Amino acid dipepetide frequency for Mycobacterium virus Brujita

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.43AlaAla: 15.43 ± 1.501
0.596AlaCys: 0.596 ± 0.235
8.344AlaAsp: 8.344 ± 0.879
8.742AlaGlu: 8.742 ± 0.963
2.649AlaPhe: 2.649 ± 0.386
9.868AlaGly: 9.868 ± 1.25
1.391AlaHis: 1.391 ± 0.362
5.96AlaIle: 5.96 ± 0.597
3.642AlaLys: 3.642 ± 0.569
9.47AlaLeu: 9.47 ± 0.774
2.45AlaMet: 2.45 ± 0.482
3.377AlaAsn: 3.377 ± 0.456
5.629AlaPro: 5.629 ± 0.709
4.636AlaGln: 4.636 ± 0.783
7.682AlaArg: 7.682 ± 0.819
5.497AlaSer: 5.497 ± 0.65
5.762AlaThr: 5.762 ± 0.748
7.682AlaVal: 7.682 ± 0.838
1.854AlaTrp: 1.854 ± 0.364
3.245AlaTyr: 3.245 ± 0.36
0.0AlaXaa: 0.0 ± 0.0
Cys
0.464CysAla: 0.464 ± 0.168
0.199CysCys: 0.199 ± 0.111
0.397CysAsp: 0.397 ± 0.154
0.397CysGlu: 0.397 ± 0.209
0.132CysPhe: 0.132 ± 0.093
1.126CysGly: 1.126 ± 0.289
0.397CysHis: 0.397 ± 0.166
0.596CysIle: 0.596 ± 0.193
0.132CysLys: 0.132 ± 0.099
0.662CysLeu: 0.662 ± 0.246
0.132CysMet: 0.132 ± 0.096
0.066CysAsn: 0.066 ± 0.068
1.06CysPro: 1.06 ± 0.422
0.199CysGln: 0.199 ± 0.116
0.927CysArg: 0.927 ± 0.262
0.662CysSer: 0.662 ± 0.234
0.596CysThr: 0.596 ± 0.249
0.265CysVal: 0.265 ± 0.12
0.265CysTrp: 0.265 ± 0.158
0.199CysTyr: 0.199 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
7.748AspAla: 7.748 ± 0.773
1.126AspCys: 1.126 ± 0.323
5.762AspAsp: 5.762 ± 0.804
5.099AspGlu: 5.099 ± 0.72
1.391AspPhe: 1.391 ± 0.415
6.556AspGly: 6.556 ± 0.693
0.861AspHis: 0.861 ± 0.306
2.914AspIle: 2.914 ± 0.449
1.854AspLys: 1.854 ± 0.396
6.358AspLeu: 6.358 ± 0.601
1.192AspMet: 1.192 ± 0.27
1.987AspAsn: 1.987 ± 0.337
4.106AspPro: 4.106 ± 0.542
1.722AspGln: 1.722 ± 0.324
4.834AspArg: 4.834 ± 0.729
2.848AspSer: 2.848 ± 0.387
4.57AspThr: 4.57 ± 0.638
4.238AspVal: 4.238 ± 0.494
1.722AspTrp: 1.722 ± 0.323
1.921AspTyr: 1.921 ± 0.363
0.0AspXaa: 0.0 ± 0.0
Glu
7.616GluAla: 7.616 ± 0.684
0.927GluCys: 0.927 ± 0.269
2.781GluAsp: 2.781 ± 0.485
3.179GluGlu: 3.179 ± 0.433
2.848GluPhe: 2.848 ± 0.548
3.974GluGly: 3.974 ± 0.491
1.788GluHis: 1.788 ± 0.482
2.781GluIle: 2.781 ± 0.52
1.987GluLys: 1.987 ± 0.424
6.225GluLeu: 6.225 ± 0.757
0.993GluMet: 0.993 ± 0.238
1.325GluAsn: 1.325 ± 0.304
2.98GluPro: 2.98 ± 0.54
1.987GluGln: 1.987 ± 0.407
4.172GluArg: 4.172 ± 0.439
2.848GluSer: 2.848 ± 0.443
3.642GluThr: 3.642 ± 0.525
4.636GluVal: 4.636 ± 0.549
1.192GluTrp: 1.192 ± 0.219
1.987GluTyr: 1.987 ± 0.289
0.0GluXaa: 0.0 ± 0.0
Phe
2.715PheAla: 2.715 ± 0.415
0.132PheCys: 0.132 ± 0.113
2.848PheAsp: 2.848 ± 0.501
1.325PheGlu: 1.325 ± 0.254
0.53PhePhe: 0.53 ± 0.178
3.907PheGly: 3.907 ± 0.552
0.331PheHis: 0.331 ± 0.165
1.523PheIle: 1.523 ± 0.273
1.06PheLys: 1.06 ± 0.305
1.921PheLeu: 1.921 ± 0.392
0.464PheMet: 0.464 ± 0.171
0.927PheAsn: 0.927 ± 0.25
1.192PhePro: 1.192 ± 0.335
1.192PheGln: 1.192 ± 0.286
1.854PheArg: 1.854 ± 0.295
1.457PheSer: 1.457 ± 0.259
1.523PheThr: 1.523 ± 0.375
2.318PheVal: 2.318 ± 0.434
0.795PheTrp: 0.795 ± 0.245
0.795PheTyr: 0.795 ± 0.289
0.0PheXaa: 0.0 ± 0.0
Gly
8.808GlyAla: 8.808 ± 0.949
0.397GlyCys: 0.397 ± 0.144
6.225GlyAsp: 6.225 ± 0.714
5.033GlyGlu: 5.033 ± 0.501
2.715GlyPhe: 2.715 ± 0.504
9.272GlyGly: 9.272 ± 1.645
1.854GlyHis: 1.854 ± 0.379
4.04GlyIle: 4.04 ± 0.845
2.98GlyLys: 2.98 ± 0.405
6.026GlyLeu: 6.026 ± 0.851
2.053GlyMet: 2.053 ± 0.425
3.841GlyAsn: 3.841 ± 0.624
5.232GlyPro: 5.232 ± 0.63
4.04GlyGln: 4.04 ± 0.593
6.623GlyArg: 6.623 ± 0.751
5.166GlySer: 5.166 ± 0.64
5.894GlyThr: 5.894 ± 0.573
5.563GlyVal: 5.563 ± 0.629
1.854GlyTrp: 1.854 ± 0.341
2.715GlyTyr: 2.715 ± 0.402
0.0GlyXaa: 0.0 ± 0.0
His
2.053HisAla: 2.053 ± 0.439
0.132HisCys: 0.132 ± 0.095
1.06HisAsp: 1.06 ± 0.292
1.126HisGlu: 1.126 ± 0.349
0.53HisPhe: 0.53 ± 0.17
1.722HisGly: 1.722 ± 0.302
0.53HisHis: 0.53 ± 0.231
0.728HisIle: 0.728 ± 0.243
0.464HisLys: 0.464 ± 0.176
1.523HisLeu: 1.523 ± 0.345
0.199HisMet: 0.199 ± 0.105
0.662HisAsn: 0.662 ± 0.215
1.06HisPro: 1.06 ± 0.28
1.325HisGln: 1.325 ± 0.321
1.258HisArg: 1.258 ± 0.363
0.662HisSer: 0.662 ± 0.189
0.927HisThr: 0.927 ± 0.224
1.523HisVal: 1.523 ± 0.371
0.728HisTrp: 0.728 ± 0.244
1.192HisTyr: 1.192 ± 0.291
0.0HisXaa: 0.0 ± 0.0
Ile
5.96IleAla: 5.96 ± 0.623
0.0IleCys: 0.0 ± 0.0
3.642IleAsp: 3.642 ± 0.485
3.113IleGlu: 3.113 ± 0.507
0.662IlePhe: 0.662 ± 0.263
4.834IleGly: 4.834 ± 0.54
0.861IleHis: 0.861 ± 0.238
1.457IleIle: 1.457 ± 0.336
1.722IleLys: 1.722 ± 0.32
2.185IleLeu: 2.185 ± 0.354
0.662IleMet: 0.662 ± 0.18
1.457IleAsn: 1.457 ± 0.274
2.715IlePro: 2.715 ± 0.364
1.06IleGln: 1.06 ± 0.305
4.238IleArg: 4.238 ± 0.517
2.517IleSer: 2.517 ± 0.394
2.583IleThr: 2.583 ± 0.42
3.377IleVal: 3.377 ± 0.373
0.464IleTrp: 0.464 ± 0.223
