal: 0.589 ± 0.033
0.107TrpTrp: 0.107 ± 0.014
0.334TrpTyr: 0.334 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.855TyrAla: 1.855 ± 0.058
0.497TyrCys: 0.497 ± 0.03
2.071TyrAsp: 2.071 ± 0.057
1.807TyrGlu: 1.807 ± 0.061
2.251TyrPhe: 2.251 ± 0.058
2.01TyrGly: 2.01 ± 0.055
0.778TyrHis: 0.778 ± 0.035
3.044TyrIle: 3.044 ± 0.072
2.706TyrLys: 2.706 ± 0.071
4.196TyrLeu: 4.196 ± 0.098
0.705TyrMet: 0.705 ± 0.032
2.352TyrAsn: 2.352 ± 0.073
1.369TyrPro: 1.369 ± 0.045
1.625TyrGln: 1.625 ± 0.05
1.263TyrArg: 1.263 ± 0.048
2.67TyrSer: 2.67 ± 0.065
1.712TyrThr: 1.712 ± 0.075
1.913TyrVal: 1.913 ± 0.057
0.428TyrTrp: 0.428 ± 0.023
1.398TyrTyr: 1.398 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2308 proteins (704008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski