Amino acid dipepetide frequency for Rhodocytophaga rosea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.768AlaAla: 5.768 ± 0.057	0.766AlaCys: 0.766 ± 0.018	3.916AlaAsp: 3.916 ± 0.048	4.177AlaGlu: 4.177 ± 0.045	3.624AlaPhe: 3.624 ± 0.043	5.764AlaGly: 5.764 ± 0.079	1.317AlaHis: 1.317 ± 0.026	5.311AlaIle: 5.311 ± 0.053	4.099AlaLys: 4.099 ± 0.05	6.903AlaLeu: 6.903 ± 0.063	1.662AlaMet: 1.662 ± 0.026	3.481AlaAsn: 3.481 ± 0.049	2.418AlaPro: 2.418 ± 0.039	3.202AlaGln: 3.202 ± 0.038	2.894AlaArg: 2.894 ± 0.038	5.135AlaSer: 5.135 ± 0.06	4.275AlaThr: 4.275 ± 0.066	4.421AlaVal: 4.421 ± 0.045	0.823AlaTrp: 0.823 ± 0.018	2.944AlaTyr: 2.944 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.485CysAla: 0.485 ± 0.016	0.122CysCys: 0.122 ± 0.007	0.324CysAsp: 0.324 ± 0.012	0.399CysGlu: 0.399 ± 0.012	0.437CysPhe: 0.437 ± 0.013	0.565CysGly: 0.565 ± 0.017	0.213CysHis: 0.213 ± 0.011	0.651CysIle: 0.651 ± 0.016	0.451CysLys: 0.451 ± 0.013	0.866CysLeu: 0.866 ± 0.023	0.188CysMet: 0.188 ± 0.009	0.363CysAsn: 0.363 ± 0.015	0.323CysPro: 0.323 ± 0.014	0.323CysGln: 0.323 ± 0.012	0.329CysArg: 0.329 ± 0.011	0.531CysSer: 0.531 ± 0.021	0.45CysThr: 0.45 ± 0.021	0.462CysVal: 0.462 ± 0.014	0.093CysTrp: 0.093 ± 0.007	0.321CysTyr: 0.321 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.417AspAla: 3.417 ± 0.039	0.372AspCys: 0.372 ± 0.013	2.01AspAsp: 2.01 ± 0.031	2.987AspGlu: 2.987 ± 0.04	2.837AspPhe: 2.837 ± 0.043	3.508AspGly: 3.508 ± 0.058	0.866AspHis: 0.866 ± 0.021	3.812AspIle: 3.812 ± 0.045	3.618AspLys: 3.618 ± 0.045	4.514AspLeu: 4.514 ± 0.048	1.127AspMet: 1.127 ± 0.026	2.458AspAsn: 2.458 ± 0.041	1.952AspPro: 1.952 ± 0.029	1.755AspGln: 1.755 ± 0.028	1.98AspArg: 1.98 ± 0.028	2.88AspSer: 2.88 ± 0.042	2.773AspThr: 2.773 ± 0.042	2.849AspVal: 2.849 ± 0.034	0.725AspTrp: 0.725 ± 0.018	2.209AspTyr: 2.209 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.592GluAla: 4.592 ± 0.05	0.334GluCys: 0.334 ± 0.014	2.807GluAsp: 2.807 ± 0.041	4.27GluGlu: 4.27 ± 0.06	2.394GluPhe: 2.394 ± 0.035	3.61GluGly: 3.61 ± 0.046	1.078GluHis: 1.078 ± 0.025	4.292GluIle: 4.292 ± 0.046	5.285GluLys: 5.285 ± 0.059	5.809GluLeu: 5.809 ± 0.054	1.493GluMet: 1.493 ± 0.029	3.5GluAsn: 3.5 ± 0.036	1.905GluPro: 1.905 ± 0.031	2.747GluGln: 2.747 ± 0.036	2.595GluArg: 2.595 ± 0.035	3.171GluSer: 3.171 ± 0.032	3.062GluThr: 3.062 ± 0.038	3.996GluVal: 3.996 ± 0.045	0.779GluTrp: 0.779 ± 0.021	2.279GluTyr: 2.279 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.274PheAla: 3.274 ± 0.036	0.44PheCys: 0.44 ± 0.014	2.542PheAsp: 2.542 ± 0.032	2.757PheGlu: 2.757 ± 0.033	2.415PhePhe: 2.415 ± 0.037	3.144PheGly: 3.144 ± 0.046	0.914PheHis: 0.914 ± 0.02	3.57PheIle: 3.57 ± 0.042	2.68PheLys: 2.68 ± 0.039	4.581PheLeu: 4.581 ± 0.055	1.047PheMet: 1.047 ± 0.019	2.517PheAsn: 2.517 ± 0.034	1.883PhePro: 1.883 ± 0.027	1.667PheGln: 1.667 ± 0.025	1.98PheArg: 1.98 ± 0.03	3.835PheSer: 3.835 ± 0.044	3.525PheThr: 3.525 ± 0.056	2.847PheVal: 2.847 ± 0.04	0.624PheTrp: 0.624 ± 0.019	1.975PheTyr: 1.975 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.271GlyAla: 4.271 ± 0.051	0.639GlyCys: 0.639 ± 0.032	3.061GlyAsp: 3.061 ± 0.054	3.62GlyGlu: 3.62 ± 0.04	3.386GlyPhe: 3.386 ± 0.044	4.69GlyGly: 4.69 ± 0.078	1.158GlyHis: 1.158 ± 0.025	5.429GlyIle: 5.429 ± 0.057	5.395GlyLys: 5.395 ± 0.052	6.267GlyLeu: 6.267 ± 0.062	1.708GlyMet: 1.708 ± 0.027	3.873GlyAsn: 3.873 ± 0.068	1.603GlyPro: 1.603 ± 0.031	2.512GlyGln: 2.512 ± 0.036	2.674GlyArg: 2.674 ± 0.04	4.339GlySer: 4.339 ± 0.058	4.313GlyThr: 4.313 ± 0.091	4.151GlyVal: 4.151 ± 0.057	0.978GlyTrp: 0.978 ± 0.021	2.972GlyTyr: 2.972 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.193HisAla: 1.193 ± 0.023	0.187HisCys: 0.187 ± 0.009	0.756HisAsp: 0.756 ± 0.02	1.019HisGlu: 1.019 ± 0.02	1.129HisPhe: 1.129 ± 0.022	1.171HisGly: 1.171 ± 0.026	0.524HisHis: 0.524 ± 0.018	1.606HisIle: 1.606 ± 0.024	1.064HisLys: 1.064 ± 0.022	2.106HisLeu: 2.106 ± 0.033	0.426HisMet: 0.426 ± 0.015	0.863HisAsn: 0.863 ± 0.018	1.169HisPro: 1.169 ± 0.025	0.98HisGln: 0.98 ± 0.022	0.799HisArg: 0.799 ± 0.018	1.253HisSer: 1.253 ± 0.027	1.399HisThr: 1.399 ± 0.026	1.023HisVal: 1.023 ± 0.022	0.299HisTrp: 0.299 ± 0.012	0.894HisTyr: 0.894 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.621IleAla: 5.621 ± 0.05	0.699IleCys: 0.699 ± 0.026	3.788IleAsp: 3.788 ± 0.045	4.398IleGlu: 4.398 ± 0.05	3.124IlePhe: 3.124 ± 0.038	4.867IleGly: 4.867 ± 0.051	1.654IleHis: 1.654 ± 0.028	5.031IleIle: 5.031 ± 0.048	4.237IleLys: 4.237 ± 0.05	6.519IleLeu: 6.519 ± 0.058	1.251IleMet: 1.251 ± 0.021	3.739IleAsn: 3.739 ± 0.051	3.301IlePro: 3.301 ± 0.041	2.912IleGln: 2.912 ± 0.035	3.335IleArg: 3.335 ± 0.036	5.29IleSer: 5.29 ± 0.053	4.735IleThr: 4.735 ± 0.067	4.182IleVal: 4.182 ± 0.044	0.806IleTrp: 0.806 ± 0.022	2.623IleTyr: 2.623 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.987LysAla: 4.987 ± 0.049	0.297LysCys: 0.297 ± 0.011	3.559LysAsp: 3.559 ± 0.041	5.013LysGlu: 5.013 ± 0.06	2.273LysPhe: 2.273 ± 0.034	4.403LysGly: 4.403 ± 0.052	1.26LysHis: 1.26 ± 0.023	4.534LysIle: 4.534 ± 0.044	4.895LysLys: 4.895 ± 0.057	5.847LysLeu: 5.847 ± 0.062	1.662LysMet: 1.662 ± 0.024	3.613LysAsn: 3.613 ± 0.042	2.767LysPro: 2.767 ± 0.043	3.116LysGln: 3.116 ± 0.043	2.682LysArg: 2.682 ± 0.039	3.66LysSer: 3.66 ± 0.038	3.658LysThr: 3.658 ± 0.04	4.348LysVal: 4.348 ± 0.048	0.78LysTrp: 0.78 ± 0.02	2.574LysTyr: 2.574 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	7.167LeuAla: 7.167 ± 0.065	0.83LeuCys: 0.83 ± 0.02	4.377LeuAsp: 4.377 ± 0.048	5.48LeuGlu: 5.48 ± 0.061	4.811LeuPhe: 4.811 ± 0.053	5.522LeuGly: 5.522 ± 0.058	1.991LeuHis: 1.991 ± 0.03	6.567LeuIle: 6.567 ± 0.06	6.311LeuLys: 6.311 ± 0.06	10.58LeuLeu: 10.58 ± 0.087	2.098LeuMet: 2.098 ± 0.033	4.769LeuAsn: 4.769 ± 0.05	4.491LeuPro: 4.491 ± 0.044	4.811LeuGln: 4.811 ± 0.046	3.787LeuArg: 3.787 ± 0.047	7.275LeuSer: 7.275 ± 0.06	5.933LeuThr: 5.933 ± 0.055	5.652LeuVal: 5.652 ± 0.05	1.208LeuTrp: 1.208 ± 0.033	3.703LeuTyr: 3.703 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.872MetAla: 1.872 ± 0.026	0.137MetCys: 0.137 ± 0.008	1.113MetAsp: 1.113 ± 0.02	1.402MetGlu: 1.402 ± 0.026	0.736MetPhe: 0.736 ± 0.018	1.507MetGly: 1.507 ± 0.027	0.528MetHis: 0.528 ± 0.016	1.403MetIle: 1.403 ± 0.027	1.751MetLys: 1.751 ± 0.029	2.162MetLeu: 2.162 ± 0.032	0.524MetMet: 0.524 ± 0.014	1.19MetAsn: 1.19 ± 0.022	1.094MetPro: 1.094 ± 0.024	1.141MetGln: 1.141 ± 0.024	1.001MetArg: 1.001 ± 0.021	1.271MetSer: 1.271 ± 0.025	0.973MetThr: 0.973 ± 0.022	1.428MetVal: 1.428 ± 0.027	0.193MetTrp: 0.193 ± 0.009	0.766MetTyr: 0.766 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.405AsnAla: 3.405 ± 0.042	0.375AsnCys: 0.375 ± 0.014	2.213AsnAsp: 2.213 ± 0.039	2.8AsnGlu: 2.8 ± 0.035	2.437AsnPhe: 2.437 ± 0.04	3.789AsnGly: 3.789 ± 0.065	0.942AsnHis: 0.942 ± 0.018	3.711AsnIle: 3.711 ± 0.043	3.348AsnLys: 3.348 ± 0.038	4.841AsnLeu: 4.841 ± 0.05	1.096AsnMet: 1.096 ± 0.021	2.903AsnAsn: 2.903 ± 0.051	2.81AsnPro: 2.81 ± 0.041	2.379AsnGln: 2.379 ± 0.034	2.396AsnArg: 2.396 ± 0.034	3.17AsnSer: 3.17 ± 0.05	3.308AsnThr: 3.308 ± 0.049	2.726AsnVal: 2.726 ± 0.036	0.685AsnTrp: 0.685 ± 0.017	2.305AsnTyr: 2.305 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.602ProAla: 3.602 ± 0.053	0.232ProCys: 0.232 ± 0.009	2.638ProAsp: 2.638 ± 0.038	3.035ProGlu: 3.035 ± 0.039	1.984ProPhe: 1.984 ± 0.034	2.825ProGly: 2.825 ± 0.035	0.781ProHis: 0.781 ± 0.019	2.398ProIle: 2.398 ± 0.031	1.979ProLys: 1.979 ± 0.029	3.622ProLeu: 3.622 ± 0.04	0.783ProMet: 0.783 ± 0.021	1.818ProAsn: 1.818 ± 0.029	1.272ProPro: 1.272 ± 0.03	1.668ProGln: 1.668 ± 0.033	1.162ProArg: 1.162 ± 0.02	2.449ProSer: 2.449 ± 0.03	2.108ProThr: 2.108 ± 0.031	3.506ProVal: 3.506 ± 0.041	0.462ProTrp: 0.462 ± 0.015	1.61ProTyr: 1.61 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.733GlnAla: 3.733 ± 0.043	0.209GlnCys: 0.209 ± 0.01	1.776GlnAsp: 1.776 ± 0.025	2.899GlnGlu: 2.899 ± 0.039	1.81GlnPhe: 1.81 ± 0.029	2.505GlnGly: 2.505 ± 0.044	0.875GlnHis: 0.875 ± 0.02	3.093GlnIle: 3.093 ± 0.038	3.002GlnLys: 3.002 ± 0.041	4.401GlnLeu: 4.401 ± 0.053	1.103GlnMet: 1.103 ± 0.025	2.052GlnAsn: 2.052 ± 0.032	1.827GlnPro: 1.827 ± 0.032	2.471GlnGln: 2.471 ± 0.037	1.583GlnArg: 1.583 ± 0.026	2.496GlnSer: 2.496 ± 0.033	2.69GlnThr: 2.69 ± 0.035	3.25GlnVal: 3.25 ± 0.043	0.609GlnTrp: 0.609 ± 0.018	1.726GlnTyr: 1.726 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.356ArgAla: 2.356 ± 0.034	0.239ArgCys: 0.239 ± 0.01	1.734ArgAsp: 1.734 ± 0.032	2.558ArgGlu: 2.558 ± 0.035	2.205ArgPhe: 2.205 ± 0.032	2.077ArgGly: 2.077 ± 0.031	0.786ArgHis: 0.786 ± 0.019	3.342ArgIle: 3.342 ± 0.041	3.258ArgLys: 3.258 ± 0.042	4.175ArgLeu: 4.175 ± 0.048	1.136ArgMet: 1.136 ± 0.023	2.405ArgAsn: 2.405 ± 0.032	1.379ArgPro: 1.379 ± 0.026	1.962ArgGln: 1.962 ± 0.034	1.8ArgArg: 1.8 ± 0.033	2.381ArgSer: 2.381 ± 0.032	2.25ArgThr: 2.25 ± 0.033	2.355ArgVal: 2.355 ± 0.036	0.548ArgTrp: 0.548 ± 0.016	1.825ArgTyr: 1.825 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	4.512SerAla: 4.512 ± 0.053	0.595SerCys: 0.595 ± 0.016	3.115SerAsp: 3.115 ± 0.041	3.371SerGlu: 3.371 ± 0.041	3.584SerPhe: 3.584 ± 0.045	5.093SerGly: 5.093 ± 0.067	1.286SerHis: 1.286 ± 0.025	4.78SerIle: 4.78 ± 0.044	3.873SerLys: 3.873 ± 0.038	6.826SerLeu: 6.826 ± 0.053	1.373SerMet: 1.373 ± 0.026	3.099SerAsn: 3.099 ± 0.049	2.525SerPro: 2.525 ± 0.036	2.839SerGln: 2.839 ± 0.034	2.793SerArg: 2.793 ± 0.037	4.403SerSer: 4.403 ± 0.069	3.784SerThr: 3.784 ± 0.044	4.132SerVal: 4.132 ± 0.047	0.804SerTrp: 0.804 ± 0.019	2.796SerTyr: 2.796 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.547ThrAla: 4.547 ± 0.066	0.42ThrCys: 0.42 ± 0.014	3.373ThrAsp: 3.373 ± 0.04	3.107ThrGlu: 3.107 ± 0.038	3.084ThrPhe: 3.084 ± 0.051	4.833ThrGly: 4.833 ± 0.069	1.302ThrHis: 1.302 ± 0.025	4.466ThrIle: 4.466 ± 0.076	2.985ThrLys: 2.985 ± 0.043	5.944ThrLeu: 5.944 ± 0.051	0.984ThrMet: 0.984 ± 0.023	2.809ThrAsn: 2.809 ± 0.05	2.734ThrPro: 2.734 ± 0.04	2.406ThrGln: 2.406 ± 0.037	2.008ThrArg: 2.008 ± 0.032	4.059ThrSer: 4.059 ± 0.068	3.784ThrThr: 3.784 ± 0.072	3.783ThrVal: 3.783 ± 0.075	0.683ThrTrp: 0.683 ± 0.017	2.564ThrTyr: 2.564 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	4.561ValAla: 4.561 ± 0.035	0.586ValCys: 0.586 ± 0.017	2.931ValAsp: 2.931 ± 0.038	3.704ValGlu: 3.704 ± 0.04	3.131ValPhe: 3.131 ± 0.039	3.786ValGly: 3.786 ± 0.047	1.21ValHis: 1.21 ± 0.022	4.458ValIle: 4.458 ± 0.046	4.263ValLys: 4.263 ± 0.052	5.974ValLeu: 5.974 ± 0.06	1.386ValMet: 1.386 ± 0.028	3.376ValAsn: 3.376 ± 0.043	2.422ValPro: 2.422 ± 0.032	2.395ValGln: 2.395 ± 0.036	2.469ValArg: 2.469 ± 0.033	4.643ValSer: 4.643 ± 0.049	3.531ValThr: 3.531 ± 0.065	4.127ValVal: 4.127 ± 0.051	0.766ValTrp: 0.766 ± 0.02	2.567ValTyr: 2.567 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.782TrpAla: 0.782 ± 0.018	0.095TrpCys: 0.095 ± 0.007	0.626TrpAsp: 0.626 ± 0.02	0.733TrpGlu: 0.733 ± 0.016	0.543TrpPhe: 0.543 ± 0.017	0.75TrpGly: 0.75 ± 0.019	0.307TrpHis: 0.307 ± 0.011	0.893TrpIle: 0.893 ± 0.025	0.915TrpLys: 0.915 ± 0.026	1.365TrpLeu: 1.365 ± 0.028	0.358TrpMet: 0.358 ± 0.013	0.713TrpAsn: 0.713 ± 0.021	0.381TrpPro: 0.381 ± 0.014	0.777TrpGln: 0.777 ± 0.022	0.575TrpArg: 0.575 ± 0.017	0.677TrpSer: 0.677 ± 0.02	0.649TrpThr: 0.649 ± 0.018	0.832TrpVal: 0.832 ± 0.024	0.211TrpTrp: 0.211 ± 0.01	0.46TrpTyr: 0.46 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.757TyrAla: 2.757 ± 0.033	0.323TyrCys: 0.323 ± 0.011	1.992TyrAsp: 1.992 ± 0.033	2.271TyrGlu: 2.271 ± 0.031	2.273TyrPhe: 2.273 ± 0.034	2.632TyrGly: 2.632 ± 0.034	0.868TyrHis: 0.868 ± 0.02	2.762TyrIle: 2.762 ± 0.037	2.517TyrLys: 2.517 ± 0.036	4.058TyrLeu: 4.058 ± 0.049	0.785TyrMet: 0.785 ± 0.02	2.098TyrAsn: 2.098 ± 0.032	1.679TyrPro: 1.679 ± 0.031	2.046TyrGln: 2.046 ± 0.037	1.929TyrArg: 1.929 ± 0.03	2.664TyrSer: 2.664 ± 0.041	2.675TyrThr: 2.675 ± 0.034	2.218TyrVal: 2.218 ± 0.033	0.565TyrTrp: 0.565 ± 0.017	1.888TyrTyr: 1.888 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6909 proteins (2421566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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