1.258IleTyr: 1.258 ± 0.239
0.0IleXaa: 0.0 ± 0.0
Lys
4.04LysAla: 4.04 ± 0.514
0.066LysCys: 0.066 ± 0.079
2.185LysAsp: 2.185 ± 0.464
1.523LysGlu: 1.523 ± 0.374
1.457LysPhe: 1.457 ± 0.435
2.649LysGly: 2.649 ± 0.474
1.126LysHis: 1.126 ± 0.309
1.457LysIle: 1.457 ± 0.363
0.861LysLys: 0.861 ± 0.227
2.384LysLeu: 2.384 ± 0.399
1.391LysMet: 1.391 ± 0.294
1.258LysAsn: 1.258 ± 0.233
3.311LysPro: 3.311 ± 0.549
0.397LysGln: 0.397 ± 0.136
2.119LysArg: 2.119 ± 0.533
1.192LysSer: 1.192 ± 0.287
1.722LysThr: 1.722 ± 0.368
2.318LysVal: 2.318 ± 0.368
0.861LysTrp: 0.861 ± 0.221
0.464LysTyr: 0.464 ± 0.192
0.0LysXaa: 0.0 ± 0.0
Leu
9.868LeuAla: 9.868 ± 0.954
0.662LeuCys: 0.662 ± 0.278
5.695LeuAsp: 5.695 ± 0.835
3.311LeuGlu: 3.311 ± 0.391
2.517LeuPhe: 2.517 ± 0.39
6.689LeuGly: 6.689 ± 0.694
1.391LeuHis: 1.391 ± 0.342
3.444LeuIle: 3.444 ± 0.381
3.51LeuLys: 3.51 ± 0.637
6.291LeuLeu: 6.291 ± 0.742
1.457LeuMet: 1.457 ± 0.321
3.245LeuAsn: 3.245 ± 0.544
5.629LeuPro: 5.629 ± 0.628
2.45LeuGln: 2.45 ± 0.403
5.364LeuArg: 5.364 ± 0.7
3.642LeuSer: 3.642 ± 0.528
4.437LeuThr: 4.437 ± 0.402
6.026LeuVal: 6.026 ± 0.508
1.258LeuTrp: 1.258 ± 0.294
1.589LeuTyr: 1.589 ± 0.398
0.0LeuXaa: 0.0 ± 0.0
Met
3.245MetAla: 3.245 ± 0.504
0.397MetCys: 0.397 ± 0.16
0.331MetAsp: 0.331 ± 0.13
1.06MetGlu: 1.06 ± 0.374
0.662MetPhe: 0.662 ± 0.197
1.258MetGly: 1.258 ± 0.446
0.596MetHis: 0.596 ± 0.197
0.662MetIle: 0.662 ± 0.256
0.662MetLys: 0.662 ± 0.203
1.921MetLeu: 1.921 ± 0.421
0.199MetMet: 0.199 ± 0.107
0.662MetAsn: 0.662 ± 0.188
1.987MetPro: 1.987 ± 0.36
0.927MetGln: 0.927 ± 0.259
1.391MetArg: 1.391 ± 0.306
2.252MetSer: 2.252 ± 0.355
2.053MetThr: 2.053 ± 0.455
0.662MetVal: 0.662 ± 0.235
0.265MetTrp: 0.265 ± 0.134
0.331MetTyr: 0.331 ± 0.143
0.0MetXaa: 0.0 ± 0.0
Asn
3.51AsnAla: 3.51 ± 0.579
0.265AsnCys: 0.265 ± 0.131
1.788AsnAsp: 1.788 ± 0.409
1.457AsnGlu: 1.457 ± 0.331
0.662AsnPhe: 0.662 ± 0.207
3.311AsnGly: 3.311 ± 0.569
0.464AsnHis: 0.464 ± 0.171
1.06AsnIle: 1.06 ± 0.326
0.795AsnLys: 0.795 ± 0.219
3.642AsnLeu: 3.642 ± 0.691
0.596AsnMet: 0.596 ± 0.194
1.06AsnAsn: 1.06 ± 0.289
3.245AsnPro: 3.245 ± 0.462
0.861AsnGln: 0.861 ± 0.262
2.45AsnArg: 2.45 ± 0.516
1.722AsnSer: 1.722 ± 0.353
1.656AsnThr: 1.656 ± 0.355
2.318AsnVal: 2.318 ± 0.324
0.993AsnTrp: 0.993 ± 0.232
0.861AsnTyr: 0.861 ± 0.255
0.0AsnXaa: 0.0 ± 0.0
Pro
5.497ProAla: 5.497 ± 0.718
0.265ProCys: 0.265 ± 0.141
4.636ProAsp: 4.636 ± 0.566
4.172ProGlu: 4.172 ± 0.596
2.45ProPhe: 2.45 ± 0.336
6.755ProGly: 6.755 ± 1.046
0.662ProHis: 0.662 ± 0.214
2.781ProIle: 2.781 ± 0.399
2.053ProLys: 2.053 ± 0.378
4.636ProLeu: 4.636 ± 0.63
1.523ProMet: 1.523 ± 0.336
2.318ProAsn: 2.318 ± 0.418
3.311ProPro: 3.311 ± 0.617
2.119ProGln: 2.119 ± 0.508
3.311ProArg: 3.311 ± 0.637
3.377ProSer: 3.377 ± 0.448
3.907ProThr: 3.907 ± 0.547
4.437ProVal: 4.437 ± 0.466
1.192ProTrp: 1.192 ± 0.268
1.258ProTyr: 1.258 ± 0.342
0.0ProXaa: 0.0 ± 0.0
Gln
4.636GlnAla: 4.636 ± 0.67
0.331GlnCys: 0.331 ± 0.156
1.325GlnAsp: 1.325 ± 0.274
1.06GlnGlu: 1.06 ± 0.28
1.06GlnPhe: 1.06 ± 0.244
2.848GlnGly: 2.848 ± 0.828
0.795GlnHis: 0.795 ± 0.272
2.053GlnIle: 2.053 ± 0.455
0.993GlnLys: 0.993 ± 0.246
2.781GlnLeu: 2.781 ± 0.616
0.861GlnMet: 0.861 ± 0.22
1.258GlnAsn: 1.258 ± 0.287
2.45GlnPro: 2.45 ± 0.306
2.45GlnGln: 2.45 ± 0.488
4.04GlnArg: 4.04 ± 0.5
1.987GlnSer: 1.987 ± 0.335
1.722GlnThr: 1.722 ± 0.294
2.384GlnVal: 2.384 ± 0.367
0.795GlnTrp: 0.795 ± 0.209
0.662GlnTyr: 0.662 ± 0.263
0.0GlnXaa: 0.0 ± 0.0
Arg
7.55ArgAla: 7.55 ± 0.852
0.728ArgCys: 0.728 ± 0.307
6.159ArgAsp: 6.159 ± 0.662
4.371ArgGlu: 4.371 ± 0.572
2.185ArgPhe: 2.185 ± 0.355
4.768ArgGly: 4.768 ± 0.541
1.788ArgHis: 1.788 ± 0.449
3.046ArgIle: 3.046 ± 0.505
2.649ArgLys: 2.649 ± 0.358
5.96ArgLeu: 5.96 ± 0.714
2.318ArgMet: 2.318 ± 0.425
2.45ArgAsn: 2.45 ± 0.344
3.576ArgPro: 3.576 ± 0.43
2.583ArgGln: 2.583 ± 0.468
7.086ArgArg: 7.086 ± 1.016
3.576ArgSer: 3.576 ± 0.539
4.172ArgThr: 4.172 ± 0.653
4.702ArgVal: 4.702 ± 0.673
1.987ArgTrp: 1.987 ± 0.447
2.119ArgTyr: 2.119 ± 0.47
0.0ArgXaa: 0.0 ± 0.0
Ser
6.093SerAla: 6.093 ± 0.665
0.53SerCys: 0.53 ± 0.228
3.51SerAsp: 3.51 ± 0.446
2.252SerGlu: 2.252 ± 0.448
1.391SerPhe: 1.391 ± 0.278
5.232SerGly: 5.232 ± 0.638
0.861SerHis: 0.861 ± 0.225
2.583SerIle: 2.583 ± 0.421
1.722SerLys: 1.722 ± 0.351
2.98SerLeu: 2.98 ± 0.507
1.523SerMet: 1.523 ± 0.272
1.722SerAsn: 1.722 ± 0.309
2.914SerPro: 2.914 ± 0.403
2.185SerGln: 2.185 ± 0.523
4.172SerArg: 4.172 ± 0.634
2.185SerSer: 2.185 ± 0.589
3.377SerThr: 3.377 ± 0.413
3.974SerVal: 3.974 ± 0.618
1.457SerTrp: 1.457 ± 0.316
0.795SerTyr: 0.795 ± 0.244
0.0SerXaa: 0.0 ± 0.0
Thr
6.623ThrAla: 6.623 ± 0.572
0.464ThrCys: 0.464 ± 0.214
3.377ThrAsp: 3.377 ± 0.463
3.51ThrGlu: 3.51 ± 0.558
1.854ThrPhe: 1.854 ± 0.413
5.497ThrGly: 5.497 ± 0.69
1.192ThrHis: 1.192 ± 0.27
3.046ThrIle: 3.046 ± 0.493
1.987ThrLys: 1.987 ± 0.349
4.768ThrLeu: 4.768 ± 0.53
1.06ThrMet: 1.06 ± 0.272
1.854ThrAsn: 1.854 ± 0.342
4.238ThrPro: 4.238 ± 0.521
1.921ThrGln: 1.921 ± 0.362
3.245ThrArg: 3.245 ± 0.524
3.311ThrSer: 3.311 ± 0.382
3.113ThrThr: 3.113 ± 0.614
4.901ThrVal: 4.901 ± 0.509
1.06ThrTrp: 1.06 ± 0.275
1.987ThrTyr: 1.987 ± 0.381
0.0ThrXaa: 0.0 ± 0.0
Val
7.748ValAla: 7.748 ± 0.852
0.861ValCys: 0.861 ± 0.264
5.099ValAsp: 5.099 ± 0.582
5.695ValGlu: 5.695 ± 0.648
1.589ValPhe: 1.589 ± 0.32
6.291ValGly: 6.291 ± 0.872
1.589ValHis: 1.589 ± 0.386
2.649ValIle: 2.649 ± 0.467
2.517ValLys: 2.517 ± 0.322
4.702ValLeu: 4.702 ± 0.592
1.391ValMet: 1.391 ± 0.241
2.252ValAsn: 2.252 ± 0.37
3.377ValPro: 3.377 ± 0.448
2.517ValGln: 2.517 ± 0.46
5.033ValArg: 5.033 ± 0.511
4.172ValSer: 4.172 ± 0.654
5.166ValThr: 5.166 ± 0.631
6.225ValVal: 6.225 ± 0.714
0.927ValTrp: 0.927 ± 0.225
1.656ValTyr: 1.656 ± 0.316
0.0ValXaa: 0.0 ± 0.0
Trp
1.854TrpAla: 1.854 ± 0.416
0.331TrpCys: 0.331 ± 0.148
1.722TrpAsp: 1.722 ± 0.384
1.258TrpGlu: 1.258 ± 0.3
0.993TrpPhe: 0.993 ± 0.25
1.06TrpGly: 1.06 ± 0.281
0.265TrpHis: 0.265 ± 0.166
0.927TrpIle: 0.927 ± 0.296
0.53TrpLys: 0.53 ± 0.159
2.119TrpLeu: 2.119 ± 0.339
0.53TrpMet: 0.53 ± 0.224
0.331TrpAsn: 0.331 ± 0.152
1.192TrpPro: 1.192 ± 0.237
0.993TrpGln: 0.993 ± 0.26
2.053TrpArg: 2.053 ± 0.451
0.993TrpSer: 0.993 ± 0.275
1.06TrpThr: 1.06 ± 0.258
1.523TrpVal: 1.523 ± 0.35
0.662TrpTrp: 0.662 ± 0.226
0.331TrpTyr: 0.331 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.45TyrAla: 2.45 ± 0.43
0.464TyrCys: 0.464 ± 0.157
1.921TyrAsp: 1.921 ± 0.373
2.185TyrGlu: 2.185 ± 0.338
0.53TyrPhe: 0.53 ± 0.174
2.715TyrGly: 2.715 ± 0.421
0.662TyrHis: 0.662 ± 0.162
1.06TyrIle: 1.06 ± 0.323
0.662TyrLys: 0.662 ± 0.197
1.921TyrLeu: 1.921 ± 0.451
0.464TyrMet: 0.464 ± 0.134
0.662TyrAsn: 0.662 ± 0.183
1.523TyrPro: 1.523 ± 0.257
0.927TyrGln: 0.927 ± 0.242
1.921TyrArg: 1.921 ± 0.347
1.391TyrSer: 1.391 ± 0.335
1.126TyrThr: 1.126 ± 0.319
2.384TyrVal: 2.384 ± 0.325
0.397TyrTrp: 0.397 ± 0.17
0.795TyrTyr: 0.795 ± 0.237
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (15101 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski