Amino acid dipepetide frequency for Alcube virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.827AlaAla: 5.827 ± 2.513
2.28AlaCys: 2.28 ± 0.786
1.52AlaAsp: 1.52 ± 0.939
3.547AlaGlu: 3.547 ± 0.16
2.027AlaPhe: 2.027 ± 1.305
2.534AlaGly: 2.534 ± 0.366
1.267AlaHis: 1.267 ± 0.502
6.334AlaIle: 6.334 ± 0.814
3.547AlaLys: 3.547 ± 3.106
4.56AlaLeu: 4.56 ± 0.901
2.787AlaMet: 2.787 ± 0.821
1.013AlaAsn: 1.013 ± 0.43
2.787AlaPro: 2.787 ± 0.951
1.013AlaGln: 1.013 ± 0.306
4.56AlaArg: 4.56 ± 0.722
2.787AlaSer: 2.787 ± 1.744
3.8AlaThr: 3.8 ± 1.759
4.814AlaVal: 4.814 ± 2.032
0.507AlaTrp: 0.507 ± 0.639
2.534AlaTyr: 2.534 ± 1.003
0.0AlaXaa: 0.0 ± 0.0
Cys
0.507CysAla: 0.507 ± 0.446
0.0CysCys: 0.0 ± 0.0
1.267CysAsp: 1.267 ± 0.49
1.52CysGlu: 1.52 ± 0.697
1.267CysPhe: 1.267 ± 0.709
0.76CysGly: 0.76 ± 0.669
1.013CysHis: 1.013 ± 0.892
1.013CysIle: 1.013 ± 0.722
3.294CysLys: 3.294 ± 0.993
2.027CysLeu: 2.027 ± 0.837
0.253CysMet: 0.253 ± 0.157
0.76CysAsn: 0.76 ± 0.349
1.013CysPro: 1.013 ± 0.343
0.76CysGln: 0.76 ± 0.349
0.507CysArg: 0.507 ± 0.393
3.547CysSer: 3.547 ± 0.957
2.534CysThr: 2.534 ± 0.458
2.787CysVal: 2.787 ± 1.511
0.0CysTrp: 0.0 ± 0.0
1.773CysTyr: 1.773 ± 0.912
0.0CysXaa: 0.0 ± 0.0
Asp
3.04AspAla: 3.04 ± 1.579
1.52AspCys: 1.52 ± 1.338
6.587AspAsp: 6.587 ± 1.122
3.547AspGlu: 3.547 ± 0.678
3.8AspPhe: 3.8 ± 1.292
2.534AspGly: 2.534 ± 0.764
1.267AspHis: 1.267 ± 0.354
3.8AspIle: 3.8 ± 1.278
2.534AspLys: 2.534 ± 0.676
5.32AspLeu: 5.32 ± 0.441
2.28AspMet: 2.28 ± 1.178
2.534AspAsn: 2.534 ± 1.106
2.027AspPro: 2.027 ± 0.626
1.773AspGln: 1.773 ± 0.479
2.28AspArg: 2.28 ± 0.851
3.8AspSer: 3.8 ± 0.894
3.294AspThr: 3.294 ± 0.853
3.04AspVal: 3.04 ± 0.575
0.507AspTrp: 0.507 ± 0.313
1.52AspTyr: 1.52 ± 0.298
0.0AspXaa: 0.0 ± 0.0
Glu
5.32GluAla: 5.32 ± 0.686
1.267GluCys: 1.267 ± 0.785
3.8GluAsp: 3.8 ± 1.465
4.814GluGlu: 4.814 ± 1.122
5.067GluPhe: 5.067 ± 1.471
5.067GluGly: 5.067 ± 1.523
1.013GluHis: 1.013 ± 0.306
2.534GluIle: 2.534 ± 0.367
3.547GluLys: 3.547 ± 0.914
6.334GluLeu: 6.334 ± 1.5
2.28GluMet: 2.28 ± 1.232
1.773GluAsn: 1.773 ± 0.637
2.534GluPro: 2.534 ± 0.471
2.28GluGln: 2.28 ± 0.332
3.547GluArg: 3.547 ± 1.144
1.773GluSer: 1.773 ± 0.338
2.534GluThr: 2.534 ± 1.116
5.32GluVal: 5.32 ± 0.676
0.507GluTrp: 0.507 ± 0.153
1.773GluTyr: 1.773 ± 0.889
0.0GluXaa: 0.0 ± 0.0
Phe
2.534PheAla: 2.534 ± 2.408
0.76PheCys: 0.76 ± 0.349
2.28PheAsp: 2.28 ± 0.754
2.787PheGlu: 2.787 ± 0.795
2.027PhePhe: 2.027 ± 0.946
2.28PheGly: 2.28 ± 0.332
1.013PheHis: 1.013 ± 0.343
2.027PheIle: 2.027 ± 0.859
2.534PheLys: 2.534 ± 0.762
3.547PheLeu: 3.547 ± 1.137
1.267PheMet: 1.267 ± 0.354
2.787PheAsn: 2.787 ± 0.481
2.027PhePro: 2.027 ± 0.508
1.267PheGln: 1.267 ± 0.807
2.28PheArg: 2.28 ± 1.032
4.56PheSer: 4.56 ± 0.722
2.787PheThr: 2.787 ± 0.84
3.8PheVal: 3.8 ± 0.762
0.76PheTrp: 0.76 ± 0.346
0.253PheTyr: 0.253 ± 0.223
0.0PheXaa: 0.0 ± 0.0
Gly
3.547GlyAla: 3.547 ± 0.57
2.027GlyCys: 2.027 ± 0.559
2.28GlyAsp: 2.28 ± 1.046
2.28GlyGlu: 2.28 ± 0.645
2.787GlyPhe: 2.787 ± 0.337
4.054GlyGly: 4.054 ± 1.304
2.28GlyHis: 2.28 ± 0.559
3.547GlyIle: 3.547 ± 0.969
2.534GlyLys: 2.534 ± 0.619
5.32GlyLeu: 5.32 ± 2.08
1.013GlyMet: 1.013 ± 0.317
2.534GlyAsn: 2.534 ± 1.419
2.787GlyPro: 2.787 ± 0.87
1.52GlyGln: 1.52 ± 0.576
3.547GlyArg: 3.547 ± 1.171
6.587GlySer: 6.587 ± 1.6
3.547GlyThr: 3.547 ± 0.719
4.56GlyVal: 4.56 ± 0.198
1.267GlyTrp: 1.267 ± 0.785
1.267GlyTyr: 1.267 ± 0.709
0.0GlyXaa: 0.0 ± 0.0
His
1.267HisAla: 1.267 ± 0.785
1.013HisCys: 1.013 ± 0.306
1.013HisAsp: 1.013 ± 0.565
1.013HisGlu: 1.013 ± 0.306
0.76HisPhe: 0.76 ± 0.346
2.027HisGly: 2.027 ± 0.545
0.253HisHis: 0.253 ± 0.223
1.52HisIle: 1.52 ± 0.429
1.013HisLys: 1.013 ± 0.343
2.027HisLeu: 2.027 ± 0.545
0.76HisMet: 0.76 ± 0.214
0.507HisAsn: 0.507 ± 0.153
1.267HisPro: 1.267 ± 0.706
1.267HisGln: 1.267 ± 0.488
2.027HisArg: 2.027 ± 0.708
2.28HisSer: 2.28 ± 0.332
0.76HisThr: 0.76 ± 0.349
1.773HisVal: 1.773 ± 0.717
0.253HisTrp: 0.253 ± 0.157
2.027HisTyr: 2.027 ± 0.708
0.0HisXaa: 0.0 ± 0.0
Ile
3.294IleAla: 3.294 ± 1.577
2.027IleCys: 2.027 ± 0.434
3.547IleAsp: 3.547 ± 0.849
4.054IleGlu: 4.054 ± 0.866
2.787IlePhe: 2.787 ± 1.149
4.56IleGly: 4.56 ± 0.804
2.027IleHis: 2.027 ± 0.611
3.8IleIle: 3.8 ± 1.454
1.773IleLys: 1.773 ± 0.698
8.107IleLeu: 8.107 ± 1.206
1.267IleMet: 1.267 ± 0.488
3.04IleAsn: 3.04 ± 0.947
1.773IlePro: 1.773 ± 0.889
2.027IleGln: 2.027 ± 0.889
3.294IleArg: 3.294 ± 1.452
5.32IleSer: 5.32 ± 1.096
2.28IleThr: 2.28 ± 0.786
4.054IleVal: 4.054 ± 0.52
1.013IleTrp: 1.013 ± 0.306
1.013IleTyr: 1.013 ± 0.626
