Amino acid dipepetide frequency for Polystyrenella longa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.414AlaAla: 7.414 ± 0.093	0.909AlaCys: 0.909 ± 0.022	4.625AlaAsp: 4.625 ± 0.053	6.173AlaGlu: 6.173 ± 0.075	2.838AlaPhe: 2.838 ± 0.042	6.189AlaGly: 6.189 ± 0.074	1.495AlaHis: 1.495 ± 0.032	4.809AlaIle: 4.809 ± 0.053	3.294AlaLys: 3.294 ± 0.051	7.124AlaLeu: 7.124 ± 0.075	1.97AlaMet: 1.97 ± 0.043	2.907AlaAsn: 2.907 ± 0.049	3.272AlaPro: 3.272 ± 0.054	2.959AlaGln: 2.959 ± 0.05	4.161AlaArg: 4.161 ± 0.058	4.916AlaSer: 4.916 ± 0.054	4.579AlaThr: 4.579 ± 0.059	5.353AlaVal: 5.353 ± 0.068	1.0AlaTrp: 1.0 ± 0.027	2.046AlaTyr: 2.046 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.673CysAla: 0.673 ± 0.022	0.273CysCys: 0.273 ± 0.022	0.638CysAsp: 0.638 ± 0.022	0.669CysGlu: 0.669 ± 0.022	0.508CysPhe: 0.508 ± 0.017	0.925CysGly: 0.925 ± 0.025	0.417CysHis: 0.417 ± 0.02	0.521CysIle: 0.521 ± 0.017	0.349CysLys: 0.349 ± 0.016	1.173CysLeu: 1.173 ± 0.03	0.238CysMet: 0.238 ± 0.011	0.335CysAsn: 0.335 ± 0.014	0.533CysPro: 0.533 ± 0.021	0.417CysGln: 0.417 ± 0.016	0.706CysArg: 0.706 ± 0.024	0.71CysSer: 0.71 ± 0.022	0.486CysThr: 0.486 ± 0.019	0.632CysVal: 0.632 ± 0.019	0.173CysTrp: 0.173 ± 0.011	0.356CysTyr: 0.356 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.234AspAla: 4.234 ± 0.056	0.593AspCys: 0.593 ± 0.021	3.549AspAsp: 3.549 ± 0.074	4.421AspGlu: 4.421 ± 0.059	2.639AspPhe: 2.639 ± 0.053	4.387AspGly: 4.387 ± 0.101	1.401AspHis: 1.401 ± 0.034	3.036AspIle: 3.036 ± 0.046	2.28AspLys: 2.28 ± 0.043	6.028AspLeu: 6.028 ± 0.072	1.142AspMet: 1.142 ± 0.029	2.015AspAsn: 2.015 ± 0.039	3.223AspPro: 3.223 ± 0.053	2.726AspGln: 2.726 ± 0.043	3.433AspArg: 3.433 ± 0.053	3.748AspSer: 3.748 ± 0.071	2.552AspThr: 2.552 ± 0.049	3.868AspVal: 3.868 ± 0.049	1.047AspTrp: 1.047 ± 0.026	1.893AspTyr: 1.893 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.604GluAla: 5.604 ± 0.064	0.552GluCys: 0.552 ± 0.018	3.527GluAsp: 3.527 ± 0.052	5.975GluGlu: 5.975 ± 0.088	2.807GluPhe: 2.807 ± 0.044	4.39GluGly: 4.39 ± 0.051	1.479GluHis: 1.479 ± 0.029	4.523GluIle: 4.523 ± 0.053	3.783GluLys: 3.783 ± 0.062	7.773GluLeu: 7.773 ± 0.092	2.036GluMet: 2.036 ± 0.033	2.89GluAsn: 2.89 ± 0.037	3.116GluPro: 3.116 ± 0.051	3.795GluGln: 3.795 ± 0.059	3.939GluArg: 3.939 ± 0.06	4.694GluSer: 4.694 ± 0.062	4.322GluThr: 4.322 ± 0.061	4.687GluVal: 4.687 ± 0.057	1.047GluTrp: 1.047 ± 0.024	2.005GluTyr: 2.005 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.045	0.595PheCys: 0.595 ± 0.022	2.837PheAsp: 2.837 ± 0.049	2.747PheGlu: 2.747 ± 0.043	1.601PhePhe: 1.601 ± 0.039	3.075PheGly: 3.075 ± 0.049	0.883PheHis: 0.883 ± 0.025	1.961PheIle: 1.961 ± 0.04	1.537PheLys: 1.537 ± 0.034	4.012PheLeu: 4.012 ± 0.054	0.839PheMet: 0.839 ± 0.022	1.629PheAsn: 1.629 ± 0.039	1.821PhePro: 1.821 ± 0.033	1.694PheGln: 1.694 ± 0.036	2.279PheArg: 2.279 ± 0.038	2.918PheSer: 2.918 ± 0.051	2.255PheThr: 2.255 ± 0.045	2.645PheVal: 2.645 ± 0.04	0.619PheTrp: 0.619 ± 0.023	1.223PheTyr: 1.223 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	4.799GlyAla: 4.799 ± 0.064	0.926GlyCys: 0.926 ± 0.027	4.185GlyAsp: 4.185 ± 0.077	4.843GlyGlu: 4.843 ± 0.055	3.037GlyPhe: 3.037 ± 0.048	5.409GlyGly: 5.409 ± 0.091	1.673GlyHis: 1.673 ± 0.032	4.314GlyIle: 4.314 ± 0.05	3.831GlyLys: 3.831 ± 0.059	6.746GlyLeu: 6.746 ± 0.08	1.908GlyMet: 1.908 ± 0.037	2.922GlyAsn: 2.922 ± 0.061	2.697GlyPro: 2.697 ± 0.047	2.83GlyGln: 2.83 ± 0.051	3.829GlyArg: 3.829 ± 0.051	4.656GlySer: 4.656 ± 0.069	4.293GlyThr: 4.293 ± 0.087	4.62GlyVal: 4.62 ± 0.06	1.163GlyTrp: 1.163 ± 0.031	2.366GlyTyr: 2.366 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.558HisAla: 1.558 ± 0.033	0.298HisCys: 0.298 ± 0.013	1.276HisAsp: 1.276 ± 0.027	1.426HisGlu: 1.426 ± 0.028	1.009HisPhe: 1.009 ± 0.025	1.6HisGly: 1.6 ± 0.039	0.747HisHis: 0.747 ± 0.025	1.1HisIle: 1.1 ± 0.028	0.768HisLys: 0.768 ± 0.024	2.436HisLeu: 2.436 ± 0.041	0.406HisMet: 0.406 ± 0.017	0.753HisAsn: 0.753 ± 0.024	1.395HisPro: 1.395 ± 0.034	1.126HisGln: 1.126 ± 0.024	1.379HisArg: 1.379 ± 0.033	1.504HisSer: 1.504 ± 0.028	0.995HisThr: 0.995 ± 0.026	1.36HisVal: 1.36 ± 0.027	0.463HisTrp: 0.463 ± 0.018	0.779HisTyr: 0.779 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.867IleAla: 4.867 ± 0.064	0.75IleCys: 0.75 ± 0.025	4.026IleAsp: 4.026 ± 0.053	4.3IleGlu: 4.3 ± 0.055	1.968IlePhe: 1.968 ± 0.039	4.032IleGly: 4.032 ± 0.061	1.27IleHis: 1.27 ± 0.026	2.728IleIle: 2.728 ± 0.045	2.372IleLys: 2.372 ± 0.037	5.162IleLeu: 5.162 ± 0.064	1.015IleMet: 1.015 ± 0.024	2.212IleAsn: 2.212 ± 0.036	3.154IlePro: 3.154 ± 0.049	2.239IleGln: 2.239 ± 0.041	3.238IleArg: 3.238 ± 0.046	3.882IleSer: 3.882 ± 0.057	3.14IleThr: 3.14 ± 0.056	3.998IleVal: 3.998 ± 0.054	0.725IleTrp: 0.725 ± 0.022	1.528IleTyr: 1.528 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.377LysAla: 3.377 ± 0.048	0.32LysCys: 0.32 ± 0.016	1.985LysAsp: 1.985 ± 0.035	3.374LysGlu: 3.374 ± 0.054	1.452LysPhe: 1.452 ± 0.028	2.666LysGly: 2.666 ± 0.047	0.957LysHis: 0.957 ± 0.026	2.54LysIle: 2.54 ± 0.039	2.59LysLys: 2.59 ± 0.06	4.635LysLeu: 4.635 ± 0.063	1.242LysMet: 1.242 ± 0.029	1.676LysAsn: 1.676 ± 0.036	2.527LysPro: 2.527 ± 0.044	2.381LysGln: 2.381 ± 0.041	2.588LysArg: 2.588 ± 0.044	3.122LysSer: 3.122 ± 0.046	2.755LysThr: 2.755 ± 0.042	2.917LysVal: 2.917 ± 0.058	0.621LysTrp: 0.621 ± 0.02	1.302LysTyr: 1.302 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	8.453LeuAla: 8.453 ± 0.074	1.105LeuCys: 1.105 ± 0.03	5.799LeuAsp: 5.799 ± 0.065	6.735LeuGlu: 6.735 ± 0.075	4.264LeuPhe: 4.264 ± 0.057	6.492LeuGly: 6.492 ± 0.082	2.11LeuHis: 2.11 ± 0.037	5.903LeuIle: 5.903 ± 0.072	5.248LeuLys: 5.248 ± 0.065	10.354LeuLeu: 10.354 ± 0.109	2.307LeuMet: 2.307 ± 0.041	4.029LeuAsn: 4.029 ± 0.055	4.994LeuPro: 4.994 ± 0.06	4.161LeuGln: 4.161 ± 0.062	5.184LeuArg: 5.184 ± 0.068	7.067LeuSer: 7.067 ± 0.078	6.003LeuThr: 6.003 ± 0.062	6.502LeuVal: 6.502 ± 0.074	1.311LeuTrp: 1.311 ± 0.033	2.432LeuTyr: 2.432 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.972MetAla: 1.972 ± 0.038	0.198MetCys: 0.198 ± 0.011	1.012MetAsp: 1.012 ± 0.024	1.407MetGlu: 1.407 ± 0.032	0.855MetPhe: 0.855 ± 0.022	1.614MetGly: 1.614 ± 0.035	0.5MetHis: 0.5 ± 0.019	1.37MetIle: 1.37 ± 0.03	1.293MetLys: 1.293 ± 0.032	2.422MetLeu: 2.422 ± 0.044	0.667MetMet: 0.667 ± 0.021	1.044MetAsn: 1.044 ± 0.027	1.162MetPro: 1.162 ± 0.03	1.036MetGln: 1.036 ± 0.029	1.209MetArg: 1.209 ± 0.029	1.708MetSer: 1.708 ± 0.033	1.586MetThr: 1.586 ± 0.035	1.504MetVal: 1.504 ± 0.035	0.237MetTrp: 0.237 ± 0.012	0.477MetTyr: 0.477 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.712AsnAla: 2.712 ± 0.044	0.433AsnCys: 0.433 ± 0.018	2.279AsnAsp: 2.279 ± 0.048	2.6AsnGlu: 2.6 ± 0.045	1.43AsnPhe: 1.43 ± 0.032	2.97AsnGly: 2.97 ± 0.062	0.885AsnHis: 0.885 ± 0.024	2.043AsnIle: 2.043 ± 0.038	1.509AsnLys: 1.509 ± 0.035	3.747AsnLeu: 3.747 ± 0.055	0.861AsnMet: 0.861 ± 0.025	1.603AsnAsn: 1.603 ± 0.047	2.41AsnPro: 2.41 ± 0.041	1.918AsnGln: 1.918 ± 0.038	2.435AsnArg: 2.435 ± 0.042	2.734AsnSer: 2.734 ± 0.047	1.841AsnThr: 1.841 ± 0.037	2.431AsnVal: 2.431 ± 0.041	0.713AsnTrp: 0.713 ± 0.021	1.169AsnTyr: 1.169 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.149ProAla: 4.149 ± 0.057	0.35ProCys: 0.35 ± 0.013	3.265ProAsp: 3.265 ± 0.044	4.746ProGlu: 4.746 ± 0.068	2.036ProPhe: 2.036 ± 0.036	3.52ProGly: 3.52 ± 0.048	1.122ProHis: 1.122 ± 0.028	2.583ProIle: 2.583 ± 0.038	1.894ProLys: 1.894 ± 0.039	4.404ProLeu: 4.404 ± 0.056	0.988ProMet: 0.988 ± 0.026	1.936ProAsn: 1.936 ± 0.041	2.337ProPro: 2.337 ± 0.049	2.047ProGln: 2.047 ± 0.043	2.203ProArg: 2.203 ± 0.037	2.998ProSer: 2.998 ± 0.047	2.806ProThr: 2.806 ± 0.046	3.831ProVal: 3.831 ± 0.052	0.64ProTrp: 0.64 ± 0.018	1.252ProTyr: 1.252 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.516GlnAla: 3.516 ± 0.06	0.329GlnCys: 0.329 ± 0.016	1.936GlnAsp: 1.936 ± 0.035	2.976GlnGlu: 2.976 ± 0.05	1.899GlnPhe: 1.899 ± 0.034	2.606GlnGly: 2.606 ± 0.044	0.983GlnHis: 0.983 ± 0.024	2.692GlnIle: 2.692 ± 0.047	2.119GlnLys: 2.119 ± 0.039	4.945GlnLeu: 4.945 ± 0.075	1.026GlnMet: 1.026 ± 0.029	1.806GlnAsn: 1.806 ± 0.042	2.138GlnPro: 2.138 ± 0.043	2.721GlnGln: 2.721 ± 0.072	2.373GlnArg: 2.373 ± 0.043	2.787GlnSer: 2.787 ± 0.044	2.548GlnThr: 2.548 ± 0.037	2.93GlnVal: 2.93 ± 0.039	0.541GlnTrp: 0.541 ± 0.018	1.231GlnTyr: 1.231 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	3.549ArgAla: 3.549 ± 0.048	0.528ArgCys: 0.528 ± 0.016	3.112ArgAsp: 3.112 ± 0.047	4.115ArgGlu: 4.115 ± 0.062	2.612ArgPhe: 2.612 ± 0.04	3.333ArgGly: 3.333 ± 0.053	1.297ArgHis: 1.297 ± 0.032	3.461ArgIle: 3.461 ± 0.046	2.804ArgLys: 2.804 ± 0.044	5.948ArgLeu: 5.948 ± 0.073	1.467ArgMet: 1.467 ± 0.032	2.205ArgAsn: 2.205 ± 0.042	2.439ArgPro: 2.439 ± 0.043	2.615ArgGln: 2.615 ± 0.05	3.571ArgArg: 3.571 ± 0.06	3.503ArgSer: 3.503 ± 0.045	2.984ArgThr: 2.984 ± 0.042	3.528ArgVal: 3.528 ± 0.046	0.891ArgTrp: 0.891 ± 0.024	1.758ArgTyr: 1.758 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.915SerAla: 4.915 ± 0.059	0.674SerCys: 0.674 ± 0.024	3.994SerAsp: 3.994 ± 0.059	4.711SerGlu: 4.711 ± 0.054	2.73SerPhe: 2.73 ± 0.042	5.347SerGly: 5.347 ± 0.083	1.523SerHis: 1.523 ± 0.033	3.707SerIle: 3.707 ± 0.065	2.618SerLys: 2.618 ± 0.041	7.035SerLeu: 7.035 ± 0.072	1.521SerMet: 1.521 ± 0.032	2.56SerAsn: 2.56 ± 0.049	3.5SerPro: 3.5 ± 0.05	2.784SerGln: 2.784 ± 0.046	3.871SerArg: 3.871 ± 0.055	4.946SerSer: 4.946 ± 0.08	3.792SerThr: 3.792 ± 0.056	4.184SerVal: 4.184 ± 0.054	0.987SerTrp: 0.987 ± 0.023	1.722SerTyr: 1.722 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.693ThrAla: 4.693 ± 0.065	0.538ThrCys: 0.538 ± 0.019	3.371ThrAsp: 3.371 ± 0.062	3.986ThrGlu: 3.986 ± 0.048	2.218ThrPhe: 2.218 ± 0.04	4.909ThrGly: 4.909 ± 0.079	1.151ThrHis: 1.151 ± 0.028	3.329ThrIle: 3.329 ± 0.052	2.059ThrLys: 2.059 ± 0.041	5.439ThrLeu: 5.439 ± 0.07	1.128ThrMet: 1.128 ± 0.027	2.024ThrAsn: 2.024 ± 0.04	3.209ThrPro: 3.209 ± 0.052	1.997ThrGln: 1.997 ± 0.032	2.9ThrArg: 2.9 ± 0.041	3.799ThrSer: 3.799 ± 0.064	3.346ThrThr: 3.346 ± 0.072	4.046ThrVal: 4.046 ± 0.065	0.854ThrTrp: 0.854 ± 0.023	1.548ThrTyr: 1.548 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	5.485ValAla: 5.485 ± 0.058	0.834ValCys: 0.834 ± 0.03	4.136ValAsp: 4.136 ± 0.062	4.904ValGlu: 4.904 ± 0.058	2.49ValPhe: 2.49 ± 0.042	4.471ValGly: 4.471 ± 0.057	1.37ValHis: 1.37 ± 0.031	3.94ValIle: 3.94 ± 0.058	2.753ValLys: 2.753 ± 0.048	6.481ValLeu: 6.481 ± 0.077	1.592ValMet: 1.592 ± 0.032	2.497ValAsn: 2.497 ± 0.041	3.19ValPro: 3.19 ± 0.049	2.482ValGln: 2.482 ± 0.041	3.707ValArg: 3.707 ± 0.051	4.489ValSer: 4.489 ± 0.052	4.047ValThr: 4.047 ± 0.062	4.811ValVal: 4.811 ± 0.058	0.954ValTrp: 0.954 ± 0.028	1.851ValTyr: 1.851 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.919TrpAla: 0.919 ± 0.026	0.156TrpCys: 0.156 ± 0.009	0.806TrpAsp: 0.806 ± 0.021	0.929TrpGlu: 0.929 ± 0.025	0.615TrpPhe: 0.615 ± 0.022	0.986TrpGly: 0.986 ± 0.024	0.367TrpHis: 0.367 ± 0.016	0.847TrpIle: 0.847 ± 0.021	0.89TrpLys: 0.89 ± 0.023	1.558TrpLeu: 1.558 ± 0.037	0.433TrpMet: 0.433 ± 0.016	0.704TrpAsn: 0.704 ± 0.022	0.579TrpPro: 0.579 ± 0.021	0.699TrpGln: 0.699 ± 0.021	0.823TrpArg: 0.823 ± 0.021	1.056TrpSer: 1.056 ± 0.031	0.822TrpThr: 0.822 ± 0.029	0.859TrpVal: 0.859 ± 0.023	0.255TrpTrp: 0.255 ± 0.014	0.444TrpTyr: 0.444 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.026TyrAla: 2.026 ± 0.036	0.37TyrCys: 0.37 ± 0.014	1.856TyrAsp: 1.856 ± 0.044	1.907TyrGlu: 1.907 ± 0.036	1.28TyrPhe: 1.28 ± 0.031	2.128TyrGly: 2.128 ± 0.04	0.746TyrHis: 0.746 ± 0.022	1.201TyrIle: 1.201 ± 0.024	1.034TyrLys: 1.034 ± 0.029	3.029TyrLeu: 3.029 ± 0.045	0.488TyrMet: 0.488 ± 0.018	0.976TyrAsn: 0.976 ± 0.028	1.412TyrPro: 1.412 ± 0.033	1.475TyrGln: 1.475 ± 0.032	1.892TyrArg: 1.892 ± 0.036	1.886TyrSer: 1.886 ± 0.038	1.391TyrThr: 1.391 ± 0.043	1.775TyrVal: 1.775 ± 0.032	0.507TyrTrp: 0.507 ± 0.02	1.067TyrTyr: 1.067 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4607 proteins (1712920 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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