0.0IleXaa: 0.0 ± 0.0
Lys
4.307LysAla: 4.307 ± 0.679
1.52LysCys: 1.52 ± 0.458
3.547LysAsp: 3.547 ± 0.719
2.534LysGlu: 2.534 ± 0.367
2.027LysPhe: 2.027 ± 1.041
4.307LysGly: 4.307 ± 1.122
0.507LysHis: 0.507 ± 0.313
4.307LysIle: 4.307 ± 1.387
4.054LysLys: 4.054 ± 0.513
5.827LysLeu: 5.827 ± 1.61
2.027LysMet: 2.027 ± 0.889
1.267LysAsn: 1.267 ± 0.49
2.534LysPro: 2.534 ± 1.0
2.027LysGln: 2.027 ± 0.545
1.267LysArg: 1.267 ± 0.5
3.547LysSer: 3.547 ± 1.669
3.294LysThr: 3.294 ± 1.772
4.56LysVal: 4.56 ± 0.198
1.773LysTrp: 1.773 ± 0.55
2.787LysTyr: 2.787 ± 0.816
0.0LysXaa: 0.0 ± 0.0
Leu
5.827LeuAla: 5.827 ± 1.024
2.027LeuCys: 2.027 ± 0.686
5.827LeuAsp: 5.827 ± 1.078
6.334LeuGlu: 6.334 ± 0.839
4.814LeuPhe: 4.814 ± 0.83
2.787LeuGly: 2.787 ± 0.481
3.294LeuHis: 3.294 ± 1.121
7.347LeuIle: 7.347 ± 1.179
5.32LeuLys: 5.32 ± 2.469
7.347LeuLeu: 7.347 ± 1.752
4.56LeuMet: 4.56 ± 0.92
4.054LeuAsn: 4.054 ± 0.203
3.04LeuPro: 3.04 ± 1.437
2.28LeuGln: 2.28 ± 0.609
4.814LeuArg: 4.814 ± 2.357
8.107LeuSer: 8.107 ± 1.297
5.32LeuThr: 5.32 ± 1.562
5.574LeuVal: 5.574 ± 2.102
0.253LeuTrp: 0.253 ± 0.417
3.8LeuTyr: 3.8 ± 0.727
0.0LeuXaa: 0.0 ± 0.0
Met
2.027MetAla: 2.027 ± 1.231
0.76MetCys: 0.76 ± 0.214
2.027MetAsp: 2.027 ± 0.94
2.28MetGlu: 2.28 ± 0.829
1.267MetPhe: 1.267 ± 0.338
2.28MetGly: 2.28 ± 0.829
1.013MetHis: 1.013 ± 0.648
1.52MetIle: 1.52 ± 0.655
2.027MetLys: 2.027 ± 0.434
2.787MetLeu: 2.787 ± 0.586
1.52MetMet: 1.52 ± 0.792
1.52MetAsn: 1.52 ± 0.639
1.52MetPro: 1.52 ± 0.298
0.76MetGln: 0.76 ± 0.47
2.027MetArg: 2.027 ± 0.428
3.8MetSer: 3.8 ± 0.957
1.773MetThr: 1.773 ± 0.637
1.267MetVal: 1.267 ± 0.488
0.0MetTrp: 0.0 ± 0.0
0.507MetTyr: 0.507 ± 0.313
0.0MetXaa: 0.0 ± 0.0
Asn
2.28AsnAla: 2.28 ± 0.645
0.507AsnCys: 0.507 ± 0.446
2.534AsnAsp: 2.534 ± 0.781
2.027AsnGlu: 2.027 ± 0.611
2.28AsnPhe: 2.28 ± 0.852
1.773AsnGly: 1.773 ± 0.55
1.013AsnHis: 1.013 ± 0.306
1.267AsnIle: 1.267 ± 0.335
2.027AsnLys: 2.027 ± 0.368
4.307AsnLeu: 4.307 ± 0.425
1.013AsnMet: 1.013 ± 0.343
1.267AsnAsn: 1.267 ± 0.49
2.534AsnPro: 2.534 ± 1.003
1.52AsnGln: 1.52 ± 0.429
1.267AsnArg: 1.267 ± 0.338
3.04AsnSer: 3.04 ± 0.682
1.013AsnThr: 1.013 ± 0.521
3.04AsnVal: 3.04 ± 0.95
0.507AsnTrp: 0.507 ± 0.313
1.267AsnTyr: 1.267 ± 0.49
0.0AsnXaa: 0.0 ± 0.0
Pro
2.534ProAla: 2.534 ± 1.75
1.013ProCys: 1.013 ± 1.166
2.787ProAsp: 2.787 ± 0.756
4.054ProGlu: 4.054 ± 1.145
1.773ProPhe: 1.773 ± 0.389
2.787ProGly: 2.787 ± 1.036
1.013ProHis: 1.013 ± 0.343
1.773ProIle: 1.773 ± 0.55
1.52ProLys: 1.52 ± 0.458
5.067ProLeu: 5.067 ± 0.698
1.267ProMet: 1.267 ± 0.502
2.027ProAsn: 2.027 ± 0.771
0.76ProPro: 0.76 ± 0.47
1.267ProGln: 1.267 ± 0.338
2.027ProArg: 2.027 ± 1.466
3.547ProSer: 3.547 ± 0.16
1.267ProThr: 1.267 ± 0.338
3.04ProVal: 3.04 ± 0.664
1.267ProTrp: 1.267 ± 0.624
1.013ProTyr: 1.013 ± 0.43
0.0ProXaa: 0.0 ± 0.0
Gln
1.773GlnAla: 1.773 ± 0.715
0.76GlnCys: 0.76 ± 0.349
0.76GlnAsp: 0.76 ± 0.214
2.787GlnGlu: 2.787 ± 1.074
1.013GlnPhe: 1.013 ± 0.313
2.027GlnGly: 2.027 ± 0.946
1.013GlnHis: 1.013 ± 0.626
2.787GlnIle: 2.787 ± 0.892
2.534GlnLys: 2.534 ± 0.98
2.28GlnLeu: 2.28 ± 1.009
1.013GlnMet: 1.013 ± 0.343
0.253GlnAsn: 0.253 ± 0.223
1.52GlnPro: 1.52 ± 0.792
0.76GlnGln: 0.76 ± 0.214
1.52GlnArg: 1.52 ± 1.338
2.787GlnSer: 2.787 ± 0.87
1.267GlnThr: 1.267 ± 0.488
1.52GlnVal: 1.52 ± 0.639
0.0GlnTrp: 0.0 ± 0.0
0.76GlnTyr: 0.76 ± 0.349
0.0GlnXaa: 0.0 ± 0.0
Arg
2.534ArgAla: 2.534 ± 0.366
1.013ArgCys: 1.013 ± 0.565
4.307ArgAsp: 4.307 ± 0.925
4.307ArgGlu: 4.307 ± 1.083
1.52ArgPhe: 1.52 ± 0.664
3.294ArgGly: 3.294 ± 0.709
0.507ArgHis: 0.507 ± 0.313
3.547ArgIle: 3.547 ± 0.59
2.28ArgLys: 2.28 ± 0.461
4.56ArgLeu: 4.56 ± 1.473
1.267ArgMet: 1.267 ± 0.624
2.027ArgAsn: 2.027 ± 0.667
3.04ArgPro: 3.04 ± 0.431
1.773ArgGln: 1.773 ± 0.338
2.787ArgArg: 2.787 ± 0.481
6.334ArgSer: 6.334 ± 2.384
3.547ArgThr: 3.547 ± 0.792
4.054ArgVal: 4.054 ± 0.821
1.52ArgTrp: 1.52 ± 0.449
0.76ArgTyr: 0.76 ± 0.47
0.0ArgXaa: 0.0 ± 0.0
Ser
5.32SerAla: 5.32 ± 0.687
3.547SerCys: 3.547 ± 2.134
4.054SerAsp: 4.054 ± 0.866
5.067SerGlu: 5.067 ± 0.534
3.547SerPhe: 3.547 ± 0.59
8.107SerGly: 8.107 ± 1.779
3.04SerHis: 3.04 ± 0.814
4.814SerIle: 4.814 ± 0.931
6.334SerLys: 6.334 ± 1.689
8.361SerLeu: 8.361 ± 0.926
2.534SerMet: 2.534 ± 1.276
1.267SerAsn: 1.267 ± 0.354
4.56SerPro: 4.56 ± 0.867
1.013SerGln: 1.013 ± 0.626
5.067SerArg: 5.067 ± 1.563
10.894SerSer: 10.894 ± 2.561
5.574SerThr: 5.574 ± 1.215
5.32SerVal: 5.32 ± 0.811
0.76SerTrp: 0.76 ± 0.214
1.773SerTyr: 1.773 ± 0.572
0.0SerXaa: 0.0 ± 0.0
Thr
2.28ThrAla: 2.28 ± 0.643
2.027ThrCys: 2.027 ± 1.13
2.787ThrAsp: 2.787 ± 0.614
3.04ThrGlu: 3.04 ± 0.595
2.534ThrPhe: 2.534 ± 0.458
2.787ThrGly: 2.787 ± 0.513
0.76ThrHis: 0.76 ± 0.349
3.04ThrIle: 3.04 ± 0.889
3.547ThrLys: 3.547 ± 1.456
6.841ThrLeu: 6.841 ± 1.469
1.013ThrMet: 1.013 ± 0.521
2.787ThrAsn: 2.787 ± 0.456
3.04ThrPro: 3.04 ± 0.95
1.52ThrGln: 1.52 ± 0.458
4.307ThrArg: 4.307 ± 0.424
6.334ThrSer: 6.334 ± 1.079
3.294ThrThr: 3.294 ± 0.453
3.294ThrVal: 3.294 ± 0.902
0.76ThrTrp: 0.76 ± 0.878
0.76ThrTyr: 0.76 ± 0.428
0.0ThrXaa: 0.0 ± 0.0
Val
3.547ValAla: 3.547 ± 1.14
2.534ValCys: 2.534 ± 1.293
4.054ValAsp: 4.054 ± 0.513
4.054ValGlu: 4.054 ± 1.393
1.267ValPhe: 1.267 ± 0.785
2.787ValGly: 2.787 ± 0.607
1.52ValHis: 1.52 ± 0.458
3.8ValIle: 3.8 ± 0.731
5.067ValLys: 5.067 ± 1.197
4.054ValLeu: 4.054 ± 0.91
3.04ValMet: 3.04 ± 0.756
3.294ValAsn: 3.294 ± 0.74
1.52ValPro: 1.52 ± 0.692
3.04ValGln: 3.04 ± 0.55
5.32ValArg: 5.32 ± 1.093
8.107ValSer: 8.107 ± 1.914
5.067ValThr: 5.067 ± 1.639
6.334ValVal: 6.334 ± 1.473
0.76ValTrp: 0.76 ± 0.214
1.013ValTyr: 1.013 ± 0.512
0.0ValXaa: 0.0 ± 0.0
Trp
0.507TrpAla: 0.507 ± 0.313
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.76TrpGlu: 0.76 ± 0.428
0.507TrpPhe: 0.507 ± 0.153
1.013TrpGly: 1.013 ± 0.751
0.0TrpHis: 0.0 ± 0.0
1.267TrpIle: 1.267 ± 0.783
0.253TrpLys: 0.253 ± 0.157
1.267TrpLeu: 1.267 ± 0.49
0.507TrpMet: 0.507 ± 0.313
0.76TrpAsn: 0.76 ± 0.349
0.507TrpPro: 0.507 ± 0.393
0.253TrpGln: 0.253 ± 0.223
1.013TrpArg: 1.013 ± 0.804
1.267TrpSer: 1.267 ± 0.338
2.28TrpThr: 2.28 ± 0.461
0.253TrpVal: 0.253 ± 0.157
0.253TrpTrp: 0.253 ± 0.157
0.253TrpTyr: 0.253 ± 0.157
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.773TyrAla: 1.773 ± 0.479
0.0TyrCys: 0.0 ± 0.0
2.027TyrAsp: 2.027 ± 1.804
2.28TyrGlu: 2.28 ± 0.625
0.507TyrPhe: 0.507 ± 0.313
1.52TyrGly: 1.52 ± 0.424
1.013TyrHis: 1.013 ± 0.343
1.013TyrIle: 1.013 ± 0.313
2.28TyrLys: 2.28 ± 0.643
2.787TyrLeu: 2.787 ± 0.357
0.76TyrMet: 0.76 ± 0.47
1.013TyrAsn: 1.013 ± 0.626
1.013TyrPro: 1.013 ± 0.873
1.013TyrGln: 1.013 ± 0.851
1.52TyrArg: 1.52 ± 0.449
2.534TyrSer: 2.534 ± 0.98
1.52TyrThr: 1.52 ± 0.458
2.027TyrVal: 2.027 ± 0.686
0.253TyrTrp: 0.253 ± 0.157
1.013TyrTyr: 1.013 ± 0.565
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski